National Institute on Aging
National Institutes of Health 		NIA Home
Research Programs
Intramural
Laboratory of Clinical Investigation
Recent Publications

  1. Bhatia P, Kolinski M, Moaddel R, Jozwiak K, Wainer IW. Determination and modelling of stereoselective interactions of ligands with drug transporters: A key dimension in the understanding of drug disposition. Xenobiotica. 2008;38(7):656-675.

  2. Cardoso CL, de Moraes MC, Carvalho Guido RV, Oliva G, Andricopulo AD, Wainer IW, Cass QB. The development of an immobilized enzyme reactor containing glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma cruzi: the effect of species' specific differences on the immobilization. Analyst. 2008;133(1):93-99.

  3. Charles C, Yuskavage J, Carlson O, John M, Tagalicud AS, Maggio M, Muller DC, Egan J, Basaria S. Effects of high-dose isoflavones on metabolic and inflammatory markers in healthy postmenopausal women. Menopause. 2008 Oct. [Epub ahead of print].

  4. Chia CW, Egan JM. Special Features: Incretin-based therapies in type 2 diabetes mellitus. J Clin Endocrinol Metab. 2008;93(10):3703-3716.

  5. Dotson CD, Zhang L, Xu H, Shin YK, Vigues S, Ott SH, Elson AE, Choi HJ, Shaw H, Egan JM, Mitchell BD, Li X, Steinle NI, Munger SD. Bitter taste receptors influence glucose homeostasis. PLoS ONE. 2008;3(12):e3974.

  6. Egan JM, Margolskee RF. Taste cells of the gut and gastrointestinal chemosensation. Mol Interv. 2008;8(2):78-81.

  7. Elahi D, Egan JM, Shannon RP, Meneilly GS, Khatri A, Habener JF, Andersen DK. GLP-1 (9-36) amide, cleavage product of GLP-1 (7-36) amide, is a glucoregulatory peptide. Obesity (Silver Spring). 2008;16(7):1501-1509.

  8. Jozwiak K, Moaddel R, Ravichandran S, Plazinska A, Kozak J, Patel S, Yamaguchi R, Wainer IW. Exploring enantiospecific ligand-protein interactions using cellular membrane affinity chromatography: Chiral recognition as a dynamic process. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 August. [Epub ahead of print].

  9. Kim HS, Wainer IW. Rapid analysis of the interactions between drugs and human serum albumin (HSA) using high-performance affinity chromatography (HPAC). J Chromatogr B Analyt Technol Biomed Life Sci. 2008;870(1):22-26.

  10. Kim W, Egan JM. The role of incretins in glucose homeostasis and diabetes treatment. Pharmacol Rev. 2008;60(4):470-512.

  11. Kitabatake T, Moaddel R, Cole R, Gandhari M, Frazier C, Hartenstein J, Rosenberg A, Bernier M, Wainer IW. Characterization of a multiple ligand-gated ion channel cellular membrane affinity chromatography column and identification of endogenously expressed receptors in astrocytoma cell lines. Anal Chem. 2008 Oct. [Epub ahead of print].

  12. Lao QZ, Kobrinsky E, Harry JB, Ravindran A, Soldatov NM. New determinant for the Cavbeta 2-subunit modulation of the Cav1.2 calcium channel. J Biol Chem. 2008;283(23):15577-15588.

  13. Marszall MP, Moaddel R, Jozwiak K, Bernier M, Wainer IW. Initial synthesis and characterization of an immobilized heat shock protein 90 column for online determination of binding affinities. Anal Biochem. 2008;373(2):313-321.

  14. Marszall MP, Moaddel R, Kole S, Gandhari M, Bernier M, Wainer IW. Ligand and protein fishing with heat shock protein 90 coated magnetic beads. Anal Chem. 2008;80(19):7571-7575.

  15. Martin B, Golden E, Carlson OD, Egan JM, Mattson MP, Maudsley S. Caloric restriction: Impact upon pituitary function and reproduction. Ageing Res Rev. 2008;7(3):209-224.

  16. Martin B, Golden E, Carlson OD, Pistell P, Zhou J, Kim W, Frank BP, Thomas S, Chadwick WA, Greig NH, Bates GP, Sathasivam K, Bernier M, Maudsley S, Mattson MP, Egan JM. Exendin-4 improves glycemic control, ameliorates brain and pancreatic pathologies and extends survival in a mouse model of Huntington's disease. Diabetes. 2008 Nov. [Epub ahead of print].

  17. Martin B, Golden E, Keselman A, Stone M, Mattson MP, Egan JM, Maudsley S. Therapeutic perspectives for the treatment of Huntington's disease: treating the whole body. Histol Histopathol. 2008;23(2):237-250.

  18. Martin B, Pearson M, Brenneman R, Golden E, Keselman A, Iyun T, Carlson OD, Egan JM, Becker KG, Wood W 3rd, Prabhu V, de Cabo R, Maudsley S, Mattson MP. Conserved and differential effects of dietary energy intake on the hippocampal transcriptomes of females and males. PLoS ONE. 2008;3(6):e2398.

  19. Metter EJ, Windham BG, Maggio M, Simonsick EM, Ling SM, Egan JM, Ferrucci L. Glucose and insulin measurements from the glucose tolerance test and mortality prediction. Diabetes Care. 2008;31(5):1026-1030.

  20. Moaddel R, Oliveira RV, Kimura T, Hyppolite P, Juhaszova M, Xiao Y, Kellar KJ, Bernier M, Wainer IW. Initial synthesis and characterization of an alpha7 nicotinic receptor cellular membrane affinity chromatography column: effect of receptor subtype and cell type. Anal Chem. 2008;80(1):48-54.

  21. Pearson KJ, Lewis KN, Price NL, Chang JW, Perez E, Cascajo MV, Tamashiro KL, Poosala S, Csiszar A, Ungvari Z, Kensler TW, Yamamoto M, Egan JM, Longo DL, Ingram DK, Navas P, de Cabo R. Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc Natl Acad Sci USA. 2008;105(7):2325-2330.

  22. Ramaswamy S, Gurkan I, Sharma B, Cascio B, Fishbein KW, Spencer RG. Assessment of tissue repair in full thickness chondral defects in the rabbit using magnetic resonance imaging transverse relaxation measurements. J Biomed Mater Res B Appl Biomater. 2008;86B(2):375-380.

  23. Ramaswamy S, Uluer MC, Leen S, Bajaj P, Fishbein KW, Spencer RG. Noninvasive assessment of glycosaminoglycan production in injectable tissue-engineered cartilage constructs using magnetic resonance imaging. Tissue Eng Part C Methods. 2008;14(3):243-249.

  24. Ravindran A, Lao QZ, Harry JB, Abrahimi P, Kobrinsky E, Soldatov NM. Calmodulin-dependent gating of Ca(v)1.2 calcium channels in the absence of Ca(v)beta subunits. Proc Natl Acad Sci USA. 2008;105(23):8154-8159.

  25. Shin YK, Martin B, Golden E, Dotson CD, Maudsley S, Kim W, Jang HJ, Mattson MP, Drucker DJ, Egan JM, Munger SD. Modulation of taste sensitivity by GLP-1 signaling. J Neurochem. 2008;106(1):455-463.

  26. Siluk D, Kim HS, Cole T, Wainer IW. HPLC-electrospray mass spectrometric assay for the determination of (R,R)-fenoterol in rat plasma. J Pharm Biomed Anal. 2008;48(3):960-964.

  27. Stranahan AM, Arumugam TV, Cutler RG, Lee K, Egan JM, Mattson MP. Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons. Nat Neurosci. 2008;11(3):309-317.

  28. Stranahan AM, Norman ED, Lee K, Cutler RG, Telljohann RS, Egan JM, Mattson MP. Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats. Hippocampus. 2008;18(11):1085-1088.

  29. Wang Y, Xie Y, Bernier M, Wainer IW. Determination of free and protein-bound glutathione in HepG2 cells using capillary electrophoresis with laser-induced fluorescence detection. J Chromatogr A. 2008 June. [Epub ahead of print].

  30. Xie Y, Kole S, Precht P, Pazin MJ, Bernier M. S-glutathionylation impairs STAT3 activation and signaling. Endocrinology. 2008 Nov. [Epub ahead of print].

  31. Basaria S, Muller DC, Carducci MA, Egan J, Dobs AS. Relation between duration of androgen deprivation therapy and degree of insulin resistance in men with prostate cancer. Arch Intern Med. 2007;167(6):612-613.

  32. Bi X, Yang X, Bostrom MP, Bartusik D, Ramaswamy S, Fishbein KW, Spencer RG, Camacho NP. Fourier transform infrared imaging and MR microscopy studies detect compositional and structural changes in cartilage in a rabbit model of osteoarthritis. Anal Bioanal Chem. 2007;387(5):1601-1612.

  33. Doyle ME, Egan JM. Mechanisms of action of glucagon-like peptide 1 in the pancreas. Pharmacol Ther. 2007;113(3):546-593.

  34. Fishbein KW, Canuto HC, Bajaj P, Camacho NP, Spencer RG. Optimal methods for the preservation of cartilage samples in MRI and correlative biochemical studies. Magn Reson Med. 2007;57(5):866-873.

  35. Fishbein KW, Gluzband YA, Kaku M, Ambia-Sobhan H, Shapses SA, Yamauchi M, Spencer RG. Effects of formalin fixation and collagen cross-linking on T(2) and magnetization transfer in bovine nasal cartilage. Magn Reson Med. 2007;57(6):1000-1011.

  36. Galban CJ, Ling SM, Galban CJ, Taub DD, Gurkan I, Fishbein KW, Spencer RG. Effects of knee injection on skeletal muscle metabolism and contractile force in rats. Osteoarthritis Cartilage. 2007;15(5):550-558.

  37. Galban CJ, Spencer RG. Measurement of spin-lattice relaxation times and chemical exchange rates in multiple-site systems using progressive saturation. Magn Reson Med. 2007;58(1):8-18.

  38. Hilmer SN, Mager DE, Simonsick EM, Cao Y, Ling SM, Windham BG, Harris TB, Hanlon JT, Rubin SM, Shorr RI, Bauer DC, Abernethy DR. A drug burden index to define the functional burden of medications in older people. Arch Intern Med. 2007;167(8):781-787.

  39. Jamieson HA, Hilmer SN, Cogger VC, Warren A, Cheluvappa R, Abernethy DR, Everitt AV, Fraser R, de Cabo R, Le Couteur DG. Caloric restriction reduces age-related pseudocapillarization of the hepatic sinusoid. Exp Gerontol. 2007;42(4):374-378.

  40. Jozwiak K, Khalid C, Tanga MJ, Berzetei-Gurske I, Jimenez L, Kozocas JA, Woo A, Zhu W, Xiao RP, Abernethy DR, Wainer IW. Comparative molecular field analysis of the binding of the stereoisomers of fenoterol and fenoterol derivatives to the beta(2) adrenergic receptor. J Med Chem. 2007;50(12):2903-2915.

  41. Laouar L, Fishbein K, McGann LE, Horton WE, Spencer RG, Jomha NM. Cryopreservation of porcine articular cartilage: MRI and biochemical results after different freezing protocols. Cryobiology. 2007;54(1):36-43.

  42. Ling SM, Conwit RA, Talbot L, Shermack M, Wood JE, Dredge EM, Weeks MJ, Abernethy DR, Metter EJ. Electromyographic patterns suggest changes in motor unit physiology associated with early osteoarthritis of the knee. Osteoarthritis Cartilage. 2007 May; [Epub ahead of print].

  43. Mager DE, Abernethy DR. Use of wavelet and fast Fourier transforms in pharmacodynamics. J Pharmacol Exp Ther. 2007;321(2):423-430.

  44. Mager DE, Kobrinsky E, Masoudieh A, Maltsev AV, Abernethy DR, Soldatov NM. Analysis of functional signaling domains from fluorescence imaging and the 2-D continuous wavelet transform. Biophys J. 2007 June; [Epub ahead of print].

  45. Maggio M, Lauretani F, Ceda GP, Bandinelli S, Basaria S, Paolisso G, Ble A, Egan JM, Metter EJ, Abbatecola AM, Zuliani G, Ruggiero C, Valenti G, Guralnik JM, Ferrucci L. Association of hormonal dysregulation with metabolic syndrome in older women: data from the InCHIANTI study. Am J Physiol Endocrinol Metab. 2007;292(1):E353-E358.

  46. Martin B, Pearson M, Kebejian L, Golden E, Keselman A, Bender M, Carlson O, Egan J, Ladenheim B, Cadet JL, Becker KG, Wood W, Duffy K, Vinayakumar P, Maudsley S, Mattson MP. Sex-dependent metabolic, neuroendocrine and cognitive responses to dietary energy restriction and excess. Endocrinology. 2007 June; [Epub ahead of print].

  47. Moaddel R, Calleri E, Massolini G, Frazier CR, Wainer IW. The synthesis and initial characterization of an immobilized purinergic receptor (P2Y1) liquid chromatography stationary phase for online screening. Anal Biochem. 2007;364(2):216-218.

  48. Moaddel R, Jozwiak K, Wainer IW. Allosteric modifiers of neuronal nicotinic acetylcholine receptors: New methods, new opportunities. Med Res Rev. 2007 Jan.; [Epub ahead of print].

  49. Moaddel R, Marszall MP, Bighi F, Yang Q, Duan X, Wainer IW. Automated ligand fishing using human serum albumin-coated magnetic beads. Anal Chem. 2007;79(14):5414-5417.

  50. Moaddel R, Ravichandran S, Bighi F, Yamaguchi R, Wainer IW. Pharmacophore modelling of stereoselective binding to the human organic cation transporter (hOCT1). Br J Pharmacol. 2007 June; [Epub ahead of print].

  51. Moaddel R, Wainer IW. Conformational mobility of immobilized proteins. J Pharm Biomed Anal. 2007;43(2):399-406

  52. Rodriguez A, Muller DC, Metter EJ, Maggio M, Harman SM, Blackman MR, Andres R. Aging, Androgens, and the metabolic syndrome in a longitudinal study of aging. J Clin Endocrinol Metab. 2007 June; [Epub ahead of print].

  53. Rodriguez-Rosas ME, Lofwall MR, Strain EC, Siluk D, Wainer IW. Simultaneous determination of buprenorphine, norbuprenorphine and the enantiomers of methadone and its metabolite (EDDP) in human plasma by liquid chromatography/mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2007;850(1-2):538-543.

  54. Siluk D, Oliveira RV, Esther-Rodriguez-Rosas M, Ling S, Bos A, Ferrucci L, Wainer IW. A validated liquid chromatography method for the simultaneous determination of vitamins A and E in human plasma. J Pharm Biomed Anal. 2007 Apr.; [Epub ahead of print].

  55. Velan SS, Durst C, Lemieux SK, Raylman RR, Sridhar R, Spencer RG, Hobbs GR, Thomas MA. Investigation of muscle lipid metabolism by localized one- and two-dimensional MRS techniques using a clinical 3T MRI/MRS scanner. J Magn Reson Imaging. 2007;25(1):192-199.

  56. Velan SS, Lemieux SK, Raylman RR, Boling W, Hobbs GR, Spencer RG, Sridhar R, Kuppusamy P, Thomas MA. Detection of cerebral metabolites by single-voxel-based PRESS and COSY techniques at 3T. J Magn Reson Imaging. 2007;26(2):405-409.

  57. Velan SS, Ramamurthy S, Ainala S, Durst C, Lemieux SK, Raylman RR, Spencer RG, Thomas MA. Implementation and validation of localized constant-time correlated spectroscopy (LCT-COSY) on a clinical 3T MRI scanner for investigation of muscle metabolism. J Magn Reson Imaging. 2007;26(2):410-417.

  58. Zhou J, Livak MF, Bernier M, Muller DC, Carlson OD, Elahi D, Maudsley S, Egan JM. Ubiquitination is involved in glucose-mediated down-regulation of GIP receptors in islets. Am J Physiol Endocrinol Metab. 2007;293(2):E538-E547.

  59. Basaria S, Muller DC, Carducci MA, Egan J, Dobs AS. Hyperglycemia and insulin resistance in men with prostate carcinoma who receive androgen-deprivation therapy. Cancer. 2006;106(3):581-588.

  60. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006;444(7117):337-342.

  61. Beigi F, Bertucci C, Zhu W, Chakir K, Wainer IW, Xiao RP, Abernethy DR. Enantioselective separation and online affinity chromatographic characterization of R,R- and S,S-fenoterol. Chirality. 2006;18(10):822-827.

  62. Bernier M, Kwon YK, Pandey SK, Zhu TN, Zhao RJ, Maciuk A, He HJ, Decabo R, Kole S. Binding of manumycin A inhibits Ik B kinase b activity. J Biol Chem. 2006;281(5):2551-2561.

  63. Bernstein ML, Devidas M, Lafreniere D, Souid AK, Meyers PA, Gebhardt M, Stine K, Nicholas R, Perlman EJ, Dubowy R, Wainer IW, Dickman PS, Link MP, Goorin A, Grier HE; Pediatric Oncology Group; Children's Cancer Group Phase II Study 9457; Children's Oncology Group. Intensive therapy with growth factor support for patients with Ewing tumor metastatic at diagnosis: Pediatric Oncology Group/Children's Cancer Group Phase II Study 9457--a report from the Children's Oncology Group. J Clin Oncol. 2006;24(1):152-159.

  64. Braga-Basaria M, Dobs AS, Muller DC, Carducci MA, John M, Egan J, Basaria S. Metabolic syndrome in men with prostate cancer undergoing long-term androgen-deprivation therapy. J Clin Oncol. 2006;24(24):3979-3983.

  65. Canuto HC, Oliveira ML, Fishbein KW, Spencer RG. Tendon and neurovascular bundle displacement in the palm with hand flexion and extension: An MRI and gross anatomy correlative study. J Magn Reson Imaging. 2006;23(5):742-746.

  66. Cardoso CL, Lima VV, Zottis A, Oliva G, Andricopulo AD, Wainer IW, Moaddel R, Cass QB. Development and characterization of an immobilized enzyme reactor (IMER) based on human glyceraldehyde-3-phosphate dehydrogenase for on-line enzymatic studies. J Chromatogr A. 2006;1120(1-2):151-157.

  67. Diabetes Prevention Program Research Group; Crandall J, Schade D, Ma Y, Fujimoto WY, Barrett-Connor E, Fowler S, Dagogo-Jack S, Andres R. The influence of age on the effects of lifestyle modification and metformin in prevention of diabetes. J Gerontol A Biol Sci Med Sci. 2006;61(10):1075-1081.

  68. Garcia CS, Curiel RE, Mwatibo JM, Pestka S, Li H, Espinoza-Delgado I. The antineoplastic agent bryostatin-1 differentially regulates IFN-g receptor subunits in monocytic cells: transcriptional and posttranscriptional control of IFN-gR2. J Immunol. 2006;177(4):2707-2716.

  69. He HJ, Zhu TN, Xie Y, Fan J, Kole S, Saxena S, Bernier M. Pyrrolidine dithiocarbamate inhibits interleukin-6 signaling through impaired STAT3 activation and association with transcriptional coactivators in hepatocytes. J Biol Chem. 2006;281(42):31369-31379.

  70. Jozwiak K, Moaddel R, Yamaguchi R, Maciuk A, Wainer IW. Non-competitive inhibitory activities of morphinan and morphine derivatives at the a3b4 neuronal nicotinic acetylcholine receptor determined using nonlinear chromatography and chemometric techniques. Pharm Res. 2006;23(9):2175-2182.

  71. Kim HS, Wainer IW. On-line drug metabolism in capillary electrophoresis. 1. Glucuronidation using rat liver microsomes. Anal Chem. 2006;78(20):7071-7077.

  72. Kobrinsky E, Stevens L, Kazmi Y, Wray D, Soldatov NM. Molecular rearrangements of the Kv2.1 potassium channel termini associated with voltage gating. J Biol Chem. 2006;281(28):19233-19240.

  73. Li H, Wojciechowski W, Dell'Agnola C, Lopez NE, Espinoza-Delgado I. IFN-g and T-bet expression in human dendritic cells from normal donors and cancer patients is controlled through mechanisms involving ERK-1/2-dependent and IL-12-independent pathways. J Immunol. 2006;177(6):3554-3563.

  74. Lucchesi BR, Abernethy DR. Speaking of pharmacology. Mol Interv. 2006;6(4):185.

  75. Mager DE, Wan R, Brown M, Cheng A, Wareski P, Abernethy DR, Mattson MP. Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats. FASEB J. 2006;20(6):631-637.

  76. McDonnell NB, Gorman BL, Mandel KW, Schurman SH, Assanah-Carroll A, Mayer SA, Najjar SS, Francomano CA. Echocardiographic findings in classical and hypermobile Ehlers-Danlos syndromes. Am J Med Genet A. 2006;140(2):129-136.

  77. Park JY, Kang HW, Moon HJ, Huh SU, Jeong SW, Soldatov NM, Lee JH. Activation of PKC augments T-type ca2+ channel activity without changing channel surface density. J Physiol. 2006;577(Pt. 2):513-523.

  78. Ramaswamy S, Wang DA, Fishbein KW, Elisseeff JH, Spencer RG. An analysis of the integration between articular cartilage and nondegradable hydrogel using magnetic resonance imaging. J Biomed Mater Res B Appl Biomater. 2006;77(1):144-148.

  79. Sambe H, Hoshina K, Moaddel R, Wainer IW, Haginaka J. Uniformly-sized, molecularly imprinted polymers for nicotine by precipitation polymerization. J Chromatogr A. 2006;1134(1-2):88-94.

  80. Spencer RG, Calton EF, Camacho NP. Statistical comparison of Fourier transform infrared spectra. J Biomed Opt. 2006;11(6):064023.

  81. Spencer RG, Fishbein KW, Cheng A, Mattson MP. Compatibility of Gd-DTPA perfusion and histologic studies of the brain. Magn Reson Imaging. 2006;24(1):27-31.

  82. Srinivasan R, Takahashi Y, McCoy JP, Espinoza-Delgado I, Dorrance C, Igarashi T, Lundqvist A, Barrett AJ, Young NS, Geller N, Childs RW. Overcoming graft rejection in heavily transfused and allo-immunised patients with bone marrow failure syndromes using fludarabine-based haematopoietic cell transplantation. Br J Haematol. 2006;133(3):305-314.

  83. Theodorakis MJ, Carlson O, Michopoulos S, Doyle ME, Juhaszova M, Petraki K, Egan JM. Human Duodenal enteroendocrine cells: source of both incretin peptides, GLP-1 and GIP. Am J Physiol Endocrinol Metab. 2006;290(3):E550-E559.

  84. Tiwari S, Zhang Y, Heller J, Abernethy DR, Soldatov NM. Atherosclerosis-related molecular alteration of the human CaV1.2 calcium channel alpha1C subunit. Proc Natl Acad Sci USA. 2006;103(45):17024-17029.

  85. Doyle ME, McConville P, Theodorakis MJ, Goetschkes MM, Bernier M, Spencer RG, Holloway HW, Greig NH, Egan JM. In vivo biological activity of exendin (1-30). Endocrine. 2005;27(1): 1-10.

  86. Gorak E, Geller N, Srinivasan R, Espinoza-Delgado I, Donohue T, Barrett AJ, Suffredini A, Childs R. Engraftment syndrome after nonmyeloablative allogeneic hematopoietic stem cell transplantation: incidence and effects on survival. Biol Blood Marrow Transplant. 2005;11(7): 542-550.

  87. Jozwiak K, Moaddel R, Yamaguchi R, Ravichandran S, Collins JR, Wainer IW. Qualitative assessment of IC(50) values of inhibitors of the neuronal nicotinic acetylcholine receptor using a single chromatographic experiment and multivariate cluster analysis. J Chromatogr B Analyt Technol Biomed Life Sci. 2005;819(1): 169-174.

  88. Kim BJ, Carlson OD, Jang HJ, Elahi D, Berry C, Egan JM. Peptide YY is secreted after oral glucose administration in aging individuals in a gender-specific manner. J Clin Endocrinol Metab. 2005;90(12): 6665-6671.

  89. Kim HS, Wainer IW. The covalent immobilization of microsomal uridine diphospho-glucuronosyltransferase (UDPGT): initial synthesis and characterization of an UDPGT immobilized enzyme reactor for the on-line study of glucuronidation. J Chromatogr B Analyt Technol Biomed Life Sci. 2005;823(2): 158-166.

  90. Kim M, Bi X, Horton WE, Spencer RG, Camacho NP. Fourier transform infrared imaging spectroscopic analysis of tissue engineered cartilage: histologic and biochemical correlations. J Biomed Opt. 2005;10(3): 031105.

  91. Kobrinsky E, Mager DE, Bentil SA, Murata SI, Abernethy DR, Soldatov NM. Identification of plasma membrane macro- and micro-domains from wavelet analysis of FRET microscopy. Biophys J. 2005;88(5): 3625-3634.

  92. Kobrinsky E, Tiwari S, Maltsev V, Harry JB, Lakatta E, Abernethy DR, Soldatov NM. Differential role of the a 1C subunit tails in regulation of the Cav1.2 channel by membrane potential, b subunits and Ca2+ ions. J Biol Chem. 2005;280(13): 12474-12485.

  93. Mager DE, Shirey JD, Cox D, Fitzgerald DJ, Abernethy DR. Mapping the dose-effect relationship of orbofiban from sparse data with an artificial neural network. J Pharm Sci. 2005;94(11): 2475-2486.

  94. McConville P, Spencer RG, Lakatta EG. Temporal dynamics of inotropic, chronotropic and metabolic responses during b1- and b2-adrenergic receptor stimulation in the isolated, perfused rat heart. Am J Physiol Endocrinol Metab. 2005;289(3): E412-E418.

  95. Moaddel R, Jozwiak K, Whittington K, Wainer IW. Conformational mobility of immobilized a3b2, a3b4, a4b2, and a4b4 nicotinic acetylcholine receptors. Anal Chem. 2005; 77(3): 895-901.

  96. Moaddel R, Jozwiak K, Yamaguchi R, Wainer IW. Direct chromatographic determination of dissociation rate constants of ligand-receptor complexes: assessment of the interaction of noncompetitive inhibitors with an immobilized nicotinic acetylcholine receptor-based liquid chromatography stationary phase. Anal Chem. 2005;77(16): 5421-5426.

  97. Moaddel R, Patel S, Jozwiak K, Yamaguchi R, Ho PC, Wainer IW. Enantioselective binding to the human organic cation transporter-1 (hOCT1) determined using an immobilized hOCT1 liquid chromatographic stationary phase. Chirality. 2005;17(8): 501-506.

  98. Moaddel R, Price GB, Juteau JM, Leffak M, Wainer IW. The synthesis and initial characterization of an immobilized DNA unwinding element binding (DUE-B) protein chromatographic stationary phase. J Chromatogr B Analyt Technol Biomed Life Sci. 2005;820(2): 197-203.

  99. Moaddel R, Yamaguchi R, Ho PC, Patel S, Hsu CP, Subrahmanyam V, Wainer IW. Development and characterization of an immobilized human organic cation transporter based liquid chromatographic stationary phase. J Chromatogr B Analyt Technol Biomed Life Sci. 2005;818(2): 263-268.

  100. Morad M, Soldatov NM. Calcium channel inactivation: possible role in signal transduction and Ca2+ signaling. Cell Calcium. 2005;38(3-4): 223-231.

  101. Murgo AJ, Espinoza-Delgado I. Development of novel anticancer agents in older patients: pharmacokinetic, pharmacodynamic, and other considerations. Cancer J. 2005;11(6): 481-487.

  102. Ramaswamy S, Wang DA, Fishbein KW, Elisseeff JH, Spencer RG. An analysis of the integration between articular cartilage and nondegradable hydrogel using magnetic resonance imaging. J Biomed Mater Res B Appl Biomater. 2005; [Epub ahead of print].

  103. Richards S, Liu ST, Majumdar A, Liu JL, Nairn RS, Bernier M, Maher V, Seidman MM. Triplex targeted genomic crosslinks enter separable deletion and base substitution pathways. Nucleic Acids Res. 2005;33(17): 5382-5393.

  104. Rodriguez-Rosas ME, Medrano JG, Epstein DH, Moolchan ET, Preston KL, Wainer IW. Determination of total and free concentrations of the enantiomers of methadone and its metabolite (2-ethylidene-1,5-dimethyl-3,3-diphenyl-pyrrolidine) in human plasma by enantioselective liquid chromatography with mass spectrometric detection. J Chromatogr A. 2005;1073(1-2): 237-248.

  105. Savani BN, Srinivasan R, Espinoza-Delgado I, Dorrance C, Takahashi Y, Igarashi T, Rezvani K, Lundqvist A, Barrett AJ, Childs RW. Treatment of relapsed blast-phase Philadelphia-chromosome-positive leukaemia after non-myeloablative stem-cell transplantation with donor lymphocytes and imatinib. Lancet Oncol. 2005;6(10): 809-812.

  106. Strigo IA, Duncan GH, Bushnell MC, Boivin M, Wainer I, Rodriguez Rosas ME, Persson J. The effects of racemic ketamine on painful stimulation of skin and viscera in human subjects. Pain. 2005;113(3): 255-264.

  107. Wojciechowski W, Li H, Marshall S, Dell'agnola C, Espinoza-Delgado I. Enhanced expression of CD20 in human tumor B cells is controlled through ERK-dependent mechanisms. J Immunol. 2005;174(12): 7859-7868.

  108. Zhang Z, McCaffery JM, Spencer RG, Francomano CA. Growth and integration of neocartilage with native cartilage in vitro. J Orthop Res. 2005;23(2): 433-439.

  109. Beigi F, Chakir K, Xiao RP, Wainer IW. G-protein-coupled receptor chromatographic stationary phases. 2. Ligand-induced conformational mobility in an immobilized b2-adrenergic receptor. Anal Chem. 2004; 76(24): 7187-7193.

  110. Bernier M. Protein tyrosine phosphatases: potential role in b-cell insulin signal transduction. Cell Biochem Biophys. 2004; 40(3 Suppl): 209-218.

  111. Bernier M, He HJ, Kwon YK, Jang HJ. The roles of phospholipase C-gamma 1 and actin-binding protein filamin A in signal transduction of the insulin receptor. Vitam Horm. 2004; 69: 221-247.

  112. Calleri E, Marrubini G, Massolini G, Lubda D, de Fazio SS, Furlanetto S, Wainer IW, Manzo L, Caccialanza G. Development of a chromatographic bioreactor based on immobilized b-glucuronidase on monolithic support for the determination of dextromethorphan and dextrorphan in human urine. J Pharm Biomed Anal. 2004; 35(5): 1179-1189.

  113. Di Marco MP, Chen J, Wainer IW, Ducharme MP. A population pharmacokinetic-metabolism model for individualizing ciprofloxacin therapy in ophthalmology. Ther Drug Monit. 2004; 26(4): 401-407.

  114. Espinoza-Delgado I, Childs RW. Nonmyeloablative transplantation for solid tumors: a new frontier for allogeneic immunotherapy. Expert Rev Anticancer Ther. 2004; 4(5): 865-875.

  115. Harry JB, Kobrinsky E, Abernethy DR, Soldatov NM. New short splice variants of the human cardiac Cavbeta2 subunit: redefining the major functional motifs implemented in modulation of the Cav1.2 channel. J Biol Chem. 2004; 279(45): 46367-46372.

  116. Jozwiak K, Ravichandran S, Collins JR, Wainer IW. Interaction of noncompetitive inhibitors with an immobilized alpha3beta4 nicotinic acetylcholine receptor investigated by affinity chromatography, quantitative-structure activity relationship analysis, and molecular docking. J Med Chem. 2004; 47(16): 4008-4021.

  117. Kobrinsky E, Kepplinger KJ, Yu A, Harry JB, Kahr H, Romanin C, Abernethy DR, Soldatov NM. Voltage-gated rearrangements associated with differential beta-subunit modulation of the L-type Ca(2+) channel inactivation. Biophys J. 2004; 87(2): 844-857.

  118. Lopez de Silanes I, Fan J, Galban CJ, Spencer RG, Becker KG, Gorospe M. Global analysis of HuR-regulated gene expression in colon cancer systems of reducing complexity. Gene Expr. 2004; 12(1): 49-59.

  119. Mager DE, Abernethy DR, Egan JM, Elahi D. Exendin-4 pharmacodynamics: insights from the hyperglycemic clamp technique. J Pharmacol Exp Ther. 2004; 311(2): 830-835.

  120. Mager DE, Merritt MM, Kasturi J, Witkin LR, Urdiqui-Macdonald M, Sollers JJ 3rd, Evans MK, Zonderman AB, Abernethy DR, Thayer JF. Kullback-Leibler clustering of continuous wavelet transform measures of heart rate variability. Biomed Sci Instrum. 2004; 40: 337-342.

  121. Markoglou N, Hsuesh R, Wainer IW. Immobilized enzyme reactors based upon the flavoenzymes monoamine oxidase A and B. J Chromatogr B Analyt Technol Biomed Life Sci. 2004; 804(2): 295-302.

  122. Moaddel R, Bullock PL, Wainer IW. Development and characterization of an open tubular column containing immobilized P-glycoprotein for rapid on-line screening for P-glycoprotein substrates. J Chromatogr B Analyt Technol Biomed Life Sci. 2004; 799(2): 255-263.

  123. Moaddel R, Jozwiak K, Yamaguchi R, Cobello C, Whittington K, Sarkar TK, Basak S, Wainer IW. On-line screening of conformationally constrained nicotines and anabasines for agonist activity at the alpha3beta4- and alpha4beta2-nicotinic acetylcholine receptors using immobilized receptor-based liquid chromatographic stationary phases. J Chromatogr B Analyt Technol Biomed Life Sci. 2004; 813(1-2): 235-240.

  124. Theodorakis MJ, Carlson O, Muller DC, Egan JM. Elevated plasma glucose-dependent insulinotropic polypeptide associates with hyperinsulinemia in impaired glucose tolerance. Diabetes Care. 2004; 27(7): 1692-1698.

  125. Urquidi-Macdonald M, Mager DE, Mascelli MA, Frederick B, Freedman J, Fitzgerald DJ, Kleiman NS, Abernethy DR. Abciximab pharmacodynamic model with neural networks used to integrate sources of patient variability. Clin Pharmacol Ther. 2004; 75(1): 60-69.

  126. Wainer IW. Finding time for allosteric interactions. Nat Biotechnol. 2004; 22(11): 1376-1377.

  127. Westin EH, Longo DL. Lymphoma and myeloma in older patients. Semin Oncol. 2004; 31(2): 198-205.

  128. Williams ML, Mager DE, Parenteau H, Gudi G, Tracy TS, Mulheran M, Wainer IW. Effects of protein calorie malnutrition on the pharmacokinetics of ketamine in rats. Drug Metab Dispos. 2004; 32(8): 786-793.

  129. Williams ML, Torres-Duarte A, Brant LJ, Bhargava P, Marshall J, Wainer IW. The relationship between a urinary cachectic factor and weight loss in advanced cancer patients. Cancer Invest. 2004; 22(6): 866-870.

  130. Zhang Z, McCaffery JM, Spencer RG, Francomano CA. Hyaline cartilage engineered by chondrocytes in pellet culture: histological, immunohistochemical and ultrastructural analysis in comparison with cartilage explants. J Anat. 2004; 205(3): 229-237.

  131. Zhu M, Miura J, Lu LX, Bernier M, DeCabo R, Lane MA, Roth GS, Ingram DK. Circulating adiponectin levels increase in rats on caloric restriction: the potential for insulin sensitization. Exp Gerontol. 2004; 39(7): 1049-1059.

  132. Bartolini M, Andrisano V, Wainer IW. Development and characterization of an immobilized enzyme reactor based on glyceraldehyde-3-phosphate dehydrogenase for on-line enzymatic studies. J Chromatogr A. 2003; 987(1-2): 331-340.

  133. Beigi F, Wainer IW. Syntheses of immobilized G protein-coupled receptor chromatographic stationary phases: characterization of immobilized mu and kappa opioid receptors. Anal Chem. 2003; 75(17): 4480-4485.

  134. Chen CT, Fishbein KW, Torzilli PA, Hilger A, Spencer RG, Horton WE Jr. Matrix fixed-charge density as determined by magnetic resonance microscopy of bioreactor-derived hyaline cartilage correlates with biochemical and biomechanical properties. Arthritis Rheum. 2003; 48(4): 1047-1056.

  135. Doyle ME, and Egan JM: Pharmacological agents that influence insulin secretion. Pharmacol Rev 2003; 55: 105-131.

  136. Doyle ME, Theodorakis MJ, Holloway HW, Bernier M, Greig NH, Egan JM. The importance of the nine-amino acid C-terminal sequence of exendin-4 for binding to the GLP-1 receptor and for biological activity. Regul Pept. 2003; 114(2-3): 153-158.

  137. Egan JM, Bulotta A, Hui H, Perfetti R. GLP-1 receptor agonists are growth and differentiation factors for pancreatic islet beta cells. Diabetes Metab Res Rev. 2003; 19(2): 115-123.

  138. Egan JM, Meneilly GS, Elahi D. Effects of 1-mo bolus subcutaneous administration of exendin-4 in type 2 diabetes. Am J Physiol Endocrinol Metab. 2003; 284(6): E1072-E1079.

  139. Galban CJ, Ellis SJ, Spencer RG. Experimental demonstration of quantitation errors in MR spectroscopy resulting from saturation corrections under changing conditions. J Magn Reson. 2003; 161(2): 148-153.

  140. Galban CJ, Spencer RG. Long repetition time experiments for measurement of concentrations in systems with chemical exchange and undergoing temporal variation-comparison of methods with and without correction for saturation. J Magn Reson. 2003; 160(2): 126-130.

  141. Gilman CP, Perry T, Furukawa K, Grieg NH, Egan JM, Mattson MP. Glucagon-like peptide 1 modulates calcium responses to glutamate and membrane depolarization in hippocampal neurons. J Neurochem. 2003; 87(5): 1137-1144.

  142. He HJ, Kole S, Kwon YK, Crow MT, Bernier M. Interaction of filamin A with the insulin receptor alters insulin-dependent activation of the mitogen-activated protein kinase pathway. J Biol Chem. 2003; 278(29): 27096-27104.

  143. He LP, Cleemann L, Soldatov NM, Morad M. Molecular determinants of cAMP-mediated regulation of the Na+-Ca2+ exchanger expressed in human cell lines. J Physiol. 2003; 548(Pt 3): 677-689.

  144. Jozwiak K, Hernandez SC, Kellar KJ, Wainer IW. Enantioselective interactions of dextromethorphan and levomethorphan with the alpha 3 beta 4-nicotinic acetylcholine receptor: comparison of chromatographic and functional data. J Chromatogr B Analyt Technol Biomed Life Sci. 2003; 797(1-2): 373-379.

  145. Kobrinsky E, Schwartz E, Abernethy DR, Soldatov NM: Voltage-gated mobility of the Ca2+ channel cytoplasmic tails and its regulatory role. J Biol Chem. 2003; 278(7): 5021-5028.

  146. Kwon YK, Jang HJ, Kole S, He HJ, Bernier M. Role of the pleckstrin homology domain of PLCgamma1 in its interaction with the insulin receptor. J Cell Biol. 2003; 163(2): 375-384.

  147. Lin T, Sandusky SB, Xue H, Fishbein KW, Spencer RG, Rao MS, Francomano CA. A central nervous system specific mouse model for thanatophoric dysplasia type II. Hum Mol Genet. 2003; 12(21): 2863-2871.

  148. Mager DE, Mascelli MA, Kleiman NS, Fitzgerald DJ, Abernethy DR. Simultaneous modeling of abciximab plasma concentrations and ex vivo pharmacodynamics in patients undergoing coronary angioplasty. J Pharmacol Exp Ther. 2003; 307(3): 969-976.

  149. McConville P, Fishbein KW, Lakatta EG, Spencer RG. Differences in the bioenergetic response of the isolated perfused rat heart to selective beta1- and beta2-adrenergic receptor stimulation. Circulation. 2003; 107(16): 2146-2152.

  150. Meneilly GS, Greig N, Tildesley H, Habener JF, Egan JM, Elahi D. Effects of 3 months of continuous subcutaneous administration of glucagon-like peptide 1 in elderly patients with type 2 diabetes. Diabetes Care. 2003; 26(10): 2835-2841.

  151. Meneilly GS, McIntosh CH, Pederson RA, Habener JF, Ehlers MR, Egan JM, Elahi D: Effect of glucagon-like peptide 1 (7-36 Amide) on insulin-mediated glucose uptake in patients With type 1 diabetes. Diabetes Care. 2003; 26(3): 837-842.

  152. Moaddel R, Wainer IW: Immobilized nicotinic receptor stationary phases: going with the flow in high-throughput screening and pharmacological studies. J Pharm Biomed Anal. 2003; 30(6): 1715-1724.

  153. Nagababu E, Ramasamy S, Abernethy DR, Rifkind JM. Active ntric oxde produced in the red cell under hypoxic conditions by deoxyhemoglobin-mediated nitrite reduction. J Biol Chem. 2003; 278(47): 46349-46356.

  154. Perry T, Lahiri DK, Sambamurti K, Chen D, Mattson MP, Egan JM, Greig NH. Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron. J Neurosci Res. 2003; 72(5): 603-612.

  155. Petersen EF, Fishbein KW, Laouar L, Spencer RG, Wenz JF. Ex vivo magnetic resonance microscopy of an osteochondral transfer. J Magn Reson Imaging. 2003; 17(5): 603-608.

  156. Poteser M, Wakabayashi I, Rosker C, Teubl M, Schindl R, Soldatov NM, Romanin C, Groschner K. Crosstalk between voltage-independent Ca2+ channels and L-type Ca2+ channels in A7r5 vascular smooth muscle cells at elevated intracellular pH: evidence for functional coupling between L-type Ca2+ channels and a 2-APB-sensitive cation channel. Circ Res. 2003; 92(8): 888-896.

  157. Rodriguez Rosas ME, Patel S, Wainer IW. Determination of the enantiomers of ketamine and norketamine in human plasma by enantioselective liquid chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2003; 794(1): 99-108.

  158. Rosas ME, Preston KL, Epstein DH, Moolchan ET, Wainer IW. Quantitative determination of the enantiomers of methadone and its metabolite (EDDP) in human saliva by enantioselective liquid chromatography with mass spectrometric detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2003; 796(2): 355-370.

  159. Ryan AS, Berman DM, Nicklas BJ, Sinha M, Gingerich RL, Meneilly GS, Egan JM, Elahi D. Plasma adiponectin and leptin levels, body composition, and glucose utilization in adult women with wide ranges of age and obesity. Diabetes Care. 2003; 26(8): 2383-2388.

  160. Soldatov NM. Ca2+ channel moving tail: link between Ca2+-induced inactivation and Ca2+ signal transduction. Trends Pharmacol Sci. 2003; 24(4): 167-171.

  161. Thayer JF, Merritt MM, Sollers JJ 3rd, Zonderman AB, Evans MK, Yie S, Abernethy DR. Effect of angiotensin-converting enzyme insertion/deletion polymorphism DD genotype on high-frequency heart rate variability in African Americans. Am J Cardiol. 2003; 92(12): 1487-1490.

  162. Theodorakis MJ, Muller DC, Carlson O, Egan JM. Assessment of insulin sensitivity and secretion indices from oral glucose tolerance testing in subjects with fasting euglycemia but impaired 2-hour plasma glucose. Metabolism. 2003; 52(11): 1523-1524; discussion 1524-1525.

  163. Woo SH, Soldatov NM, Morad M. Modulation of Ca2+ signalling in rat atrial myocytes: possible role of the alpha1C carboxyl terminal. J Physiol. 2003; 552(Pt 2): 437-447.

  164. Zhang ZJ, Huckle J, Francomano CA, Spencer RG. The effects of pulsed low-intensity ultrasound on chondrocyte viability, proliferation, gene expression and matrix production. Ultrasound Med Biol. 2003; 29(11): 1645-1651.

  165. Abernethy DR, Pezzullo J, Mascelli MA, Frederick B, Kleiman NS, Freedman J: Pharmacodynamics of abciximab during angioplasty: Comparison to healthy subjects. Clin Pharmacol Ther 2002; 71: 186-195.

  166. Abernethy DR, and Soldatov, NM: Structure-functional diversity of human L-type Ca2+ channels: Perspectives for new pharmacological targets. J Pharm Exp Ther 2002; 300: 724-728.

  167. Baynham MT, Patel S, Moaddel R and Wainer IW: Multidimensional on-line screening for ligands to the a3b4-neuronal nicotinic acetylcholine receptor using an immobilized nicotinic receptor liquid chromatographic stationary phase. J Chromatogr B 2002; 772: 155-161.

  168. Cassiano NM, Cass QB, Degani ALG and Wainer IW: The determination of the plasma levels of metyrapone and its enantiomeric metyrapol metabolites by direct plasma injection and multidimensional achiral-chiral chromatography. Chirality 2002; 14: 731-735.

  169. Di Marco MP, Edwards DJ, Wainer IW and Ducharme MP: The effect of grapefruit juice and Seville orange juice on the pharmacokinetics of dextromethorphan: The role of gut CYP3A and P-glycoprotein. Life Sc 2002; 71: 1149-1160.

  170. Doyle ME and Egan JM: GLP-1 and its agonists. Recent Progress in Hormone Research 2002; 6: 377-399.

  171. Egan JM, Clocquet AR, Elahi D: The insulinotropic effect of exendin-4 administered to humans: Comparison of non-diabetic state to type 2 diabetes. J Clin Endocrinol Metab 2002; 87: 1282-1290.

  172. Egan JM, Meneilly, GS, Elahi D: Effects of one month bolus subcutaneous administration of exendin-4 in type 2 diabetes. Am J Physiol 2002 Dec. [epub ahead of print].

  173. Egan JM, Meneilly GS, Habener JF, Elahi D: Glucagon-like peptide-1 augments insulin mediated glucose uptake in the obese state. J Clin Endocrinol Metab 2002; 87: 3768-3773.

  174. Elahi D, Muller DC, Egan JM, Andres R, Veldhuis J, Meneilly GS: Glucose tolerance, glucose utilization and insulin secretion in aging. Chapter in a book titled "Endocrine Facets of Ageing". Novartis Found Symp 2002; 242: 222-242.

  175. Espinoza-Delgado, I and Longo, DL: Non-Hodgkin's Lymphoma: Allogeneic Stem Cell Transplantation. In Allogeneic Stem Cell Transplantation, Lazarus, H.M. and Laughlin, M.J. eds. The Humana Press Inc Totowa, NJ 2002; 7: 83-99.

  176. Freedman J, Mascelli MA, Pezzullo JC, Barnathan E, Frederick B, Jordan RE, Abernethy DR: Pharmacodynamic profile of acute re-administration of Abciximab in normal subjects. Am Heart J 2002; 143: 87-94.

  177. Fried KM, Young AE, Yasuda SU and Wainer IW: The enantioselective determination of chlorpheniramine and its major metabolites in human plasma using chiral chromatography on a b-cyclodextrin chiral stationary phase and mass spectrometric detection. J. Pharm Biomed Anal, 2002; 27: 479-488.

  178. Galban CJ and Spencer RGS: Optimized pulse parameters for reducing quantitation errors due to saturation factor changes in magnetic resonance spectroscopy. J Magn Reson 2002; 156: 161-170.

  179. Jozwiak K, Haginaka J, Moaddel R and Wainer IW: Displacement and non-linear chromatographic techniques in the investigation of the interaction of noncompetitive inhibitors with an immobilized a3b4 nicotinic acetylcholine receptor liquid chromatographic stationary phase. Anal Chem 2002; 74: 4618-4624.

  180. Markoglou N and Wainer IW: Biosynthesis in an on-line immobilized-enzyme reactor containing phenylethanolamine N-methyl-transferase in single-enzyme and coupled-enzyme formats: J Chromatogr A 2002; 948: 249-256.

  181. Markoglou N and Wainer IW: On-line synthesis utilizing immobilized enzyme reactors based upon immobilized dopamine beta-hydroxylase, J. Chromatrogr B 2002; 766: 145-151.

  182. Marshall JL, Rizvi N, Kauh J, Dahut W, Figuera M, Kang MH, Figg WD, Wainer I, Chaissang C, Li MZ, and Hawkins MJ: A phase I trial of Depsipeptide (FR901228) in patients with advanced cancer. J Exp Ther and Oncol 2002; 2(6): 325.

  183. Moaddel R, Cloix J-F, Ertem G and Wainer IW: Multiple receptor liquid chromatographic stationary phases: Development of a co-immobilized nicotinic receptor, g-g-amino-butyric acid receptor and N-methyl-D-aspartate receptor stationary phase. Pharm Res 2002; 19: 104-107.

  184. Moaddel R, Lu L, Baynham M and Wainer IW: Immobilized receptor- and transporter-based liquid chromatographic phases for on-line pharmacological and biochemical studies: A mini-review. J Chromatogr B 2002; 768: 41-53.

  185. Perry TA, Haughey NJ, Mattson M, Egan JM, Greig NH: Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4. J Pharmacol Exp Ther 2002; 302: 881-888.

  186. Perry T, Lahiri DK, Chen D, Zhou J, Shaw KT, Egan JM, Greig NH: A novel neurotrophic property of glucagon-like peptide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cells. J Pharmacol Exp Ther 2002; 300: 958-966.

  187. Petersen EF, Spencer RGS and McFarland EW: Microengineering Neocartilage Scaffolds. Biotech Bioeng 2002; 78: 802-805.

  188. Shibukawa A, Ishizawa N, Kimura T, Sakamoto Y, Ogita K, Matso Y, Kuroda Y, Matayatsuk C, Nakagawa T and Wainer IW: Plasma protein binding study of oxybutynin by high-performance frontal analysis, J Chromatogr B 2002; 768: 177-188.

  189. Shibukawa A Yoshikawa Y, Kimura T, Kuroda Y, Nakagawa T and Wainer IW: Binding studies of desethyloxybutynin using high performance frontal analysis method. J Chromatrogr B 2002; 768: 189-197.

  190. Shi C and Soldatov N.M: Molecular determinant of voltage dependent slow inactivation of Ca2+ channel. J Biol Chem 2002; 277: 6813-6821.

  191. Tanus-Santos JE, Desai M, Deak LR, Pezzullo JC, Abernethy DR, Flockhart DA, Freedman JE: Effects of endothelial nitric oxide synthase gene polymorphisms on platelet function, nitric oxide release and interactions with estradiol. Pharmacogenetics 2002; 1: 407-413.

  192. Terry TA, Zhou J, Shaw K, Lehiri D, Egan JM, Greig NH: Induction of differentiation by glucagon-like peptide 1: a novel neurotrophic factor in PC12 cells. J Pharmacol ExpTherapeutics 2002; 300: 958-696.

  193. Williams ML and Wainer IW: Genotype/phenotype comparisons: A probe for the effect of disease progression on drug metabolism. Current Opinions in Drug Discovery & Development 2002; 5: 144-149.

  194. Williams ML and Wainer IW: The role of chiral chromatography in therapeutic drug onitoring and clinical forensic toxicology. Therap Drug Monitor 2002; 24: 290-296.

  195. Zhang Z-J, Huckle J, Francomano CA, and Spencer RGS: The influence of pulsed low-Iitensity ultrasound on matrix production of chondrocytes at different stages of differentiation: An Explant Study. Ultrasound in Medicine and Biology 2002; 28: 1547-1553.

  196. Zhou J, Pineyro MA, Wang X, Doyle ME, Egan JM: Exendin-4 differentiation of a human pancreatic cell line into endocrine cells; Involvement of PDX-1 and HNF3ßß transcription factors. J Cell Physiol 2002; 192: 304-314.

  197. Abernethy DR: Drug Therapy in the Elderly In Principles of Clinical Pharmacology, AJ.Atkinson, CE Daniels, RL Dedrick, CV Grudzinskas, SP Markey eds. Academic Press, New York, 2001; Chapter 24, pp 301-317.

  198. Abernethy DR, Barbey JT, Franc J, Brown KS, Feirrera I, Ford N, Salazar DE: Loratadine and terfenadine interaction with nefazodone: Both antihistamines are associated with QTc prolongation. Clin Pharmacol Ther 2001; 69: 96-103.

  199. Abernethy DR, Wesche DL, Barbey JT, Ohrt C, Mohanty S, Pezzullo JC, Schuster BG: Stereoselective halofantrine disposition and effect: Concentration-related QTc prolongation. Br J Clin Pharmacol 2001; 51: 231-238.

  200. Bansal R, Chen HX, Marshall JL, Tan J, Glazer RI, and Wainer IW: Detection of a fixed-backbone oligonucleotide (GEMR231) in liver and tumor tissues by capillary electrophoresis. J. Chromatogr. B 2001; 750: 129-135.

  201. Bendriss E-K, Markoglou N and Wainer IW: High-performance liquid chromatography assay for simultaneous determination of dextromethorphan and its main metabolites in urine and in microsomal preparations. J Chromatogr B 2001; 754: 209-215.

  202. Cabal-Manzano R, Bhargava P, Torres-Duarte A, Marshall J, Bhargava P and Wainer IW: Protolysis inducing factor is expressed in tumours of patients with gastrointestinal cancers and correlates with weight loss. Br J Cancer 2001; 84: 1599.

  203. Caldwell J and Wainer IW: Stereochemistry: Definitions and a note on nomenclature. Hum Psychopharmacol Clin Exp 2001; 6: S105-S107.

  204. Cloix JF and Wainer IW: Development of an immobilized brain glutamine synthetase liquid chromatographic stationary phase for on-line biochemical studies. J Chromatogr A 2001; 913: 133-142.

  205. Curiel R, Garcia CS, Farouk L, Aguero M, and Espinoza-Delgado I: Bryostatin-1 and IL-2 synergize to induce IFN-gamma expression in human peripheral blood T cells. Implications for cancer immunotherapy, J. Immunol 2001; 167: 4828.

  206. Davydova NN, Glisic J and Wainer IW: Determination of 8-chloroadenosince 3',5'-monophosphate in dog plasma by capillary electrophoresis. J Pharm Biomed Anal 2001; 24: 857-862.

  207. Doyle ME, Greig NH, Betkey JA, Holloway HW, Bernier M, Egan JM: Insertion of an N-terminal 6-aminohexanoic acid after the 7-amino acid position of glucagon-like peptide-1 produces a long-acting hypoglycemic agent. Endocrinology 2001; 142: 4462-4468.

  208. Ellis SJ, Velayutham M, Velan SS, Petersen E, Zweier JL, Kuppusamy P, and Spencer RGS: EPR oxygen mapping (EPROM) of engineered cartilage grown in a hollow fiber bioreactor. Magn Reson in Med 2001; 46: 819-826.

  209. Fishbein KW, McConville P, and Spencer RGS: The lever coil. A simple, inexpensive sensor for respiratory and cardiac motion in MRI experiments. Magn Reson Imaging 2001; 19: 881-889.

  210. Korosi J, McIntosh CHS, Pederson RA, Demuth H-U, Gingerich R, Egan JM, Elahi D, Meneilly GS: Effect of aging and diabetes on the enteroinsular axis. J Gerontol: Med Sci 2001; 56: M575-M579.

  211. Kyriakides ZS, Dimitrios T, Kremastinos DT, Karayannakos, P, Gowdak LHW, Poliakova L,Wang X, Lakatta EG, Talan M, Fishbein KW, Spencer RGS, Kovesdi I, Zacheo A, Palumbo R, Straino S, Emanueli C, Marrocco-Trischitta M, Capogrossi MC, and Anversa P: Estrogen stimulates angiogenesis in normoperfused skeletal muscle in rabbits Response. Circulation 2001; 103(21): e107-e108.

  212. Lu L, Leonessa F, Baynham MT, Clarke R, Gimenez F, Pham Y-T, Roux F, and Wainer IW: The enantioselective binding of mefloquine enantiomers to P-glycoprotein determined using an immobilized P-glycoprotein liquid chromatographic stationary phase. Pharm Res 2001; 18: 1327-1330.

  213. Lu L, Leonessa F, Clarke R, and Wainer IW: Competitive and allosteric interactions in ligand binding to P-glycoprotein as observed on an immobilized P-glycoprotein liquid chromatographic stationary phase. Mol Pharmacol 2001; 658: 1-7.

  214. Markoglou N, and Wainer IW: Synthesis and characterization of an immobilized phenylethanolamine N-methyltransferase liquid chromatographic stationary phase. Anal Biochem 2001; 288: 83-88.

  215. Markoglou N, and Wainer IW: Synthesis and characterization of immobilized dopamine b-hydroxylase in membrane bound and solubilized formats. J Biochem Biophys Methods 2001; 48: 61-75.

  216. Massolini G, De Lorenzi E, Callweri E, Bertucci C, Monaco HL, Perduca M, Caccialanza G and Wainer IW: Properties of a stationary phase based on immobilized chicken liver basic fatty acid-binding protein. J Chromatogr B 2001; 751: 117-130.

  217. Meneilly GS, McIntosh CHS, Pederson RA, Habener JF, Gingerich R, Egan JM, Elahi DE: Glucagon-like peptide-1 (7-37) augments insulin secretion in elderly patients with diabetes. Diabetes Care 2001; 24: 964-965.

  218. Meneilly GS, McIntosh CHS, Pederson RA, Habener JF, Gingerich R, Egan JM, Elahi DE: Glucagon-like peptide-1 (7-37) augments insulin-mediated glucose uptake in elderly patients with diabetes. J Gerontol: Med Sci 2001; 56: M681-M685.

  219. Meneilly GS, McIntosh CHS, Pederson RA, Habener JF, Gingerich R, Egan JM, Finegood D, Elahi DE: Effect of GLP-1 on non-insulin-mediated glucose uptake in the elderly patient with Diabetes Mellitus. Diabetes Care 2001; 24: 1951-1956.

  220. Potter K, Kidder LH, Levin IW, Lewis EN, and Spencer RGS: Imaging of collagen and proteoglycan in cartilage sections using fourier transform infrared spectral imaging. Arthr and Rheum 2001; 44: 846-855.

  221. Potter K, Landis WJ, and Spencer RGS: Histomorphometry of the embryonic avian growth plate by proton NMR microscopy. J Bone and Mineral Res 2001; 16: 1092-1100.

  222. Spencer RGS, Fishbein KW, Galban CJ: Pitfalls in the measurement of metabolite concentrations using the one-pulse experiment in vivo NMR. Commentary on: "On neglecting chemical exchange effects when correcting in-vivo 31P MRS data for partial saturation". J Magn Reson 2001; 149: 251-257.

  223. Vila Petroff MG, Egan JM, Wang X, Sollott SJ. Glucagon-like peptide-1 increases AMP, but fails to augment contraction, in adult rat cardiac myocytes. Circ Res 2001; 89: 445-452.

  224. Wainer IW: The therapeutic promise of single enantiomers: Introduction. Hum Psycho Pharmacol Clin Exp 2001; 16: S73-S77.

  225. Wang X, Zhou J, Doyle ME, Egan JM: GLP-1 causes PDX-1 translocation to the nuclei of ßß-cells by a PKA-dependent process. Endocrinology 2001; 142: 1820-1827.

  226. Westin EH and Longo DL: Lymphocytic Lymphomas and Hodgkin's Diseases. In: Austen, Frank, Atkinson and Cantor (Eds.): Samter's Immunologic Diseases, Sixth Edition, Lippincott, Williams and Wilkins Baltimore 2001; pp 359-379.

  227. Westin EH and Longo DL: T-Small Cell Disorders. Current Treatment Options in Oncology, Current Science Inc New York 2001; Vol. 1, pp 225-235.

  228. Wolbach JP, Lloyd, DK and Wainer IW: Approaches to quantitative structure enantioselectivity relationships modeling of chiral separations using capillary electrophoresis. J Chromatogr A 2001; 914: 299-314.

IRP Home     What's New     Contact Us     Accessibility     Disclaimer     Privacy     Site Search     Site Map     NIA Home    
NIH logo-link to NIH Home Page DHHS logo-link to DHHS Web Site FirstGov logo-link to FirstGov Web Site
Updated: Wednesday January 28, 2009