University of Cambridge, U.K, B.A., 1971, Chemistry
University of Cambridge, U.K., M.A., 1973, Chemistry
University of Sussex, U.K., M.Sc.,1972, Chemistry
University of Sussex, U.K. Ph.D., 1975, Chemistry

Experience:

• 1979-1981 Research Assistant, University of York, York, U.K.
• 1981-1982 Research Assistant, Middlesex Hospital Medical School, London, UK.
• 1982-1987 Research Associate, Middlesex Hospital Medical School and University College London, London, UK.
• 1987-1994 Associate Research Assistant, Head of Cancer Research Campaign (UK) Protein Sequencing Facility, University College London, London, UK.
• 1995-1997 ORISE Fellowship at the National Center for Toxicological Research, Jefferson, AR.
• 1997-1999 Assistant Professor, Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, AR/Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, AR.
• 1999-present: Staff Fellow, Division of Molecular Epidemiology, FDA laboratories of the National Center for Toxicological Research/Adjunct Associate Assistant Professor, Department of Surgery, University of Arkansas for Medical Sciences.

Current Research Interests:

• Role of glutathione S-transferases (GSTs) as catalysts of detoxification of chemical carcinogens and chemotherapeutics.
• Organ-specific and interindividual variation of GST expression as determinants of individual susceptibility to cancer and of individual response to efficacy of chemotherapy.
• Genetic polymorphisms in GSTs and their role in determining protein expression and cancer susceptibility.
• Effect of genotype/phenotype for enzymes of carcinogen activation and detoxification in the epidemiology of pancreatic, colon, lung and breast cancers.

Publications (selected from a total of 65):

• Quantitative analysis of inter-individual variation of glutathione S-transferase expression in human pancreas and the ambiguity of correlating genotype with phenotype. B.F. Coles, K.E. Anderson, D.R. Doerge, M.I. Churchwell, N. P. Lang and F.F. Kadlubar, Cancer Research, 60, 573-579, 2000.

• Glutathione S-transferase (GSTM1) genetic polymorphisms do not affect human breast cancer risk, regardless of dietary antioxidants. C.B. Ambrosone, B.F. Coles J.L. Freudenheim and P.G. Shields. J. Nutrition, supplement, 565S-568S, 1999.

• Comparison of DNA adduct levels associated with exogenous and endogenous exposures in human pancreas in relation to metabolic genotype. P.A. Thompson, F. Seyedi, N.P. lang, S.L. MacLeod, G.N. Wogan, K.E. Anderson, Y-M. Tang, B. Coles and F.F. Kadlubar. Mutat. Res. 424, 263-274,1999.

• Electrosynthetic modification of proteins: electrooxidations at methionine and tryptophan in hen egg-white lysozyme. D.J. Walton, P.G. Richards, J. Heptinstall and B. Coles. Electrochimica Acta, 42, 2285-2294, 1997.

• Effects of administration of the chemoprotective agent oltipraz on CYP1A and CYP2B in rat liver and rat hepatocytes in culture.S.Langouët, K.maheo, F.Berthou, F. Morel, Lagadic-Gossman, D.Glaise, B.Coles, B. Ketterer and A. Guillouzo.Carcinogenesis,18, 1343-1349, 1997.

• Metabolism of aflatoxin B1 by human hepatocytes in primary culture. S.Langouët, B.Coles, F.Morel, K. Maheo, B.Ketterer and A.Guillouzo. Adv. Exp. Med. Biol., 387, 439-442, 1996.

• Toxic chemicals by cytochrome P450 enzymes: regio- and stereoselective oxidation of aflatoxin B1. F.P. Guengerich,Y.F. Ueng, B.R. Kim, S.Langouet, B. Coles, R.S.Iyer, R.Thier, T.M.Harris, T.Shimada, H.Yamazaki, B.Ketterer and A. Guillozo. Adv. Exp. Med. Biol., 387, 7-15,1996.

• Characterization of a cancer cachectic factor. P. Todorov, P. Cariuk, T. McDevitt, B. Coles, K. Fearon and M. Tisdale, Nature, 379, 739-742, 1996.

• Inhibition of CYP1A2 and CYP3A4 by oltipraz results in reduction of aflatoxin B1 metabolism in human hepatocytes in primary culture. S. Langouet, B. Coles, F. Morel, L. Becquemont, P. Beaune, F.P. Guengerich, B. Ketterer and A. Guillouzo. Cancer Res., 55, 5574-5579, 1995.

• Interactions of ingested food, beverage, and tobacco components involving human cytochrome P4501A2, 2A6, 2E1, and 3A4 enzymes. F.P. Guengerich, T. Shimada, C.H. Yun, H. Yamazaki, K.D. Raney, R.Thier, B. Coles and T.M. Harris. Environmental Health Perspectives. 102, 49-53, 1994.

• DNA adduction by the potent carcinogen aflatoxin B1: mechanistic studies. R. Iyer, B. Coles, K. Raney, R. Thier, F.P. Guengerich and T.M. Harris, J. Amer. Chem. Soc.,116, 1603-1609, 1994.

• Quantitation of tissue- and sex-specific induction of rat GSH transferase subunits by dietary 1,2-dithiole-3-thiones. D.J. Meyer, J.M. Harris, K.S. Gilmore, B. Coles T.W. Kensler and B. Ketterer, Carcinogenesis, 14, 567-572, 1993.

• The endo-8,9-epoxide of aflatoxin B1: a new metabolite. K.D. Raney, B. Coles, F.P. Guengerich and T.M. Harris. Chem. Res. Toxicol., 5, 333-335, 1992.

• Glutathione transferases and products of oxygen. B. Ketterer and B. Coles. In Oxidative stress: oxidants and antioxidants, H. Sies, Ed., 171-194, 1991.

• A novel glutathione transferase (13-13) isolated from the matrix of rat liver mitochondria having structural similarity to class Theta enzymes. J.M. Harris, D.J. Meyer, B. Coles and B. Ketterer, Biochem. J., 278, 137-141, 1991.

• Theta, a new class of glutathione transferases purified from rat and man. D.J. Meyer, B. Coles, S.E. Pemble, K.S. Gilmore, G.M. Fraser and B. Ketterer. Biochem. J., 274, 409-414, 1991.

• The role of glutathione and glutathione transferases in chemical carcinogenesis. B. Coles and B. Ketterer. Crit. Rev. Biochem. Molecular Biol., 25, 47-70. 1990.

• Purification and characterization of a labile rat glutathione transferase of the Mu class. A. Kispert, D.J. Meyer, E. Lalor, B. Coles and B. Ketterer, Biochem. J., 260, 789-793, 1989.

• The separation of glutathione transferase subunits by using reverse-phase high- pressure liquid chromatography. A.K. Ostlund- Farrants, D.J. Meyer, B. Coles, C. Southan, A. Aitken, P.J. Johnson and B. Ketterer, Biochem. J., 245, 423-428, 1987.

• Effects of modifying structure on electrophilic reactions with biological nucleophiles. B. Coles. Drug Metab. Rev., 15, 1307-1334, 1985.

• The role of glutathione in detoxication. B. Ketterer, B. Coles and D.J. Meyer, Environ. Health Perspectives, 49, 59-69, 1983.