Dworkin BM, Seaton T, Wormser G; International Conference on AIDS.

Int Conf AIDS. 1990 Jun 20-23; 6: 218 (abstract no. Th.B.386).

New York Medical College, Valhalla, N.Y., USA

Patients infected with Human Immunodeficiency Virus (HIV) frequently become cachectic. To evaluate the roles of TNF and hypermetabolism in seropositive HIV patients, we studied 33 clinically stable, afebrile outpatients, staged by CDC criteria as stage 4 (N=33). Resting metabolic rate (RMR) was measured by indirect calorimetry and body composition by bioelectrical impedance analysis and anthropometrics in 19 cases. TNF ELISA assay was performed in all. The patients had a mean (+/-S.E.M.) weight loss of 16.5+/-3.9 lbs. The % predicted RMR (Actual/Harris-Benedict) was 0.99+/-0.14. 27% had elevated TNF levels with a mean of 31.6+/-11.4 pc/ml. There were no differences in weight loss or % RMR in those with or without elevated TNF levels. An inverse relationship between TNF and albumin was noted (r=-0.41;p less than 0.02) and a correlation between % RMR and wt. loss was present (r=0.48;p less than 0.05). TNF did not correlate with any body composition parameter. CONCLUSION: Clinically stable, HIV patients are not significantly hypermetabolic compared to predicted RMR, and TNF levels are poorly correlated with metabolic or nutritional parameters, including weight loss. However, RMR and weight loss are related. This could suggest impaired metabolic adaptation to weight loss in AIDS cases.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• Body Composition
• Cachexia
• Calorimetry, Indirect
• Energy Metabolism
• HIV Seropositivity
• Humans
• Protein Binding
• TNF protein, human
• Tumor Necrosis Factor-alpha
• Weight Loss

Other ID:

• 10038690

UI: 102181952

From Meeting Abstracts