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Sponsors and Collaborators: |
German Cancer Research Center University of Heidelberg |
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Information provided by: | German Cancer Research Center |
ClinicalTrials.gov Identifier: | NCT00196885 |
The purpose of the study is to tests the hypothesis, that N-acetylcysteine (a thiol-antioxidant)improves the exercise training effect on cancer patients that experience weight loss (cachexia) as assessed by muscle mass and function as well as histomorphology.
Condition | Intervention | Phase |
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Gastrointestinal Neoplasms Bronchial Carcinoma Hodgkin Disease Non-Hodgkin Lymphoma Weight Loss |
Drug: N-acetylcysteine |
Phase II |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Safety/Efficacy Study |
Official Title: | Effect of N-Acetylcysteine on Skeletal Muscle in Cachectic Cancer Patients Undergoing a Resistance Training Program (Phase 2 Study) |
Estimated Enrollment: | 60 |
Study Start Date: | December 2003 |
Study Completion Date: | December 2006 |
Ages Eligible for Study: | 20 Years to 80 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Germany, Baden-Württemberg | |
German Cancer Research Center, D020 | |
Heidelberg, Baden-Württemberg, Germany, 69120 |
Study Director: | Wulf Hildebrandt, MD | German Cancer Research Center |
Study ID Numbers: | whilde157/2003 |
Study First Received: | September 12, 2005 |
Last Updated: | June 18, 2008 |
ClinicalTrials.gov Identifier: | NCT00196885 |
Health Authority: | Germany: Federal Institute for Drugs and Medical Devices |
cancer cachexia muscle wasting weight loss proteolysis |
Thoracic Neoplasms Hodgkin's disease Gastrointestinal Diseases Hodgkin lymphoma, adult Lymphoma, small cleaved-cell, diffuse Cachexia Body Weight Signs and Symptoms Respiratory Tract Diseases Lung Neoplasms Weight Loss Body Weight Changes Acetylcysteine Hodgkin Disease |
Lymphoma Muscular Atrophy Digestive System Neoplasms Immunoproliferative Disorders Carcinoma Lymphatic Diseases Digestive System Diseases Lung Diseases Gastrointestinal Neoplasms Carcinoma, Bronchogenic Lymphoma, Non-Hodgkin Lymphoproliferative Disorders N-monoacetylcystine Neoplasms, Glandular and Epithelial |
Anti-Infective Agents Respiratory Tract Neoplasms Respiratory System Agents Neoplasms by Histologic Type Antioxidants Immune System Diseases Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs Protective Agents |
Antiviral Agents Pharmacologic Actions Neoplasms Neoplasms by Site Expectorants Therapeutic Uses Free Radical Scavengers Antidotes |