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Title Resistance to infection with Eimeria vermiformis in mouse radiation chimeras is determined by donor bone-marrow cells
Creator/Author Joysey, H.S. ; Wakelin, D. ; Rose, M.E.
Publication Date1988 May 01
OSTI IdentifierOSTI ID: 7025079
Other Number(s)CODEN: INFIB
Resource TypeJournal Article
Resource RelationInfect. Immun. ; Vol/Issue: 56:5
Research OrgInstitute for Animal Health, Huntingdon (England)
Subject560152 -- Radiation Effects on Animals-- Animals; BONE MARROW CELLS-- GENOTYPE;PARASITES-- INFECTIVITY; IMMUNITY;LYMPHOCYTES;MICE;PHENOTYPE;RADIATION CHIMERAS
Related SubjectANIMAL CELLS;ANIMALS;BIOLOGICAL MATERIALS;BLOOD;BLOOD CELLS;BODY FLUIDS;CHIMERAS;CONNECTIVE TISSUE CELLS;LEUKOCYTES;MAMMALS;MATERIALS;MOSAICISM;RODENTS;SOMATIC CELLS;VERTEBRATES
Description/Abstract The course of infection with Eimeria vermiformis was determined in BALB/b, BALB/c, and C57BL/10ScSn (B10) mice and in radiation chimeras prepared from the H-2-compatible BALB/b and B10 mice.^The BALB strains, irrespective of H-2 haplotype, were resistant, the B10 mice were susceptible, and in the chimeras infection was characterized by the genotype of the donated bone-marrow cells and not by the phenotype of the recipient.^Thus, the genetic control of relative resistance or susceptibility to infection with this parasite is expressed through bone-marrow-derived cells.
Country of PublicationUnited States
LanguageEnglish
FormatPages: 1399-1401
System Entry Date2001 May 13

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