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Sponsored by: |
Wake Forest University |
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Information provided by: | Wake Forest University |
ClinicalTrials.gov Identifier: | NCT00691769 |
The purpose of this research study is to see if a specific protein that we are interested in is involved in scarring hair loss. If these proteins are involved, further genetic work may also better define the disease as well as future treatment options.
Condition |
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Central Centrifugal Scarring Alopecia Lichen Planopilaris Discoid Lupus Erythematosus |
Study Type: | Observational |
Study Design: | Case Control, Prospective |
Official Title: | Expression of Fas Protein in Skin Biopsies of Participants With Scarring Alopecia |
Two, 4mm punch biopsies will be obtained of skin tissue.
Estimated Enrollment: | 25 |
Study Start Date: | April 2006 |
Estimated Study Completion Date: | October 2008 |
Estimated Primary Completion Date: | October 2008 (Final data collection date for primary outcome measure) |
Groups/Cohorts |
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I
CCSA subjects will be recruited from patients who have been diagnosed through biopsy with CCSA and treated with standard of care for up to eight months in the Department of Dermatology clinic of Wake Forest University School of Medicine.
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II
patients with lichen planopilaris (LP) and patients with discoid lupus erythematosous (DLE) will be collected from patients who have been diagnosed through biopsy in the clinic.
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III
Healthy study subjects will be patients from the Wake Forest University School of Medicine Department of Dermatology population undergoing excisions for cosmetic purposes or excision of free margins around tumors that would have otherwise been discarded.
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This is a single-center study, designed to evaluate the expression of Fas protein in skin biopsies of patients with scarring alopecia including fourteen patients with central centrifugal scarring alopecia (CCSA), three patients with lichen planopilaris (LP) and three patients with discoid lupus erythematosous (DLE). Skin biopsies of five healthy participants will be used as controls.
Ages Eligible for Study: | 30 Years and older |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Wake Forest University Health Sciences Dermatology Clinic.
Inclusion Criteria:
Exclusion Criteria:
United States, North Carolina | |
Wake Forest University Health Sciences Dermatology | |
Winston Salem, North Carolina, United States, 27157 |
Principal Investigator: | Amy McMichael, MD | Wake Forest University |
Responsible Party: | Wake Forest University Health Sciences ( Amy McMichael, MD ) |
Study ID Numbers: | 00000301, 31050 |
Study First Received: | June 2, 2008 |
Last Updated: | June 10, 2008 |
ClinicalTrials.gov Identifier: | NCT00691769 |
Health Authority: | United States: Institutional Review Board |
Lichen Planus Pathological Conditions, Anatomical Skin Diseases Lupus Erythematosus, Cutaneous Lupus Lichen planus follicularis Lupus Erythematosus, Discoid |
Exanthema Alopecia Connective Tissue Diseases Lassueur-Graham-Little syndrome Skin Diseases, Papulosquamous Cutaneous lupus erythematosus Cicatrix |
Hair Diseases Hypotrichosis Lichenoid Eruptions |