National Toxicology Program

Selected information from two of the National Library of Medicine's databases: ChemIDPlus¹ and HSDB².

Names (NTP)

• Piperonyl butoxide
• 5-((2-(2-BUTOXYETHOXY)ETHOXY)METHYL)-6-PROPYL-1,3-BENZODIOXOLE (9CI)

Structure

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Chemical Properties²

Property	Description
Color/Form	Colorless liquid PALE YELLISH LIQ
Odor	ODORLESS Odor: mild.
Taste	FAINT BITTER TASTE
Boiling Point	180 deg C @ 1 mm Hg
Melting Point	None found
Molecular Weight	338.43
Corrosivity	NONCORROSIVE
Critical Temperature & Pressure	None found
Density/Specific Gravity	1.06 @ 20 deg C
Disassociation Constants	None found
Heat of Combustion	None found
Heat of Vaporization	None found
log P (octanol-water)	log Kow= 4.75
pH	None found
Solubilities	Miscible with methanol, ethanol, benzene, freons, geons, petroleum oils, and other organic solvents In water, 14.3 mg/l @ 25 deg C
Spectral Properties	Index of refraction: 1.50 @ 20 deg C/D Intense mass spectral peaks: 176 m/z (100%), 177 m/z (41%), 194 m/z (26%), 57 m/z (19%)
Surface Tension	None found
Vapor Density	None found
Vapor Pressure	None found
Relative Evaporation Rate	None found
Viscosity	40 cP @ 25 deg C
Other Properties	Resistant to hydrolysis Yellow oil /Technical product/

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Uses²

• For Piperonyl butoxide (USEPA/OPP Pesticide Code: 067501) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./
  
• Insecticide synergist, esp for pyrethrum and rotenone
  
• Synergist for the pyrethrins and related insecticides
  
• MEDICATION **PEER REVIEWED**
  
• Anvil is a pesticide product that is used to control mosquitoes in outdoor residential and recreational areas. It contains sumithrin, piperonyl butoxide and petroleum solvents. ... Piperonyl butoxide does not directly kill insects on its own but acts to increase the ability of sumithrin to kill insects. Other pesticide products containing these ingredients are used indoors and on pets to control insects such as fleas, ticks, and ants.
  

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Superlist Classes¹

• Overall Carcinogenic Evaluation: Group 3
  

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Notes (Sources: NTP,HSDB,RTECS,MESH)¹

• None found

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Other Registry Numbers¹

• 12750-92-4
  

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Synonyms (Sources: NTP, HSDB,RTECS,MESH)¹

• 4-19-00-00779 (Beilstein Handbook Reference)
• 1,3-Benzodioxole, 5-((2-(2-butoxyethoxy)ethoxy)methyl)-6-propyl-
• BRN 0288063
• Butacide
• Butocide
• Butoxide
• Butoxide (synergist)
• alpha-(2-(2-n-Butoxyethoxy)-ethoxy)-4,5-methylenedioxy-2-propyltoluene
• alpha-(2-(2-Butoxyethoxy)ethoxy)-4,5-methylenedioxy-2-propyltoluene
• 5-((2-(2-Butoxyethoxy)ethoxy)methyl)-6-propyl-1,3-benzodioxole
• Butyl carbitol 6-propylpiperonyl ether
• Butyl-carbityl (6-propylpiperonyl) ether
• ENT 14,250
• FMC 5273
• HSDB 1755
• 3,4-Methylenedioxy-6-propylbenzyl n-butyl diethyleneglycol ether
• 3,4-Methylenedioxy-6-propylbenzyl n-butyldiethyleneglycol ether
• NCI-C02813
• NIA 5273
• Nusyn-noxfish
• PB
• Piperonyl butoxide
• 6-Propylpiperonyl butyl diethylene glycol ether
• 6-(Propylpiperonyl)-butyl carbityl ether
• Pyrenone 606
• Toluene, alpha-(2-(2-butoxyethoxy)ethoxy)-4,5-(methylenedioxy)-2-propyl-

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Links to Additional Information¹

• PubMed AIDS
• PubMed Cancer
• CCRIS
• DART
• EINECS
• EMIC
• GENETOX
• Household Products
• HSDB
• PubMed
• MeSH Heading
• MeSH
• PubMed Toxicology
• TOXLINE
• TOXMAP
• TRI2000
• TRI2001
• TRI2002
• TRI2003
• TRI2004
• TRI95
• TRI96
• TRI97
• TRI98
• TRI99
• PubChem
• DrugPortal
• TRI2005

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Footnotes

¹ Source: the National Library of Medicine's ChemIDPlus, 10/28/2007.

² Source: the National Library of Medicine's Hazardous Substance Database, 10/28/2007.