National Toxicology Program

CASRN: 111-46-6

Formula: C4-H10-O3

Synonyms/Common Names:

• 2,2'-OXYBISETHANOL (9CI)

Known Uses:

IN ANTIFREEZE SOL'N, TEXTILE LUBRICATING AGENT, VAT DYE SOLVENT, CORK COMPOSITES, GLUES, GELATIN, PASTES, PHOTOGRAPHIC DEVELOPER(MERCK 1989). TOBACCO HUMECTANT, CASEIN, SYNTHETIC SPONGES, PAPER PRODUCTS, ADHESIVES, COSMETICS, LACQUERS (HSDB 1990)

Special Studies

• Absorption Disposition Metabolism Elimination (Intravenous; Dosed-Water; Gavage)  (S0219) Completed 
  • Citation: MATHEWS, J.M., PARKER, M.K. & MATTHEWS, H.B., METABOLISM & DISPOSITION OF DIETHYLENE GLYCOL IN RAT & DOG, DRUG METABOL & DISP., 19(6):1066-1070, 1991.
  • M Rats: F344/N; M Rats: F344/N; M Rats: F344/N; F Dog: Beagles
  • Dose: RATS: IV 50 MG/KG, ORAL 0.3,1.0 & 3.0%, GAV 50 & 5000 MK/KG; DOGS GAV 500 MG/KG.

Genetic Toxicology

• Salmonella  (248390) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
  •  Negative 

Organ Systems Toxicity

• CONT EXPOS, 120 D MINIMUM Continuous Breeding (Dosed-Water)  (RACB83086) Completed 
  • NTIS No. PB85-212926
    Citation: Final Report - Diethylene Glycol: Reproduction and Fertility Assessment in CD-1 Mice When Administered In the Drinking Water
  • M/F Mice: Swiss
  • Dose: N/A; 0,.35,1.75,3.5%; N/A; N/A
• 8 CONS D (MTD PHASE), GD 7-14 (REPRO PHASE) Short-Term in vivo Repro. Tox. (Gavage)  (T0075A) Completed 
  • NTIS No. PB83-258616
    Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
  • F Mice: Swiss
  • Dose: 11,180 MG(10ML UNDILUTED)/KG BODY WEIGHT
• GD 6-15 Conventional Teratology (Gavage)  (TER89001) Completed 
  • NTIS No. PB91-159327
    Citation: Final Report on the Developmental Toxicity of Diethylene Glycol in CD-1 Swiss Mice
  • F Mice: Swiss CD-1
  • Mice Maternal Positive 
  • Mice Fetal Positive 
  • Dose: 0, 1250, 5000, 10000 MG/KG/DAY