Testing Information

Testing Status of Agents at NTP

o-Anthranilic acid

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http://ntp.niehs.nih.gov/go/TS-C01730

CASRN: 118-92-3

Formula: C7 H7 N O2

Synonyms/Common Names:

  • BENZOIC ACID, O-AMINO

Known Uses:

INTERMEDIATE IN DYE SYNTHESIS, VITAMINS, NECESSARY FOR LACTATION (MERCK 1989)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C01730) Completed 
    • NTIS No. PB278883  (Peer Review 11/28/1977)
      Citation: Bioassay of Anthranilic Acid for Possible Carcinogenicity (CAS No. 118-92-3)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C01730) Completed 
    • NTIS No. PB278883  (Peer Review 11/28/1977)
      Citation: Bioassay of Anthranilic Acid for Possible Carcinogenicity (CAS No. 118-92-3)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: MR&MM: 0,1000,50000 PPM/5 PER GROUP

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C01730) Report Complete 
    • TR-036 (NTIS No. PB278883)  (Peer Review 11/28/1977)
      Bioassay of Anthranilic Acid for Possible Carcinogenicity (CAS No. 118-92-3)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0,15000,30000, M: 0,25000,50000 PPM/35 PER GROUP

Genetic Toxicology

  • Chromosome Aberrations  (919747) Completed 
    • Mice
    • Chromosome Aberation  Equivocal 
  • In Vitro Cytogenetics (CA/SCE)  (313261) Completed 
    • Chromosome Aberation Weakly Positive 
    • Sister Chromatid Exchange Positive 
  • Mouse Lymphoma (NCI)  (217797) Completed 
    • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
    • Mouse Lymphoma-NCI  Positive 
  • Mouse Lymphoma (NCI)  (879005) Completed 
    • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
    • Mouse Lymphoma-NCI  Positive 
  • Salmonella  (988097) Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
    •  Negative 
  • Sister Chromatid Exchanges  (919747) Completed 
    • Mice
    • Sister Chromatid  Positive 

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Web page last updated on January 22, 2009