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Akabani, G., S. J. Kennel,
and M. R. Zalutsky, "Microdosimetric analysis of alpha-particle-emitting
targeted radiotherapeutics using histological images," J.
Nucl. Med. 44(5):792-805 (May 2003).
Allain, L. R., D. N. Stratis,
C. M. Cullum, J. Mobley, M. R. Hajaligol, and T. Vo-Dinh, "Real-time
detection of PAH mixtures in the vapor phase at high temperatures,"
J. Anal. Appl. Pyrolysis 66(1-2):145-154 (January
2003).
Chain, P., J. Lamerdin,
F. Larimer, W. Regala, V. Lao, M. Land, L. Hauser, A. Hooper, M.
Klotz, J. Norton, L. Sayavedra- Soto, D. Arciero, N. Hommes, M.
Whittaker, and D. Arp, "Complete Genome Sequence of the Ammonia-Oxidizing
Bacterium and Obligate Chemolithoautotroph NitrosomonaseEuropaea,"
J. Bacteriology 185(9):2759-2773 (May 2003).
Chao, H.H.J., S. E. Mentzer,
J. C. Schimenti, and Y. You, "Overlapping Deletions Define
Novel Embryonic Lethal Loci in the Mouse t Complex,"
Genesis 35:133-142 (February 2003).
Chen, Y., and D. Xu, "Computational
analyses of high-throughput protein-protein interaction data,"
Current Protein & Peptide Science 4(3):159-180
(June 2003).
Chen, Y., T. Joshi, Y.
Xu, and D. Xu, "Towards Automated Derivation of Biological
Pathways Using High-Throughput Biological Date," in Proc.
of the 3rd IEEE Symposium on Bioinformatics and Bioengineering,
IEEE/CS Press, pp. 18-25 (2003).
Chen, Z. Z., T. Jiant,
G. H. Lin, J. J. Wen, D. Xu, J. B. Xu, and Y. Xu, "Approximation
algorithms for NMR spectral peak assignment," Theor. Comp.
Sci. 299(1-3):211-229 (April 2003).
Christofidou-Solomidou,
M., A. Scherpereel, A. Bohen, E. Arguiri, V. Sahuvaev, S. Kennel,
and V. Muzykantov, "Hyperoxia potentiates oxidative injury
in murine lungs induced by glucose oxidase targeted to thrombomodulin,"
FASEB Journal 17(4):A247, Part 1, Suppl. S (March
2003).
Davison, B. H., and M.
Finkelstein, "Introduction to the Proceedings of the Twenty-Fourth
Symposium on Biotechnology for Fuels and Chemicals," Appl.
Biochem. & Biotech. 105:III-VII (Spring 2003).
Espinosa, G., and R. B.
Gammage, "A representative survey of indoor radon in the sixteen
regions in Mexico City," Rad. Prot. Dosim. 103(1):73-76
(2003).
Gunter, L. E., G. T. Roberts,
K. Lee, F. W. Larimer, and G. A. Tuskan, "The development of
two flanking SCAR markers linked to a sex determination locus in
Salix viminalis L.," J. Heredity 94(2):185-189
(March 2003).
Guo, J. T., D. Xu, D.
Kim, and Y. Xu, "Improving the performance of DomainParser
for structural domain partition using neural network," Nucl.
Acids Res. 31(3):944-952 (February 2003).
Gupta, R. K., S. V. Dobritsa,
C. A. Stiles, M. E. Essington, Z. Y. Liu, C. H. Chen, E. H. Serpersu,
and B. C. Mullin, "Metallohistins: A New Class of Plant Metal-Binding
Proteins," J. Protein Chem. 21(8):529-536 (November
2002).
Hanson, B. L., C. A. Schall,
and G. J. Bunick, "New techniques in macromolecular cryocrystallography:
macromolecular crystal annealing and cryogenic helium," J.
Struc. Biol. 142(1):44-87 (April 2003).
Heo, Y. R., K. Claycombe,
G. E. Truett, P. Wright, W. Banz, M. Maher, M. Zemel, B. H. Jones,
and N. Moustaid-Moussa, "Effects of fatty (fa) allele and high-fat
diet on adipose tissue leptin and lipid metabolism," Horm.
Metab. Res. 34(11 12):686-690 (2003).
Higley, K. A., S. L. Domotor,
E. J. Antonio, and D. C. Kocher (LSD retired), "Derivation
of a Screening Methodology for Evaluating Radiation Dose to Aquatic
and Terrestrial Biota," J. Env. Radioactivity 66(1-2):41-59
(2003).
Horita, J. and A. A. Vass,
"Stable-Isotope Fingerprints of Biological Agents as Forensic
Tools," J. Forensic Sci. 48(1):122-126 (January
2003).
Hoyt, P. R., L. Tack,
B. H. Jones, J. Van Dinther, S. Staat, and M. J. Doktycz, "Automated
High-Throughput Probe Production for DNA Microarray Analysis,"
Biotechniques 34(2):402-407 (February 2003).
Isola, N. R., Z. Liu,
S. L. Allman, N. I. Taranenko, Y. Kong, and C. H. Chen, "Matrix-assisted
laser desorption/ionization detection of polymerase chain reaction
products by utilizing the 5'-3' exonuclease activity of Thermus
aquaticus DNA polymerase," Rapid Commun. in Mass Spectrom.
17(6):532-537 (2003).
Jones, D., S. Domotor,
K. Higley, D. Kocher (LSD retired), and G. Bilyard, "Principles
and Issues in Radiological Ecological Risk Assessment," J.
Env. Radioactivity 66(1-2):19-39 (2003).
Kasili, R. M., B. M. Cullum,
G. D. Griffin, and T. Vo-Dinh, "Nanosensor for in vivo measurement
of the carcinogen benzo[a]pyrene in a single cell," J. Nanosci.
& Nanotech. 2(6):653-658 (December 2002).
Kennel, S. J., "531-2A,
22A, 30Aq 32A anti-CD44," Hybridoma and Hybridomics
21(6):506 (December 2002).
Kim, S., S. Urs, F. Massiera,
P. Wortman, R. Joshi, Y. R. Heo, B. Anderson, H. Kobayashi, M. Teboul,
G. Aihaud, A. Quignard-Boulange, A. Fukamizu, B. H. Jones, J. H.
Kim, and N. Moustaid-Moussa, "Effects of high-fat diet, angiotensinogen
(agt) gene inactivation, and targeted expression to adipose tissue
on lipid metabolism and renal gene expression," Hormone
and Metabolic Res. 34(11-12):721-725 (November/December
2002).
Lin, G., D. Xu, Z.-Z.
Chen, T. Jiang, J. Wen, and Y. Xu, "Computational Assignments
of Protein Backbone NMR Peaks by Efficient Bounding and Filtering,"
J. Bioinformatic and Computational Biology 31:944-952
(2003).
Mehta, A., P. Kumar, M.
D. Dadmun, J. Zheng, R. M. Dickson, T. Thundat, B. G. Sumpter, and
M. D. Barnes, "Oriented nanostructures from single molecules
of a semiconducting polymer: Polarization evidence for highly aligned
intramolecular geometries," Nano Letters 3(5):603-6097
(May 2003).
Mehta, A., T. Thundat,
M. D. Barnes, V. Chhabra, R. Bhargava, A. P. Bartko, and R. M. Dickson,
"Size-correlated spectroscopy and imaging of rare-earth-doped
nanocrystals," Applied Optics 42(12):2132-2139
(April 2003).
Melechko, A. V., T. E.
McKnight, M. A. Guillorn, V. I. Merkulov, B. Ilic, M. J. Doktycz,
D. H. Lowndes, and M. L. Simpson, "Vertically Aligned Carbon
Nanofibers as Sacrificial Templates for Nanofluidic Structures,"
Appl. Phys. Lett. 82(6):976-978 (February 2003).
Melechko, A. V., T. E.
McKnight, M. A. Guillorn, D. W. Austin, B. Ilic, V. I. Merkulov,
M. J. Doktycz, D. H. Lowndes, and M. L. Simpson, "Nanopipe
Fabrication Using Vertically Aligned Carbon Nanofiber Templates,"
J. Vac. Sci. Tech. B 20(6):2730-2733 (November-December
2002).
Moreno-Bondi, M. C., J.
P. Alarie, and T. Vo-Dinh, "Multi-Analyte Analysis System Using
an Antibody-Based Biochip," Anal. Bioanal. Chem. 375(1):120-124
(January 2003).
Olman, V., D. Xu, and
Y. Xu, "Identification of Regulatory Binding Sites Using Minimum
Spanning Trees," in Proc. 2003 Pacific Symp. on Biocomputing
(PSB), pp. 327-338 (2003).
Olman, V., D. Xu, and
Y. Xu, "CUBIC: Identification of Regulatory Binding Sites through
Data Clustering," J. Bioinformatics and Computational Biology
1:20-40 (2003).
Passian, A., P. G. Evans,
V. K. Varma, T. L. Ferrell, and T. Thundat, "Piezoresistive
Detection of Acoustic Waves," Rev. Sci. Instrum. 74(2):1031-1035
(February 2003).
Passian, A., R. J. Warmack,
T. L. Ferrell, and T. Thundat, "Thermal transpiration at the
microscale: A Crookes cantilever," Phys. Rev. Ltrs.
90(12), article no. 124503 (March 2003).
Rajaraman, S., L. K. Wood,
D. K. Willhite, L. B. Russell, and M. A. Bedell, "Effects of
spontaneious Kitl(Steel) mutations on survival and red blood
cells of mice," Mamm. Gen. 14(3):168-174 (March
2003).
Reyes-Lopez, M., A. Mendez-Tenorio,
R. Maldonaldo-Rodriguez, M. J. Doktycz, J. T. Fleming, and K. L.
Beattie, "Fingerprinting of prokaryotic 16S rRNA genes
using oligodeoxyribonucleotide microarrays and virtual hybridization,"
Nucl. Acids Res. 31(2):779-789 (January 2003).
Rinchik, E. M., D. K.
Johnson, D. Miller, C. T. Culiat, and E. J. Michaud, "Chemical
mutagenesis of the mouse germline: New models for genetic diseases
and for dissecting basic biological processes," FASEB Journal
17(5):A1168, Part 2, Suppl. S (March 2003).
Shah, M., S. Passovets,
D. Kim, K. Ellrott, L. Wang, I. Vokler, P. LoCascio, D. Xu, and
Y. Xu, "A Computational Pipeline for Protein Structure Prediction
and Analysis at Genome Scale," in Proc. of the 3rd IEEE
Symposium on Bioinformatics and Bioengineering, IEEE/CS Press,
pp. 3-10 (2003).
Sharp, J. S., J. M. Becker,
and R. L. Hettich, "Protein surface mapping by chemical oxidation:
Structural analysis by mass spectrometry," Anal. Biochem.
313(2):216-225 (February 2003).
Sharp, J. S., J. M. Becker,
R. L. Hettich, "Topology characterization of model proteins
by photochemical side chain oxidation and mass spectrometry,"
FASEB Journal 17(5):A988, Part 2 Suppl. S (March 2003).
Song, J. M., J. Mobley,
and T. Vo-Dinh, "Detection of bactyerial pathogen DNA using
an integrated complementary metal oxide semiconductor microchip
system with capillary array electrophoresis," J. Chrom.
B-Anal. Tech. Biomed. Life Sci. 783(2):501-508 (January
2003).
Stratis-Collum, D. N.,
G. D. Griffin, J. Mobley, A. A. Vass, and T. Vo-Dinh, "A miniature
biochip system for detection of aerosolized Bacillus globigii spores,"
Anal. Chem. 75(2):275-280 (January 2003).
Vo-Dinh, T., "Nanobiosensors:
Probing the Sanctuary of Individual Living Cells," J. Cell
Biochem. Supp. 39:154-161 (2002).
Vo-Dinh, T., G. Griffin,
D. L. Stokes, and A. Wintenberg, "Multi-functional biochip
for medical diagnostics and pathogen detection," Sensors
and Actuators B - Chemical 90(1-3):104-111, Sp. Iss.
SI (April 2003).
Wang, L. H., and B. E.
Hingerty, "Conformational analysis of model estrogen-DNA adducts,
N-2-(2-hydroxyestron-a,
b-yl)-2'-deoxyguanosine and N-6-(2-hydroxyestron-6a,
b-yl-2'-deoxyadenosine in duplex B-DNA,"
Chem. Res. in Toxicol. 15(12):67 (December 2002).
Waters, K. R., M. S. Hughes,
J. Mobley, and J. G. Miller, "Differential Forms of the Karmers-Kronig
Dispersion Relations," IEEE Trans. On Ultrasonics Ferroelectrics
and Frequency Control 50(1):68-76 (January 2003).
Witt, K. L., L. A. Hughes,
L. T. Burka, A. F. McFee, J. M. Mathews, S. L. Black, and J. B.
Bishop, "Mouse Bone Marrow Micronucleus Test Results Do Not
Predict the Germ Cell Mutagenicity of N-Hydroxymethylacrylamide
in the Mouse Dominant Lethal Assay," Env. Mol. Mut.
41(2):111-120 (2003).
Wu, M., E. J. Michaud,
and D. K. Johnson, "Cloning, functional study and comparative
mapping of Luzp2 to mouse chromosome 7 and human chromosome
11p13-11p14," Mamm. Gen. 14(5):323-334 (May 2003).
Yan, X. D., Y. Lvov, H.-F.
Ji, A. Singh, and T. Thundat, "A general microcantilever surface
modification method using a multilayer for biospecific recognition,"
Organic & Biomolecular Chemistry 1(3):460-462
(February 2003).
Yang, Y. M., H. F. Ji,
and T. Thundat, "Nerve Agents Detection Using a Cu2+/L-cysteine
Bilayer-Coated Microcantilever," J. Amer. Chem. Soc.
125(5):1124-1125 (February 2003).
Zhang, Q. H., N. S. Murcia,
L. R. Chittenden, W. G. Richards, E. J. Michaud, R. P. Woychik,
and B. K. Yoder, "Loss of the Tg737 protein results
in skeletal patterning defects," Dev. Dyn. 227(1):78-90
(May 2003).
Reports (ORNL-TMs)
Barton, John W., and Roger
D. Spence, Evaluation of FWENC Process for Treatment of MVST
Sludges, Supernates, and Surrogates. ORNL/TM-2003/30, U.S. Department
of Energy, Oak Ridge, Tennessee.
Klasson, K. T., R. M. Counce,
L. W. Perkins, S. R. Drescher, and C. J. Perilloux, Nitro-Hydrolysis:
An Energy Efficient Source Reduction and Chemical Production Process
for Wastewater Treatment Plant Biosolids. ORNL/TM-2003/3, Oak
Ridge National Laboratory (January 2003).
Presentations
Barton, John W., Sandie
A. Jones, Christopher D. Vodraska, and Brian H. Davison, "Enhanced
Solubility of TCE and Other Contaminants Due to the Presence of
Biological Material," presented at the 225th American Chemical
Doktycz, M. J., P. R.
Hoyt, and D. P. Allison, "Immobilization and Imaging of Bacterial
Cells," presented at the Oxford 2003 Scanning Probe Microscopy,
Sensors and Nanostructure Meeting, Oxford, England, May 23-26, 2003.
Erdmann, Natalie, Yie
Liu, and Lea Harrington, "Progressive Haplo insufficiency in
m tert +/- Mice Leads to Accelerated Sterility in m tert
-/- Mice," presented at the Cold Spring Harbor Meeting,
April 30-May 4, 2003.
Johnson, D. K., "Screening
for age-onset abnormal phenotypes and increased longevity in ENU-mutagenized
mice," presented at the 3rd Annual Tennessee Mouse Genome Consortium
Retreat, Murfreesboro, Tennessee, January 16-18, 2003 (presented
as representative of the TMGC)(poster).
Johnson, D. K., "The
TMGC Aging Program," presented to the External Advisory Panel
Meeting for the Tennessee Mouse Genome Consortium, University of
Tennessee Health Science Center, Memphis, Tennessee, March 2-4,
2003 (Invited).
Johnson, D. K., "A
Phenotyping Pipeline," presented at the U.S. Department of
Energy Genome Meeting, Santa Fe, New Mexico, March 30-April 2, 2003
(Invited).
Johnson, D. K., "Phenotype-
and Gene-Driven Approaches to Discovering the Functions of Mammalian
Genes," presented at the American Society for Nutritional Sciences
(ASNS) for the 2003 Experimental Biology Conference, San Diego,
California, April 11 15, 2003 (Invited).
Johnson, D. K., "How
Mice Can Help People," presented at the Willowbrook Elementary
School, Oak Ridge, Tennessee, May 7, 2003 (Invited).
Johnson, D. K., "Mouse
Models/BSL-3," presented at Homeland Security Meeting, Oak
Ridge National Laboratory, Oak Ridge, Tennessee, May 9, 2003 (Invited).
Johnson, D. K., "Genetics
of Age-Onset Disorders and Longevity," presented at the Science
Lunchtime Seminar, Oak Ridge National Laboratory, Oak Ridge, Tennessee,
May 28, 2003 (Invited).
Johnson, D. K., "Are
Mice Good Models for Human Gene Functions," presented to summer
students at Oak Ridge National Laboratory, Oak Ridge, Tennessee,
June 11, 2003 (Invited).
Jones, B. H., "Hairy
Issues: Combining hairless mice, classical biology, genomics and
computation to understand gene regulatory networks," presented
at the Comparative and Experimental Medicine Seminar Series, University
of Tennessee Medical Research Center, Knoxville, Tennessee, January
14, 2003.
Klasson, K. T., "Reaching
Part Per Trillion Clean-Up Criteria for Mercury in Water,"
presented at WM'03, the 29th Annual Waste Management Symposium,
Tucson, Arizona, February 23-27, 2003.
Klasson, K. T., "Treatment
of Mercury Contaminated Oils," presented at WM'03, the 29th
Annual Waste Management Symposium, Tucson, Arizona, February 23-27,
2003.
Liu, Yie, Bryan E. Snow,
Wen Zhou, Natalie Erdmann, Karuna Chourey, Marla Gomez, Murray O.
Robinson, and Lea Harrington, "Elucidating fhe Role of Two
Mammalian Telomerase-Associated Protein Components In Vivo -
TERT and VPARP," presented at the U.S. Department of Energy
Genome Meeting, Santa Fe, New Mexico, March 30-April 2, 2003 (Invited).
Michaud, E. J. et al.,
"Functional Annotation of Human Genes by Gene-Driven Chemical
Mutagenesis in Mice," presented at the U.S. Department of Energy
Genome Meeting, Santa Fe, New Mexico, March 30-April 2, 2003 (Inrited).
Michaud, E. J., "Functional Annotation of Human Genes by Gene-Driven
Chemical Mutagenesis in Mice," presented at the 3rd Annual
Tennessee Mouse Genome Consortium Retreat, Murfreesboro, Tennessee,
January 16-18, 2003 (poster).
Miller, D. R., "An Update and Summary of the Administrative
Core of the NIMH Project," presented to the External Advisory
Panel Meeting for the Tennessee Mouse Genome Consortium, University
of Tennessee Health Science Center, Memphis, Tennessee, March 2-4,
2003 (Invited).
Pinnaduwage, L. A., J. E. Hawk, V. Voiadjiev, and T. Thundat, "Explosive/Water
Vapor Adsorption on Microcantilevers Coated with a Self-Assembled
Monolayer of Mercaptobenzoic Acid," presented at Oxford 2003
Scanning Probe Microscopy, Sensors and Nanostructure Meeting, Oxford,
England, May 23-26, 2003.
Pinnaduwage, L.A., T. Thundat, A. Gehl, D. Yi, D. L. Hedden, and
R. T. Lareau, "Adsorption/Desorption Characteristics of Explosive
Vapors on Uncoated Silicon Microcantilever Surfaces," presented
at the Oxford 2003 Scanning probe Microscopy, Sensors and Nanostructure
Meeting, Oxford, England, May 23-26, 2003.
Rinchik, E. M., "The Mutagenesis Core of the NIMH Project,
" presented to the External Advisory Panel Meeting for the
Tennessee Mouse Genome Consortium, University of Tennessee Health
Science Center, Memphis, Tennessee, March 2-4, 2003 (Invited).
Rinchik, E. M., "Long-Term Vision for the Collective DOE Mouse
Programs," presented at the U.S. Department of Energy Genome
Meeting, Santa Fe, New Mexico, March 30-April 2, 2003 (Invited).
Rinchik, E. M. (presenter), D. R. Miller, D. K. Johnson, C. T. Culiat,
E. J. Michaud, and the Tennessee Mouse Genome Consortium, "Chemical
Mutagenesis of the Mouse Germline: New Models for Genetic Diseases
and for Dissecting Basic Biological Processes," presented at
the Federation of American Societies for Experimental Biology, San
Diego, California, April 11-15, 2003 (Invited).
Rinchik, E. M., "Heritability Update," presented at the
Tennessee Mouse Genome Consortium Meeting, University of Tennessee
Health Science Center, Memphis, Tennessee, May 13, 2003 (Invited).
Rinchik, E. M., "The Tennessee Mouse Genome Consortium Neuromutagenesis
Project," presented at the Tennessee Mouse Genome Consortium
Meeting, University of Tennessee Health Science Center, Memphis,
Tennessee, May 13, 2003 (Invited).
Spence, Roger D., John W. Barton, and Mike Morris, "Stabilization
of Mercury in High pH Tank Sludges," presented at WM'03, the
29th Annual Waste Management Symposium, Tucson, Arizona, February
23-27, 2003.
Wig, A., A. Passian, E. T. Arakawa, T. L. Ferrell, and T. Thundat,
"Interference Effects in Optically Activated Microcantilevers,"
presented at the Oxford 2003 Scanning Probe Microscopy, Sensors
and Nanostructure Meeting, Oxford, England, May 23-26, 2003.
1997-98 Life Sciences Division Progress
Report
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