Energy Citations Database

Bibliographic Citation

 
Document
For copies of Journal Articles, please contact the Publisher or your local public or university library and refer to the information in the Resource Relation field.
For copies of other documents, please see the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or Document Availability.
Title Genetic control of resistance to Coccidioides immitis: a single gene that is expressed in spleen cells determines resistance
Creator/Author Kirkland, T.N. ; Fierer, J.
Publication Date1985 Jul 01
OSTI IdentifierOSTI ID: 6431156
Other Number(s)CODEN: JOIMA
Resource TypeJournal Article
Resource RelationJ. Immunol. ; Vol/Issue: 1
Subject560152 -- Radiation Effects on Animals-- Animals; MICE-- DISEASE RESISTANCE;SPLEEN CELLS-- TRANSPLANTS; GENES;IMMUNE REACTIONS;PERITONITIS;RADIATION CHIMERAS
Related SubjectANIMAL CELLS;ANIMALS;CHIMERAS;DIGESTIVE SYSTEM DISEASES;DISEASES;MAMMALS;MOSAICISM;RODENTS;SOMATIC CELLS;VERTEBRATES
Description/Abstract The authors have previously reported that inbred mice vary widely in their resistance to Coccidioides immitis peritonitis.^To investigate the number of genes controlling resistance, (susceptible X resistant)F1 X susceptible backcross mice were tested for resistance to infection.^A 1:1 ratio of resistant:susceptible offspring was observed, which is consistent with a single dominant gene determining resistance.^To find out whether this gene, which was designated Cms, is expressed in the immune and/or the inflammatory responses, radiation chimeras were constructed by transplanting spleen cells from the resistant F1 mice into the susceptible parental strain.^These chimeras were consistently more resistant to infection than the susceptible parental strain.^The authors concluded that resistance to C. immitis is determined primarily by a single gene, and that this gene is expressed by spleen cells.
Country of PublicationUnited States
LanguageEnglish
FormatPages: 548-552
System Entry Date2001 May 13

Top