Bibliographic Citation
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Title | Genetic control of resistance to Coccidioides immitis: a single gene that is expressed in spleen cells determines resistance |
Creator/Author | Kirkland, T.N. ; Fierer, J. |
Publication Date | 1985 Jul 01 |
OSTI Identifier | OSTI ID: 6431156 |
Other Number(s) | CODEN: JOIMA |
Resource Type | Journal Article |
Resource Relation | J. Immunol. ; Vol/Issue: 1 |
Subject | 560152 -- Radiation Effects on Animals-- Animals; MICE-- DISEASE RESISTANCE;SPLEEN CELLS-- TRANSPLANTS; GENES;IMMUNE REACTIONS;PERITONITIS;RADIATION CHIMERAS |
Related Subject | ANIMAL CELLS;ANIMALS;CHIMERAS;DIGESTIVE SYSTEM DISEASES;DISEASES;MAMMALS;MOSAICISM;RODENTS;SOMATIC CELLS;VERTEBRATES |
Description/Abstract | The authors have previously reported that inbred mice vary widely in their resistance to Coccidioides immitis peritonitis.^To investigate the number of genes controlling resistance, (susceptible X resistant)F1 X susceptible backcross mice were tested for resistance to infection.^A 1:1 ratio of resistant:susceptible offspring was observed, which is consistent with a single dominant gene determining resistance.^To find out whether this gene, which was designated Cms, is expressed in the immune and/or the inflammatory responses, radiation chimeras were constructed by transplanting spleen cells from the resistant F1 mice into the susceptible parental strain.^These chimeras were consistently more resistant to infection than the susceptible parental strain.^The authors concluded that resistance to C. immitis is determined primarily by a single gene, and that this gene is expressed by spleen cells. |
Country of Publication | United States |
Language | English |
Format | Pages: 548-552 |
System Entry Date | 2001 May 13 |
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