AVILES P, PATEMAN A, SAN ROMAN R, GUILLEN MJ, GARGALLO-VIOLA D; Interscience Conference on Antimicrobial Agents and Chemotherapy.

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2000 Sep 17-20; 40: 388.

GlaxoWellcome, S.A., Tres Cantos, Spain

GW 471558 and GW 531920 belong to a new family of antifungal compounds, azasordarin. Pharmacokinetic (PK) properties of GW 471558 and GW 531920 have been studied after intravenous (iv) administration in CD1 male mice, SD male rats and male Beagle dog. Compounds were dissolved in sterile water at desired concentration and administered by venipuncture in the tail vein in mice. Rats were cannulated in the jugular vein 24 h before PK studies. Admin. in dogs was done in cephalic vein. In all cases blood samples were collected, centrifuged and sera were kept at -80 degrees C until analysis. Specific HPLC or bioassay were used as convenient. PK parameters were calculated by non-compartmental analysis. The main PK parameters were as follows [table: see text]. Azasordarin derivatives have PK properties that can be forescast inter animal species. These results suggest that these compounds have PK properties compatible with therapeutic administration as antifungal agents in animals.KEYWORDS: Antifungal; Azasordarins; Pharmacokinetics

Publication Types:

• Meeting Abstracts

Keywords:

• Animals
• Antibiotics, Antifungal
• Chromatography, High Pressure Liquid
• Dogs
• GW 471558
• Male
• Mice
• Muridae
• Rats
• Rats, Sprague-Dawley
• pharmacokinetics

Other ID:

• GWAIDS0010311

UI: 102247809

From Meeting Abstracts