29067 |
cd00148 |
PROF |
Profilin binds actin monomers, membrane polyphosphoinositides such as PI(4,5)P2, and poly-L-proline. Profilin can inhibit actin polymerization into F-actin by binding to monomeric actin (G-actin) and terminal F-actin subunits, but - as a regulator of the cytoskeleton - it may also promote actin polymerization. It plays a role in the assembly of branched actin filament networks, by activating WASP via binding to WASP's proline rich domain. Profilin may link the cytoskeleton with major signalling pathways by interacting with components of the phosphatidylinositol cycle and Ras pathway. |
Profilin binds actin monomers, membrane polyphosphoinositides such as PI(4,5)P2, and... |
true |
false |
true |
127 |
2e-23 |
102.63 |
100.00 |
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1CF0_B 1 GWNAYID-NLMADGTCQDAAIVGYkDSPSVWAAVPGktFVNITPAEVGVLVG--KDRSSFYVNGLTLGGQKCSVIRDSll 77
cd00148 1 SWQAYVDdNLLGTGKVDSAAIVGH-DDGSVWAASAG--GFNLTPEEVGTLVAgfKDPDGVFSTGLTLGGQKYMVIRAD-- 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
1CF0_B 78 qdgEFSMDLRTKSTGGAptfnvtVTKTDKTLVLLMGKEGVHGGLINKKCYEMASHLRRSQY 138
cd00148 76 ---DRSIYGKKGAGGVV------IVKTKQALVIGMYEEGVQPGQANKVVEKLADYLRSQGY 127
|
|
cl00123 |
119548 |
PROF |
Profilin binds actin monomers, membrane polyphosphoinositides such as PI(4,5)P2, and poly-L-proline. Profilin can inhibit actin polymerization into F-actin by binding to monomeric actin (G-actin) and terminal F-actin subunits, but - as a regulator of the cytoskeleton - it may also promote actin polymerization. It plays a role in the assembly of branched actin filament networks, by activating WASP via binding to WASP's proline rich domain. Profilin may link the cytoskeleton with major signalling pathways by interacting with components of the phosphatidylinositol cycle and Ras pathway. |
Profilin binds actin monomers, membrane polyphosphoinositides such as PI(4,5)P2, and... |
0 |
109299 |
pfam00235 |
Profilin |
Profilin |
Profilin |
false |
false |
false |
122 |
2e-25 |
109.34 |
100.00 |
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1CF0_B 1 GWNAYIDN-LMADGTCQDAAIVGYKDspSVWAAVPGKTFVNItpAEVGVLVG--KDRSSFYVNGLTLGGQKCSVIRDsll 77
pfam00235 1 SWQAYVDNlLMGTGKVQGAAIVGYDG--NVWAASAGFTFTKI--GEIANIAAgfDNPAGFFSNGITLGGQKYMVIRD--- 73
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
1CF0_B 78 qDGEFSMDLRTKSTGgaptfnVTVTKTDKTLVLLMGKEGVHGGLINKKCYEMASHL 133
pfam00235 74 -DADRSIYGKKGAGG------VVIVKTGQALVIGHYKETVQPGQANKVVEKLADYL 122
|
|
cl00123 |
119548 |
PROF |
Profilin binds actin monomers, membrane polyphosphoinositides such as PI(4,5)P2, and poly-L-proline. Profilin can inhibit actin polymerization into F-actin by binding to monomeric actin (G-actin) and terminal F-actin subunits, but - as a regulator of the cytoskeleton - it may also promote actin polymerization. It plays a role in the assembly of branched actin filament networks, by activating WASP via binding to WASP's proline rich domain. Profilin may link the cytoskeleton with major signalling pathways by interacting with components of the phosphatidylinositol cycle and Ras pathway. |
Profilin binds actin monomers, membrane polyphosphoinositides such as PI(4,5)P2, and... |
-1 |
47705 |
smart00392 |
PROF |
Profilin; Binds actin monomers, membrane polyphosphoinositides and poly-L-proline. |
Profilin; Binds actin monomers, membrane polyphosphoinositides and poly-L-proline. |
false |
false |
false |
129 |
4e-24 |
104.95 |
99.22 |
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1CF0_B 1 GWNAYIDNLMADGTCQDAAIVGYKDSpSVWAAVPGKTFVNITPAEVGVLVGKDRS--SFYVNGLTLGGQKCSVIRDsllq 78
smart00392 2 SWQAYVDNLLVGSGFVDGAAIGGKDG-SVWAASAGRNFQIITPEEIAAIAALFNSlaGVFSNGITLGGQKYMVIRA---- 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
1CF0_B 79 DGEFSMDLRtkstggaPTFNVTVTKTDKTLVLLMGKEGVHGGLINKKCYEMASHLRRSQY 138
smart00392 77 DDRSIMGKK-------GAGGVVIVKTKQAIVIGMYEEGVQPGQANKTVEKLADYLRSSGY 129
|
|
cl00123 |
119548 |
PROF |
Profilin binds actin monomers, membrane polyphosphoinositides such as PI(4,5)P2, and poly-L-proline. Profilin can inhibit actin polymerization into F-actin by binding to monomeric actin (G-actin) and terminal F-actin subunits, but - as a regulator of the cytoskeleton - it may also promote actin polymerization. It plays a role in the assembly of branched actin filament networks, by activating WASP via binding to WASP's proline rich domain. Profilin may link the cytoskeleton with major signalling pathways by interacting with components of the phosphatidylinositol cycle and Ras pathway. |
Profilin binds actin monomers, membrane polyphosphoinositides such as PI(4,5)P2, and... |
-1 |