NTP EXP/TEST: 98007-03 SODIUM THIOGLYCOLATE PAGE: 1 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 10/27/04 ROUTE: SKIN APPLICATION TIME: 15:06:38 EIS REPORT 37 FACILITY: BIORELIANCE NTP C#: C98007 CONTRACT NUMBER: N01-ES-75408 CAS NUMBER: 367-51-1 ANIMAL SUPPLIER: TACONIC FARMS CAGE RANGE: ALL DATE RANGE: ALL REASONS FOR REMOVAL: ALL REMOVAL DATE RANGE: ALL TREATMENT GROUPS: INCLUDE ALL NTP EXP/TEST: 98007-03 SODIUM THIOGLYCOLATE PAGE: 2 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 10/27/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 15:06:38 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 7 ROOM/AREA: 37 FIRST DOSE: 12/17/02 SEX: FEMALE TRT: VEHICLE CONTROL PROCEDURE SET: 2 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP. NTP EXP/TEST: 98007-03 SODIUM THIOGLYCOLATE PAGE: 3 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 10/27/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 15:06:38 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 8 ROOM/AREA: 37 FIRST DOSE: 12/17/02 SEX: FEMALE TRT: 11.25 MG/KG PROCEDURE SET: 2 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 71 71 29 01/14/03 85 03/11/03 3/14 Irritation Site Of Application REMOVED ** CID 71 ** REASON - TSAC 93 03/19/03 Unremarkable 72 72 29 01/14/03 85 03/11/03 8/14 Irritation Site Of Application REMOVED ** CID 72 ** REASON - TSAC 93 03/19/03 Unremarkable 73 73 29 01/14/03 93 03/19/03 8/14 Irritation Site Of Application REMOVED ** CID 73 ** REASON - TSAC 93 03/19/03 Irritation Site Of Application 74 74 36 01/21/03 64 02/18/03 2/14 Irritation Site Of Application REMOVED ** CID 74 ** REASON - TSAC 93 03/19/03 Unremarkable 75 75 29 01/14/03 93 03/19/03 5/14 Irritation Site Of Application REMOVED ** CID 75 ** REASON - TSAC 93 03/19/03 Irritation Site Of Application 76 76 71 02/25/03 78 03/04/03 2/14 Irritation Site Of Application REMOVED ** CID 76 ** REASON - TSAC 93 03/19/03 Unremarkable 77 77 57 02/11/03 93 03/19/03 5/14 Irritation Site Of Application REMOVED ** CID 77 ** REASON - TSAC 93 03/19/03 Irritation Site Of Application 78 78 71 02/25/03 93 03/19/03 4/14 Irritation Site Of Application REMOVED ** CID 78 ** REASON - TSAC 93 03/19/03 Irritation Site Of Application NTP EXP/TEST: 98007-03 SODIUM THIOGLYCOLATE PAGE: 4 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 10/27/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 15:06:38 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 8 ROOM/AREA: 37 FIRST DOSE: 12/17/02 SEX: FEMALE TRT: 11.25 MG/KG PROCEDURE SET: 2 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 79 79 64 02/18/03 85 03/11/03 2/14 Irritation Site Of Application REMOVED ** CID 79 ** REASON - TSAC 93 03/19/03 Unremarkable 80 80 29 01/14/03 36 01/21/03 2/14 Irritation Site Of Application REMOVED ** CID 80 ** REASON - TSAC 93 03/19/03 Unremarkable NTP EXP/TEST: 98007-03 SODIUM THIOGLYCOLATE PAGE: 5 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 10/27/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 15:06:38 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 9 ROOM/AREA: 37 FIRST DOSE: 12/17/02 SEX: FEMALE TRT: 22.5 MG/KG PROCEDURE SET: 2 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 81 81 29 01/14/03 85 03/11/03 5/14 Irritation Site Of Application REMOVED ** CID 81 ** REASON - TSAC 93 03/19/03 Unremarkable 82 82 29 01/14/03 78 03/04/03 6/14 Irritation Site Of Application REMOVED ** CID 82 ** REASON - TSAC 93 03/19/03 Unremarkable 83 83 29 01/14/03 78 03/04/03 7/14 Irritation Site Of Application REMOVED ** CID 83 ** REASON - TSAC 93 03/19/03 Unremarkable 84 84 29 01/14/03 78 03/04/03 6/14 Irritation Site Of Application REMOVED ** CID 84 ** REASON - TSAC 93 03/19/03 Unremarkable 85 85 29 01/14/03 85 03/11/03 5/14 Irritation Site Of Application REMOVED ** CID 85 ** REASON - TSAC 93 03/19/03 Unremarkable 86 86 29 01/14/03 78 03/04/03 6/14 Irritation Site Of Application REMOVED ** CID 86 ** REASON - TSAC 93 03/19/03 Unremarkable 87 87 29 01/14/03 78 03/04/03 6/14 Irritation Site Of Application REMOVED ** CID 87 ** REASON - TSAC 93 03/19/03 Unremarkable 88 88 29 01/14/03 85 03/11/03 6/14 Irritation Site Of Application REMOVED ** CID 88 ** REASON - TSAC 93 03/19/03 Unremarkable NTP EXP/TEST: 98007-03 SODIUM THIOGLYCOLATE PAGE: 6 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 10/27/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 15:06:38 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 9 ROOM/AREA: 37 FIRST DOSE: 12/17/02 SEX: FEMALE TRT: 22.5 MG/KG PROCEDURE SET: 2 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 89 89 29 01/14/03 93 03/19/03 8/14 Irritation Site Of Application REMOVED ** CID 89 ** REASON - TSAC 93 03/19/03 Irritation Site Of Application 90 90 29 01/14/03 85 03/11/03 6/14 Irritation Site Of Application REMOVED ** CID 90 ** REASON - TSAC 93 03/19/03 Unremarkable NTP EXP/TEST: 98007-03 SODIUM THIOGLYCOLATE PAGE: 7 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 10/27/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 15:06:38 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 10 ROOM/AREA: 37 FIRST DOSE: 12/17/02 SEX: FEMALE TRT: 45.0 MG/KG PROCEDURE SET: 2 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 91 91 85 03/11/03 85 03/11/03 1/14 Thickened Site Of Application 22 01/07/03 93 03/19/03 8/14 Irritation Site Of Application REMOVED ** CID 91 ** REASON - TSAC 93 03/19/03 Irritation Site Of Application 92 92 22 01/07/03 93 03/19/03 9/14 Irritation Site Of Application REMOVED ** CID 92 ** REASON - TSAC 93 03/19/03 Irritation Site Of Application 93 93 85 03/11/03 85 03/11/03 1/14 Thickened Site Of Application 22 01/07/03 93 03/19/03 9/14 Irritation Site Of Application REMOVED ** CID 93 ** REASON - TSAC 93 03/19/03 Irritation Site Of Application 94 94 22 01/07/03 93 03/19/03 10/14 Irritation Site Of Application 64 02/18/03 85 03/11/03 2/14 Thickened Site Of Application REMOVED ** CID 94 ** REASON - TSAC 93 03/19/03 Irritation Site Of Application 95 95 29 01/14/03 93 03/19/03 10/14 Irritation Site Of Application REMOVED ** CID 95 ** REASON - TSAC 93 03/19/03 Irritation Site Of Application 96 96 22 01/07/03 85 03/11/03 6/14 Irritation Site Of Application REMOVED ** CID 96 ** REASON - TSAC 93 03/19/03 Unremarkable 97 97 22 01/07/03 93 03/19/03 9/14 Irritation Site Of Application REMOVED ** CID 97 ** REASON - TSAC 93 03/19/03 Irritation Site Of Application 98 98 22 01/07/03 93 03/19/03 10/14 Irritation Site Of Application REMOVED ** CID 98 ** REASON - TSAC NTP EXP/TEST: 98007-03 SODIUM THIOGLYCOLATE PAGE: 8 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 10/27/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 15:06:38 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 10 ROOM/AREA: 37 FIRST DOSE: 12/17/02 SEX: FEMALE TRT: 45.0 MG/KG PROCEDURE SET: 2 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS REMOVAL DATA - 98 98 93 03/19/03 Irritation Site Of Application 99 99 22 01/07/03 93 03/19/03 9/14 Irritation Site Of Application REMOVED ** CID 99 ** REASON - TSAC 93 03/19/03 Irritation Site Of Application 100 100 22 01/07/03 93 03/19/03 9/14 Irritation Site Of Application REMOVED ** CID 100 ** REASON - TSAC 93 03/19/03 Irritation Site Of Application NTP EXP/TEST: 98007-03 SODIUM THIOGLYCOLATE PAGE: 9 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 10/27/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 15:06:38 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 11 ROOM/AREA: 37 FIRST DOSE: 12/17/02 SEX: FEMALE TRT: 90.0 MG/KG PROCEDURE SET: 2 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 101 101 22 01/07/03 93 03/19/03 11/14 Irritation Site Of Application 50 02/04/03 93 03/19/03 5/14 Thickened Site Of Application 57 02/11/03 78 03/04/03 3/14 Ulcer 1 REMOVED ** CID 101 ** REASON - TSAC 93 03/19/03 Thickened Site Of Application 93 03/19/03 Irritation Site Of Application 102 102 22 01/07/03 85 03/11/03 4/14 Thickened Site Of Application 15 12/31/02 93 03/19/03 12/14 Irritation Site Of Application 57 02/11/03 71 02/25/03 2/14 Ulcer 1 REMOVED ** CID 102 ** REASON - TSAC 93 03/19/03 Irritation Site Of Application 103 103 57 02/11/03 93 03/19/03 2/14 Thickened Site Of Application 22 01/07/03 93 03/19/03 11/14 Irritation Site Of Application 57 02/11/03 93 03/19/03 3/14 Ulcer 1 REMOVED ** CID 103 ** REASON - TSAC 93 03/19/03 Ulcer 1 93 03/19/03 Thickened Site Of Application 93 03/19/03 Irritation Site Of Application 104 104 78 03/04/03 78 03/04/03 1/14 Thickened Site Of Application 22 01/07/03 93 03/19/03 9/14 Irritation Site Of Application 78 03/04/03 78 03/04/03 1/14 Ulcer 1 REMOVED ** CID 104 ** REASON - TSAC 93 03/19/03 Irritation Site Of Application 105 105 22 01/07/03 93 03/19/03 10/14 Irritation Site Of Application 22 01/07/03 85 03/11/03 8/14 Thickened Site Of Application 64 02/18/03 85 03/11/03 4/14 Ulcer 1 REMOVED ** CID 105 ** REASON - TSAC 93 03/19/03 Irritation Site Of Application 106 106 22 01/07/03 93 03/19/03 11/14 Irritation Site Of Application 57 02/11/03 78 03/04/03 4/14 Thickened Site Of Application 57 02/11/03 85 03/11/03 4/14 Ulcer 1 REMOVED ** CID 106 ** REASON - TSAC NTP EXP/TEST: 98007-03 SODIUM THIOGLYCOLATE PAGE: 10 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 10/27/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 15:06:38 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 11 ROOM/AREA: 37 FIRST DOSE: 12/17/02 SEX: FEMALE TRT: 90.0 MG/KG PROCEDURE SET: 2 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS REMOVAL DATA - 106 106 93 03/19/03 Irritation Site Of Application 107 107 29 01/14/03 78 03/04/03 5/14 Thickened Site Of Application 22 01/07/03 93 03/19/03 11/14 Irritation Site Of Application 78 03/04/03 93 03/19/03 2/14 Ulcer 1 REMOVED ** CID 107 ** REASON - TSAC 93 03/19/03 Ulcer 1 93 03/19/03 Irritation Site Of Application 108 108 15 12/31/02 93 03/19/03 12/14 Irritation Site Of Application 22 01/07/03 93 03/19/03 7/14 Thickened Site Of Application 93 03/19/03 93 03/19/03 1/14 Ulcer 1 REMOVED ** CID 108 ** REASON - TSAC 93 03/19/03 Ulcer 1 93 03/19/03 Thickened Site Of Application 93 03/19/03 Irritation Site Of Application 109 109 57 02/11/03 78 03/04/03 2/14 Thickened Site Of Application 22 01/07/03 93 03/19/03 10/14 Irritation Site Of Application 78 03/04/03 78 03/04/03 1/14 Ulcer 1 REMOVED ** CID 109 ** REASON - TSAC 93 03/19/03 Irritation Site Of Application 110 110 15 12/31/02 93 03/19/03 12/14 Irritation Site Of Application 22 01/07/03 93 03/19/03 6/14 Thickened Site Of Application 50 02/04/03 93 03/19/03 4/14 Ulcer 1 REMOVED ** CID 110 ** REASON - TSAC 93 03/19/03 Ulcer 1 93 03/19/03 Thickened Site Of Application 93 03/19/03 Irritation Site Of Application NTP EXP/TEST: 98007-03 SODIUM THIOGLYCOLATE PAGE: 11 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 10/27/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 15:06:38 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 12 ROOM/AREA: 37 FIRST DOSE: 12/17/02 SEX: FEMALE TRT: 180.0 MG/KG PROCEDURE SET: 2 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 111 111 29 01/14/03 78 03/04/03 7/14 Thickened Site Of Application 22 01/07/03 93 03/19/03 11/14 Irritation Site Of Application 50 02/04/03 78 03/04/03 3/14 Ulcer 1 REMOVED ** CID 111 ** REASON - TSAC 93 03/19/03 Irritation Site Of Application 112 112 15 12/31/02 93 03/19/03 12/14 Irritation Site Of Application 22 01/07/03 93 03/19/03 7/14 Thickened Site Of Application 57 02/11/03 85 03/11/03 5/14 Ulcer 1 REMOVED ** CID 112 ** REASON - TSAC 93 03/19/03 Thickened Site Of Application 93 03/19/03 Irritation Site Of Application 113 113 22 01/07/03 93 03/19/03 11/14 Irritation Site Of Application 22 01/07/03 78 03/04/03 6/14 Thickened Site Of Application 50 02/04/03 85 03/11/03 5/14 Ulcer 1 REMOVED ** CID 113 ** REASON - TSAC 93 03/19/03 Irritation Site Of Application 114 114 22 01/07/03 93 03/19/03 11/14 Irritation Site Of Application 22 01/07/03 78 03/04/03 7/14 Thickened Site Of Application 57 02/11/03 85 03/11/03 3/14 Ulcer 1 REMOVED ** CID 114 ** REASON - TSAC 93 03/19/03 Irritation Site Of Application 115 115 22 01/07/03 93 03/19/03 11/14 Irritation Site Of Application 22 01/07/03 93 03/19/03 6/14 Thickened Site Of Application 64 02/18/03 93 03/19/03 3/14 Ulcer 1 REMOVED ** CID 115 ** REASON - TSAC 93 03/19/03 Ulcer 1 93 03/19/03 Thickened Site Of Application 93 03/19/03 Irritation Site Of Application 116 116 57 02/11/03 93 03/19/03 4/14 Thickened Site Of Application 22 01/07/03 93 03/19/03 11/14 Irritation Site Of Application 50 02/04/03 93 03/19/03 5/14 Ulcer 1 REMOVED ** CID 116 ** REASON - TSAC NTP EXP/TEST: 98007-03 SODIUM THIOGLYCOLATE PAGE: 12 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 10/27/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 15:06:38 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 12 ROOM/AREA: 37 FIRST DOSE: 12/17/02 SEX: FEMALE TRT: 180.0 MG/KG PROCEDURE SET: 2 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS REMOVAL DATA - 116 116 93 03/19/03 Ulcer 1 93 03/19/03 Thickened Site Of Application 93 03/19/03 Irritation Site Of Application 117 117 15 12/31/02 93 03/19/03 12/14 Irritation Site Of Application 22 01/07/03 85 03/11/03 4/14 Thickened Site Of Application 57 02/11/03 93 03/19/03 4/14 Ulcer 1 REMOVED ** CID 117 ** REASON - TSAC 93 03/19/03 Ulcer 1 93 03/19/03 Irritation Site Of Application 118 118 22 01/07/03 93 03/19/03 6/14 Thickened Site Of Application 15 12/31/02 93 03/19/03 12/14 Irritation Site Of Application 64 02/18/03 93 03/19/03 4/14 Ulcer 1 REMOVED ** CID 118 ** REASON - TSAC 93 03/19/03 Ulcer 1 93 03/19/03 Thickened Site Of Application 93 03/19/03 Irritation Site Of Application 119 119 22 01/07/03 93 03/19/03 11/14 Irritation Site Of Application 22 01/07/03 64 02/18/03 5/14 Thickened Site Of Application 22 01/07/03 78 03/04/03 4/14 Ulcer 1 REMOVED ** CID 119 ** REASON - TSAC 93 03/19/03 Irritation Site Of Application 120 120 22 01/07/03 85 03/11/03 6/14 Thickened Site Of Application 22 01/07/03 93 03/19/03 11/14 Irritation Site Of Application 50 02/04/03 64 02/18/03 3/14 Ulcer 1 REMOVED ** CID 120 ** REASON - TSAC 93 03/19/03 Irritation Site Of Application NTP EXP/TEST: 98007-03 SODIUM THIOGLYCOLATE PAGE: 13 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 10/27/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 15:06:38 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 1 ROOM/AREA: 37 FIRST DOSE: 12/16/02 SEX: MALE TRT: VEHICLE CONTROL PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 2 2 64 02/17/03 64 02/17/03 1/15 Irritation Site Of Application REMOVED ** CID 2 ** REASON - TSAC 93 03/18/03 Unremarkable 3 3 64 02/17/03 64 02/17/03 1/15 Irritation Site Of Application REMOVED ** CID 3 ** REASON - TSAC 93 03/18/03 Unremarkable 5 5 64 02/17/03 64 02/17/03 1/15 Irritation Site Of Application REMOVED ** CID 5 ** REASON - TSAC 93 03/18/03 Unremarkable 10 10 85 03/10/03 85 03/10/03 1/15 Irritation Site Of Application REMOVED ** CID 10 ** REASON - TSAC 93 03/18/03 Unremarkable NTP EXP/TEST: 98007-03 SODIUM THIOGLYCOLATE PAGE: 14 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 10/27/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 15:06:38 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 2 ROOM/AREA: 37 FIRST DOSE: 12/16/02 SEX: MALE TRT: 11.25 MG/KG PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 11 11 50 02/03/03 71 02/24/03 3/15 Irritation Site Of Application REMOVED ** CID 11 ** REASON - TSAC 93 03/18/03 Unremarkable 12 12 22 01/06/03 71 02/24/03 3/15 Irritation Site Of Application REMOVED ** CID 12 ** REASON - TSAC 93 03/18/03 Unremarkable 13 13 29 01/13/03 93 03/18/03 4/15 Irritation Site Of Application REMOVED ** CID 13 ** REASON - TSAC 93 03/18/03 Irritation Site Of Application 14 14 64 02/17/03 64 02/17/03 1/15 Irritation Site Of Application REMOVED ** CID 14 ** REASON - TSAC 93 03/18/03 Unremarkable 15 15 78 03/03/03 78 03/03/03 1/15 Irritation Site Of Application REMOVED ** CID 15 ** REASON - TSAC 93 03/18/03 Unremarkable 16 16 64 02/17/03 85 03/10/03 3/15 Irritation Site Of Application REMOVED ** CID 16 ** REASON - TSAC 93 03/18/03 Unremarkable 17 17 64 02/17/03 85 03/10/03 2/15 Irritation Site Of Application REMOVED ** CID 17 ** REASON - TSAC 93 03/18/03 Unremarkable 18 18 64 02/17/03 85 03/10/03 3/15 Irritation Site Of Application 64 02/17/03 64 02/17/03 1/15 Ulcer 1 REMOVED ** CID 18 ** REASON - TSAC 93 03/18/03 Unremarkable NTP EXP/TEST: 98007-03 SODIUM THIOGLYCOLATE PAGE: 15 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 10/27/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 15:06:38 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 2 ROOM/AREA: 37 FIRST DOSE: 12/16/02 SEX: MALE TRT: 11.25 MG/KG PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 19 19 22 01/06/03 85 03/10/03 6/15 Irritation Site Of Application REMOVED ** CID 19 ** REASON - TSAC 93 03/18/03 Unremarkable 20 20 22 01/06/03 93 03/18/03 9/15 Irritation Site Of Application REMOVED ** CID 20 ** REASON - TSAC 93 03/18/03 Irritation Site Of Application NTP EXP/TEST: 98007-03 SODIUM THIOGLYCOLATE PAGE: 16 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 10/27/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 15:06:38 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 3 ROOM/AREA: 37 FIRST DOSE: 12/16/02 SEX: MALE TRT: 22.5 MG/KG PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 21 21 43 01/27/03 93 03/18/03 7/15 Irritation Site Of Application REMOVED ** CID 21 ** REASON - TSAC 93 03/18/03 Irritation Site Of Application 22 22 43 01/27/03 93 03/18/03 7/15 Irritation Site Of Application REMOVED ** CID 22 ** REASON - TSAC 93 03/18/03 Irritation Site Of Application 23 23 22 01/06/03 93 03/18/03 9/15 Irritation Site Of Application 50 02/03/03 50 02/03/03 1/15 Ulcer 1 REMOVED ** CID 23 ** REASON - TSAC 93 03/18/03 Irritation Site Of Application 24 24 22 01/06/03 93 03/18/03 9/15 Irritation Site Of Application REMOVED ** CID 24 ** REASON - TSAC 93 03/18/03 Irritation Site Of Application 25 25 22 01/06/03 85 03/10/03 9/15 Irritation Site Of Application REMOVED ** CID 25 ** REASON - TSAC 93 03/18/03 Unremarkable 26 26 22 01/06/03 93 03/18/03 11/15 Irritation Site Of Application REMOVED ** CID 26 ** REASON - TSAC 93 03/18/03 Irritation Site Of Application 27 27 22 01/06/03 93 03/18/03 8/15 Irritation Site Of Application REMOVED ** CID 27 ** REASON - TSAC 93 03/18/03 Irritation Site Of Application 28 28 22 01/06/03 93 03/18/03 9/15 Irritation Site Of Application REMOVED ** CID 28 ** REASON - TSAC 93 03/18/03 Irritation Site Of Application NTP EXP/TEST: 98007-03 SODIUM THIOGLYCOLATE PAGE: 17 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 10/27/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 15:06:38 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 3 ROOM/AREA: 37 FIRST DOSE: 12/16/02 SEX: MALE TRT: 22.5 MG/KG PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 29 29 22 01/06/03 93 03/18/03 10/15 Irritation Site Of Application REMOVED ** CID 29 ** REASON - TSAC 93 03/18/03 Irritation Site Of Application 30 30 22 01/06/03 93 03/18/03 8/15 Irritation Site Of Application REMOVED ** CID 30 ** REASON - TSAC 93 03/18/03 Irritation Site Of Application NTP EXP/TEST: 98007-03 SODIUM THIOGLYCOLATE PAGE: 18 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 10/27/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 15:06:38 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 4 ROOM/AREA: 37 FIRST DOSE: 12/16/02 SEX: MALE TRT: 45.0 MG/KG PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 31 31 15 12/30/02 93 03/18/03 11/15 Irritation Site Of Application REMOVED ** CID 31 ** REASON - TSAC 93 03/18/03 Irritation Site Of Application 32 32 15 12/30/02 93 03/18/03 11/15 Irritation Site Of Application REMOVED ** CID 32 ** REASON - TSAC 93 03/18/03 Irritation Site Of Application 33 33 15 12/30/02 93 03/18/03 11/15 Irritation Site Of Application REMOVED ** CID 33 ** REASON - TSAC 93 03/18/03 Irritation Site Of Application 34 34 15 12/30/02 93 03/18/03 10/15 Irritation Site Of Application REMOVED ** CID 34 ** REASON - TSAC 93 03/18/03 Irritation Site Of Application 35 35 15 12/30/02 93 03/18/03 11/15 Irritation Site Of Application REMOVED ** CID 35 ** REASON - TSAC 93 03/18/03 Irritation Site Of Application 36 36 15 12/30/02 93 03/18/03 12/15 Irritation Site Of Application REMOVED ** CID 36 ** REASON - TSAC 93 03/18/03 Irritation Site Of Application 37 37 15 12/30/02 93 03/18/03 11/15 Irritation Site Of Application REMOVED ** CID 37 ** REASON - TSAC 93 03/18/03 Irritation Site Of Application 38 38 15 12/30/02 93 03/18/03 11/15 Irritation Site Of Application REMOVED ** CID 38 ** REASON - TSAC 93 03/18/03 Irritation Site Of Application NTP EXP/TEST: 98007-03 SODIUM THIOGLYCOLATE PAGE: 19 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 10/27/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 15:06:38 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 4 ROOM/AREA: 37 FIRST DOSE: 12/16/02 SEX: MALE TRT: 45.0 MG/KG PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 39 39 15 12/30/02 93 03/18/03 11/15 Irritation Site Of Application REMOVED ** CID 39 ** REASON - TSAC 93 03/18/03 Irritation Site Of Application 40 40 15 12/30/02 93 03/18/03 10/15 Irritation Site Of Application REMOVED ** CID 40 ** REASON - TSAC 93 03/18/03 Irritation Site Of Application NTP EXP/TEST: 98007-03 SODIUM THIOGLYCOLATE PAGE: 20 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 10/27/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 15:06:38 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 5 ROOM/AREA: 37 FIRST DOSE: 12/16/02 SEX: MALE TRT: 90.0 MG/KG PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 41 41 15 12/30/02 78 03/03/03 10/15 Irritation Site Of Application 50 02/03/03 50 02/03/03 1/15 Ulcer 1 REMOVED ** CID 41 ** REASON - TSAC 93 03/18/03 Unremarkable 42 42 15 12/30/02 93 03/18/03 11/15 Irritation Site Of Application REMOVED ** CID 42 ** REASON - TSAC 93 03/18/03 Irritation Site Of Application 43 43 15 12/30/02 85 03/10/03 10/15 Irritation Site Of Application 43 01/27/03 85 03/10/03 2/15 Ulcer 1 REMOVED ** CID 43 ** REASON - TSAC 93 03/18/03 Unremarkable 44 44 15 12/30/02 93 03/18/03 12/15 Irritation Site Of Application 85 03/10/03 85 03/10/03 1/15 Ulcer 1 REMOVED ** CID 44 ** REASON - TSAC 93 03/18/03 Irritation Site Of Application 45 45 15 12/30/02 93 03/18/03 11/15 Irritation Site Of Application REMOVED ** CID 45 ** REASON - TSAC 93 03/18/03 Irritation Site Of Application 46 46 15 12/30/02 93 03/18/03 12/15 Irritation Site Of Application REMOVED ** CID 46 ** REASON - TSAC 93 03/18/03 Irritation Site Of Application 47 47 15 12/30/02 93 03/18/03 11/15 Irritation Site Of Application 85 03/10/03 85 03/10/03 1/15 Ulcer 1 REMOVED ** CID 47 ** REASON - TSAC 93 03/18/03 Irritation Site Of Application 48 48 15 12/30/02 93 03/18/03 12/15 Irritation Site Of Application REMOVED ** CID 48 ** REASON - TSAC NTP EXP/TEST: 98007-03 SODIUM THIOGLYCOLATE PAGE: 21 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 10/27/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 15:06:38 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 5 ROOM/AREA: 37 FIRST DOSE: 12/16/02 SEX: MALE TRT: 90.0 MG/KG PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS REMOVAL DATA - 48 48 93 03/18/03 Irritation Site Of Application 49 49 15 12/30/02 93 03/18/03 12/15 Irritation Site Of Application 50 02/03/03 85 03/10/03 2/15 Ulcer 1 REMOVED ** CID 49 ** REASON - TSAC 93 03/18/03 Irritation Site Of Application 50 50 50 02/03/03 57 02/10/03 2/15 Thickened Site Of Application 15 12/30/02 93 03/18/03 12/15 Irritation Site Of Application REMOVED ** CID 50 ** REASON - TSAC 93 03/18/03 Irritation Site Of Application NTP EXP/TEST: 98007-03 SODIUM THIOGLYCOLATE PAGE: 22 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 10/27/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 15:06:38 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 6 ROOM/AREA: 37 FIRST DOSE: 12/16/02 SEX: MALE TRT: 180.0 MG/KG PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ 51 51 15 12/30/02 93 03/18/03 12/15 Irritation Site Of Application REMOVED ** CID 51 ** REASON - TSAC 93 03/18/03 Irritation Site Of Application 52 52 15 12/30/02 93 03/18/03 12/15 Irritation Site Of Application REMOVED ** CID 52 ** REASON - TSAC 93 03/18/03 Irritation Site Of Application 53 53 15 12/30/02 93 03/18/03 12/15 Irritation Site Of Application 50 02/03/03 93 03/18/03 2/15 Ulcer 1 REMOVED ** CID 53 ** REASON - TSAC 93 03/18/03 Ulcer 1 93 03/18/03 Irritation Site Of Application 54 54 15 12/30/02 93 03/18/03 12/15 Irritation Site Of Application 50 02/03/03 93 03/18/03 2/15 Ulcer 1 REMOVED ** CID 54 ** REASON - TSAC 93 03/18/03 Ulcer 1 93 03/18/03 Irritation Site Of Application 55 55 15 12/30/02 93 03/18/03 12/15 Irritation Site Of Application 50 02/03/03 93 03/18/03 2/15 Ulcer 1 REMOVED ** CID 55 ** REASON - TSAC 93 03/18/03 Ulcer 1 93 03/18/03 Irritation Site Of Application 56 56 15 12/30/02 93 03/18/03 12/15 Irritation Site Of Application 93 03/18/03 93 03/18/03 1/15 Ulcer 1 REMOVED ** CID 56 ** REASON - TSAC 93 03/18/03 Ulcer 1 93 03/18/03 Irritation Site Of Application 57 57 15 12/30/02 93 03/18/03 12/15 Irritation Site Of Application 85 03/10/03 85 03/10/03 1/15 Ulcer 1 REMOVED ** CID 57 ** REASON - TSAC NTP EXP/TEST: 98007-03 SODIUM THIOGLYCOLATE PAGE: 23 TEST TYPE: SUBCHRON 90-DAY DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL DATE: 10/27/04 ROUTE: SKIN APPLICATION EISRPT37 TIME: 15:06:38 ------------------------------------------------------------------------------------------------------------------------------------ SPECIES-STRAIN: RATS-F 344 TRT#: 6 ROOM/AREA: 37 FIRST DOSE: 12/16/02 SEX: MALE TRT: 180.0 MG/KG PROCEDURE SET: 1 ------------------------------------------------------------------------------------------------------------------------------------ FIRST OCCUR'D LAST OCCUR'D FREQ/ CAGE ANIMAL DAY DATE DAY DATE TOT OBS CLINICAL OBSERVATION ---- ------ ------------- ------------- ------- ------------------------------ - CONTINUATION OF PREVIOUS REMOVAL DATA - 57 57 93 03/18/03 Irritation Site Of Application 58 58 15 12/30/02 85 03/10/03 11/15 Irritation Site Of Application 85 03/10/03 85 03/10/03 1/15 Thickened Site Of Application 85 03/10/03 85 03/10/03 1/15 Ulcer 1 REMOVED ** CID 58 ** REASON - TSAC 93 03/18/03 Unremarkable 59 59 85 03/10/03 85 03/10/03 1/15 Thickened Site Of Application 15 12/30/02 93 03/18/03 12/15 Irritation Site Of Application 85 03/10/03 85 03/10/03 1/15 Ulcer 1 REMOVED ** CID 59 ** REASON - TSAC 93 03/18/03 Irritation Site Of Application 60 60 15 12/30/02 93 03/18/03 12/15 Irritation Site Of Application 50 02/03/03 93 03/18/03 2/15 Ulcer 1 REMOVED ** CID 60 ** REASON - TSAC 93 03/18/03 Ulcer 1 93 03/18/03 Irritation Site Of Application ----------------------------------- ---------- END-OF-REPORT ---------- -----------------------------------