Bibliographic Citation
| Document | For copies of Journal Articles, please contact the Publisher or your local public or university library and refer to the information in the Resource Relation field. For copies of other documents, please see the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or Document Availability. |
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| Title | Neurogenically mediated leakage of plasma protein occurs from blood vessels in dura mater but not brain |
| Creator/Author | Markowitz, S. ; Saito, K. ; Moskowitz, M.A. |
| Publication Date | 1987 Dec 01 |
| OSTI Identifier | OSTI ID: 5640383 |
| Other Number(s) | CODEN: JNRSD |
| Resource Type | Journal Article |
| Resource Relation | J. Neurosci. ; Vol/Issue: 7:12 |
| Research Org | Massachusetts General Hospital, Boston |
| Subject | 550201 -- Biochemistry-- Tracer Techniques; BLOOD VESSELS-- INFLAMMATION;PEPTIDES-- BIOLOGICAL FUNCTIONS;PROTEINS-- SECRETION; BRAIN;DOSE-RESPONSE RELATIONSHIPS;GUINEA PIGS;INTRAVENOUS INJECTION;IODINE 125;NERVES;RATS;TRACER TECHNIQUES |
| Related Subject | ANIMALS;BETA DECAY RADIOISOTOPES;BODY;CARDIOVASCULAR SYSTEM;CENTRAL NERVOUS SYSTEM;DAYS LIVING RADIOISOTOPES;ELECTRON CAPTURE RADIOISOTOPES;FUNCTIONS;INJECTION;INTAKE;INTERMEDIATE MASS NUCLEI;IODINE ISOTOPES;ISOTOPE APPLICATIONS;ISOTOPES;MAMMALS;NERVOUS SYSTEM;NUCLEI;ODD-EVEN NUCLEI;ORGANIC COMPOUNDS;ORGANS;PATHOLOGICAL CHANGES;PROTEINS;RADIOISOTOPES;RODENTS;SYMPTOMS;VERTEBRATES |
| Description/Abstract | Utilizing /sup 125/I-BSA administered intravenously, a simple, reliable, and sensitive method was established for the detection of plasma protein extravasation in the dura of rats and guinea pigs following chemical, electrical, or immunological stimulation.^Extravasated /sup 125/I-BSA or Evans blue was noted in the dura and conjunctiva but not in the temporalis muscle of saline-perfused rats following intravenous capsaicin, 1 mumol/kg.^Capsaicin-induced extravasation was mediated by unmyelinated and small myelinated fibers since leakage did not develop in adult animals in whom these fibers were destroyed by capsaicin pretreatment (50 mg/kg) as neonates.^An ipsilateral increase in Evans blue and /sup 125/I-BSA was found in the dura, eyelids, lips and gingival mucosa, and snout following electrical stimulation of the rat trigeminal ganglion.^This increase was also C-fiber dependent.^Among those peptides contained in perivascular afferent fibers and administered intravenously, substance P (SP) and neurokinin A (NKA), but not calcitonin gene-related peptide, caused a dose-dependent extravasation in the dura and conjunctiva of rats.^Neonatal capsaicin pretreatment did not attenuate SP- nor NKA-induced effects in the dura and actually increased extravasation in the conjunctiva.^Intravenous administration of 5-HT or bradykinin to normal adult rats or adult rats pretreated as neonates with capsaicin increased levels of /sup 125/I-BSA in both the dura and the conjunctiva.^Histamine and prostaglandin E2, on the other hand, caused protein leakage in the conjunctiva but not in the dura of rats; however, histamine did induce extravasation in the dura of guinea pigs. |
| Country of Publication | United States |
| Language | English |
| Format | Pages: 4129-4136 |
| System Entry Date | 2001 May 13 |
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