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Title Effect of alcohol consumption selenium bioavailability in rats
Creator/Author Cho, H.K.
Publication Date1986 Jan 01
OSTI IdentifierOSTI ID: 6514338
Resource TypeThesis/Dissertation
Resource RelationThesis (Ph. D.)
Research OrgOhio State Univ., Columbus (USA)
Subject560300 -- Chemicals Metabolism & Toxicology; ALCOHOLS-- BIOLOGICAL EFFECTS;SELENIUM COMPOUNDS-- BIOLOGICAL AVAILABILITY;SELENIUM COMPOUNDS-- BLOOD CHEMISTRY; DIET;ENZYME ACTIVITY;RATS;TRIGLYCERIDES
Related SubjectANIMALS;ESTERS;HYDROXY COMPOUNDS;LIPIDS;MAMMALS;ORGANIC COMPOUNDS;RODENTS;VERTEBRATES
Description/Abstract This study was done to determine the effects of alcohol consumption on selenium bioavailability in initially Se-depleted rats.^Weanling male rats were fed a Se deficient basal diet for 4 weeks and then for the subsequent 4 weeks were supplemented at 0.031 mg Se/Kg or at 0.085 mg Se/Kg of diet in the form of high Se yeast.^During the Se repletion period alcohol replaced medium chain triglycerides in the diet at three levels: 0%, 10% and 20% of calories.^Dietary Se level significantly affected urinary Se, fecal Se, Se absorption, Se balance whole blood Se, whole blood glutathione peroxidase activity, liver Se concentration, and total liver Se content.^Alcohol consumption significantly increased liver Se concentrations and total liver Se in rats fed the adequate Se diet.^In rates fed the low Se diet, this pattern was not shown.^There was a significant interaction between alcohol and Se level in terms of liver Se concentration and total liver Se.^In the first week of Se repletion, fecal Se.^Se absorption and Se balance were significantly higher in the 10% alcohol group fed the low Se repletion diet compared to rats given 0% and 20% alcohol in the same Se group.^In the final week Se repletion the parameters of Se balance were not affected by alcohol consumption.^Alcohol consumption did not influence whole blood Se and whole blood glutathione peroxidase activity; however alcohol consumption significantly reduced growth rate at both Se levels.
PublisherOhio State Univ.,Columbus, OH
Country of PublicationUnited States
LanguageEnglish
FormatPages: 147
AvailabilityUniversity Microfilms Order No. 86-12,360.
System Entry Date2001 May 13

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