Goetz MG, Alkasspooles S, Latham W; Conference on Retroviruses and Opportunistic Infections.

Program Abstr 6th Conf Retrovir Oppor Infect Conf Retrovir Oppor Infect 6th 1999 Chic Ill. 1999 Jan 31-Feb 4; 6th: 131 (abstract no. 335).

West Los Angeles VA Medical Center, CA.

Objective: We evaluated whether the rate of CD4+ lymphocyte (CD4+) repletion was slower in HIV-infected patients > 50 than in younger HIV-infected patients who were started on highly active anti-retroviral therapy (HAART) and who had at least six months of follow-up data. CD4+ repletion was evaluated by examining absolute changes in the CD4+ count (CD4+#) and CD4+ percentage (CD4+%), and the time-normalized per month changes in these values (nCD4+# and nCD4+%). Results: We identified 25 patients (P) (mean age 46.3; 17 < 50 and 8 > 50 years age) who had a > 2 log decrease of the log10 HIV RNA viral load (VL) by the RT-PCR assay) after 6 months of therapy. The baseline CD4+# (180 +/- 141), CD4+% (11.6 +/- 7.8), and viral load (4.93 +/- 0.28) values did not differ between the age groups. After 6 months of follow-up, the nCD4+# showed a significantly greater increase in the younger vs. the older group (78 +/- 43 vs. 36 +/- 42; p < 0.05). Although the increase of the CD4+# , CD4+%, and nCD4+% tended to also be greater in younger P (112 +/- 89 vs. 69 +/- 38 cells/microliter, 4.1 +/- 4.0 vs 3.7 +/- 2.8%, and 2.6 +/- 2.7 vs. 1.8 +/- 1.6, respectively), these values did not reach statistical significance (p is > 0.05, all comparisons). All but 4 P (2 in each group) achieved a VL of < 400 copies/ml. Conclusion: These data indicate that, after controlling for virologic responsiveness, the rate of CD4+ reconstitution is diminished in older HIV-infected P. Previous studies have demonstrated that elderly HIV infected P more often present with HIV wasting and encephalopathy. Our data suggest that even with aggressive anti-retroviral therapy, older P more fail to have the same immune reconstitution as do younger P.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• Aged
• Antiretroviral Therapy, Highly Active
• CD4 Lymphocyte Count
• CD4-Positive T-Lymphocytes
• HIV Infections
• HIV Seropositivity
• Humans
• Viral Load
• virology

Other ID:

• 20711576

UI: 102188993

From Meeting Abstracts