Bibliographic Citation
Document | For copies of Journal Articles, please contact the Publisher or your local public or university library and refer to the information in the Resource Relation field. For copies of other documents, please see the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or Document Availability. |
---|---|
Title | Role of ploidy in radiosensitivity of cells (experiments on yeast organisms of different species and genotypes) |
Creator/Author | Korogodin, V.I. ; Bliznik, K.M. ; Kapul`tsevich, Yu.G. ; Petin, V.G. ; Savchenko, G.V. ; Tolstorukov, I.I. |
Publication Date | 1977 Jan 01 |
OSTI Identifier | OSTI ID: 5166671 |
Other Number(s) | CODEN: RADBA |
Resource Type | Journal Article |
Resource Relation | Radiobiology (USSR) (Engl. Transl.) ; Vol/Issue: 17:5; Translated from Radiobiologiya; 17: No. 5, 700-710(1977) |
Research Org | All-Union Scientific Research Inst. of Genetics and Breeding of Industrial Microorganisms, Moscow |
Subject | 560131 -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987); ;ALPHA PARTICLES-- RBE;PLOIDY-- RADIOSENSITIVITY EFFECTS;YEASTS-- BIOLOGICAL RADIATION EFFECTS; CHROMOSOMES;GAMMA RADIATION |
Related Subject | BIOLOGICAL EFFECTS;BIOMASS;CHARGED PARTICLES;ELECTROMAGNETIC RADIATION;ENERGY SOURCES;FUNGI;IONIZING RADIATIONS;MICROORGANISMS;PLANTS;RADIATION EFFECTS;RADIATIONS;RENEWABLE ENERGY SOURCES |
Description/Abstract | It was established that the sensitivity of artificially obtained diploid cells from natural haplonts Pichia pinus and Pichia guilliermondii is twice as sensitive to ..gamma..-rays and ..cap alpha..-particles as haploid cells and, consequently, there is no relationship to ploidy per chromosome set.^The haplonts are similar to diplont Saccharomyces cerevisiae bearing the rad 51 mutation, and they are very different from S. cerevisiae of the ``wild`` type, in which haploid cells are much more radiosensitive than diploids.^It was also established that the RBE of ..cap alpha..-particles for yeast of the strains studied decreases with increase in radiosensitivity, changing from 4.6 to 1.0.^The following conclusions are derived: the radiation lesion to haploid and diploid yeast cells is based on similar injuries, the probability of which is determined by the size of the ``target`` (DNA content) and effectiveness of repair systems; the presence in the cell of at least two sets of chromosomes is a prerequisite for effective function of repair systems; the higher radioresistance of diploid cells, as compared to haploids, in diplont yeast is due primarily to effective function of repair systems; the greater radiosensitivity of diploid cells, as compared to haploids, in haplont yeast is apparently due to a deficiency in this yeast with regard to repair systems; repair processes play a large role in determining the RBE of radiations with different linear energy transfer. |
Country of Publication | United States |
Language | English |
Format | Pages: 71-83 |
System Entry Date | 2001 May 13 |
Top |