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Title Role of ploidy in radiosensitivity of cells (experiments on yeast organisms of different species and genotypes)
Creator/Author Korogodin, V.I. ; Bliznik, K.M. ; Kapul`tsevich, Yu.G. ; Petin, V.G. ; Savchenko, G.V. ; Tolstorukov, I.I.
Publication Date1977 Jan 01
OSTI IdentifierOSTI ID: 5166671
Other Number(s)CODEN: RADBA
Resource TypeJournal Article
Resource RelationRadiobiology (USSR) (Engl. Transl.) ; Vol/Issue: 17:5; Translated from Radiobiologiya; 17: No. 5, 700-710(1977)
Research OrgAll-Union Scientific Research Inst. of Genetics and Breeding of Industrial Microorganisms, Moscow
Subject560131 -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987); ;ALPHA PARTICLES-- RBE;PLOIDY-- RADIOSENSITIVITY EFFECTS;YEASTS-- BIOLOGICAL RADIATION EFFECTS; CHROMOSOMES;GAMMA RADIATION
Related SubjectBIOLOGICAL EFFECTS;BIOMASS;CHARGED PARTICLES;ELECTROMAGNETIC RADIATION;ENERGY SOURCES;FUNGI;IONIZING RADIATIONS;MICROORGANISMS;PLANTS;RADIATION EFFECTS;RADIATIONS;RENEWABLE ENERGY SOURCES
Description/Abstract It was established that the sensitivity of artificially obtained diploid cells from natural haplonts Pichia pinus and Pichia guilliermondii is twice as sensitive to ..gamma..-rays and ..cap alpha..-particles as haploid cells and, consequently, there is no relationship to ploidy per chromosome set.^The haplonts are similar to diplont Saccharomyces cerevisiae bearing the rad 51 mutation, and they are very different from S. cerevisiae of the ``wild`` type, in which haploid cells are much more radiosensitive than diploids.^It was also established that the RBE of ..cap alpha..-particles for yeast of the strains studied decreases with increase in radiosensitivity, changing from 4.6 to 1.0.^The following conclusions are derived: the radiation lesion to haploid and diploid yeast cells is based on similar injuries, the probability of which is determined by the size of the ``target`` (DNA content) and effectiveness of repair systems; the presence in the cell of at least two sets of chromosomes is a prerequisite for effective function of repair systems; the higher radioresistance of diploid cells, as compared to haploids, in diplont yeast is due primarily to effective function of repair systems; the greater radiosensitivity of diploid cells, as compared to haploids, in haplont yeast is apparently due to a deficiency in this yeast with regard to repair systems; repair processes play a large role in determining the RBE of radiations with different linear energy transfer.
Country of PublicationUnited States
LanguageEnglish
FormatPages: 71-83
System Entry Date2001 May 13

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