DAVID Gene Report
3027768
chemokine (c-c motif) ligand 3 Related Genes Homo sapiens
SP_COMMENT
PTM:N-terminal processed form LD78-alpha(4-69) is produced by proteolytic cleavage after secretion from HTLV1-transformed T-cells.,
function:Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).,
induction:By TPA or PHA (TPA = 12-O-tetradecanoyl phorbol-13 acetate (tumor promoter); PHA = phytohemagglutinin (T-cell mitogen)).,
similarity:Belongs to the intercrine beta (chemokine CC) family.,
subcellular location:Secreted.,
subunit:Self-associates. Also heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69).,
OMIM_DISEASE
HIV infection, resistance to ,
REFSEQ_PROTEIN
NP_002974 ,
ENTREZ_GENE_SUMMARY
Macrophage inflammatory protein-1 is a so-called monokine that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes (Wolpe et al., 1988). Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha and beta.[supplied by OMIM],
REFSEQ_MRNA
NM_002983 ,
GENPEPT_ACCESSION
AAA35858 ,
AAA36316 ,
AAA57255 ,
AAB47170 ,
AAC03539 ,
AAH71834 ,
ALT_SEQ ,
BAA00029 ,
BAA09855 ,
BAA14172 ,
CAA27388 ,
CAA27643 ,
EAW80100 ,
Genomic_DNA ,
mRNA ,
GENE_SYMBOL
CCL3 ,
GENE_NAME
C-C motif chemokine 3 precursor,
C-C motif chemokine 3 precursor (Small-inducible cytokine A3) (Macrophage inflammatory protein 1-alpha) (MIP-1-alpha) (Tonsillar lymphocyte LD78 alpha protein) (G0/G1 switch regulatory protein 19-1) (G0S19-1 protein) (SIS-beta) (PAT 464.1) [Contains: MIP-1-alpha(4-69) (LD78-alpha(4-69))],
Chemokine (C-C motif) ligand 3,
G0/G1 switch regulatory protein 19-1,
G0S19-1 protein,
LD78 alpha beta precursor,
LD78 alpha beta precursor (Fragment),
MIP-1-alpha,
Macrophage inflammatory protein 1-alpha,
PAT 464.1,
SIS-beta,
Small-inducible cytokine A3,
Tonsillar lymphocyte LD78 alpha protein,
GENERIF_SUMMARY
Inhibition of macrophage inflammatory protein-1 alpha production by Epstein-Barr virus. ,
enhances the migration of bone marrow stromal cells ,
role in the development of osteolytic lesions in multiple myeloma ,
Expression of MIP-1 alpha is induced by stimulation of monocytic cells through Fc gamma receptors and involves activation of CCAAT/enhancer-binding protein beta sites. ,
Burned patients seem to be more susceptible to infectious complications when the production of MIP-1 alpha is impaired. ,
role of IL-12 and IFN-gamma on inducing inflammatory chemokine (MIP-1alpha) secretion and down-regulating CCR5 expression in human T cells ,
After stimulation via high-affinity FcepsilonRI, the transcriptional levels of I-309 (CCL1), MIP-1alpha (CCL3) and MIP-1beta (CCL4) were found among the 10 most increased human and mouse transcripts from approximately 12 000 genes ,
Lymphotactin, (MIP)-1alpha, and MIP-1beta chemokines were all rapidly induced by engagement of CD28 and were calcineurin sensitive. ,
MIP-1alpha and MIP-1beta show diverging signaling capacities [review] ,
The polymorphisms of the MCP-1 and MIP-1A genes do not play a substantial role in genetic predisposition for sarcoidosis or in clinical manifestations of sarcoidosis in this Japanese population. ,
may not only mark a subset of patients with a greater risk of having more severe disease but also may play a relevant pathophysiological role in human schistosomiasis mansoni ,
Besides its role in development of osteolytic bone destruction, MIP-1 alpha also directly affects cell signaling pathways mediating growth, survival, and migration in MM cells and might play a pivotal role in the pathogenesis of MM. ,
AML-1A and AML-1B regulate the expression of this protein in multiple myeloma cells. ,
IL-1beta-induced MIP-1alpha and -1beta expression in NT2-N cells ,
Cathepsin D specifically cleaves this protein that is expressed in human breast cancer. ,
Potential interaction between CCR1 and its ligand, this protein is enduced by endogenously produced interleukin-1 in human hepatomas. ,
Transcriptional activation of the MIP-1alpha promoter by RUNX1 and MOZ. ,
Therefore, soluble factors such as prostaglandin E(2) released from lung fibroblasts are responsible for the co-culture-induced inhibition of macrophage-derived MIP-1alpha production. ,
MIP-1-alpha is substantially regulated upon monocyte contact with various cell wall components from Gran-positive and Gram-negative bacteria. ,
Collagen II-reactive T cells in rheumatoid arthritis joints can increase the production of chemokines such as IL-8, MCP-1, and MIP-1 alpha through interaction with synoviocytes. ,
lymphocytes of HIV patients display a disrupted capacity to secrete the beta-chemokines MIP-1 alpha and MIP-1 beta, which may constitute a mechanism of immune dysfunction in progressive HIV infection ,
produced by neonatal natural killer cells and contributes to suppession of HIV replication ,
Role in the development of bronchiolitis associated with influenza and RSV infections in infants and children. ,
severe periodontal tissue destruction in Papillon-Lefevre syndrome may be related to excess accumulation of LD78beta and LD78alpha and dysregulation of the microbial-induced inflammatory response in the periodontium ,
Involvement of the 3 10 helical-turn motif in chemokine function identifies a novel, functionally essential motif within chemokines. ,
Higher amounts of MIP-1alpha, MIP-1beta, and RANTES were detected in plasma of HIV-1-positive individuals, particularly those with concomitant pulmonary tuberculosis, although the increase was not found to be statistically significant. ,
HIV p17 was able to reduce MIP-1alpha secretion in IL-15 stimulated monocytes ,
High levels of CCL3 are present in synovial fluid of children with juvenile idiopathic arthritis. ,
MIP-1 alpha promoter function, gene expression, and protein secretion were each down-regulated following inhibition of FGFR3 signaling. ,
findings show that CCL3, CCL4 and CCL5 bind on the Leishmania promastigotes ,
MIP-1alpha and other chemokines may constitute a link between the innate immune system and familial Mediterranean fever ,
CCL3 concentration was much lower in CSF than in serum of the tickborne encephalitis patients, which argues against its significant role as chemoattractant in this condition. ,
found a negative correlation between the tear levels of MIP-1alpha and clinical severity in Cystic fibrosis (CF) patients and a positive correlation between the tear levels of MIP-1alpha and the presence of dry eye findings in CF patients ,
brain Alzheimer's disease-derived microvessels express high levels of MIP-1alpha mRNA and release high levels of MIP-1alpha protein ,
CHROMOSOME
17,
ENTREZ_GENE_ID
6348 ,
PIR_SUMMARY
Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).,
UNIGENE
Hs.514107 ,
UNIREF100_ID
UniRef100_P10147 ,
UniRef100_Q14745 ,
PIR_NREF_ID
NF00074246,
NF00088185,
NF00111557,
NF00139552,
UNIPROT_ID
CCL3_HUMAN ,
Q14745_HUMAN ,
CYTOBAND
17q11-q21,
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