National Toxicology Program

Selected toxicity information from HSDB, one of the National Library of Medicine's databases. ¹

Names (NTP)

• Chloroprene
• 2-CHLORO-1,3-BUTADIENE

Human Toxicity Excerpts

• SYMPTOMS OF CHRONIC ... EXPOSURE ... HEPATOMEGALY, WITH DECR IN LIVER FUNCTION TESTS, TOXIC HEPATITIS, DYSTROPHY OF MYOCARDIUM & CHANGES IN NERVOUS SYSTEM, CIRCULATORY CHANGES, ... ALTERED ENZYME ACTIVITIES & DYSFUNCTION OF BOTH CENTRAL & PERIPHERAL NERVOUS SYSTEMS, PARTICULARLY CHOLINERGIC BRANCH HAVE ... BEEN REPORTED. [IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V19 138 (1979)]**PEER REVIEWED**
  
• PRIMARY EFFECTS OF ACUTE EXPOSURE TO HIGH CONCN OF CHLOROPRENE IN AIR ARE CNS DEPRESSION, INJURY TO LUNGS, LIVER & KIDNEYS, IRRITATION OF SKIN & MUCOUS MEMBRANES & RESP DIFFICULTIES. [IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V19 138 (1979)]**PEER REVIEWED**
  
• INHALATION ... CAUSES PATHOMORPHOLOGICAL CHANGES IN PERIODONTIUM: PERIODONTITIS (49%), GINGIVITIS (22%), EROSION OF TEETH (17%) & CARIES (5%). [IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V19 139 (1979)]**PEER REVIEWED**
  
• FUNCTIONAL DISTURBANCES IN SPERMATOGENESIS & MORPHOLOGICAL ABNORMALITIES OF SPERM WERE OBSERVED AMONG WORKERS OCCUPATIONALLY EXPOSED TO CHLOROPRENE. 3 FOLD EXCESS OF SPONTANEOUS ABORTIONS HAS BEEN REPORTED IN WIVES OF CHLOROPRENE WORKERS. [IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V19 139 (1979)]**PEER REVIEWED**
  
• SIGNIFICANT RISE IN NUMBER OF CHROMOSOME ABERRATIONS ... IN BLOOD CELLS FROM 18 WORKERS EXPOSED TO AVG ... CONCN OF 18 MG/CU M (5 PPM) FOR 2 TO MORE THAN 10 YR. FREQUENCY OF 4.7% ... ABERRATIONS & 3.7% GAPS ... IN ... /EXPOSED/ GROUP, AS COMPARED WITH 0.65 & 1.14%, RESPECTIVELY, IN CONTROL GROUP ... AMONG 56 WORKERS EXPOSED TO CHLOROPRENE ... (THE CONCN ... IN AIR BEING ABOUT 6 MG/CU M (1.6 PPM)) THE INCIDENCE OF CHROMOSOMAL ABERRATIONS (MAINLY SINGLE BREAKS AND DOUBLE FRAGMENTS) IN CULTURED PERIPHERAL BLOOD LYMPHOCYTES WAS 2.78%, COMPARED WITH 0.53 AND 1.14% CHROMOSOME ABERRATIONS IN TWO GROUPS OF CONTROLS. [IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V19 139 (1979)]**PEER REVIEWED**
  
• ... CASES OF CHILDREN BORN WITH PHYSICAL & MENTAL DEFECTS TO FEMALE WORKERS IN POLYMERIZATION AREA OF CHLOROPRENE RUBBER FACTORY /REPORTED/. [IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V19 139 (1979)]**PEER REVIEWED**
  
• ... AN INCR FREQUENCY OF CHROMOSOME ABERRATIONS IN LYMPHOCYTE CULTURES FROM 28 FEMALE WORKERS WHO WERE EXPOSED FOR 1-20 YR TO 1-7 MG/KG ... . [IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V19 139 (1979)]**PEER REVIEWED**
  
• Swedish and Russian investigators reported a variety of biochemical and hematological alterations in chloroprene-exposed workers. An evaluation of the biochemical and hematological status of active chloroprene workers at a DuPont Company (USA) plant was undertaken. Distributions of biochemical and hematological values of 336 currently exposed and 227 previously exposed chloroprene workers were compared to those of 283 workers never exposed to chloroprene. Comparative analysis did not indicate or suggest that chloroprene workers had biochemical or hematological alterations (or both) of medical significance. [Gooch JJ et al; J Occup Med 23 (4): 268-72 (1981)]**PEER REVIEWED**
  
• REPORT FROM SOVIET UNION IN 1972 OF EPIDEMIOLOGIC SURVEY OF WORKERS HAVING ... CONTACT WITH CHLOROPRENE PRODUCTS SHOWED SIGNIFICANTLY INCR INCIDENCE OF SKIN CANCER (1.6-3% VERSUS 0.12-0.66% FOR OTHER WORKERS NOT ... EXPOSED). LUNG CANCER INCIDENCE INCR WAS ALSO CLAIMED BY SAME AUTHOR. /IN ANOTHER STUDY, INVESTIGATOR/ ... FOUND NO INCR OF LUNG CANCER ATTRIBUTABLE TO CHLOROPRENE AMONG 1946 WORKERS WHO HAD BEEN EXPOSED TO ITS VAPOR BETWEEN 1931 & 1957. EARLY EXPOSURES APPARENTLY EXCEEDED THE 25 PPM LIMIT BY WIDE MARGIN. IN CONTRASTS TO REPORTS OF SWEDISH & RUSSIAN, /INVESTIGATORS/ FAILED TO FIND ABNORMAL BIOCHEMICAL OR HEMATOLOGICAL VALUE DISTRIBUTIONS AMONG 533 WORKERS CURRENTLY OR PREVIOUSLY EXPOSED TO CHLOROPRENE. [American Conference of Governmental Industrial Hygienists. Documentation of the Threshold Limit Values and Biological Exposure Indices. 5th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, 1986., p. 135]**PEER REVIEWED**
  
• Beta-chloroprene is a very unstable cmpd, which, unless handled with extreme care, epoxidizes and polymerizes to toxic compounds. ... Alleged effects in humans may be due to this same cause or to the use of different chem processes which produce different types of impurities. [Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994., p. 4234-5]**PEER REVIEWED**
  
• Both case control and cohort studies were undertaken from July 1, 1969 to June 30, 1983 to ascertain whether exposure to chloroprene increases the risk of cancer. Fifty-five cases of cancer deaths were verified, 16 of which had histories of exposure to chloroprene ranging from 3 to 23 years (median 11 years) with a latent period of 8-27 years, except for one case of 3 years (median 12.5 years). Fifty-four pairs were obtained by matching the cancer deaths to noncancer deaths in accordance with strict requirements. The odds ratio for the paired data was 13, X2= 8.64, P< 0.005. The average at death from cancer workers exposed to chloroprene was 12.7 years younger than that of unexposed workers, t'= 2.98, P< 0.001. The total cohort consisted of 1213 persons, among whom 149 (11.6%) had histories of exposure for over 25 years, 381 (31.5%) for over 20 years, and 852 (70.2%) for over 15 years. The SMR for the total cohort was 2.38 (P< 0.01), and all SMRs for the high-exposure occupations were of significance (P< 0.05 or P< 0.01), in contrast to those of the low exposure groups whose SMRs were low or zero. Thus, a dose response relationship existed. Among the high exposure occupations, maintenance mechanics seem to have the highest risk of cancers, and SMRs for liver, lung, and lymphatic cancers were significant in this group. These results suggested that chloroprene exposure increases the risk of developing cancer. [Li SQ et al; Biomed Environ Sci 2 (2): 141-9 (1989)]**PEER REVIEWED**
  

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Non-Human Toxicity Excerpts

• ... RATS ... TOLERATE A DAILY EXPOSURE OF 8 HR TO CONCN OF 0.3 MG/L ... FOR 13 WEEKS. A CONCN OF 1.2 MG/L WAS FATAL AFTER DAILY EXPOSURES FOR 6, 9, & 13 WEEKS. ... SOME SYSTEMIC TOXICITY FROM REPEATED TOPICAL APPLICATION ... TO THE SKIN OF RATS ... SYSTEMIC POISONING /REPORTED/ FROM TOPICAL APPLICATION ... TO GUINEA PIGS. [Patty, F. (ed.). Industrial Hygiene and Toxicology: Volume II: Toxicology. 2nd ed. New York: Interscience Publishers, 1963., p. 1320]**PEER REVIEWED**
  
• THE DOSE THAT KILLED ABOUT 100% OF ANIMALS AFTER 8 HR INHALATION EXPOSURE WAS APPROX 7.5 G/CU M IN RABBITS & FROM 15-20 G/CU M IN RATS. SYMPTOMS INCL INFLAMMATION OF MUCOUS MEMBRANES OF EYES & NOSE, FOLLOWED BY DEPRESSION OF CNS, /AND/ DEATH ... FROM RESP FAILURE. [IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V19 136 (1979)]**PEER REVIEWED**
  
• IN RATS, REPEATED EXPOSURE TO CHLOROPRENE BY INHALATION FOR 6 HR/DAY ON 5 DAYS/WK FOR 4 WK RESULTED IN SLIGHT GROWTH DEPRESSION & BEHAVIORAL EFFECTS WITH 1.4 G/CU M ... & LOSS OF HAIR, GROWTH RETARDATION & MORPHOLOGICAL LIVER DAMAGE WITH 5.8 G/CU M ... & 22.5 G/CU M ... IN HAMSTERS, THIS EXPOSURE RESULTED IN SLIGHT IRRITATION AND RESTLESSNESS WITH 1.4 G/CU M ... GROWTH RETARDATION, IRRITATION AND LIVER DAMAGE WITH 5.8 G/CU M AND DEATH WITH 22.5 G/CU M ... . [IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V19 137 (1979)]**PEER REVIEWED**
  
• EMBRYOTOXIC EFFECT ... IN ... RATS THAT INHALED ... CONCN ... RANGING FROM 0.13-53.4 MG/CU M. HIGHEST EMBRYOTOXIC EFFECT ... OBSERVED WHEN 4 MG/CU M (1.1 PPM) ... INHALED DURING THE ENTIRE PREGNANCY, OR INTERMITTENTLY ON DAYS 1-2, 3-4 OR 11-12, OR ... ORALLY ... 0.5 MG/KG ... /DAY FOR 14 DAYS OR ON DAYS 3-4 OR 11-12. [IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V19 137 (1979)]**PEER REVIEWED**
  
• ... REPRODUCTION OF MALE MICE & RATS WAS AFFECTED AFTER INHALATION OF CHLOROPRENE @ CONCN OF 42-540 MG/CU M FOR MICE & 430-22,400 MG/CU M FOR RATS. TESTICULAR ATROPHY, OR REDN IN NUMBERS & MOTILITY OF SPERM IN RATS WITH NON-ATROPHIED TESTES, OCCURRED @ EXPOSURE LEVEL OF 0.15 MG/CU M ... . [IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V19 138 (1979)]**PEER REVIEWED**
  
• CHLOROPRENE INDUCED DOMINANT LETHAL MUTATIONS & CHROMOSOME ABERRATIONS IN BONE MARROW CELLS OF RATS EXPOSED TO 0.14-3.6 MG/CU M IN AIR & DOMINANT LETHAL MUTATIONS IN MICE EXPOSED TO 1.85-3.5 MG/CU M IN AIR ... . [IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V19 138 (1979)]**PEER REVIEWED**
  
• GROUP OF 110 RANDOM BRED ALBINO RATS RECEIVED 10 SC INJECTIONS OF 400 MG/KG BODY WT CHLOROPRENE IN SUNFLOWER OIL; 88 ... SURVIVED 6 MO OR MORE. ANOTHER GROUP OF 100 ... RECEIVED 50 INJECTIONS OF 200 MG/KG ... 46 SURVIVED 6 MO OR MORE. NO LOCAL SARCOMAS ... IN EITHER GROUP WITHIN 2 YR. [IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V19 136 (1979)]**PEER REVIEWED**
  
• PREGNANT RATS WERE EXPOSED TO 0, 1, 10 & 25 PPM 4 HR DAILY. DAMS IN ONE STUDY WERE EXPOSED ON DAYS 1-12 & KILLED ON DAY 17 TO EVALUATE EMBRYOTOXICITY. DAMS IN A TERATOLOGY STUDY WERE EXPOSED ON DAYS 3-20 & SACRIFICED ON 21ST DAY OF GESTATION. NO MATERNAL, EMBRYONAL OR FETAL TOXICITY WAS OBSERVED IN THESE STUDIES. [CULIK R ET AL; TOXICOL APPL PHARMACOL 44 (1): 81-8 (1978)]**PEER REVIEWED**
  
• 3 GROUPS OF ... MICE RECEIVED EITHER (A) 50 TWICE WEEKLY SKIN APPLICATIONS OF 50% SOLN ... IN BENZENE FOR 25 WK OR (B) 50 TWICE WEEKLY ... APPLICATIONS OF 0.1% 9,10-DIMETHYL-1,2-BENZANTHRACENE ... IN BENZENE, OR (C) 50 ... APPLICATIONS OF 50% CHLOROPRENE SOLN IN BENZENE & 5 ... OF 0.01% DMBA SOLN IN BENZENE. NO TUMORS WERE REPORTED IN MICE TREATED WITH CHLOROPRENE. [IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V19 135 (1979)]**PEER REVIEWED**
  
• VARIETY OF IMMUNOLOGICAL EFFECTS HAVE RESULTED FROM CHLOROPRENE EXPOSURE, INCL DECR IN NUMBER OF ANTIBODY FORMING CELLS IN SPLEEN & ENHANCEMENT OF TRANSPLANTED TUMOR GROWTH. [IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V19 137 (1979)]**PEER REVIEWED**
  
• CHLOROPRENE VAPORS INDUCED REVERSE MUTATIONS IN SALMONELLA TYPHIMURIUM TA100 & TA1530. ADDN OF A 9000XG SUPERNATANT OF LIVER FROM MICE OR ONE HUMAN SURGICAL SPECIMEN ENHANCED MUTAGENICITY. IN DROSOPHILA MELANOGASTER, RECESSIVE LETHAL MUTATIONS WERE INDUCED BY FEEDING MALE FLIES 5.7 & 11.4 MMOLE CHLOROPRENE FOR 3 DAYS. [IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V19 137 (1979)]**PEER REVIEWED**
  
• ENZYMES OF KREBS CYCLE STUDIED FOLLOWING IP ADMIN OF CHLOROPRENE TO RATS. AFTER 15 DAY PERIOD, CITRATE SYNTHASE ACTIVITY SHARPLY INCR & RETURNED TO NORMAL AT 30 DAYS. [MKHITARYAN LV, MKHITARYAN VG; ZH EKSP KLIN MED 18 (1): 3-12 (1978)]**PEER REVIEWED**
  
• APPLICATION OF CHLOROPRENE IN MICE BY SKIN SMEARS, SC INJECTIONS, INTRAGASTRIC & INTRATRACHEAL ADMIN FAILED TO INDUCE TUMORS. NO TUMORS WERE OBSERVED AFTER USING COMBINATION OF CHLOROPRENE & SMALL DOSES OF DIMETHYLBENZ(A)ANTHRACENE. [ZILFYAN VN ET AL; VOPR ONKOL (LENINGR) 23 (4): 61-5 (1977)]**PEER REVIEWED**
  
• CHLOROPRENE DISSOLVED IN OLIVE OIL WAS ADMIN ORALLY (150 MG/KG) TO RATS ON 17TH DAY OF GESTATION & THEIR OFFSPRINGS WERE TREATED WEEKLY WITH 50 MG/KG BY STOMACH TUBE FROM TIME OF WEANING FOR LIFE SPAN. TOTAL INCIDENCE OF TUMORS WAS SIMILAR IN TREATED & UNTREATED ANIMALS. [PONOMARKOV V, TOMATIS ET; ONCOLOGY (BASEL) 37 (3): 136-41 (1980)]**PEER REVIEWED**
  
• AFTER 20 DAYS OF DAILY ORAL ADMIN OF 0.5 MG, BETA-GALACTOSIDASE ACTIVITY INCR IN RAT SERUM & LACTATE DEHYDROGENASE ISOENZYME SPECTRUM WAS ALTERED IN SEMINAL FLUID. 0.05 MG/KG DAILY FOR 6 MO ORALLY TO RATS DECR WT GAIN & INCR WT OF LIVER, SPLEEN & TESTIS. SPERMATOZOID OSMOTIC RESISTANCE DECR & MOTILITY WAS ALTERED. HEPATIC & GONADAL BETA-GALACTOSIDASE WAS STIMULATED & INHIBITED RESPECTIVELY. [KRASOVSKII GN ET AL; GIG SANIT 2: 17-9 (1980)]**PEER REVIEWED**
  
• Normal Hamster lung cells from an established line were treated with 1-500 ug/ml 2-chlorobutadiene. those treated with 1 ug/ml of the compound showed malignant transformations 14 weeks after treatment. The treatment with higher concentrations did not accelerate the transformation process. [Menezes S et al; CR Seances Acad Sci D; 288 (10): 923-6 (1979)]**PEER REVIEWED**
  
• MUTAGENICITY OF CHLOROPRENE WAS TESTED IN V79 CHINESE HAMSTER CELLS IN PRESENCE OF LIVER SUPERNATANT FROM PHENOBARBITONE PRETREATED RATS & MICE. VAPOR INDUCED DOSE RELATED TOXICITY, BUT WAS NOT MUTAGENIC IN V79 CHINESE HAMSTER CELLS. [DREVON C, KUROKI T; MUTAT RES 67 (2): 173-82 (1979)]**PEER REVIEWED**
  
• FASTED RATS WERE EXPOSED TO 100, 150, 225 & 300 PPM FOR 4 HR & KILLED AT 24 HR. NONPROTEIN SULFHYDRYL CONCN IN LIVER WAS INCR AFTER ALL EXPOSURES. LUNG NONPROTEIN SULFHYDRYL CONCN DECR AFTER 100-300 PPM. SERUM LACTATE DEHYDROGENASE ACTIVITY WAS INCR AFTER EXPOSURE TO 300 PPM. [PLUGGE H, JAEGER RJ; TOXICOL APPL PHARMACOL 50 (3): 565-72 (1979)]**PEER REVIEWED**
  
• Chloroprene was evaluated for mutagenicity in the Salmonella/microsome preincubation assay using a standard protocol approved by NTP. Chloroprene was tested at doses of 0, 3, 10, 33, 100, 333, 1000, and 3333 ug/plate in four Salmonella typhimurium strains (TA98, TA100, TA1535, and TA1537) in the presence and absence of Aroclor-induced rat or hamster liver S9. Chloroprene was negative in these tests and the highest ineffective dose level tested in any Salmonella tester strain was 1000 ug/plate. The 3333 ug/plate dose level induced slight or total clearing of the background lawn in all strains tested. [Zeiger E et al; Environ Mutagen 9: 1-110 (1987)]**PEER REVIEWED**
  
• Pathomorphological changes in rat organs after chronic exposure to chloroprene are described. Many of these changes were dystrophic and the liver was most affected. Protein deficiency aggravated these toxic changes and protein rich diet had a favorable effect. [Aznauryan AV et al; Zh Eksp Klin Med 21 (2): 136-40 (1981)]**PEER REVIEWED**
  
• Studies of the induction of genotoxic and cytotoxic damage induced in bone marrow cells of mice after inhaling chloroprene showed that chloroprene did not induce genotoxic damage in bone marrow, suggesting that if it has any carcinogenic activity, the tumors would be very site specific. [Tice RR; Cell Biol Toxicol 4 (4): 475-86 (1988)]**PEER REVIEWED**
  
• Chloroprene treatments involved 6 hr/day exposures on 12 exposure days at concentrations of 0, 12, 32, 80, and 200 ppm for chloroprene in B6C3F1 mice. Chloroprene gave negative results for all cytogenetic end points assessed in bone marrow cells. [Shelby MD; Environ Health Perspect 86: 71-3 (1990)]**PEER REVIEWED**
  
• Kunming albino mice weaned at 2 weeks were subjected to inhaling 0, 2.0 + or - 0.3, 19.2 + or - 1.9, and 189.0 + or - 13.3 mg/cu m chloroprene (GC purity, 99.8%) 4 hr daily (except Sunday) for 7 months. All survivors were killed at the end of the 8th month or when moribund. No lung tumors were found before the 6th month. Thus, survivors at the 6th month were counted as effective animals. Most lung tumors observed were papilloadenomas (50/57), and a few were adenomas (7/57). The tumor incidence in the 2.9 mg/cu m group was 8.1% in comparison to 1.3% in the control group, with the significance level at P< 0.05. The higher the concentration, the higher the incidence. Examination of the multiplicity of tumor induction also demonstrated a dose response relationship, and the number of tumors per mouse in the 189 mg/cu m group was significant at P< 0.01. [Dong QA et al; Biomed Environ Sci 2 (2): 150-3 (1989)]**PEER REVIEWED**
  
• CONCLUSIONS: Under the conditions of these 2 yr inhalation studies, there was clear evidence of carcinogenic activity of chloroprene in male F344/N rats based on incr incidences of neoplasms in the oral cavity; incr incidences of neoplasms of the thyroid gland, lung and kidney were also attributed to chloroprene exposure. There was clear evidence of carcinogenic activity of chloroprene in female F344/N rats based on incr incidences of neoplasms of the thyroid gland, mammary gland and kidney were also attributed to exposure to chloroprene. ... There was clear evidence of carcinogenic activity of chloroprene in male B6C3F1 mice based on incr incidences of neoplasms of the lung, circulatory system (hemangiomas and hemangiosarcomas) and harderian gland; incr incidences of neoplasms of the forestomach and kidney were also attributed to exposure to chloroprene. There was clear evidence of carcinogenic activity of chloroprene in female B6C3F1 mice based on incr incidences of neoplasms of the lung, circulatory system (hemangiomas and hemangiosarcomas), harderian gland, mammary land, liver, skin and mesentery; incr incidences of neoplasms of the forestomach and Zymbal's gland were also attributed exposure to chloroprene. [Toxicology & Carcinogenesis Studies of Chloroprene in F344/N Rats and B6C3F1 Mice (Inhalation Studies) p.7 Technical Report Series No. 467 (1998) NIH Publication No. 98-3957 U.S. Department of Health and Human Services, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709]**PEER REVIEWED**
  

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Human Toxicity Values

• None found

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Non-Human Toxicity Values

• LD50 Rat oral 450 mg/kg [Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 2392]**PEER REVIEWED**
  
• LC50 Rat inhalation 11,800 mg/cu m/4 hr [Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 2392]**PEER REVIEWED**
  
• LD50 Mouse oral 146 mg/kg [Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 2392]**PEER REVIEWED**
  
• LC50 Mouse inhalation 2300 mg/cu m [Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 2392]**PEER REVIEWED**
  

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Absorption, Distribution and Excretion

• ... RAPIDLY ABSORBED BY SKIN ... . [Lefaux, R. Practical Toxicology of Plastics. Cleveland: CRC Press Inc., 1968., p. 70]**PEER REVIEWED**
  

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Metabolism/Metabolites

• WHEN MIXT OF CHLOROPRENE IN AIR WAS PASSED THROUGH A MOUSE LIVER MICROSOMAL PREPN, A VOLATILE ALKYLATING METABOLITE WAS FORMED, AS DEMONSTRATED BY TRAPPING WITH 4-(4-NITROBENZYL)PYRIDINE. [IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V19 137 (1979)]**PEER REVIEWED**
  

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TSCA Test Submissions

• None found

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Footnotes

¹ Source: the National Library of Medicine's Hazardous Substance Database, 10/28/2007.