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Sponsors and Collaborators: |
Translational Research Informatics Center, Kobe, Hyogo, Japan ArBlast Co.,Ltd. Nagoya University |
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Information provided by: | Translational Research Informatics Center, Kobe, Hyogo, Japan |
ClinicalTrials.gov Identifier: | NCT00221130 |
Adult periodontitis is a chronic infective disease affecting the periodontium. Periodontitis induce the destruction of attachment apparatus of teeth, resulting in periodontal pocket formation and teeth loss. This study will test the safety and efficacy of alveolous bone reproduction by the transplantation of mixture named periodontium injectable gel for the adult periodontitis patients. Injectable gel is the mixture of ex-vivo cultured mesenchymal stem stem cells, ex-vivo cultured osteoblast-like cells differentiated from mesenchymal stem cells and scaffold (include, platelet rich plasma, human thrombin and calcium chloride).
Condition | Intervention | Phase |
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Adult Periodontitis |
Procedure: surgical operation of cell transplantation |
Phase I Phase II |
Study Type: | Interventional |
Study Design: | Treatment, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Safety/Efficacy Study |
Official Title: | Clinical Trial of Regenerative Periodontal Tissue by Transplanting Mesenchymal Stem Cells and Osteoblast Cells - I, II Phase- |
Estimated Enrollment: | 10 |
Study Start Date: | July 2004 |
Estimated Study Completion Date: | December 2005 |
Periodontal disease is an infectious disease. Gingivitis and periodontitis are the 2 major forms of this. Their primary etiology is bacterial plaque, which can induce destruction of the periodontal apparatus. Gingivitis is inflammation of the gingival that does not result in clinical attachment loss. Periodontitis is inflammation of the gingival and is characterized by loss of connective tissue attachment and alveolar bone.
Therapeutic approaches for periodontitis are divided into two categories: 1) anti-infective treatment; 2) regenerative therapy.
Several surgical techniques have been developed to regenerate periodontal tissues including guided tissue regeneration, bone grafting, the use of enamel matrix derivative. However, these techniques are not reached for complete regeneration of the periodontium.
This study will test the safety and efficacy of alveolous bone reproduction by the transplantation of mixture named periodontium injectable gel for the adult periodontitis patients. Injectable gel is the mixture of ex-vivo cultured mesenchymal stem stem cells, ex-vivo cultured osteoblast-like cells differentiated from mesenchymal stem cells and scaffold (include, platelet rich plasma, human thrombin and calcium chloride).
Ages Eligible for Study: | 35 Years to 60 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Japan, Hyogo Pref. | |
Institute of Biomedical Research and Innovation | |
Kobe, Hyogo Pref., Japan, 650-0047 |
Principal Investigator: | Shunsuke Baba, D.D.S, PhD | Institute of Biomedical Research and Innovation |
Study ID Numbers: | BRI PDT03-01 |
Study First Received: | September 13, 2005 |
Last Updated: | February 6, 2009 |
ClinicalTrials.gov Identifier: | NCT00221130 |
Health Authority: | Japan: Ministry of Health, Labor and Welfare; Japan: Ministry of Education, Culture, Sports, Science and Technology |
Regenerative medicine Periodontal tissue |
Mouth Diseases Periodontal Diseases Periodontitis Stomatognathic Diseases |