From: cbb1-bounces@ncbi.nlm.nih.gov on behalf of Bryant, Steve
(NIH/NLM/NCBI) [bryant@ncbi.nlm.nih.gov]
Sent: Tuesday, May 20, 2003 9:39 AM
To: 'cbb1@ncbi.nlm.nih.gov'
Subject: FW: Seminar Wednesday, 11am

Hi Everyone,

Jon Moore is a potential postdoc candidate, visiting tomorrow. Perhaps some
of you will be interested in his seminar topic, so I'm forwarding the
particulars. Thanks!

Steve


-----Original Message-----
From: Bryant, Steve (NIH/NLM/NCBI)
To: 'structure@ncbi.nlm.nih.gov'
Sent: 5/19/2003 5:41 PM
Subject: Seminar Wednesday, 11am


Hi Everyone,

We have a visitor this Wednesday, Jon Moore from UCLA. He's offered to
give
a seminar on his PhD thesis research. His title and abstract follow. The
talk will be at 11am, May 21, in the LHC5 conference room. Thanks!

Steve

  

Gene Structure Prediction in Syntenic DNA Segments

The accurate prediction of gene structures and regulatory elements
directly from genomic sequences of higher eukaryotes remains an elusive
goal.  Comparative approaches are becoming increasingly practical and
valuable for identifying genes and regulatory elements.  We have devised
a
comparative method called pattern filtering which utilizes synteny
between
genomic segments for the annotation of genomic sequences.  Pattern
filtering employs the optimal linear filter (Wiener filter) to detect
the
signatures of conserved functional elements despite the noise inherent
in
the evolutionary processes.  In gene-finding tests, pattern filtering
substantially outperforms GENSCAN, a standard-bearer in the field.  We
anticipate that pattern filtering will facilitate sequence annotation
and
the discovery of new functional elements by the genetics and genomics
community.