| Antimicrob Agents Chemother. 1992 October; 36(10): 2331–2333. | PMCID: PMC245498 |
Effects of diclofenac on ceftriaxone pharmacokinetics in humans. M Merle-Melet, L Bresler, F Lokiec, C Dopff, P Boissel, and J B Dureux Infectious Diseases Department, Centre Hospitalier Universitaire Nancy-Brabois, Vandoeuvre les Nancy, France. Abstract The effects of diclofenac, a nonsteroidal antiinflammatory drug, on the biliary and urinary excretion of ceftriaxone were evaluated in subjects with a T drain in the common bile duct. The kinetic study was carried out on the sixth postoperative day of treatment with ceftriaxone alone (2 g intravenously; group 1) or ceftriaxone combined with diclofenac (50 mg every 12 h orally from postoperative days 3 to 6; group 2). A significant increase in the elimination half-life of ceftriaxone was observed in group 2 patients. Diclofenac caused a significant rise in ceftriaxone biliary excretion. This increase was not sufficient to balance the significant deficit of urinary excretion of ceftriaxone. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (561K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. These references are in PubMed. This may not be the complete list of references from this article. - ANTON, AH. A drug-induced change in the distribution and renal excretion of sulfonamides. J Pharmacol Exp Ther. 1961 Dec;134:291–303. [PubMed]
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