National Heart, Lung, and Blood Institute (NHLBI)
Second International Role of Nitrite in Physiology, Pathophysiology, and Therapeutics Meeting
September 6–7, 2007 • Bethesda, MD
Agenda
| Thursday, September 6 |
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| Session 1: The Nitrate-Nitrite-NO Pathway in Physiology and Therapeutics Session Chairs: Mark T. Gladwin, M.D. and Jon O. Lundberg, M.D., Ph.D. |
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| 8:00 a.m. | Welcome and Opening Mark T. Gladwin, M.D. |
| 8:05 a.m. | NO and the Regulation of Hypoxic Mitochondrial Function |
| 8:55 a.m. | Overview of Role of Nitrate in Human Physiology and Therapeutics Jon O. Lundberg, M.D., Ph.D. |
| 9:25 a.m. | Overview of Role of Nitrite in Human Physiology and Therapeutics Mark T. Gladwin, M.D. |
| 9:55 a.m. | Break |
| Session 2: Mechanisms of Nitrite Bioactivation Session Chairs: Jay L. Zweier, M.D., Ph.D. and Martin Feelisch, Ph.D. |
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| 10:15 a.m. | Mechanisms of Activation in Tissue Martin Feelisch, Ph.D. |
| 10:45 a.m. | XOR and Acidic Reduction Jay L. Zweier, Ph.D., M.D. |
| 11:15 a.m. | Mitochondrial Reduction of Nitrite to NO Robert O. Poyton, Ph.D. |
| 11:40 a.m. | NOS-Mediated Nitrite Reduction E. E. van Faassen, Ph.D. |
| 12:05 p.m. | Lunch |
| Session 3: Nitrite and Vasodilation Session Chairs: Richard O. Cannon, III, M.D. and Eddie Weitzberg, M.D., Ph.D. |
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| 1:05 p.m. | Mechanisms of Nitrite Vasodilation in Aorta Rings Angela Fago, Ph.D. |
| 1:30 p.m. | Mechanisms of Nitrite Vasodilation in Fish Models Frank Bo Jensen, Ds.C. |
| 1:55 p.m. | Mechanisms of Nitrite Vasodilation in Human Circulation Andre Dejam, M.D., Ph.D. |
| 2:20 p.m. | Break |
| Session 4: Nitrite-Heme Biochemistry Session Chairs: Alan N. Schechter, M.D., H. Franklin Bunn, M.D. and Neil Hogg, Ph.D. |
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| 2:40 p.m. | Mechanism of Nitrite Formation in the Erythrocyte Alan N. Schechter, M.D. |
| 3:05 p.m. | Allosteric Nitrite Reduction Studies in Sol Gel Joel M. Friedman, D.D.S. |
| 3:30 p.m. | NO Reactions with Nitrite Bound to Methemoglobin/Oxidative Denitrosylation Daniel B. Kim-Shapiro, Ph.D. |
| 3:55 p.m. | Nitrite Reactions with Heme-Reductive Nitrosylation and Oxygen Transfer Peter C. Ford, Ph.D. |
| 4:20 p.m. | Nitrite Reduction and NO-Methemoglobin Intermediates Joseph M. Rifkind, Ph.D. |
| 4:45 p.m. | Poster Viewing and Discussions Wine, Cheese, and Light Refreshments |
| Friday, September 7 |
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| Session 5: Nitrite, Ischemia-Reperfusion, and Mitochondrial Respiration Session Chairs: David J. Lefer, Ph.D. and Elizabeth Murphy, Ph.D. |
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| 8:00 a.m. | NO, Nitrite, and Nitrate and Hypoxic Adaptation in Tibetan Highlanders Cynthia M. Beall, Ph.D. |
| 8:40 a.m. | Dietary Nitrate/Nitrite and IR Injury David J. Lefer, Ph.D. |
| 9:10 a.m. | Modulation of Mitochondrial Electron Transfer by Nitrite in IR Sruti Shiva, Ph.D. |
| 9:35 a.m. | Role of Nitrite in Stroke Jae-Kyu Roh, M.D., Ph.D. |
| 10:00 a.m. | Break |
| 10:20 a.m. | Role of Nitrite and Xanthine Oxidase in Kidney and Heart IR Amrita Ahluwalia, Ph.D. |
| Session 6: Nitrite and Cardiac Energetics Session Chairs: Malte Kelm, M.D., Ph.D. and David A. Wink, Jr., Ph.D. |
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| 10:45 a.m. | New Cardiac Imaging Modalities Assessing Effects of NO/Nitrite Malte Kelm, M.D., Ph.D. |
| 11:10 a.m. | Nitrite Reductase Activity of Myoglobin in the Heart Tienush Rassaf, M.D. |
| 11:35 a.m. | Potent Negative Inotropic Effects of Nitrite on Beating Heart Bruno Tota, M.D. |
| 12:00 noon | Lunch |
| Session 7: Nitrite Therapeutics Session Chairs: Jon O. Lundberg, M.D., Ph.D. and Nigel Benjamin, M.D., Ph.D. |
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| 1:00 p.m. | The Dark Side of Nitrate and Nitrite Steven R. Tannenbaum, Ph.D. |
| 1:30 p.m. | Gastric Ulceration and Nitrate Lena Holm, Ph.D. |
| 1:55 p.m. | Nitrite, Angiogenesis, and Hypoxic Vasodilation Chris G. Kevil, Ph.D. |
| 2:20 p.m. | Effects of Inhaled NO on Human Liver IR—Role of Circulating Nitrite or S-NO? Rakesh P. Patel, Ph.D. |
| 2:45 p.m. | Break |
| 3:05 p.m. | Effects of Nitrite on Blood Pressure and Oxygen Utilization in Man Eddie Weitzberg, M.D., Ph.D. |
| 3:30 p.m. | Effects of Nitrite on Pulmonary Hypertension Brian Zuckerman, M.D., Ph.D. |
| Oral Podium Presentations—Shorts Session Chairs: Martin Feelisch, Ph.D. and Mark T. Gladwin, M.D. |
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| 3:55 p.m. | Poster 1 |
| 4:05 p.m. | Poster 2 |
| 4:15 p.m. | Poster 3 |
| 4:25 p.m. | Poster 4 |
| 4:35 p.m. | Poster 5 |
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