Chromatin Unfolding and Activation by HMGN proteins  

Michael Bustin, Ph.D.,
Chief, Protein Section, LM, CCR, NCI, NIH
Home  |  NIH  |  bustin@helix.nih.gov
 

HMGN proteins unfold the higher order structure of chromatin and enhance access to the nucleosomal DNA for both transcriptional activators and repressors.

 

 

Electron micrographs of minichromosomes assembled in either the presence or absence of HMGN

small picture of EM of minichromosomes assembled in Xenopus extracts		 small picture of figure showing transcription assay and conversion of a single stranded plasmid into a minichromosome small picture of HMGN colocalizing with nascent transcripts
EM of minichromosomes HMGN enhance transcription from chromatin but not from DNA HMGN colocalize with nascent transcripts (confocal microscopy)

 
Home  | HMG Proteins  |  Research Goals  |  Knock-out mice... 

 

chromatin unfolding...  |  Intracellular Trafficking...  |   Organization of HMG...
New HMG...  |  Linker Histone...  |  Modifications...  |  Development...

 

 

 


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Last revised on July 18, 2003 by Linda G. Byrd, Ph.D.

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