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Our Science – Bustin Website

Michael Bustin, Ph.D.

Selected Publications
1)  Cherukuri S, Hock R, Ueda T, Catez F, Rochman M, Bustin M.
Cell Cycle-dependent Binding of HMGN Proteins to Chromatin.
Mol. Biol. Cell. 19: 1816-1824, 2008. [Journal]
2)  Belova GI, Postnikov YV, Furusawa T, Birger Y, Bustin M.
Chromosomal protein HMGN1 enhances the heat shock-induced remodeling of Hsp70 chromatin.
J. Biol. Chem. 283: 8080-8, 2008. [Journal]
3)  Ueda T, Catez F, Gerlitz G, Bustin M.
Delineation of the protein module that anchors HMGN proteins to nucleosomes in the chromatin of living cells.
Mol. Cell. Biol. 28: 2872-83, 2008. [Journal]
4)  Lucey MM, Wang Y, Bustin M, Duncan MK.
Differential expression of the HMGN family of chromatin proteins during ocular development.
Gene Expr. Patterns. 8: 433-7, 2008. [Journal]
5)  Hock R, Furusawa T, Ueda T, Bustin M.
HMG chromosomal proteins in development and disease.
Trends Cell Biol. 17: 72-9, 2007. [Journal]
6)  Gerlitz G, Livnat I, Ziv C, Yarden O, Bustin M, Reiner O.
Migration cues induce chromatin alterations.
Traffic. 8: 1521-9, 2007. [Journal]
7)  Birger Y, Davis J, Furusawa T, Rand E, Piatigorsky J, Bustin M.
A role for chromosomal protein HMGN1 in corneal maturation.
Differentiation. 74: 19-29, 2006. [Journal]
8)  Postnikov YV, Belova GI, Lim JH, Bustin M.
Chromosomal protein HMGN1 modulates the phosphorylation of serine 1 in histone H2A.
Biochemistry. 45: 15092-9, 2006. [Journal]
9)  Catez F, Ueda T, Bustin M.
Determinants of histone H1 mobility and chromatin binding in living cells.
Nat. Struct. Mol. Biol. 13: 305-10, 2006. [Journal]
10)  Ueda T, Postnikov YV, Bustin M.
Distinct domains in high mobility group N variants modulate specific chromatin modifications.
J. Biol. Chem. 281: 10182-7, 2006. [Journal]
11)  Furusawa T, Lim JH, Catez F, Birger Y, Mackem S, Bustin M.
Down-regulation of nucleosomal binding protein HMGN1 expression during embryogenesis modulates Sox9 expression in chondrocytes.
Mol. Cell. Biol. 26: 592-604, 2006. [Journal]
12)  Yang D, Chen Q, Yang H, Tracey KJ, Bustin M, Oppenheim JJ.
High mobility group box-1 (HMGB1) protein induces the migration and activation of human dendritic cells and acts as an alarmin.
J Leukoc Biol. 2006. [Journal]
13)  Lim JH, West KL, Rubinstein Y, Bergel M, Postnikov YV, Bustin M.
Chromosomal protein HMGN1 enhances the acetylation of lysine 14 in histone H3.
EMBO J. 24: 3038-48, 2005. [Journal]
14)  Rubinstein YR, Furusawa T, Lim JH, Postnikov YV, West KL, Birger Y, Lee S, Nguyen P, Trepel JB, Bustin M.
Chromosomal protein HMGN1 modulates the expression of N-cadherin.
FEBS J. 272: 5853-63, 2005. [Journal]
15)  Birger Y, Catez F, Furusawa T, Lim JH, Prymakowska-Bosak M, West KL, Postnikov YV, Haines DC, Bustin M.
Increased tumorigenicity and sensitivity to ionizing radiation upon loss of chromosomal protein HMGN1.
Cancer Res. 65: 6711-6718, 2005. [Journal]
16)  Bustin M, Catez F, Lim JH.
The dynamics of histone H1 function in chromatin.
Mol Cell. 17: 617-20, 2005. [Journal]
17)  Lim JH, Catez F, Birger Y, West KL, Prymakowska-Bosak M, Postnikov YV, Bustin M.
Chromosomal protein HMGN1 modulates histone H3 phosphorylation.
Mol Cell. 15: 573-84, 2004. [Journal]
18)  West KL, Castellini MA, Duncan MK, Bustin M.
Chromosomal proteins HMGN3a and HMGN3b regulate the expression of glycine transporter 1.
Mol Cell Biol. 24: 3747-56, 2004. [Journal]
19)  West KL, Castellini MA, Duncan MK, Bustin M.
Chromosomal proteins HMGN3a and HMGN3b regulate the expression of glycine transporter 1.
Mol Cell Biol. 24: 3747-56, 2004. [Journal]
20)  Harrer M, Lührs H, Bustin M, Scheer U, Hock R.
Dynamic interaction of HMGA1a proteins with chromatin.
J Cell Sci. 117: 3459-71, 2004. [Journal]
21)  Phair RD, Scaffidi P, Elbi C, Vecerová J, Dey A, Ozato K, Brown DT, Hager G, Bustin M, Misteli T.
Global nature of dynamic protein-chromatin interactions in vivo: three-dimensional genome scanning and dynamic interaction networks of chromatin proteins.
Mol Cell Biol. 24: 6393-402, 2004. [Journal]
22)  Bustin M, Robinson RC, Friedman FK.
Immunochemical analysis of chromatin.
Methods Enzymol. 376: 209-20, 2004. [Journal]
23)  Catez F, Yang H, Tracey KJ, Reeves R, Misteli T, Bustin M.
Network of dynamic interactions between histone H1 and high-mobility-group proteins in chromatin.
Mol Cell Biol. 24: 4321-8, 2004. [Journal]
24)  Birger Y, West KL, Postnikov YV, Lim JH, Furusawa T, Wagner JP, Laufer CS, Kraemer KH, Bustin M.
Chromosomal protein HMGN1 enhances the rate of DNA repair in chromatin.
EMBO J. 22: 1665-75, 2003. [Journal]
25)  Körner U, Bustin M, Scheer U, Hock R.
Developmental role of HMGN proteins in Xenopus laevis.
Mech Dev. 120: 1177-92, 2003. [Journal]
26)  Hashimshony T, Zhang J, Keshet I, Bustin M, Cedar H.
The role of DNA methylation in setting up chromatin structure during development.
Nat Genet. 34: 187-92, 2003. [Journal]
27)  Birger Y, West KL, Postnikov YV, Lim JH, Furusawa T, Wagner JP, Laufer CS, Kraemer KH, Bustin M.
Chromosomal protein HMGN1 enhances the rate of DNA repair in chromatin.
EMBO J. 22(7): 1665-75, 2003. [Journal]
28)  Catez F, Brown DT, Misteli T, Bustin M.
Competition between histone H1 and HMGN proteins for chromatin binding sites.
EMBO Rep. 3: 760-6, 2002. [Journal]
29)  Herrera JE, West KL, Schiltz RL, Nakatani Y, Bustin M.
Histone H1 is a specific repressor of core histone acetylation in chromatin.
Mol Cell Biol. 20: 523-9, 2000. [Journal]
30)  Bustin M.
Regulation of DNA-dependent activities by the functional motifs of the high-mobility-group chromosomal proteins.
Mol Cell Biol. 19: 5237-46, 1999. [Journal]
31)  Bustin M, Robinson RC, Friedman FK.
Immunochemical analysis of chromatin.
Methods Enzymol. 376: 209-20, 2004. [Journal]
32)  Lim JH, Catez F, Birger Y, Postnikov YV, Bustin M.
Preparation and functional analysis of HMGN proteins.
Methods Enzymol. 375: 323-42, 2004. [Journal]
33)  West KL, Postnikov YV, Birger Y, Bustin M.
Chromatin decompaction method by HMGN proteins.
Methods Enzymol. 371: 521-36, 2003. [Journal]
34)  Birger Y, West KL, Postnikov YV, Lim JH, Furusawa T, Wagner JP, Laufer CS, Kraemer KH, Bustin M.
Chromosomal protein HMGN1 enhances the rate of DNA repair in chromatin.
EMBO J. 22: 1665-75, 2003. [Journal]
35)  Körner U, Bustin M, Scheer U, Hock R.
Developmental role of HMGN proteins in Xenopus laevis.
Mech Dev. 120: 1177-92, 2003. [Journal]
36)  Catez F, Lim JH, Hock R, Postnikov YV, Bustin M.
HMGN dynamics and chromatin function.
Biochem Cell Biol. 81: 113-22, 2003. [Journal]
37)  Strichman-Almashanu LZ, Bustin M, Landsman D.
Retroposed copies of the HMG genes: a window to genome dynamics.
Genome Res. 13: 800-12, 2003. [Journal]
38)  Strichman-Almashanu LZ, Bustin M, Landsman D.
Retroposed copies of the HMG genes: a window to genome dynamics.
Genome Res. 13: 800-12, 2003. [Journal]
39)  Hashimshony T, Zhang J, Keshet I, Bustin M, Cedar H.
The role of DNA methylation in setting up chromatin structure during development.
Nat Genet. 34: 187-92, 2003. [Journal]
40)  Hashimshony T, Zhang J, Keshet I, Bustin M, Cedar H.
The role of DNA methylation in setting up chromatin structure during development.
Nat Genet. 34: 187-92, 2003. [Journal]
41)  Bustin M.
At the crossroads of necrosis and apoptosis: signaling to multiple cellular targets by HMGB1.
Sci STKE. 2002: PE39, 2002. [Journal]
42)  Kim JH, Nam KH, Kwon OS, Kim IG, Bustin M, Choy HE, Park SC.
Histone cross-linking by transglutaminase.
Biochem Biophys Res Commun. 293: 1453-7, 2002. [Journal]
43)  Ito Y, Bustin M.
Immunohistochemical localization of the nucleosome-binding protein HMGN3 in mouse brain.
J Histochem Cytochem. 50: 1273-5, 2002. [Journal]
44)  Lim JH, Bustin M, Ogryzko VV, Postnikov YV.
Metastable macromolecular complexes containing high mobility group nucleosome-binding chromosomal proteins in HeLa nuclei.
J Biol Chem. 277: 20774-82, 2002. [Journal]
45)  Prymakowska-Bosak M, Hock R, Catez F, Lim JH, Birger Y, Shirakawa H, Lee K, Bustin M.
Mitotic phosphorylation of chromosomal protein HMGN1 inhibits nuclear import and promotes interaction with 14.3.3 proteins.
Mol Cell Biol. 22: 6809-19, 2002. [Journal]
46)  Lührs H, Hock R, Schauber J, Weihrauch M, Harrer M, Melcher R, Scheppach W, Bustin M, Menzel T.
Modulation of HMG-N2 binding to chromatin by butyrate-induced acetylation in human colon adenocarcinoma cells.
Int J Cancer. 97: 567-73, 2002. [Journal]
47)  Lührs H, Hock R, Schauber J, Weihrauch M, Harrer M, Melcher R, Scheppach W, Bustin M, Menzel T.
Modulation of HMG-N2 binding to chromatin by butyrate-induced acetylation in human colon adenocarcinoma cells.
Int J Cancer. 97: 567-73, 2002. [Journal]
48)  Bustin M.
Chromatin unfolding and activation by HMGN(*) chromosomal proteins.
Trends Biochem Sci. 26: 431-7, 2001. [Journal]
49)  Mohamed OA, Bustin M, Clarke HJ.
High-mobility group proteins 14 and 17 maintain the timing of early embryonic development in the mouse.
Dev Biol. 229: 237-49, 2001. [Journal]
50)  West KL, Ito Y, Birger Y, Postnikov Y, Shirakawa H, Bustin M.
HMGN3a and HMGN3b, two protein isoforms with a tissue-specific expression pattern, expand the cellular repertoire of nucleosome-binding proteins.
J Biol Chem. 276: 25959-69, 2001. [Journal]
51)  Birger Y, Ito Y, West KL, Landsman D, Bustin M.
HMGN4, a newly discovered nucleosome-binding protein encoded by an intronless gene.
DNA Cell Biol. 20: 257-64, 2001. [Journal]
52)  Prymakowska-Bosak M, Misteli T, Herrera JE, Shirakawa H, Birger Y, Garfield S, Bustin M.
Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin.
Mol Cell Biol. 21: 5169-78, 2001. [Journal]
53)  Bustin M.
Revised nomenclature for high mobility group (HMG) chromosomal proteins.
Trends Biochem Sci. 26: 152-3, 2001. [Journal]
54)  Chaya D, Hayamizu T, Bustin M, Zaret KS.
Transcription factor FoxA (HNF3) on a nucleosome at an enhancer complex in liver chromatin.
J Biol Chem. 276: 44385-9, 2001. [Journal]
55)  Bergel M, Herrera JE, Thatcher BJ, Prymakowska-Bosak M, Vassilev A, Nakatani Y, Martin B, Bustin M.
Acetylation of novel sites in the nucleosomal binding domain of chromosomal protein HMG-14 by p300 alters its interaction with nucleosomes.
J Biol Chem. 275: 11514-20, 2000. [Journal]
56)  Misteli T, Gunjan A, Hock R, Bustin M, Brown DT.
Dynamic binding of histone H1 to chromatin in living cells.
Nature. 408: 877-81, 2000. [Journal]
57)  Shirakawa H, Landsman D, Postnikov YV, Bustin M.
NBP-45, a novel nucleosomal binding protein with a tissue-specific and developmentally regulated expression.
J Biol Chem. 275: 6368-74, 2000. [Journal]
58)  Shirakawa H, Herrera JE, Bustin M, Postnikov Y.
Targeting of high mobility group-14/-17 proteins in chromatin is independent of DNA sequence.
J Biol Chem. 275: 37937-44, 2000. [Journal]
59)  Herrera JE, Schiltz RL, Bustin M.
The accessibility of histone H3 tails in chromatin modulates their acetylation by P300/CBP-associated factor.
J Biol Chem. 275: 12994-9, 2000. [Journal]
60)  Postnikov YV, Bustin M.
Analysis of HMG-14/-17-containing chromatin.
Methods Mol Biol. 119: 303-10, 1999. [Journal]
61)  Postnikov YV, Bustin M.
Reconstitution of high mobility group 14/17 proteins into nucleosomes and chromatin.
Methods Enzymol. 304: 133-55, 1999. [Journal]
62)  Herrera JE, Sakaguchi K, Bergel M, Trieschmann L, Nakatani Y, Bustin M.
Specific acetylation of chromosomal protein HMG-17 by PCAF alters its interaction with nucleosomes.
Mol Cell Biol. 19: 3466-73, 1999. [Journal]
63)  Hock R, Scheer U, Bustin M.
Chromosomal proteins HMG-14 and HMG-17 are released from mitotic chromosomes and imported into the nucleus by active transport.
J Cell Biol. 143: 1427-36, 1998. [Journal]
64)  Sakaguchi K, Herrera JE, Saito S, Miki T, Bustin M, Vassilev A, Anderson CW, Appella E.
DNA damage activates p53 through a phosphorylation-acetylation cascade.
Genes Dev. 12: 2831-41, 1998. [Journal]
65)  Hock R, Wilde F, Scheer U, Bustin M.
Dynamic relocation of chromosomal protein HMG-17 in the nucleus is dependent on transcriptional activity.
EMBO J. 17: 6992-7001, 1998. [Journal]
66)  Jayaraman L, Moorthy NC, Murthy KG, Manley JL, Bustin M, Prives C.
High mobility group protein-1 (HMG-1) is a unique activator of p53.
Genes Dev. 12: 462-72, 1998. [Journal]
67)  Vestner B, Bustin M, Gruss C.
Stimulation of replication efficiency of a chromatin template by chromosomal protein HMG-17.
J Biol Chem. 273: 9409-14, 1998. [Journal]
68)  Trieschmann L, Martin B, Bustin M.
The chromatin unfolding domain of chromosomal protein HMG-14 targets the N-terminal tail of histone H3 in nucleosomes.
Proc Natl Acad Sci U S A. 95: 5468-73, 1998. [Journal]
69)  Ding HF, Bustin M, Hansen U.
Alleviation of histone H1-mediated transcriptional repression and chromatin compaction by the acidic activation region in chromosomal protein HMG-14.
Mol Cell Biol. 17: 5843-55, 1997. [Journal]
70)  Clarke HJ, Bustin M, Oblin C.
Chromatin modifications during oogenesis in the mouse: removal of somatic subtypes of histone H1 from oocyte chromatin occurs post-natally through a post-transcriptional mechanism.
J Cell Sci. 110 ( Pt 4): 477-87, 1997. [Journal]
71)  Postnikov YV, Herrera JE, Hock R, Scheer U, Bustin M.
Clusters of nucleosomes containing chromosomal protein HMG-17 in chromatin.
J Mol Biol. 274: 454-65, 1997. [Journal]
72)  Weigmann N, Trieschmann L, Bustin M.
Enhancement of the transcription potential of nascent chromatin by chromosomal proteins HMG-14/-17 is coupled to nucleosome assembly and not DNA synthesis.
DNA Cell Biol. 16: 1207-16, 1997. [Journal]
73)  Verrier CS, Roodi N, Yee CJ, Bailey LR, Jensen RA, Bustin M, Parl FF.
High-mobility group (HMG) protein HMG-1 and TATA-binding protein-associated factor TAF(II)30 affect estrogen receptor-mediated transcriptional activation.
Mol Endocrinol. 11: 1009-19, 1997. [Journal]
74)  Herrera JE, Bergel M, Yang XJ, Nakatani Y, Bustin M.
The histone acetyltransferase activity of human GCN5 and PCAF is stabilized by coenzymes.
J Biol Chem. 272: 27253-8, 1997. [Journal]
75)  Sawchuk DJ, Weis-Garcia F, Malik S, Besmer E, Bustin M, Nussenzweig MC, Cortes P.
V(D)J recombination: modulation of RAG1 and RAG2 cleavage activity on 12/23 substrates by whole cell extract and DNA-bending proteins.
J Exp Med. 185: 2025-32, 1997. [Journal]
76)  Morton RL, David H, O'Connor PM, Bustin M.
Chromosomal proteins HMG-14 and HMG-17 are synthesized throughout the S-phase in Burkitt's lymphoma.
Biochem Biophys Res Commun. 222: 368-73, 1996. [Journal]
77)  Bustin M, Reeves R.
High-mobility-group chromosomal proteins: architectural components that facilitate chromatin function.
Prog Nucleic Acid Res Mol Biol. 54: 35-100, 1996. [Journal]

This page was last updated on 9/9/2008.