NTP Study Reports
NIEHS AIDS Therapeutics - Report No. 3
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NIEHS AIDS Therapeutics -- Toxicity Report No. 3 |
Appendix A |
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APPENDIX A HEMATOLOGY RESULTS
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Table A1 |
Hematology Data for Male Swiss (CD-1®) Mice in the Reproductive, Developmental, and General Toxicity Study of AZT and Isoniazid Combinations |
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Table A2 |
Hematology Data for Female-A Swiss (CD-1®) Mice in the Reproductive, Developmental, and General Toxicity Study of AZT and Isoniazid Combinations |
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Table A3 |
Hematology Data for Female-B Swiss (CD-1®) Mice in the Reproductive, Developmental, and General Toxicity Study of AZT and Isoniazid Combinations |
Table A1
Hematology Data for Male Swiss (CD-1®) Mice in the Reproductive, Developmental, and General Toxicity Study of AZT and Isoniazid Combinationsa
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| Vehicle Control |
100 + 0 |
200 + 0 |
400 + 0 |
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n |
10 |
10 |
10 |
10 |
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Hematocrit (%) |
45.1 ± 2.8 |
41.3 ± 3.3 |
40.9 ± 3.9b |
40.7 ± 3.6 |
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Hemoglobin (g/dL) |
15.3 ± 0.8 |
13.6 ± 1.4* |
13.9 ± 1.4b |
13.4 ± 1.2** |
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Erythrocytes (106/µL) |
9.77 ± 0.38 |
8.29 ± 0.76** |
8.41 ± 0.66**b |
7.99 ± 0.66** |
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Reticulocytes (105/µL) |
3.3 ± 0.60 |
3.7 ± 0.85 |
3.7 ± 0.50 |
4.3 ± 0.53 |
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Mean cell volume (fL) |
46.2 ± 2.3 |
50.0 ± 2.7* |
48.7 ± 3.6b |
51.0 ± 3.1** |
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Mean cell hemoglobin (pg) |
15.7 ± 0.6 |
16.4 ± 0.7 |
16.5 ± 1.3b |
16.7 ± 0.9 |
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Mean cell hemoglobin concentration (g/dL) |
34.0 ± 1.0 |
32.8 ± 1.3 |
33.9 ± 0.7b |
32.8 ± 0.6 |
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Platelets (103/µL) |
1,421 ± 290.4 |
1,567 ± 311.0 |
1,608 ± 442.2b |
1,686 ± 501.2 |
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Leukocytes (103/µL)c |
7.74 ± 2.28 |
7.70 ± 2.46 |
8.44 ± 2.40b |
6.84 ± 3.59 |
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Segmented neutrophils (103/µL) |
1.31 ± 0.67 |
0.98 ± 0.41 |
2.06 ± 2.53 |
1.87 ± 3.19 |
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Lymphocytes (103/µL) |
5.82 ± 0.36 |
6.11 ± 2.05 |
5.67 ± 1.54 |
4.42 ± 1.52 |
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Monocytes (103/µL) |
0.18 ± 0.09 |
0.19 ± 0.08 |
0.31 ± 0.21 |
0.21 ± 0.10 |
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Basophils (103/µL) |
0.02 ± 0.021 |
0.02 ± 0.018 |
0.02 ± 0.013 |
0.02 ± 0.014 |
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Eosinophils (103/µL) |
0.39 ± 0.19 |
0.40 ± 0.21 |
0.35 ± 0.22 |
0.25 ± 0.16 |
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Large unstained cells (103/µL) |
0.02 ± 0.01d |
0.03 ± 0.02e |
0.04 ± 0.04d |
0.08 ± 0.17b |
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0 + 50 |
100 + 50 |
200 + 50 |
400 + 50 |
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n |
10 |
10 |
10 |
10 |
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Hematocrit (%) |
42.2 ± 3.8 |
42.5 ± 2.7 |
38.9 ± 2.2** |
38.2 ± 2.1** |
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Hemoglobin (g/dL) |
14.2 ± 1.3 |
14.3 ± 0.8 |
13.1 ± 0.9** |
12.8 ± 0.8** |
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Erythrocytes (106/µL) |
9.15 ± 0.80 |
8.75 ± 0.38* |
7.86 ± 0.68** |
7.81 ± 0.61** |
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Reticulocytes (105/µL) |
4.2 ± 1.61 |
4.1 ± 0.61 |
3.9 ± 0.43 |
4.3 ± 0.67 |
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Mean cell volume (fL) |
46.1 ± 1.3 |
48.5 ± 1.8 |
49.7 ± 2.7 |
49.0 ± 2.8 |
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Mean cell hemoglobin (pg) |
15.5 ± 0.5 |
16.3 ± 0.6 |
16.7 ± 0.6 |
16.4 ± 0.8 |
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Mean cell hemoglobin concentration (g/dL) |
33.7 ± 0.7 |
33.7 ± 0.6 |
33.6 ± 1.3 |
33.6 ± 0.7 |
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Platelets (103/µL) |
1,516 ± 269.6 |
1,502 ± 357.2 |
1,625 ± 223.0 |
1,599 ± 215.8 |
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Leukocytes (103/µL) |
10.03 ± 7.53 |
7.82 ± 2.28 |
7.05 ± 1.91 |
8.21 ± 1.41 |
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Segmented neutrophils (103/µL) |
3.35 ± 6.18 |
1.36 ± 1.07 |
1.19 ± 0.43 |
1.34 ± 0.49 |
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Lymphocytes (103/µL) |
5.80 ± 2.49 |
5.93 ± 1.40 |
5.20 ± 1.45 |
6.34 ± 1.43 |
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Monocytes (103/µL) |
0.34 ± 0.25 |
0.23 ± 0.11 |
0.26 ± 0.19 |
0.25 ± 0.16 |
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Basophils (103/µL) |
0.03 ± 0.027 |
0.03 ± 0.028 |
0.02 ± 0.013 |
0.01 ± 0.020 |
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Eosinophils (103/µL) |
0.41 ± 0.38 |
0.27 ± 0.19 |
0.35 ± 0.20 |
0.25 ± 0.15 |
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Large unstained cells (103/µL) |
0.10 ± 0.20b |
0.03 ± 0.01e |
0.03 ± 0.01e |
0.03 ± 0.02f |
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0 + 100 |
100 + 100 |
200 + 100 |
400 + 100 |
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n |
10 |
8 |
10 |
10 |
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Hematocrit (%) |
43.2 ± 2.7 |
40.2 ± 3.9 |
38.8 ± 7.2** |
36.7 ± 3.7** |
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Hemoglobin (g/dL) |
14.4 ± 0.7 |
13.4 ± 1.3* |
12.9 ± 2.1** |
12.2 ± 1.3** |
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Erythrocytes (106/µL) |
9.44 ± 0.61 |
8.23 ± 0.68** |
7.67 ± 0.97** |
7.26 ± 0.70** |
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Reticulocytes (105/µL) |
4.2 ± 0.67 |
4.5 ± 1.23* |
4.5 ± 0.78* |
4.5 ± 1.04* |
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Mean cell volume (fL) |
45.8 ± 2.0 |
49.0 ± 3.8 |
50.1 ± 5.2* |
50.5 ± 2.4* |
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Mean cell hemoglobin (pg) |
15.3 ± 0.5 |
16.3 ± 1.3 |
16.7 ± 1.3 |
16.8 ± 0.7* |
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Mean cell hemoglobin concentration (g/dL) |
33.4 ± 0.7 |
33.3 ± 0.7 |
33.5 ± 1.7 |
33.3 ± 1.1 |
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Platelets (103/µL) |
1,475 ± 313.5 |
1,612 ± 419.7 |
1,854 ± 769.9 |
1,863 ± 323.2 |
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Leukocytes (103/µL) |
8.18 ± 2.27 |
7.56 ± 2.52 |
13.37 ± 22.71 |
6.67 ± 1.74 |
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Segmented neutrophils (103/µL) |
1.49 ± 0.62 |
1.93 ± 1.16 |
7.17 ± 19.55 |
0.82 ± 0.24 |
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Lymphocytes (103/µL) |
5.92 ± 1.85 |
5.08 ± 1.44 |
6.01 ± 3.65 |
5.19 ± 1.35 |
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Monocytes (103/µL) |
0.34 ± 0.13 |
0.27 ± 0.24 |
0.31 ± 0.44 |
0.27 ± 0.14 |
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Basophils (103/µL) |
0.02 ± 0.013 |
0.01 ± 0.016 |
0.01 ± 0.013 |
0.02 ± 0.013 |
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Eosinophils (103/µL) |
0.39 ± 0.21 |
0.25 ± 0.10 |
0.24 ± 0.21 |
0.35 ± 0.21 |
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Large unstained cells (103/µL) |
0.03 ± 0.01e |
0.04 ± 0.02f |
0.03 ± 0.02g |
0.03 ± 0.02e |
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0 + 150 |
100 + 150 |
200 + 150 |
400 + 150 |
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n |
10 |
10 |
10 |
10 |
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Hematocrit (%) |
41.5 ± 2.7 |
37.0 ± 2.9** |
35.9 ± 2.9** |
30.8 ± 6.0** |
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Hemoglobin (g/dL) |
13.8 ± 1.2 |
12.3 ± 1.0* |
11.9 ± 1.1** |
10.2 ± 1.9** |
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Erythrocytes (106/µL) |
9.17 ± 0.62 |
7.74 ± 0.69** |
7.32 ± 0.64** |
6.23 ± 0.94** |
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Reticulocytes (105/µL) |
4.9 ± 0.66** |
4.5 ± 0.71* |
5.2 ± 1.09** |
3.9 ± 1.41 |
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Mean cell volume (fL) |
45.3 ± 2.4 |
48.0 ± 3.1 |
49.2 ± 3.1 |
49.2 ± 2.9 |
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Mean cell hemoglobin (pg) |
15.1 ± 0.8 |
15.9 ± 1.0 |
16.3 ± 0.7 |
16.4 ± 1.0 |
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Mean cell hemoglobin concentration (g/dL) |
33.3 ± 1.1 |
33.2 ± 0.9 |
33.2 ± 1.6 |
33.4 ± 1.0 |
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Platelets (103/µL) |
1,514 ± 409.7 |
1,689 ± 238.3 |
1,834 ± 172.3 |
2,214 ± 345.5** |
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Leukocytes (103/µL) |
7.71 ± 2.58 |
6.83 ± 1.88 |
6.89 ± 2.02 |
6.53 ± 2.00 |
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Segmented neutrophils (103/µL) |
1.22 ± 0.62 |
0.93 ± 0.36 |
1.00 ± 0.47 |
1.15 ± 1.30 |
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Lymphocytes (103/µL) |
5.96 ± 2.38 |
5.40 ± 1.65 |
5.08 ± 2.09 |
5.32 ± 1.61 |
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Monocytes (103/µL) |
0.27 ± 0.12 |
0.23 ± 0.17 |
0.24 ± 0.09 |
0.22 ± 0.08 |
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Basophils (103/µL) |
0.02 ± 0.016 |
0.02 ± 0.012 |
0.02 ± 0.016 |
0.02 ± 0.010 |
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Eosinophils (103/µL) |
0.22 ± 0.14 |
0.22 ± 0.14 |
0.32 ± 0.11 |
0.36 ± 0.27 |
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Large unstained cells (103/µL) |
0.03 ± 0.02h |
0.03 ± 0.01e |
0.03 ± 0.01h |
0.03 ± 0.02e |
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* Significantly different (P<0.05) from the vehicle control group using analysis of variance followed by Dunnett’s test ** P<0.01 a Daily gavage doses of AZT + isoniazid (mg/kg per day). Data are given as mean ± standard error. Statistical tests were performed on unrounded data. b n=9 c Leukocyte counts corrected for nucleated erythrocyte counts greater than 10 per 100 leukocytes d n=6 e n=8 f n=4 g n=5 h n=7 |
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Table A2
Hematology Data for Female-A Swiss (CD-1®) Mice in the Reproductive, Developmental, and General Toxicity Study of AZT and Isoniazid Combinationsa
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| Vehicle Control |
100 + 0 |
200 + 0 |
400 + 0 |
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n |
20 |
20 |
20 |
20 |
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Hematocrit (%) |
41.1 ± 3.0 |
40.8 ± 2.8 |
42.0 ± 2.9 |
41.0 ± 3.3 |
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Hemoglobin (f/µL) |
14.1 ± 1.1 |
13.9 ± 1.1 |
14.2 ± 1.1 |
13.7 ± 1.3 |
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Erythrocytes (106/µL) |
8.33 ± 0.68 |
7.56 ± 0.71 |
7.61 ± 0.73 |
7.45 ± 0.64 |
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Reticulocytes (105/µL) |
3.8 ± 1.19b |
3.4 ± 0.76 |
3.8 ± 0.78 |
3.5 ± 0.73 |
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Mean cell volume (fL) |
49.5 ± 2.6 |
54.2 ± 2.4** |
55.4 ± 2.5** |
55.1 ± 2.8** |
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Mean cell hemoglobin (pg) |
17.0 ± 1.0 |
18.4 ± 1.0** |
18.7 ± 0.9** |
18.5 ± 1.1** |
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Mean cell hemoglobin concentration (g/dL) |
34.3 ± 1.2 |
34.0 ± 1.1 |
33.7 ± 1.2 |
33.5 ± 1.0 |
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Platelets (103/µL) |
1,363 ± 222.8 |
1,409 ± 303.3 |
1,422 ± 356.3 |
1,479 ± 415.1 |
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Leukocytes (103/µL)c |
7.49 ± 1.55 |
6.25 ± 1.43 |
6.43 ± 1.58 |
5.71 ± 1.60** |
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Segmented neutrophils (103/µL) |
2.27 ± 0.58 |
1.41 ± 0.74** |
1.26 ± 0.57** |
0.76 ± 0.47** |
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Lymphocytes (103/µL) |
4.62 ± 1.29 |
4.29 ± 1.07 |
4.72 ± 1.48 |
4.56 ± 1.47 |
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Monocytes (103/µL) |
0.31 ± 0.08 |
0.22 ± 0.08 |
0.18 ± 0.11** |
0.13 ± 0.11** |
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Basophils (103/µL) |
0.02 ± 0.009 |
0.01 ± 0.010 |
0.02 ± 0.010 |
0.01 ± 0.011 |
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Eosinophils (103/µL) |
0.25 ± 0.15 |
0.29 ± 0.20 |
0.23 ± 0.15 |
0.23 ± 0.14 |
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Large unstained cells (103/µL) |
0.02 ± 0.01 |
0.02 ± 0.01b |
0.02 ± 0.01d |
0.02 ± 0.01e |
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0 + 50 |
100 + 50 |
200 + 50 |
400 + 50 |
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n |
20 |
20 |
20 |
20 |
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Hematocrit (%) |
39.8 ± 3.9 |
39.9 ± 2.3 |
40.4 ± 3.8 |
39.6 ± 2.8 |
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Hemoglobin (g/dL) |
13.6 ± 1.4 |
13.5 ± 0.9 |
13.7 ± 1.5 |
13.2 ± 1.0 |
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Erythrocytes (106/µL) |
8.11 ± 0.69 |
7.56 ± 0.60 |
7.48 ± 0.74 |
7.12 ± 0.55** |
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Reticulocytes (105/µL) |
3.5 ± 1.17 |
3.5 ± 0.70b |
3.6 ± 1.02 |
4.3 ± 1.23 |
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Mean cell volume (fL) |
49.0 ± 2.0 |
53.0 ± 3.2* |
54.1 ± 2.0** |
55.7 ± 2.2** |
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Mean cell hemoglobin (pg) |
16.7 ± 0.7 |
17.9 ± 0.9 |
18.4 ± 1.0** |
18.5 ± 0.9** |
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Mean cell hemoglobin concentration (g/dL) |
34.1 ± 1.0 |
33.8 ± 1.1 |
33.9 ± 1.2 |
33.2 ± 0.8 |
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Platelets (103/µL) |
1,507 ± 276.0 |
1,528 ± 271.0 |
1,509 ± 398.7 |
1,549 ± 417.4 |
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Leukocytes (103/µL) |
8.03 ± 2.09 |
6.64 ± 2.14 |
6.16 ± 1.21 |
5.52 ± 1.96** |
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Segmented neutrophils (103/µL) |
2.81 ± 1.36 |
1.52 ± 0.90* |
1.19 ± 0.85** |
0.83 ± 0.40** |
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Lymphocytes (103/µL) |
4.64 ± 1.29 |
4.61 ± 1.67 |
4.56 ± 0.95 |
4.25 ± 1.72 |
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Monocytes (103/µL) |
0.33 ± 0.16 |
0.24 ± 0.16 |
0.17 ± 0.08** |
0.17 ± 0.07** |
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Basophils (103/µL) |
0.02 ± 0.010 |
0.02 ± 0.012 |
0.01 ± 0.009 |
0.01 ± 0.011 |
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Eosinophils (103/µL) |
0.22 ± 0.14 |
0.23 ± 0.16 |
0.21 ± 0.17 |
0.24 ± 0.18 |
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Large unstained cells (103/µL) |
0.02 ± 0.01f |
0.02 ± 0.02f |
0.02 ± 0.01g |
0.02 ± 0.01h |
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0 + 100 |
100 + 100 |
200 + 100 |
400 + 100 |
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n |
20 |
20 |
20 |
19 |
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Hematocrit (%) |
39.9 ± 3.1 |
38.8 ± 3.6 |
36.4 ± 8.3* |
35.4 ± 10.1* |
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Hemoglobin (g/dL) |
13.4 ± 1.1 |
12.6 ± 1.1* |
12.2 ± 2.8** |
11.6 ± 3.2** |
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Erythrocytes (106/µL) |
8.48 ± 0.78 |
7.01 ± 0.79** |
6.57 ± 1.36** |
6.26 ± 1.60** |
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Reticulocytes (105/µL) |
4.4 ± 1.27b |
4.5 ± 1.94 |
4.5 ± 1.87 |
4.4 ± 2.42 |
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Mean cell volume (fL) |
47.1 ± 2.3 |
55.6 ± 3.5** |
54.9 ± 4.5** |
55.4 ± 5.7** |
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Mean cell hemoglobin (pg) |
15.9 ± 0.9* |
18.1 ± 1.2* |
18.4 ± 1.6** |
18.3 ± 1.5** |
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Mean cell hemoglobin concentration (g/dL) |
33.7 ± 1.0 |
32.5 ± 1.0** |
33.5 ± 1.0 |
33.2 ± 1.5 |
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Platelets (103/µL) |
1,631 ± 300.9 |
1,705 ± 216.6* |
1,792 ± 425.5** |
1,772 ± 575.1 |
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Leukocytes (103/µL) |
7.34 ± 1.63 |
5.95 ± 1.10* |
5.60 ± 1.85** |
5.00 ± 1.43** |
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Segmented neutrophils (103/µL) |
2.13 ± 0.85 |
1.50 ± 0.62* |
1.13 ± 1.26** |
0.67 ± 0.40** |
|
Lymphocytes (103/µL) |
4.70 ± 1.24 |
4.01 ± 0.81 |
4.09 ± 0.85 |
4.00 ± 1.23 |
|
Monocytes (103/µL) |
0.27 ± 0.11 |
0.22 ± 0.08 |
0.17 ± 0.15** |
0.13 ± 0.08** |
|
Basophils (103/µL) |
0.02 ± 0.009 |
0.01 ± 0.007** |
0.01 ± 0.008 |
0.01 ± 0.007** |
|
Eosinophils (103/µL) |
0.20 ± 0.18 |
0.20 ± 0.19 |
0.19 ± 0.15 |
0.19 ± 0.17 |
|
Large unstained cells (103/µL) |
0.01 ± 0.01b |
0.02 ± 0.01g |
0.01 ± 0.01d |
0.01 ± 0.01i |
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|
|
0 + 150 |
100 + 150 |
200 + 150 |
400 + 150 |
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|
|
|
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n |
20 |
20 |
17 |
18 |
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|
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|
|
Hematocrit (%) |
39.6 ± 3.3 |
36.5 ± 5.0 |
30.2 ± 11.7** |
26.4 ± 12.4** |
|
Hemoglobin (g/dL) |
13.1 ± 1.2 |
11.9 ± 1.6** |
9.9 ± 3.7** |
8.9 ± 3.9** |
|
Erythrocytes (106/µL) |
8.31 ± 0.90 |
6.70 ± 0.98** |
5.46 ± 1.94** |
4.82 ± 1.94** |
|
Reticulocytes (105/µL) |
5.2 ± 2.00 |
4.9 ± 1.88 |
4.8 ± 3.17 |
3.3 ± 2.22 |
|
Mean cell volume (fL) |
47.8 ± 2.7 |
54.7 ± 3.8** |
54.0 ± 7.4** |
52.3 ± 7.2 |
|
Mean cell hemoglobin (pg) |
15.8 ± 1.0* |
17.8 ± 1.1 |
17.8 ± 1.8 |
17.9 ± 1.8 |
|
Mean cell hemoglobin concentration (g/dL) |
33.0 ± 1.1** |
32.6 ± 1.0** |
33.1 ± 1.9* |
34.4 ± 2.0 |
|
Platelets (103/µL) |
1,482 ± 453.2 |
1,732 ± 421.4* |
2,025 ± 455.3** |
2,347 ± 731.8** |
|
Leukocytes (103/µL) |
7.01 ± 1.66 |
6.09 ± 1.43 |
5.07 ± 1.62** |
5.06 ± 1.50** |
|
Segmented neutrophils (103/µL) |
1.75 ± 1.08 |
1.25 ± 0.65** |
0.90 ± 0.79** |
0.65 ± 0.34** |
|
Lymphocytes (103/µL) |
4.81 ± 1.30 |
4.43 ± 1.16 |
3.84 ± 1.07 |
4.10 ± 1.30 |
|
Monocytes (103/µL) |
0.25 ± 0.11 |
0.20 ± 0.12* |
0.16 ± 0.10** |
0.14 ± 0.10** |
|
Basophils (103/µL) |
0.02 ± 0.010 |
0.01 ± 0.009 |
0.01 ± 0.007 |
0.01 ± 0.006* |
|
Eosinophils (103/µL) |
0.17 ± 0.13 |
0.19 ± 0.15 |
0.15 ± 0.11 |
0.15 ± 0.10 |
|
Large unstained cells (103/µL) |
0.02 ± 0.01f |
0.02 ± 0.01d |
0.01 ± 0.01d |
0.02 ± 0.01i |
* Significantly different (P<0.05) from the vehicle control group using analysis of variance followed by Dunnett’s test ** P<0.01 a Daily gavage doses of AZT + isoniazid (mg/kg per day). Data are given as mean ± standard error. Statistical tests were performed on unrounded data. b n=19 c Leukocyte counts corrected for nucleated erythrocyte counts greater than 10 per 100 leukocytes d n=16 e n=11 f n=18 g n=15 h n=14 i n=13 |
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Table A3
Hematology Data for Female-B Swiss (CD-1®) Mice in the Reproductive, Developmental, and General Toxicity Study of AZT and Isoniazid Combinationsa
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| Vehicle Control |
100 + 0 |
200 + 0 |
400 + 0 |
|
|
|
||||
|
n |
20 |
20 |
20 |
20 |
|
|
|
|
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|
|
Hematocrit (%) |
42.3 ± 2.8 |
42.0 ± 2.5 |
41.3 ± 5.7 |
40.9 ± 2.7 |
|
Hemoglobin (g/dL) |
14.2 ± 0.8 |
14.1 ± 1.1 |
13.8 ± 2.2 |
13.7 ± 1.2 |
|
Erythrocytes (106/µL) |
8.52 ± 0.60 |
8.08 ± 0.74 |
7.87 ± 1.52 |
7.75 ± 0.67 |
|
Reticulocytes (105/µL)b |
4.9 ± 1.19 |
5.2 ± 2.12 |
5.9 ± 1.35 |
5.8 ± 1.77 |
|
Mean cell volume (fL) |
49.7 ± 1.6 |
52.1 ± 2.2 |
53.2 ± 4.3 |
53.0 ± 4.0 |
|
Mean cell hemoglobin (pg) |
16.7 ± 0.5 |
17.4 ± 0.8 |
17.6 ± 1.0 |
17.7 ± 1.1* |
|
Mean cell hemoglobin concentration (g/dL) |
33.6 ± 0.8 |
33.4 ± 1.1 |
33.2 ± 1.7 |
33.5 ± 1.9 |
|
Platelets (103/µL) |
1,497 ± 351.0 |
1,413 ± 309.9 |
1,417 ± 360.9 |
1,380 ± 234.1 |
|
Leukocytes (103/µL)c |
7.03 ± 1.78 |
6.99 ± 1.69 |
7.05 ± 0.85 |
7.33 ± 2.11 |
|
Segmented neutrophils (103/µL)b |
1.77 ± 0.65 |
1.73 ± 0.51 |
1.73 ± 0.77 |
1.58 ± 0.54 |
|
Lymphocytes (103/µL)b |
4.86 ± 1.14 |
4.69 ± 1.45 |
4.82 ± 1.06 |
5.23 ± 1.70 |
|
Monocytes (103/µL)b |
0.20 ± 0.14 |
0.23 ± 0.08 |
0.22 ± 0.09 |
0.22 ± 0.12 |
|
Basophils (103/µL)b |
0.01 ± 0.015 |
0.01 ± 0.012 |
0.01 ± 0.012 |
0.02 ± 0.016 |
|
Eosinophils (103/µL)b |
0.20 ± 0.20 |
0.31 ± 0.22 |
0.27 ± 0.20 |
0.27 ± 0.18 |
|
Large unstained cells (103/µL)b |
0.03 ± 0.02 |
0.02 ± 0.01 |
0.02 ± 0.01 |
0.03 ± 0.02 |
|
|
|
|
|
|
|
|
0 + 50 |
100 + 50 |
200 + 50 |
400 + 50 |
|
|
|
|
|
|
|
n |
20 |
20 |
20 |
20 |
|
|
|
|
|
|
|
Hematocrit (%) |
42.9 ± 2.7 |
41.1 ± 2.5 |
40.1 ± 3.9 |
41.9 ± 2.6 |
|
Hemoglobin (g/dL) |
14.2 ± 1.0 |
13.6 ± 0.8 |
13.4 ± 1.1 |
13.8 ± 0.8 |
|
Erythrocytes (106/µL) |
8.68 ± 0.74 |
7.87 ± 0.57 |
7.72 ± 0.74 |
7.76 ± 0.43 |
|
Reticulocytes (105/µL) |
5.5 ± 1.94 |
5.6 ± 2.15 |
5.7 ± 1.56 |
5.4 ± 1.93 |
|
Mean cell volume (fL) |
49.6 ± 2.5 |
52.3 ± 3.3 |
51.9 ± 2.5 |
54.0 ± 3.1 |
|
Mean cell hemoglobin (pg) |
16.4 ± 0.8 |
17.3 ± 0.8 |
17.4 ± 0.6 |
17.8 ± 1.1* |
|
Mean cell hemoglobin concentration (g/dL) |
33.1 ± 0.7 |
33.1 ± 1.2 |
33.6 ± 1.4 |
32.9 ± 1.0 |
|
Platelets (103/µL) |
1,583 ± 271.4 |
1,580 ± 330.1 |
1,572 ± 428.4 |
1,495 ± 347.1 |
|
Leukocytes (103/µL) |
6.93 ± 1.97 |
7.54 ± 1.95 |
7.49 ± 2.80 |
6.44 ± 1.92 |
|
Segmented neutrophils (103/µL) |
1.78 ± 0.67 |
1.49 ± 0.48 |
2.06 ± 1.00 |
1.74 ± 0.51 |
|
Lymphocytes (103/µL) |
4.81 ± 1.58 |
5.63 ± 1.77 |
4.83 ± 1.85 |
4.19 ± 1.30 |
|
Monocytes (103/µL) |
0.15 ± 0.14 |
0.23 ± 0.06 |
0.25 ± 0.19 |
0.23 ± 0.14 |
|
Basophils (103/µL) |
0.01 ± 0.009 |
0.02 ± 0.019 |
0.02 ± 0.018 |
0.02 ± 0.017 |
|
Eosinophils (103/µL) |
0.17 ± 0.22 |
0.16 ± 0.15 |
0.32± 0.37 |
0.25 ± 0.25 |
|
Large unstained cells (103/µL) |
0.02 ± 0.01 |
0.03 ± 0.02 |
0.02 ± 0.02 |
0.02 ± 0.01 |
|
|
|
|
|
|
|
|
0 + 100 |
100 + 100 |
200 + 100 |
400 + 100 |
|
|
|
|
|
|
|
n |
13 or 14 |
13 or 14 |
13 or 14 |
13 or 14 |
|
|
|
|
|
|
|
Hematocrit (%) |
41.0 ± 4.6 |
40.7 ± 3.3 |
42.8 ± 3.1 |
42.5 ± 3.2 |
|
Hemoglobin (g/dL) |
13.6 ± 1.6 |
13.5 ± 1.2 |
14.1 ± 0.9 |
14.2 ± 1.0 |
|
Erythrocytes (106/µL) |
8.23 ± 1.00 |
7.81 ± 0.53 |
8.15 ± 0.77 |
8.02 ± 0.73 |
|
Reticulocytes (105/µL) |
5.2 ± 1.68 |
6.0 ± 1.34 |
5.4 ± 2.21 |
6.7 ± 5.23 |
|
Mean cell volume (fL) |
49.9 ± 2.2 |
52.1 ± 3.1 |
52.7 ± 3.2 |
53.2 ± 4.5 |
|
Mean cell hemoglobin (pg) |
16.6 ± 0.9 |
17.3 ± 0.8 |
17.3 ± 1.1 |
17.7 ± 1.1* |
|
Mean cell hemoglobin concentration (g/dL) |
33.2 ± 1.0 |
32.2 ± 1.0 |
32.9 ± 0.5 |
33.4 ± 1.0 |
|
Platelets (103/µL) |
1,458 ± 327.8 |
1,438 ± 234.0 |
1,461 ± 227.3 |
1,500 ± 212.7 |
|
Leukocytes (103/µL) |
6.86 ± 1.42 |
6.01 ± 0.86 |
7.52 ± 2.21 |
6.39 ± 1.40 |
|
Segmented neutrophils (103/µL) |
1.94 ± 0.77 |
1.70 ± 0.90 |
1.92 ± 0.86 |
1.63 ± 0.56 |
|
Lymphocytes (103/µL) |
4.38 ± 0.84 |
3.94 ± 0.66 |
5.09 ± 1.80 |
4.28 ± 1.48 |
|
Monocytes (103/µL) |
0.23 ± 0.12 |
0.20 ± 0.10 |
0.23 ± 0.24 |
0.19 ± 0.14 |
|
Basophils (103/µL) |
0.02 ± 0.012 |
0.01 ± 0.009 |
0.01 ± 0.015 |
0.01 ± 0.012 |
|
Eosinophils (103/µL) |
0.27 ± 0.25 |
0.16 ± 0.17 |
0.26 ± 0.21 |
0.26 ± 0.26 |
|
Large unstained cells (103/µL) |
0.02 ± 0.01 |
0.02 ± 0.01 |
0.02 ± 0.01 |
0.03 ± 0.01 |
|
|
|
|
|
|
|
|
0 + 150 |
100 + 150 |
200 + 150 |
400 + 150 |
|
|
|
|
|
|
|
n |
13 or 14 |
13 or 14 |
13 or 14 |
13 or 14 |
|
|
|
|
|
|
|
Hematocrit (%) |
42.4 ± 3.5 |
43.7 ± 3.7 |
42.6 ± 2.8 |
44.6 ± 3.3 |
|
Hemoglobin (g/dL) |
14.1 ± 1.3 |
14.3 ± 1.3 |
14.1 ± 1.2 |
14.9 ± 1.2 |
|
Erythrocytes (106/µL) |
8.60 ± 0.86 |
8.37 ± 1.01 |
8.06 ± 0.74 |
8.49 ± 0.71 |
|
Reticulocytes (105/µL) |
4.8 ± 1.46 |
6.0 ± 1.80 |
6.2 ± 4.09 |
3.2 ± 1.97 |
|
Mean cell volume (fL) |
49.5 ± 2.2 |
52.5 ± 4.1 |
53.1 ± 4.4 |
52.6 ± 2.6 |
|
Mean cell hemoglobin (pg) |
16.4 ± 0.7 |
17.2 ± 1.4 |
17.5 ± 1.2 |
17.6 ± 0.9 |
|
Mean cell hemoglobin concentration (g/dL) |
33.2 ± 1.0 |
32.7 ± 1.2 |
33.0 ± 1.3 |
33.5 ± 1.0 |
|
Platelets (103/µL) |
1,557 ± 304.2 |
1,435 ± 405.9 |
1,450 ± 313.9 |
1,483 ± 228.9 |
|
Leukocytes (103/µL) |
7.19 ± 1.74 |
6.64 ± 2.08 |
6.58 ± 1.68 |
7.01 ± 1.72 |
|
Segmented neutrophils (103/µL) |
1.90 ± 0.76 |
1.73 ± 0.75 |
1.29 ± 0.45 |
1.63 ± 0.70 |
|
Lymphocytes (103/µL) |
4.79 ± 1.01 |
4.41 ± 1.66 |
4.74 ± 1.59 |
4.75 ± 1.54 |
|
Monocytes (103/µL) |
0.19 ± 0.12 |
0.21 ± 0.13 |
0.23 ± 0.09 |
0.24 ± 0.11 |
|
Basophils (103/µL) |
0.02 ± 0.020 |
0.01 ± 0.015 |
0.02 ± 0.014 |
0.02 ± 0.015 |
|
Eosinophils (103/µL) |
0.28 ± 0.35 |
0.28 ± 0.33 |
0.28 ± 0.17 |
0.35 ± 0.11 |
|
Large unstained cells (103/µL) |
0.03 ± 0.02 |
0.02 ± 0.01 |
0.02 ± 0.01 |
0.03 ± 0.01 |
* Significantly different (P<0.05) from the vehicle control group using analysis of variance followed by Dunnett’s test a Daily gavage doses of AZT + isoniazid (mg/kg per day). Data are given as mean ± standard error. Statistical tests were performed on unrounded data. b n=13 or 14 c Leukocyte counts corrected for nucleated erythrocyte counts greater than 10 per 100 leukocytes |
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Web page last updated on October 07, 2004
