Bibliographic Citation
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Title | Effect of hematocrit and systolic blood pressure on cerebral blood flow in newborn infants |
Creator/Author | Younkin, D.P. ; Reivich, M. ; Jaggi, J.L. ; Obrist, W.D. ; Delivoria-Papadopoulos, M. |
Publication Date | 1987 Jun 01 |
OSTI Identifier | OSTI ID: 6468181 |
Other Number(s) | CODEN: JCBMD |
Resource Type | Journal Article |
Resource Relation | J. Cereb. Blood Flow Metab. ; Vol/Issue: 3 |
Research Org | Univ. of Pennsylvania, Philadelphia |
Subject | 551001 -- Physiological Systems-- Tracer Techniques; BRAIN-- BLOOD FLOW; BLOOD COUNT;BLOOD PRESSURE;CLEARANCE;DYNAMIC FUNCTION STUDIES;HOMEOSTASIS;INFANTS;TRACER TECHNIQUES;XENON 133 |
Related Subject | AGE GROUPS;BETA DECAY RADIOISOTOPES;BETA-MINUS DECAY RADIOISOTOPES;BODY;CENTRAL NERVOUS SYSTEM;CHILDREN;DAYS LIVING RADIOISOTOPES;EVEN-ODD NUCLEI;INTERMEDIATE MASS NUCLEI;INTERNAL CONVERSION RADIOISOTOPES;ISOMERIC TRANSITION ISOTOPES;ISOTOPE APPLICATIONS;ISOTOPES;NERVOUS SYSTEM;NUCLEI;ORGANS;RADIOISOTOPES;XENON ISOTOPES |
Description/Abstract | The effects of hematocrit and systolic blood pressure on cerebral blood flow were measured in 15 stable, low birth weight babies.^CBF was measured with a modification of the xenon-133 (/sup 133/Xe) clearance technique, which uses an intravenous bolus of /sup 133/Xe, an external chest detector to estimate arterial /sup 133/Xe concentration, eight external cranial detectors to measure cephalic /sup 133/Xe clearance curves, and a two-compartmental analysis of the cephalic /sup 133/Xe clearance curves to estimate CBF.^There was a significant inverse correlation between hematocrit and CBF, presumably due to alterations in arterial oxygen content and blood viscosity.^Newborn CBF varied independently of systolic blood pressure between 60 and 84 mm Hg, suggesting an intact cerebrovascular autoregulatory mechanism.^These results indicate that at least two of the factors that affect newborn animal CBF are operational in human newborns and may have important clinical implications. |
Country of Publication | United States |
Language | English |
Format | Pages: 295-299 |
System Entry Date | 2001 May 13 |
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