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Abstract

Grant Number:	5R44HL055120-03
Project Title:	NONINVASIC OPTICAL SENSOR FOR HEMOGLOBIN MEASUREMENTS

PI Information:	Name	Email	Title
	WINCHESTER, LEONARD WILLIAM.	lww@cwoptics.com	CHIEF SCIENTIST

Abstract: DESCRIPTION (Adapted from applicant's abstract): In Phase I CW Optics demonstrated the ability to apply differential absorption spectroscopy and multiple scattering techniques to the measurement of hemoglobin moieties. The objective for Phase II is the development of a noninvasive real-time blood sensor for the measurement of levels of four major hemoglobin moieties and hematocrit. The moieties to be measured are levels of oxyhemoglobin (O2Hb) reduced or deoxyhemoglobin (RHb), carboxyhemoglobin (COHb) and methemoglobin (MetHb). It also became evident that the approach could also be used to estimate hematocrit. In Phase II it is planned to modify and improve the Phase I algorithms to incorporate hematocrit measurement, to manufacture prototype devices and demonstrate the efficiency of this device in a clinical study and then to explore a suitable design for a commercial instrument. The effects of band width on the accuracy of the measurements will be examined. It is also planned to produce an integrated sensor for noninvasive real-time monitoring of hematocrit and the individual Hb components in a clinical setting. Such real time noninvasive monitoring of hemoglobin components and hematocrit is very attractive in that it avoids blood sampling, reduces the therapeutic decision time and also eliminates the risk of infection. This type of instrumentation clearly has commercial potential and should be of interest to an assortment of health care providers. PROPOSED COMMERCIAL APPLICATION: Not available.

Public Health Relevance:
This Public Health Relevance is not available.

Thesaurus Terms:
biomedical equipment development, blood cell count, diagnosis design /evaluation, hemoglobin, noninvasive diagnosis, optics, spectrometry
artificial intelligence, biotechnology, carboxyhemoglobin, methemoglobin, oxyhemoglobin
human tissue

Institution:	CW OPTICS, INC.
	1103 MOORE HOUSE RD
	YORKTOWN, VA 236903620
Fiscal Year:	1999
Department:
Project Start:	10-APR-1998
Project End:	31-JUL-2000
ICD:	NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
IRG:	ZRG7

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