Diethylcarbamazine - PubChem Public Chemical Database

Diethylcarbamazine - Compound Summary (CID 79300)

An anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa.

Table of Contents

Drug and Chemical Information

Pharmacological Action

Pharmacological Classification

Chemical Classification

Safety and Toxicology

Substance Information

Category

Exports

Drug and Chemical Information: (Total:1)

Diethylcarbamazine

Pharmacological Action

Filaricides - Pharmacological agents destructive to nematodes in the superfamily Filarioidea.

Lipoxygenase Inhibitors - Compounds or agents that combine with lipoxygenase and thereby prevent its substrate-enzyme combination with arachidonic acid and the ... show more

Pharmacological Classification

Chemical Actions and Uses

Pharmacologic Actions

Molecular Mechanisms of Pharmacological Action

Enzyme Inhibitors

Lipoxygenase Inhibitors

Therapeutic Uses

Anti-Infective Agents

Antiparasitic Agents

Anthelmintics

Antinematodal Agents

Filaricides

Chemical Classification

Heterocyclic Compounds

Heterocyclic Compounds, 1-Ring

Piperazines

Diethylcarbamazine

Organic Chemicals

Carboxylic Acids

Acids, Acyclic

Carbamates

Diethylcarbamazine

Safety and Toxicology

HSDB - Peer-reviewed summary of toxicity and biomedical effects

EINECS - European Inventory of Existing Commercial Chemical Substances

TOXLINE - Citations to the toxicological literature

ClinicalTrials.gov - Registry of federal and private clinical trials

Literature Choose by Subheadings:

administration and dosage	adverse effects	analogs and derivatives
analysis	antagonists and inhibitors	blood
chemical synthesis	chemistry	contraindications
diagnostic use	economics	immunology
isolation and purification	metabolism	pharmacokinetics
pharmacology	standards	supply and distribution
therapeutic use	therapy	toxicity
urine

Literature Keyword Mining Tool

BioActivity Results:

Tested in BioAssays: All: 7 Inactive: 7
BioActivity Summary: This Compound

with Similar Compounds

AID: 179 Source: DTP/NCI
NCI AIDS Antiviral Assay

AID: 175 Source: DTP/NCI
NCI Yeast Anticancer Drug Screen. Data for the mlh1 rad18 strain

AID: 167 Source: DTP/NCI
NCI Yeast Anticancer Drug Screen. Data for the bub3 strain

AID: 165 Source: DTP/NCI
NCI Yeast Anticancer Drug Screen. Data for the cln2 rad14 strain

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Properties Computed from Structure:

Molecular Weight	235.75418 [g/mol]
Molecular Formula	C₁₀H₂₂ClN₃O
H-Bond Donor	1
H-Bond Acceptor	2
Rotatable Bond Count	2
Exact Mass	235.14514
MonoIsotopic Mass	235.14514
Topological Polar Surface Area	26.8
Heavy Atom Count	15
Formal Charge	0
Complexity	184
Isotope Atom Count	0
Defined Atom StereoCenter Count	0
Undefined Atom StereoCenter Count	0
Defined Bond StereoCenter Count	0
Undefined Bond StereoCenter Count	0
Covalently-Bonded Unit Count	2

Descriptors Computed from Structure:

IUPAC Name: N,N-diethyl-4-methylpiperazine-1-carboxamide hydrochloride
Canonical SMILES: CCN(CC)C(=O)N1CCN(CC1)C.Cl
InChI: InChI=1S/C10H21N3O.ClH/c1-4-12(5-2)10(14)13-8-6-11(3)7-9-13;/h4-9H2,
1-3H3;1H

InChIKey: WCJHPDVYERQRGZ-UHFFFAOYSA-N

Compound Information:

CID 79300

Create Date: 2005-08-08

Parent CID 3052

Unique Components: 2 Links

Similar Compounds: 15 Links