Testing Information

Testing Status of Agents at NTP

CAS Registry Number: 112-80-1 Toxicity Effects

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Selected toxicity information from HSDB, one of the National Library of Medicine's databases. 1

Names (NTP)

  • Oleic acid
  • (Z)-9-OCTADECANOIC ACID

Human Toxicity Excerpts

  • Neutrophils from healthy volunteers were isolated and incubated with albumin-bound oleic acid. Standard in vitro function tests including phagocytosis, bactericidal activity, and chemotaxis were performed after the incubation. Oleic acid caused no changes in bactericidal activity and only moderate decreases in phagocytosis and chemotaxis at high conc. [Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 4966]**PEER REVIEWED**
  • Oleic acid in human blood reversibly altered the shape of erythrocytes, led to the reduction of viscosity of the blood in vitro, and reduced the erythrocyte sedimentation rate. [Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 4966]**PEER REVIEWED**

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Non-Human Toxicity Excerpts

  • ... Oleic acid or neutralized sodium oleate injected into the corneas of rabbits caused the eyes to become inflamed within a few hours, to develop corneal abscess within a few days, and to become extensively scarred and vascularized. There was necrosis in the immediate region of the injection, and formation of fat droplets in surviving surrounding corneal cells. [Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986., p. 675]**PEER REVIEWED**
  • UNDILUTED, IT IS A DEPILATORY ON MICE & RABBITS. [Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 398]**PEER REVIEWED**
  • THE FREE ACID IN VACCINES (... MANNIDE MONOOLEATE) HAS BEEN ASSOCIATED WITH STERILE ABSCESSES. [Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 398]**PEER REVIEWED**
  • Oleic acid was found to be negative when tested for mutagenicity using the Salmonella/microsome preincubation assay, using the standard protocol approved by the National Toxicology Program (NTP). Oleic acid was tested in as many as 5 Salmonella typhimurium strains (TA1535, TA1537, TA97, TA98, and TA100) in the presence and absence of rat and hamster liver S-9, at doses of 0.100, 0.300, 1.000, 3.300, 10.000, 33.000, 100.000, and 333.000 ug/plate. The highest ineffective dose tested in any S. typhimurium strain was 333.000 ug/plate. Slight clearing of the background bacterial lawn occurred at 10.000 ug/plate in cultures without activation (the highest dose tested without S-9). In cultures tested with activation, clearing of the background lawn was not seen until the dose reached 333.000 ug/plate. [Mortelmans K et al; Environ Mutagen 8: 1-119 (1986)]**PEER REVIEWED**
  • Dogs received weekly injections of 0.09 g/kg of oleic acid over a period of 1 to 3 months and responded with a variety of pulmonary changes. Early changes were thromboses and cellular necrosis. These changes were followed by a repair stage with proliferation of type 2 cells and fibrotic foci in subpleural areas. A later change was pulmonary fibrosis. The extent of lesions was related to the number of oleic acid injections. [Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 4965]**PEER REVIEWED**
  • The effect of oleic acid on insulin secretion was studied in the isolated perfused rat pancreas. In the absence of glucose a continuous infusion of oleic acid (1500 uM) induced a biphasic insulin release. The results suggest that high conc of oleic acid stimulate insulin release from the isolated perfused rat pancreas and modulate the insulin response to arginine or glucose. [Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 4965]**PEER REVIEWED**
  • THERE WAS AN INCREASE IN OLEIC ACID OF LECITHIN IN ALCOHOLICS, (OBSERVED IN BOTH LECITHIN & TRIGLYCERIDES), AS COMPARED TO NORMALS. [ALLING C ET AL; ACTA MED SCAND SUPPL 631: 38 (1979)]**PEER REVIEWED**
  • % COMPOSITION OF OLEIC ACID IN LIPID FRAGMENTS DECREASED WITH METHYLMERCURY CHLORIDE (DOSAGE: 1-10 MG/KG) EXCEPT FOR THAT IN PHOSPHOLIPIDS OF KIDNEY OF RATS RECEIVING LOWEST DOSE. [ANDO T ET AL; BULL ENVIRON CONTAM TOXICOL 22 (1-2): 214 (1979)]**PEER REVIEWED**
  • SODIUM HYDROCORTISONE 21-PHOSPHATE (5 MG/KG, IP, DAILY FOR 14 DAYS) LOWERED THE PERCENTAGE OF OLEIC ACID. [DAVE G ET AL; COMP BIOCHEM PHYSIOL A 64A (1): 37 (1979)]**PEER REVIEWED**
  • WITHIN 30-60 SECONDS AFTER IMPLANTATION OF POLYMETHYL METHACRYLATE BONE CEMENT, OLEIC ACID CONTENT DOUBLED IN VENA CAVA BLOOD. [SEIDEL H ET AL; ANAESTHESIOL INTENSIVEMED (BERLIN) 125: 391 (1980)]**PEER REVIEWED**
  • RATS WERE GIVEN IV INJECTIONS OF 3% METHYLNITROSOUREA (60 MG/KG) FOR 6 CONSECUTIVE DAYS. PHOSPHATIDYLCHOLINE & PLASMALOGEN WERE CHARACTERIZED BY A DIMINISHED CONTENT OF OLEIC ACID (18:1). [WENDER M ET AL; NEUROPATOL POL 18 (1): 53 (1980)]**PEER REVIEWED**
  • FREE OLEIC ACID IN PLASMA WAS INCREASED IN 12 HEALTHY MALE VOLUNTEERS TREATED WITH DAILY ORAL DOSES OF HYDROCHLOROTHIAZIDE 100 MG, CHLORTHALIDONE 100 MG, OR FUROSEMIDE 80 MG FOR 3 WEEKS IN CROSS-OVER TRIAL. [JOOS C ET AL; EUR J CLIN PHARMACOL 17 (4): 251 (1980)]**PEER REVIEWED**
  • OLEIC ACID CONJUGATE OF DDT WAS RETAINED IN VIVO IN LIVERS & SPLEEN OF MALE & FEMALE RATS GIVEN CHRONIC IP DDT INJECTIONS. [LEIGHTY EG ET AL; TOXICOLOGY 15 (2): 77 (1980)]**PEER REVIEWED**
  • The capacity of stearic, monochlorostearic, dichlorostearic and oleic acids to cause membrane damage was measured as their ability to induce leakage of adenosine triphosphate (ATP) from mammalian tumour cells in vitro. Chlorinated stearic acids, and oleic acid, caused ATP leakage at lower concentrations than normal stearic acid. The membrane disturbing properties are suggested to be a result of the different molecular geometries of the chlorinated stearic acids and oleic acid, compared to non-chlorinated stearic acid. [Ewald G, Sundin P; Pharmacol & Toxicol 73 (3): 159-62 (1993)]**PEER REVIEWED**
  • It has recently been shown that the infusion of oleic acid into the rat pancreaticobiliary duct causes a reproducible and long-lasting atrophy of exocrine pancreas. The effects of this pancreatic atrophy on non-invasive pancreatic function tests have not been fully characterized. This study was undertaken to determine which pancreatic function test was most useful in determining pancreatic insufficiency in this model. Pancreatic insufficiency (PI) was induced in male Wistar rats by oleic acid infusion and three pancreatic function tests were compared in these animals and saline controls. The coefficient of fat absorption on a 5 or 45% fat diet and bentiromide testing could not differentiate animals with or without pancreatic insufficiency but fecal chymotrypsin levels were excellent discriminators. All animals with pancreatic insufficiency had fecal-chymotrypsin levels below 67 U/g feces whereas all saline controls were above this level. [Henry JP, Steinberg WM; Pancreas 8 (5): 622-6 (1993)]**PEER REVIEWED**
  • The influence of various dietary constituents--phenethylisothiocyanate (PEITC), oleic acid (OA), triolein (TO), and vitamin A (ROL)--on the genotoxic activity of nitrosamines (NDMA, NDELA, NPYR) was investigated. For this purpose differential DNA repair assays with Escherichia coli K-12 strains were performed in vitro and in vivo with mice. Under in vitro conditions (liquid holding), all compounds reduced nitrosamine induced DNA-damage in the indicator bacteria in the dose range 1-10 ug/ml, the ranking order of efficiency being pheneethylisothiocyanate greater than vitamin A greater than or equal to triolein. [Knasmuller S et al; Carcinogenesis 13 (9): 1643-50 (1992)]**PEER REVIEWED**
  • O1eic acid injection produces acute lung injury and pulmonary hypertension in adult animals. In other types of acute lung injury, such as that caused by E coli endotoxin, metabolites of arachidonic acid are important mediators of pulmonary hypertension. Oleic acid /was injected/ into awake, chronically instrumented newborn lambs. The hemodynamic response of lambs to injection of oleic acid alone was compared to their response after pretreatment with either FPL57231, a putative leukotriene receptor antagonist, or indomethacin, a cyclooxygenase synthesis inhibitor. Oleic acid caused acute pulmonary hypertension associated with an increase in protein-rich lung lymph fluid. Systemic hemodynamic effects were variable. FPL57231 completely blocked the oleic acid induced pulmonary hypertension while indomethacin significantly attenuated the response. Therefore, metabolites of arachidonic acid metabolism appear to be important mediators of oleic acid induced pulmonary hypertension in newborn lambs. [Schreiber MD, Soifer SJ; J Dev Physiol 16 (3): 167-72 (1991)]**PEER REVIEWED**

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Human Toxicity Values

  • None found

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Non-Human Toxicity Values

  • None found

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Absorption, Distribution and Excretion

  • METABOLISM OF TRITIATED OLEIC ACID WAS STUDIED IN RATS DURING 600 DAYS. DURING FIRST 4 DAYS, HALF ACTIVITY IS FIXED TO WATER & HALF IS STORED IN ADIPOSE TISSUE WHICH IT LEAVES QUICKLY, THEN MORE SLOWLY WITH T/2 OF ABOUT 200 DAYS. [JEANMAIRE L ET AL; REPORT ISS CEA-R-4975 34 (1979)]**PEER REVIEWED**

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Metabolism/Metabolites

  • The normal metabolic pathway of palmitic and stearic acids in mammals produces oleic acid. Oleic acid, on a series of elongation and desaturation steps, may be converted into longer chain eicosatrienoic and nervonic acid. [Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 4966]**PEER REVIEWED**

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TSCA Test Submissions

  • None found

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Footnotes

1 Source: the National Library of Medicine's Hazardous Substance Database, 10/28/2007.

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Web page last updated on May 14, 2008