CLUSTAL W (1.74) multiple sequence alignment PH0152 -----------------------------------------------------MIHVGTC PAB2251 -----------------------------------------------------MIRVGTC AF0792 --------------------------MSDVYIFCLSMGSPTLNTRVLTNS--MELKVGCC BS_yunF --------------------------MSVIYIGLTGWG----------DH--DSIYPPKT BH3455 ----------------------------MIYIGLTGWG----------DH--DELYTMGT Ta0973 ----------------------------MIHLGCSGWS---YD----EWE--KVFYPE-- TVN1119 ----------------------------MIFVGCSGWS---YE----EWN--GVFYPK-- Ta0990 ---------------------------MNIRIGCSGWY---YP----HWA--GKFYPSDL TVN0475 --------------------------MVKFFIGCSGWF---YL----HWK--GRFYPEDI aq_926 ------------------MGKERTEGSKLYYLGCSGYF---YP----GWR--GKFYPKDL DR0541 --------------MMKLLEPPQHQKTQHVALGTAGWG---LS----REQ--QERFGPG- mlr4414 ------------------------MGKQGCFIGTAGWG---IP----TRY--KEDLPQP- yecE ----------------------------MIYIGLPQWS---HP----KWV--RLGITS-- ZyecE ----------------------------MIYIGLPQWS---HP----KWV--RLGITS-- VC1165 -----------------------MTSSLPLRLGLTLWS---HP----AWQ--SEFYGSGT mlr0752 -----------------------MSKSGTIRSGMGGWT---FE----PWD--TSFYPDKL CC3109 MGAARRLPSALFLLGCRTRTRGEHAHMGKIRTGIGGWT---FE----PWR--GTFYPDDL PA3683 ------------------------MVSLPYFLGCPSWN-------EAAWR--GSFYPREL PA2157 -----------------------MSAPARLRIGISGWR---YA----PWR--GDFYPEGL APE2180 ------------------------------------------------------------ TM1631 ----------------------------MVYVGTSGFS-------FEDWK--GVVYPEHL aq_1408 -----------------------MGKYKNLYIGCSGFS---YR----DWK--GTFYPSHI DR0758 ---------------------------MRVYIGCGGYT-------DEDWTAPGLIYEG-V PM0108 ------------------------------------------------------------ PH0152 GFCEAREKYFKDFDA--VEVQQTFYKVLQEKTLERWRKKAP-EEFTFSIKAFQGVT--HP PAB2251 GFCEGKRKYFKDFDT--VEIQQTFYRIMQERTLRRWKEEAP-EGFTFSIKAFQGIT--HP AF0792 GFPVSMKRYFETFDV--VEVQKTFYKPPEVKTAEKWRKSAP-EDFEFTIKAWQVIT--HP BS_yunF ASQKKLQAYSSHFPI--VELDASFYAIQPARNNEKWVKETP-ETFQFIVKAYQGMTG-HQ BH3455 KPSEKLYTYGSHFPA--VEVDSSFYAIQPKRNMEKWASDTP-ECFRFVVKAYQGLTG-HQ Ta0973 HTADRLSFYSMIFNT--VEVDSTFYRIPPKNVARQWGKAMSGKHFLFAVKVPGDIT--HD TVN1119 SKINKLKFYSTMFNT--VEVNSTFYREINNDIINRWIETVRGKNFIFSIKVPQNIT--HK Ta0990 NKSEWFRYYAQKFDT--VEINSTFYSFPNAARVRSWVKGSP-ENFVFSVKVNRTIT--HV TVN0475 HTKYWFRYYSSRFNT--VELNSTFYRFPSDKTALGWYNSSP-ENFTYSLKINRSIT--HI aq_926 KPKDWLKYYSKFFNT--VEINSTFYHFPNEKNLRRLYRETP-KDFKFSVKVNRNIT--HY DR0541 --DSVLQRYATRFNA--AEINSSFYRPHRPATYARWAASVQ-QGFRFSVKVPKAVT---H mlr4414 --GSHLERYARHLPI--VEIDTSFHKPHRRETYERWARSVP-EHFRFAVKTPKAMT---H yecE -----LEEYARHFNC--VEGNTTLYALPKPEVVLRWREQTT-DDFRFCFKFPATIS---H ZyecE -----LEEYARHFNC--VEGNTTLYALPKPEVVLRWREQTT-DDFRFCFKFPATIS---H VC1165 QASERLAKYASVFHT--VEGNTTFYASPSPSTVLNWRAATH-DDFRFTFKLPKSIT---H mlr0752 SKAKQLQYASRQVPS--IEVNGTYYSSFKEPTFVKWASEAP-DGFVYSLKGNRFVT---N CC3109 KQKDELKYAASKLTS--IEINGTYYSTFKPNSWMKWRDETP-DDFVFSVKASRFCT---N PA3683 RSADYLGHYGGIFNA--VEGNTTFYARPSAETVRRWAETMP-AGFRFCAKFPRDIS---H PA2157 RQKDELRFASRAVNS--IEINGTFYALQTPERFRGWAEDTP-EDFVFSVKAPRYIT---H APE2180 -------MHYKLLDA--VEVQQTFYDPPPRSRLDSWRSEAP-EDFEFTVKAWMLVTHGYN TM1631 KPSQFLKYYWAVLGFRIVELNFTYYTQPSWRSFVQMLRKTP-PDFYFTVKTPGSVT---H aq_1408 PESEMIIYYEQFFNV--VEINYTYYTMPHPYTFQSFLEKTK--RLRFAVKANQVFT---H DR0758 KKDAFLETYAHHFDA--VELNSSFYAIPGLKAFEGMVRKSG-GWVRFAVKLNKVFT---H PM0108 -----MAVYSQHYDA--VEINSTFHAPIGAKSLLGMVEKAQ-GRLQFSVKLHQDFS---H * : : : . : * : PH0152 SNSPTWRRSNVKPSKNVGLLRP-TNEVLHYWRITLKEAKVLGARFILIQLPRSFKEGE-- PAB2251 PSSPTWRRSNVKPSRNVGLLKP-TSEVFHYWRLTLKEAEVLGARFILIQLPRSFKENE-- AF0792 PSSPTYKKAGIK-FENCGFFRP-TEVVFMAWEETKKIAKALKAEIIVFQTPKSFRDTA-- BS_yunF RGEIPFDSKEEMFDAFKVSLTP-YLHSNKLAMVLFQFPPWFDCKKENVAYLRWCKHQM-- BH3455 RGEIPFSSKEEMFAAFVESLQP-LLESNKLAMVLFQFPPWFDCTKEHVRYLRYCKQQM-- Ta0973 AIFTDMDRSCSIFRTFEQNVLNELSTSGVLGPILFQMPPRFSVDNV--ERLISFMECV-- TVN1119 AILEKDSNSKSLYETFIDKTVRPIRNARMLGAVLVQLPPSFNSNLQ--TELLDTICCE-- Ta0990 KRLKDCDEEIGLFYEIIG------SLGKMLGCVLFQFPPSFKYSHD--NLIMIEKALD-- TVN0475 KRLRDTDEEILKFYNVAG------KLKEKLGCLLFQFPPSFKYSEE--NVSLIAKIPL-- aq_926 RKFKDVKELIKNFYEVCRN-----GLREKLGCVLFQLPPSYTYTKE--NLERILENLD-- DR0541 TARLR--ECAAPLAEFVEQ---VSHLGEKLGPLLVQLPPSL-SFERDVVEDFFSLLHGM- mlr4414 EHRLA--GGDALAEMFLQQ---VEGLGEKLSVLLVQLPPSL-PFEPDIACGFFDMLGRR- yecE QAALR--HCDDLVTEFLTR---MSPLAPRIGQYWLQLPATFGPRELPALWHFLDSLP--- ZyecE QAALR--HCDDLVTEFLTR---MSPLAPRIGQYWLQLPATFGPRELPALWHFLDSLP--- VC1165 QHLLR--DCKEELLSFLRL---MQPLHDRIGMWTIQLPAAFGPEHLAQLKNFRDWFP--- mlr0752 RRVLG--EAGESMMRFLGSG--VAALGDKLGPILWQFAPTK-KFDPDDFEAFLKLLPEK- CC3109 RRVLS--ENNDSLEKFLSQG--LEELGPKLGPINWQFMATK-KFDPADFEGFLKLLPSE- PA3683 EGDLR--ERLEAAGDFLEL---LAPLGERVSPLWLQLSAAFTPQRLGELLYFLDELS--- PA2157 VRRLR--EIDEPLANFFASG--PLALRQRLGPFLWQFPPSM-RFDRELFADFLARLPRDG APE2180 PRLWRRLKRRVAGDRSAYGGFKLTRENLWAWSVTLEAAEALKARIIVVQTPASFEASI-- TM1631 VLWKEGKDPKEDMENFTRQIEP-LIEEQRLKMTLAQFPFSFKFSRKNVEYLEKLRES--- aq_1408 ERNYT----KEDVKKFIEGIKPLLEEEERFIAILFQFPESFRYTPENLEYIKRLSLDF-- DR0758 VRAPT----DTDFDRMLQSPEP-LREAGMMGPYLAQFPYSFHRTAANRKYLALLTERF-- PM0108 KRTAT----REQAKVFLAALQP-LKDQDCLANLFIQFPISFERTPANRYYLAELVSWF-- : PH0152 -------------------------ESFENAEKFFNAIDR--GDFEIGVELRGWSEKG-- PAB2251 -------------------------ESFSNAEKFFNSIER--KDFEIAVELRGWSEKG-- AF0792 -------------------------ENMENMRAFFSSID---GSFTFCFEPRGWSEES-- BS_yunF -------------------------GDIPCALEFRNRSWFS-PPFYEQTLSFMKAEGW-- BH3455 -------------------------GEIPVALEFRHQSWFR-PSVRERTLSYMREEGW-- Ta0973 -------------------------HVRNAAVEVRNMTLYENRKFREAIEGLG------- TVN1119 -------------------------NEYRTAVEVRNKDLYSNEELRKELEKRG------- Ta0990 -------------------------QRFCNVVEFRNISWFS-EDARCDLEKSD------- TVN0475 -------------------------SKYCRVLEFRHKSWFD-KKILSSLVDNG------- aq_926 -------------------------FGFKNVLEFRHISWWN-EEVFKILKERN------- DR0541 -------------------------TLARTVCEPRHASWFTP-EVDALLR---------- mlr4414 -------------------------TKARLACEPRHPSWFEA-EAETLLA---------- yecE -------------------------GEFNYGVEVRHPQFFAKGEEEQTLNRGL------- ZyecE -------------------------GEFNYGVEVRHPQFFAKGEEEQTLNRGL------- VC1165 -------------------------ADFPLGVEVRHLAFFGKGEAEKALNQWL------- mlr0752 ----------------------QDGVALRHALEVRNDSFFVP-EFAALARKY-------- CC3109 ----------------------QKGVRLRHAMEVRSPTFACQ-QFYDLCAQY-------- PA3683 -------------------------PRR-IAVEVRHPAFFDKGEDERLLNRHLR------ PA2157 AAAQKLARHSAARLHREGYLDGDPAQRLRHAVEIRHESFVDP-TFIELLREYR------- APE2180 -------------------------ENSERIVEFFNKAER--GGFIIAWEPRGAWWENPN TM1631 -------------------------YPYELAVEFRHYSWDR-EETYEFLRNHG------- aq_1408 -------------------------AGIDRVIEVRHRSFAN-REFYEFVEEVG------- DR0758 -------------------------AGHELAVELRHASWDK-PEVREGMGEFG------- PM0108 -------------------------QEEVLAIEFRHPSWHN-QSVLDYFRGKE------- PH0152 --VKRFVREFDVI-DVTDPLLRIPLHKGSVNYYRLHGK-----------YEGG----KII PAB2251 --IKEFVREFDVI-DVTDPLVRIPLHKGKVRYYRLHGR-----------YEEG----KII AF0792 --VRAICEELDLV-HVVDPFVSKQLY-GEICYYRLHG------------FD--------- BS_yunF --IHSVCDEPQIG-EGSVPTVLRATD-ENKTLVRFHGRNKQGWM----KPDGGKNWREVR BH3455 --IHSICDEPQAG-EGSVPTVLVPSN-EENVLVRFHGRNVEGWR----RPQEG-NWREVR Ta0973 ------VAMVDVD-STERRLNRIESG-LKWAYVRLHGRN----------PGGW--KAENP TVN1119 ------IAIVDVD-STEHPLSNLNSG-LKWSYVRLHGRA----------QLGW--KSQNP Ta0990 ------LHVVAVS-SERIPLWIKE---DSVVYVRLHG-------------------NVNG TVN0475 ------FHIATVS-SKDLPFLLIQ---DVIIYMRMHG-------------------DTNG aq_926 ------VTFCSVS-APNLPESLIET--SETVYIRFHG-------------------KTSW DR0541 ----DLNVSRVAA-DPA-KVPAAAHPGGSLSMVYYRW-----------------HGSPKM mlr4414 ----DRRIARVAA-DPA-PVPAAAMPGGWAGLAYFRW-----------------HGVPRV yecE ---HQRGVNRVIL-DSR-PVHAARPHSEAIRDAQRKK-----------------PKVPVH ZyecE ---HQRGVNQVIL-DSR-PVHAARPHSEAIRDAQRKK-----------------PKVPVH VC1165 ---IEQNIDRIIM-DSR-PVFSALPNTEAVIDAHEKK-----------------PKVPVH mlr0752 ----KAAIVYA---DHA-KYPDIADVTGDFVYARLQTGS---------------DDNPDC CC3109 ----GVAIVYAVD-DEAPEWPRIDQPTADFTYARLMCSR---------------EDEPTG PA3683 ----ERGVERICL-DSR-ALFSCRSDDPAVLHAQSKK-----------------PRLPIR PA2157 -------VALVVA-DTAGKWPLLGDVCADFLYLRLHGDKELYRSGYSEAALGQWQARIRA APE2180 LLAETARKAGLVI-AGDVLRGRLPPDEQELLYARLHGLG----------------GGEVN TM1631 ----ITFVVVDEP-KLPGLFPYRPITTTDYAYFRFHGRN----------ERWFEAEGEER aq_1408 ---FSTLVNVDAP-KVKGLLIGPWVSVGTINYVRLHGRNKE--------KWHAHKEAYER DR0758 ----IIWVSPDYPPVGGMPEPQVHVT-GDVGYLRLHGRNRE--------TWWEGQSAGER PM0108 ---KLIWCNVDYPQNIGLPAFQFYAN-QRTAYLRLHGRNP---------NWWQAQSAQER PH0152 YNHSYSDEELKKIRERV--LGWNVEESFVFFNNTSMCRDAKRFKLILDLH---------- PAB2251 YNHSYSDEELKKLRERV--LGWNIEESFVFFNNVAMCKDAKRFKSLLDLH---------- AF0792 YKHKYTDDELEKL------LGIVDRDGYVMFNNVHMFDDALRFKKLVERE--AKSK---- BS_yunF YLYRYNQQELEDWKKHLNELQQQCKDVFVLFNNNSGGDAADNGKQMLELL--DIEYSGLA BH3455 YLYRYSKDELAEWAEHLKQLAAQVKDVYVLFNNNSGGDAAANAKQMLELL--EIEYRGLT Ta0973 FDYRYTDAELREIASKIK--SVNYDDIFVYFNNHPHGSAPVNAMALSRMV--GVSNNAFF TVN1119 YDYRYSEQEISDLSSKIM--AKNYDEIFVYFNNHPRGSAPINALKMASCL--GISNNWFF Ta0990 YATDYNEEYLTDLAQRII--DVKPQSLYVYFNNDYSGYAPKNAIMLKSII--NNLIL--- TVN0475 YATDYPLEKLKDMLNRII--DLSPDYAYIYFNNDYNGYAPKNAEEIKSLL--LSKT---- aq_926 YKYNYSERELKSWAKKIK--KSGAKEIFAYFNNDYNAYAPQNCLKLKELL--GLLTVN-- DR0541 YSSSYLDSQLARLAAQVQANSG---DVWVIFDNTAVGAAVENGLILRNLL--SSAQSERQ mlr4414 YYSDYDPESLDRIGRQVQAAAASGAEVWGIFDNTAAGHALGNALAIAATV--D------- yecE AVLTATNPLIRFIGSDDMTQNRELFQVWLQKLAQWH-QTTTPYLFLHTPD--IAQAPELV ZyecE AVLTATNPLIRFIGSDDMTQNRELFQVWLQKLAQWH-QTTTPYLFLHTPD--IAQAPELV VC1165 AIATAKHPMIRFIGHPEIEANLPFFGAWLHKLPEWIAQGKQPYLMIHTPD--NDFAPQLA mlr0752 YTPKGLDEWAARAKIWAEGKQPADLRRADPATDAPV-QPRDVFVYFITEG--KVRAPFGA CC3109 MTSEELDGVVAQTHKWAE--------RGD------------VFAYFIAGA--KVRNPAAA PA3683 PAAFSDTPQVRFIGGPDLPANEVFLLPWVDKVADWIEAGLTPYVFLHTPD--NHLAAQQA PA2157 WAGGGQADDLRRASQDAP-AKATARDLYCYFDNDVKVRAPYDARRLLQLL--ELDGGLRT APE2180 YKYKYTDDDLKRLATTIC--GGLWSEAYVMFNNVYSFDDALRFKQVLREA--CKQ----- TM1631 YDYLYSEEELKTLFEDVVELSRRVKETYVFFNNCYKGQAAINALQFKKML--EERV---- aq_1408 YDYLYSIEELEEIKEKILR-IYEGKDTYVFFNNHYRGKGALNALQLKELFGEEVKIPKGL DR0758 HDYLYNRAEMDEWAEKIAAVAGDLSELYVFFQNTTGGHALKNIPMLREALN-ARGVPVQT PM0108 HDYRYNDTELQNLANLLNQYRNEFDQLYLYFQNTTKSHSFYNIEQLKAYLAEYGFEVKPK . PH0152 ---------------------------------- PAB2251 ---------------------------------- AF0792 ---------------------------------- BS_yunF PR--QLDLF------------------------- BH3455 PK--QLNLFE------------------------ Ta0973 ---------------------------------- TVN1119 ---------------------------------- Ta0990 ---------------------------------- TVN0475 ---------------------------------- aq_926 ---------------------------------- DR0541 TS--CQPDPK------------------------ mlr4414 ---------------------------------- yecE HT--LWEDLRK---TLPEIGAVPAIPQQS--SLF ZyecE HT--LWEDLRK---TLPEIGAVPAIPQQS--SLF VC1165 VQ--LYQQLQQAI-ALPDLAPFPVTPEQPQLSMF mlr0752 MA--LMKRIAG----------------------- CC3109 MA--LIGKLGG----------------------- PA3683 QR--FHALLGQRLPGLPALPEPIPAPEVEQLGLL PA2157 VPGQLPDDLRESAA-------------------- APE2180 ---------------------------------- TM1631 ---------------------------------- aq_1408 LSTFAPKLWE------------------------ DR0758 PEAHDGGRLL------------------------ PM0108 PEFLTGQQSLF-----------------------