Faye-Ndao MA, Diack-Mbaye A, Woto-Gaye G, Critchlow C, Langley C, Kiviat N, Coll-Seck AM; International Conference on AIDS.
Int Conf AIDS. 1992 Jul 19-24; 8: Tu32 (abstract no. TuB 0531).
Faculty of Medicine, Dakar, Senegal.
OBJECTIVES: To determine whether an association exists between HIV infection and cervical dysplasia. METHODOLOGY: A case-control study has been underway at the Infectious Diseases Department in Dakar (Senegal) from June 1991 to February 1992. Women enrolled in the study underwent a standardized interview and clinical and gynecological exam. Cervical specimens for cytology, vaginal specimens for microbiology and blood samples for serologic assessment of past exposure to HIV1 and 2 and to T. pallidum were obtained. Sera were screened for antibody to T. pallidum by TPHA and RPR, and to HIV using ELISA, with confirmation by Western Blot. Standard microscopy and cytology were used to identify genital tract infection and to diagnose the presence of dysplasia. Screening for human papillomavirus (HPV) was performed using dot-blot hybridization, Southern Blot and polymerase chain reaction (PCR). RESULTS: 102 women have been enrolled: 18 HIV1, 17 HIV2, 1 HIV1/2 and 66 seronegative controls. The prevalence of cervical intra-epithelial lesions (dysplasia) was remarkably increased among HIV seropositive women (OR = 11.6); 27% of seropositive women had dysplasia, with comparable rates associated with HIV1 and HIV2 infection. Data on the presence and specific types of HPV will be presented. CONCLUSION: Our study shows a marked association between HIV1 or HIV2 infection and cervical dysplasia, with HIV1 and HIV2 infection associated with comparable rates of dysplasia. Longitudinal studies will be important to clarify the relationship between HIV-infection, immunosuppression and dysplasia.
Publication Types:
Keywords:
- Case-Control Studies
- Cervical Intraepithelial Neoplasia
- Female
- HIV Infections
- HIV Seropositivity
- HIV-1
- HIV-2
- Humans
- Longitudinal Studies
- Mass Screening
- Papillomaviridae
- Prevalence
- Senegal
- Uterine Cervical Diseases
- Uterine Cervical Dysplasia
Other ID:
UI: 102197903
From Meeting Abstracts