John F. Bowyer, Ph.D.

John F. Bowyer, Ph.D., is a research pharmacologist with the Division of Neurotoxicology, National Center of Toxicological Research, Food and Drug Administration, in Jefferson, Arkansas. He earned his Ph.D. in pharmacology/toxicology from the University of California-Davis. He has been active in research related to the neurotoxicology of substituted amphetamines (e.g., amphetamine, methamphetamine, ecstasy) and the role of catecholaminergic systems in neurotoxicity for over 20 years. His current work has focused on the characterization of the various aspects of the neurotoxicity produced by substituted amphetamines that have previously been unknown or ignored using immunohistochemistry, neurochemistry and gene expression to understand the mechanisms behind these neurotoxicities. Recently he completed research on a National Toxicology Program project that involved assessing the gene expression changes produced by exposure to toxic doses of acrylamide. On-going projects include evaluating the overall gene expression changes resulting in a mutant mouse deficient for the enzyme necessary for arylformamidase, an important enzyme in brain and immune function and monitoring gene expression changes in the meninges and associated vasculature after neurotoxic insults.

John F. Bowyer, Ph.D.

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