University of California, B.S., 1977, Genetics, Davis, California
University of California, Ph. D., 1982, Pharmacology/Toxicology, Davis, California

Experience:

• 1970-1974 Computer Operator (E-4 enlisted), U.S. Air Force
• 1982-1989 Postdoctoral Fellow, University of Colorado Health Sciences Center, Denver, CO
• 1992-Present: Research Pharmacologist, Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR.

Honors:

• NCTR Excellence in Laboratory Science Award, 2000.
• Nominated by the Division of Neurotoxicology for FDA "Best Young Scientist of the Year" award , 1994.
• Awarded a Drug Abuse Training Grant from NIDA , 1983

Current Primary Research Interests: Neurotoxicology Relating to Aromatic Monoamine Systems.

• Defining the physiological interactions of hyperthermia and seizure activity with substituted amphetamines that subsequently lead to neurotoxicity.
• Characterization of neuroregulatory and phenotypic changes in the forebrain that result from neurotoxic insults.
• Implementing DNA array technology to search for biomarkers and phenotypic adaptations to neurotoxic insults

Most Recent Publications (from a total of 51 publications):

• Bowyer, J.F., Newport, G.D., Slikker, W. Jr., Gough, B., Ferguson, S.A. and Tor-Agbidye, J. "An Evaluation of l-Ephedrine Neurotoxicity with Respect to Hyperthermia and Caudate/Putamen Microdialysate Levels of Ephedrine, Dopamine, Serotonin and Glutamate." Toxicol. Sci. 55: 133-142 (2000).
  
  
• Bowyer, J.F. and Davies, D.L. "Changes in mRNA levels for heat-shock/stress proteins (Hsp) and a secretory vesicle associated cysteine-string protein (Csp1) after amphetamine (AMPH) exposure." Ann. NY.Acad..Sci. 890: 314-329 (1999).
  

• Clausing, P. and Bowyer, J.F. "Time Course of Brain Temperature and Caudate/Putamen Microdialysate Levels of Amphetamine and Dopamine in Rats after Multiple Doses of d-Amphetamine." Ann. NY.Acad..Sci. 890: 495-504 (1999).
  

• Schmued, L., Slikker Jr., W., Clausing, P. and Bowyer, J.F. "d-Fenfluramine produces neuronal degeneration in localized regions of the cortex, thalamus, and cerebellum of the rat." Toxicol. Sci. 48: 100-106 (1999).
  
  
• Bowyer, J.F., Peterson, S.l., Rountree, R.L., Tor-Agbidye, J. and Wang, G.J. "Neuronal degeneration in rat forebrain resulting from D-amphetamine-induced convulsions is dependent on seizure severity and age." Brain Res. 809:77-99 (1998).
  

• Bowyer, J.F., Frame L.T., Clausing, P., Nagamoto-Combs, K., Osterhout, C.A., Sterling, C. and Tank, A.W. "Long-Term effects of amphetamine neurotoxicity on tyrosine hydroxylase mRNA and protein in aged rats". J. Pharmacol. Exp. Ther. 286:1074-1085 (1998).