Basic Search | Intermediate Search | Gene Image Map |  Home

Actinobacillus actinomycetemcomitans Search Results

Record: 1 of 1  
MiniMap IGR1136 IGR1135 IGR1132 IGR1133 IGR1131 IGR1137 IGR1130 IGR1128 IGR1129 IGR1134 AA01745 prfB, - AA01744 lysS,lysU, - AA01743 AA01753 cbiO, - AA01757 cbiM, - AA01755 cbiQ, - AA01756 dsbA, - AA01748 dsbC,xprA, - AA01746 pfs,mtn, - AA01750 AA01751 hypB, - AA01758 recJ, - AA01747 AA01745 prfB, - AA01744 lysS,lysU, - AA01743 AA01753 cbiO, - AA01757 cbiM, - AA01755 cbiQ, - AA01756 dsbA, - AA01748 dsbC,xprA, - AA01746 pfs,mtn, - AA01750 AA01751 hypB, - AA01758 recJ, - AA01747 AA01745 prfB, - AA01744 lysS,lysU, - AA01743 cbiO, - AA01757 cbiM, - AA01755 cbiQ, - AA01756 dsbA, - AA01748 dsbC,xprA, - AA01746 pfs,mtn, - AA01750 AA01751 hypB, - AA01758 recJ, - AA01747 AA01753


Gene ID:AA01748

DNA Molecule Name:
1  

GenBank ID:


Gene Name:
dsbA  

Definition:
thiol:disulfide interchange protein

Cellular Location:
Cytoplasm, Periplasm, Inner membrane [Evidence]

Gene Start:
1183202

Gene Stop:
1183870

Gene Length:
669

Molecular Weight*:
25640

pI*:


Net Charge*:


EC:
5.3.4.1  

Functional Class:
Translation; Protein modification and translation factors  

Gene Ontology:

Pathway: pathway table

Secondary Evidence:
Grauschopf,U., Winther,J.R., Korber,P., Zander,T., Dallinger,P. and Bardwell,J.C.
Why is DsbA such an oxidizing disulfide catalyst? Cell. 83 (6), 947-955 (1995) PubMed: 8521518

Akiyama,Y., Kamitani,S., Kusukawa,N. and Ito,K.
In vitro catalysis of oxidative folding of disulfide-bonded proteins by the Escherichia coli dsbA (ppfA) gene product The Journal of biological chemistry. 267 (31), 22440-22445 (1992) PubMed: 1429594

Martin,J.L., Bardwell,J.C. and Kuriyan,J.
Crystal structure of the DsbA protein required for disulphide bond formation in vivo Nature. 365 (6445), 464-468 (1993) PubMed: 8413591

Guddat,L.W., Bardwell,J.C., Zander,T. and Martin,J.L.
The uncharged surface features surrounding the active site of
Escherichia coli DsbA are conserved and are implicated in peptide binding Protein science : a publication of the Protein Society. 6 (6), 1148-1156 (1997) PubMed: 9194175

Comment:
[FUNCTION] Involved in disulfide-bond formation. Acts by transferring its disulfide bond to other proteins. Involved in the
production of protease and alkaline phosphatase, motility, metal resistance, and multi-drug resistance.
[SUBCELLULAR LOCATION] Periplasmic (by similarity).
[SIMILARITY] Belongs to the thioredoxin family. dsbA subfamily.

View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|145631270|ref|ZP_01787043.1|  predicted lysine/cadaverine...   227   5e-58
 gi|145633054|ref|ZP_01788786.1|  hypothetical protein CGSHi3...   226   9e-58
 gi|46128810|ref|ZP_00201938.1|  COG0526: Thiol-disulfide iso...   225   1e-57
 gi|145627796|ref|ZP_01783597.1|  thiol-disulfide interchange...   225   1e-57
 gi|46133352|ref|ZP_00157055.2|  COG0526: Thiol-disulfide iso...   224   2e-57
 gi|68249761|ref|YP_248873.1|  hypothetical protein NTHI1387 ...   224   3e-57
 gi|145637030|ref|ZP_01792693.1|  hypothetical protein CGSHiH...   224   3e-57
 gi|145639264|ref|ZP_01794870.1|  thiol-disulfide interchange...   224   4e-57
 gi|145635064|ref|ZP_01790770.1|  lysyl-tRNA synthetase [Haem...   223   5e-57
 gi|148826176|ref|YP_001290929.1|  hypothetical protein CGSHi...   223   5e-57


InterPro Summary:  InterProScan

InterPro
IPR012335
Domain
Thioredoxin fold
G3DSA:3.40.30.10 [39-223]T 1.3e-25 G3DSA:3.40.30.10 no description no description
noIPR
unintegrated
unintegrated
signalp [1-21]? NA signalp signal-peptide signal-peptide


COGS Summary:  COGS Search
BeTs to 6 clades of COG0526
COG name: Thiol-disulfide isomerase and thioredoxins
Functional Class: O,C
The phylogenetic pattern of COG0526 is aompkzyqvdrlbcefghsnujxitw
Number of proteins in this genome belonging to this COG is
Blocks Summary:  Blocks Search

Significant hit ( 6.3e-06) to 3/4 blocks of the IPB001853 family, which is described as "DSBA oxidoreductase". Interpro entry for IPR001853.
    IPB001853A    38-50    31
    IPB001853B    66-80    81
    IPB001853D    161-199    0.00092

 ProDom Summary:  Protein Domain Search

Residues 41 to 222 match (5e-56) PD:PD415819 which is described as COMPLETE PROTEOME HI1215 PM0193 SIGNAL PRECURSOR

Paralogs:  Local Blast Search

AA01748 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.


Pfam Summary:  Pfam Search


 Structural Feature(s):
Feature Type  Start  Stop
Cleavable N-term signal seq  
1  
21

Top PDB Hits:


Gene Protein Sequence:
MLRVGLFIMLLCVGGFAAAQAGDESVAPDPAVLLDEESPEFEDGKDYFSY
EYPIAMPARNDHRVIIQFFFDYDCRVCSSAQDILELYTQINRDRVVLEEF
PVATNKARFTAGVFFSLQALNVEHLSSALLFETSERQRYIKLSRIENLVH
WLQKQGIERDSFLEMYHSDQIHQKVNDAVLMTEEYGVFTFPYVIINGKYV
LTASTLYNDDYALAVLDFLVNRK

Gene Nucleotide Sequence:  Sequence Viewer
ATGTTGCGGGTCGGATTGTTTATCATGCTATTATGCGTAGGCGGATTCGC
TGCGGCACAAGCCGGTGATGAATCCGTTGCGCCTGATCCTGCTGTTTTGC
TTGATGAAGAAAGTCCGGAATTTGAAGATGGCAAAGATTATTTCTCTTAC
GAATATCCTATCGCCATGCCTGCCCGTAATGATCACCGCGTTATTATTCA
GTTCTTTTTTGATTATGACTGCCGTGTTTGTTCCTCCGCACAGGATATTT
TAGAACTTTACACGCAAATCAACCGTGATCGTGTAGTGTTGGAAGAATTC
CCCGTCGCTACCAACAAAGCGCGCTTCACTGCCGGTGTTTTCTTCAGTTT
ACAAGCTTTAAATGTGGAGCATCTGTCTTCCGCATTACTGTTTGAAACCT
CGGAACGGCAGCGTTATATCAAATTATCCCGCATTGAAAATCTGGTACAT
TGGCTGCAAAAACAAGGCATTGAGCGCGATAGTTTCTTGGAAATGTATCA
TTCCGATCAGATTCACCAAAAAGTGAATGACGCCGTGCTGATGACGGAAG
AGTATGGTGTGTTCACCTTTCCTTATGTGATCATCAACGGCAAATACGTT
TTGACCGCCAGCACGCTGTATAACGATGATTATGCGCTCGCCGTGTTGGA
TTTTTTAGTAAATAGAAAA

Los Alamos National Laboratory • Est 1943

Operated by Los Alamos National Security, LLC for the U.S. Department of Energy's National Nuclear Security Administration
Inside | © Copyright 2006 LANS LLC All rights reserved | Disclaimer/Privacy