PUMA2: 4.1.1.18

		PUMA2 -- Evolutionary Analysis of Metabolism

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EC-number: 4.1.1.18 ----- lysine decarboxylase

EC-NUMBER	4.1.1.18
ENZYME-NAME	lysine decarboxylase
ENZYME-SYSNAME	A pyridoxal-phosphate protein. Also acts on 5-hydroxy-L-lysine.
ENZYME-CLASS	Lyases Carbon-carbon lyases Carboxy-lyases
SYNONYMS	>>more synonyms
REACTION	L-lysine = cadaverine + CO2 [RN:R00462]
PATHWAY	EMP-PATHWAYS: Lysine--Cadaverine,_CO(,2)_Catabolism; >>more EMP pathways
	KEGG-PATHWAYS: Lysine degradation; Alkaloid biosynthesis II; >>more KEGG pathways
GO_TERM	GO:0008923:lysine decarboxylase activity
ENZYME-COMMENT	L-lysine carboxy-lyase

ExternalDB ----- DBLINKS

Diseases

Structure

Gene

Motif

Ortholog

Literature

Other

InterPro Domains found in sequences annotated as EC 4.1.1.18
	IPR000183	Orn/DAP/Arg decarboxylase 2
	IPR000276	Rhodopsin-like GPCR superfamily
	IPR000310	Orn/Lys/Arg decarboxylase, major region
	IPR000577	Carbohydrate kinase, FGGY
	IPR001789	Response regulator receiver
	IPR002433	Ornithine decarboxylase
	IPR005269	Conserved hypothetical protein 730
	IPR005308	Orn/Lys/Arg decarboxylase, N-terminal
	IPR005479	Carbamoyl-phosphate synthase L chain, ATP-binding
	IPR006025	Peptidase M, neutral zinc metallopeptidases, zinc-binding site
	IPR006035	Arginase/agmatinase/formiminoglutamase
	IPR008286	Orn/Lys/Arg decarboxylase, C-terminal
	IPR009006	Alanine racemase/group IV decarboxylase, C-terminal
	IPR011006	CheY-like
	IPR011185	Lysine decarboxylase
	IPR011193	Ornithine/lysine/arginine decarboxylase

PIR SuperFamilies containing EC 4.1.1.18
SF001335	ornithine decarboxylase
SF005938	lysine decarboxylase
SF006620	lysine decarboxylase
SF009393	ornithine/lysine/arginine decarboxylase

Taxonomic breakdown of EC 4.1.1.18 sequences

To perform phylogenetic analysis, first select some protein ids by clicking on their checkboxes, then click on one of the buttons below.

Additional gi numbers:

Bacteria

Cyanobacteria

Prochlorococcus marinus

33240562

IPR000310	Orn/Lys/Arg decarboxylase, major region
IPR008286	Orn/Lys/Arg decarboxylase, C-terminal
IPR011185	Lysine decarboxylase

33640786

IPR000310	Orn/Lys/Arg decarboxylase, major region
IPR008286	Orn/Lys/Arg decarboxylase, C-terminal
IPR011185	Lysine decarboxylase

33861640

IPR000310	Orn/Lys/Arg decarboxylase, major region
IPR008286	Orn/Lys/Arg decarboxylase, C-terminal
IPR011185	Lysine decarboxylase

Synechococcus sp. WH 8102

33632647

IPR000310	Orn/Lys/Arg decarboxylase, major region
IPR008286	Orn/Lys/Arg decarboxylase, C-terminal
IPR011185	Lysine decarboxylase

Firmicutes

Bacilli

Bacillus cereus

42735023

IPR000310	Orn/Lys/Arg decarboxylase, major region
IPR008286	Orn/Lys/Arg decarboxylase, C-terminal
IPR011185	Lysine decarboxylase

42738985

IPR000310	Orn/Lys/Arg decarboxylase, major region
IPR008286	Orn/Lys/Arg decarboxylase, C-terminal
IPR011185	Lysine decarboxylase

51978657

IPR000310	Orn/Lys/Arg decarboxylase, major region
IPR008286	Orn/Lys/Arg decarboxylase, C-terminal
IPR011185	Lysine decarboxylase

Bacillus clausii

56961831

IPR000310	Orn/Lys/Arg decarboxylase, major region
IPR008286	Orn/Lys/Arg decarboxylase, C-terminal
IPR011185	Lysine decarboxylase

56963702

IPR005269

Conserved hypothetical protein 730

Bacillus subtilis

580835

IPR000310	Orn/Lys/Arg decarboxylase, major region
IPR008286	Orn/Lys/Arg decarboxylase, C-terminal
IPR011185	Lysine decarboxylase

Bacillus thuringiensis

49479955

IPR000310	Orn/Lys/Arg decarboxylase, major region
IPR008286	Orn/Lys/Arg decarboxylase, C-terminal
IPR011185	Lysine decarboxylase

49480016

IPR000310	Orn/Lys/Arg decarboxylase, major region
IPR008286	Orn/Lys/Arg decarboxylase, C-terminal
IPR011185	Lysine decarboxylase

Geobacillus kaustophilus

56419600

IPR000310	Orn/Lys/Arg decarboxylase, major region
IPR008286	Orn/Lys/Arg decarboxylase, C-terminal
IPR011185	Lysine decarboxylase

Oceanobacillus iheyensis

23097490

IPR000310	Orn/Lys/Arg decarboxylase, major region
IPR008286	Orn/Lys/Arg decarboxylase, C-terminal
IPR011185	Lysine decarboxylase

Streptococcus pneumoniae

15458416

IPR000310	Orn/Lys/Arg decarboxylase, major region
IPR006035	Arginase/agmatinase/formiminoglutamase
IPR008286	Orn/Lys/Arg decarboxylase, C-terminal
IPR011185	Lysine decarboxylase

Clostridia

Carboxydothermus hydrogenoformans

78045175

Selenomonas ruminantium

28804806

IPR000183	Orn/DAP/Arg decarboxylase 2
IPR002433	Ornithine decarboxylase
IPR009006	Alanine racemase/group IV decarboxylase, C-terminal

Proteobacteria

Betaproteobacteria

Burkholderia sp. 383

78061629

78062921

78067232

Chromobacterium violaceum

34497447

IPR000310	Orn/Lys/Arg decarboxylase, major region
IPR008286	Orn/Lys/Arg decarboxylase, C-terminal
IPR011185	Lysine decarboxylase

Cupriavidus necator

73540395

IPR000310	Orn/Lys/Arg decarboxylase, major region
IPR006025	Peptidase M, neutral zinc metallopeptidases, zinc-binding site
IPR008286	Orn/Lys/Arg decarboxylase, C-terminal
IPR011006	CheY-like
IPR011193	Ornithine/lysine/arginine decarboxylase

Thiobacillus denitrificans

74318124

IPR000310	Orn/Lys/Arg decarboxylase, major region
IPR008286	Orn/Lys/Arg decarboxylase, C-terminal
IPR011006	CheY-like
IPR011193	Ornithine/lysine/arginine decarboxylase

Gammaproteobacteria

Escherichia coli

145458

IPR000276	Rhodopsin-like GPCR superfamily
IPR000310	Orn/Lys/Arg decarboxylase, major region
IPR005308	Orn/Lys/Arg decarboxylase, N-terminal
IPR008286	Orn/Lys/Arg decarboxylase, C-terminal
IPR011193	Ornithine/lysine/arginine decarboxylase

1552763

IPR000310	Orn/Lys/Arg decarboxylase, major region
IPR005308	Orn/Lys/Arg decarboxylase, N-terminal
IPR008286	Orn/Lys/Arg decarboxylase, C-terminal
IPR011193	Ornithine/lysine/arginine decarboxylase

26246133

IPR000310	Orn/Lys/Arg decarboxylase, major region
IPR005308	Orn/Lys/Arg decarboxylase, N-terminal
IPR008286	Orn/Lys/Arg decarboxylase, C-terminal
IPR011193	Ornithine/lysine/arginine decarboxylase

26250948

IPR000276	Rhodopsin-like GPCR superfamily
IPR000310	Orn/Lys/Arg decarboxylase, major region
IPR005308	Orn/Lys/Arg decarboxylase, N-terminal
IPR008286	Orn/Lys/Arg decarboxylase, C-terminal
IPR011193	Ornithine/lysine/arginine decarboxylase

Francisella tularensis

56707555

IPR000310	Orn/Lys/Arg decarboxylase, major region
IPR008286	Orn/Lys/Arg decarboxylase, C-terminal
IPR011193	Ornithine/lysine/arginine decarboxylase

Hafnia alvei

43439

IPR000310	Orn/Lys/Arg decarboxylase, major region
IPR005308	Orn/Lys/Arg decarboxylase, N-terminal
IPR008286	Orn/Lys/Arg decarboxylase, C-terminal
IPR011193	Ornithine/lysine/arginine decarboxylase

Pseudoalteromonas haloplanktis

77360037

IPR000310	Orn/Lys/Arg decarboxylase, major region
IPR008286	Orn/Lys/Arg decarboxylase, C-terminal
IPR011006	CheY-like

Salmonella enterica

29140831

Salmonella typhimurium

16418739

IPR000310	Orn/Lys/Arg decarboxylase, major region
IPR005308	Orn/Lys/Arg decarboxylase, N-terminal
IPR008286	Orn/Lys/Arg decarboxylase, C-terminal
IPR011193	Ornithine/lysine/arginine decarboxylase

29140831

IPR000310	Orn/Lys/Arg decarboxylase, major region
IPR005308	Orn/Lys/Arg decarboxylase, N-terminal
IPR008286	Orn/Lys/Arg decarboxylase, C-terminal
IPR011193	Ornithine/lysine/arginine decarboxylase

Vibrio fischeri

59712664

IPR000310	Orn/Lys/Arg decarboxylase, major region
IPR005308	Orn/Lys/Arg decarboxylase, N-terminal
IPR005479	Carbamoyl-phosphate synthase L chain, ATP-binding
IPR008286	Orn/Lys/Arg decarboxylase, C-terminal
IPR011193	Ornithine/lysine/arginine decarboxylase

Vibrio parahaemolyticus

40646044

IPR000310	Orn/Lys/Arg decarboxylase, major region
IPR005308	Orn/Lys/Arg decarboxylase, N-terminal
IPR005479	Carbamoyl-phosphate synthase L chain, ATP-binding
IPR008286	Orn/Lys/Arg decarboxylase, C-terminal
IPR011193	Ornithine/lysine/arginine decarboxylase

44886080

IPR000310	Orn/Lys/Arg decarboxylase, major region
IPR005308	Orn/Lys/Arg decarboxylase, N-terminal
IPR005479	Carbamoyl-phosphate synthase L chain, ATP-binding
IPR008286	Orn/Lys/Arg decarboxylase, C-terminal
IPR011193	Ornithine/lysine/arginine decarboxylase

Eukaryota

Apicomplexa

Plasmodium falciparum

23510046

IPR000310	Orn/Lys/Arg decarboxylase, major region
IPR008286	Orn/Lys/Arg decarboxylase, C-terminal

Additional gi numbers:

To perform phylogenetic analysis:

Select some ids by clicking on their checkboxes.
Click on one of the buttons above.