AborIlOrl

effect of marernzl rmoking. 437. 438
Accnaphthylenc

in cigar. pipe, and cagaxtt~ woke. 548
AcrUldchyde

Icvclr. effects of IODI" size. amount of
tobacco burned. and venUlatmn.
487490,494

2s suqxctcd conulbutor to health haz-
   ards of smokmg. 629
ACClO"C

as suspected contilbutor to health
   hazards of smokmg. 619
ACctOfllldC

a, surpbctcd conmbutor to health
   hazards of unokmg. 629
ACIOlCl"

cffccu of mhalatlon of. I" rats. 151
as urrtant ,n tobacco smoke. 51 I
levels. cffccts of room UC. anlounl of
tobacco burned. and venularion.
487-190.494

as probable contributor 10 health haz-
   ard$ of smoking. 628
AClylO"ltdC
as  surpcacd contiibutor IO health
   hazards of smoking. 629
Adcnocucmoma

prevalence WI male and female mlokcrs
   and nonrmokerr. 216
relstronxhlp of c&ret:c smoking 10.
   272-275.322
Adcnuma

papdIary. inductIon m rats by exposure
   to ClgaJctlc firs.. 374
pulmonary. mductmn I" mice by c~ga-
   rctw Imoke mhalatlon. 375
renal. rclationsh~p of smoking to. 322
Adrcnai glands

calccholaminc release from, nicotine
effects on. 32

Advisory Commrttce on Smoking and
Health

rcporl on c~garcttc smoke and conden-
   YlCS effects on oral cavity of
   animdr. 314
Aerobic capaary

effect of cc~xa`,o" of smoking. 613
e~cC:Jof CXCI`IY and smoking. 613,614
.Agc

atypical nuclei in esophageal eprrhelium
   arranged by rmoklng and. 405406
cl-feels on CHD, 23-35
Air poUuUo"

II ~a"% of COPD. 178.201.242-243
in cl~olog~ of lung "coplarmr. 302
and human CO burden. 142
relationshIp 0f lung n~~phns. rmoking

and place of rcr~dcncc. 278.281
rummary of ICCC"I Iindmgr. 5134

A:cohol
crhx.nol.  pcnrtrablllty of  d1550lvcd
   bcnzo(a)pyrcnc I" m,ce crophqcal
   cplthcbum. 319

Alcohol consumption
cffec1 on  crophacxl ncoplarms in
   smokar. 31s. 319
cffcct on laryngeal neoplasn~r in tobacco
   USCII. 306

effect on tobacco amblyopla. 531.532
and heavy ynokmg, effect on oral
ncophrmr. 314
smoking and. in esophageal ncopljrm
ct~olo~`. 64,66.67.570
smoking and.  in laIyngea1 ne0pbr.n
etiology. 567

smoking and, u1 oral ncoplavn e:~ology.
563

smoking and. in neoplasm development.
   570
Aicohohsm

paucnrr. smokmg 3nd ventilator func-
   ton in. 239
Allergy

effect on cardlovawular abnormah:ler.
   521
tobacco and. 5 13.521
tobacco smoke ~lr,ta"ts and. S20
Alpha-1-anutryps," delicrency
COPD prcdqovno" from. 176
determinal:on  USl"g  rmmunocleclro-
   phorcns. 177
in emphysema etwlogy. 520
smoki"g and, 520
Amblyopta, tobacco
alcohol conrumptm" effect on. 53 I-532
characteruarlon of, 531
incidence oi. 531
American Heart Arsoc~atlon
poolmg project on Cf1D. 19. 24. 26. 35
Ammonia
as  suspected contributor to health
   hazards of smoking. 629
Angina pectonr
effects of mcreased carboxyhemoglobin
   levels, in passwe smokers. 491, 497
incidence t" pipe and cl&v smokers.485

A"U"alS

esophageal neoplarmr I". induction by

niuoummer. 3 18
reqwarory tract of. neoplastic changes
foliowng cigarette smoke mhalatro".
  264.265

ski" of, carcinogcmclty of tobacco tars.
   264.293
A"lhIXC"C

in ciga. pipe, and c~garctte smoke. 548
Anthrantic acid. 3hydroxy-
urmary cxcretton of, rmokmg effects on.
   322

635


AnIleen-anlibody rcattlonl
a"crgya"d.S13-517
~,mokcr~ vs. nanrmokcrr. 515. SZl
tobacco and. 514-517
Aorllc ~ncuwrm
,mokmg and. 63.67.71
Aromatrc compounds
carclnogcnlc propcrues i"  cgdIcctc
   xmokc from. 290.29 I
dctecuon in ~rme usmg chcmdummcs-
   ccncc techmque. 323
&omat,c hydrocarbons. polycyctic
cffccc dorm8 prcenancy I" laboratory
   nnimalr.431.432
matcm&fctal exchange and. 433
Anhythmlar

formatIon in  NCOti"e  srlmuhtcd
   damaged myocadium. 54
hscnic

lung neoplasm monabcy i" smeller
   workers exposed to. 283
rcsplrarory tract carcinoma m workers
   cxpowd to. 282, 283
ArtWitS

aneurysm in aortic. cwaetrc rmokmg
eifectr on. 63,67.71
nrherosclcrortc.  increased by ti~arctte
smokmg. 59

now of c;uot>d. c$a~ct~c s"wkm8 effects
on.63

occlunonr of. cigarette rmoklng effects
on, 69
walls of.  mecharosm of lipoprorcin
infiltration. 59

walls of, mcotme-induced necrosis, 59
Artenorcleroslr
in aorta and coronary artcncr. cigarette
   smokingeffects 0".41.48-52
development of. carbon monoxrde cf-
   fects 0". 59

development of, effects of nicotme on,
34

lesion development in. ynoking cnhance-
mcnt. 32

peripheral. cigarette smoking effects on.
68-69

see also Cardlovavular diseases; Core
  nxy diseases

Aryl hydrocarbon hydroxylax
effect of bcnzo(a)pyrenc UI pregnant
   rats. 433
Ada

Central and Southeast, relationship of
   tobacco use and neoplabnr of oral
   cavity. 392
Asthma

bronchzd, cigareIIc smoking effects on,
   201
Alherosclcrovs

aortic, long term smoking effects. 48-52
Athlcbc pcrformancc
ru"ni"g.effcctof smoking.613.614
smokers vs. nonsmokers. 613.614
swimmmg. effect of smoking. 614
Atxopme

effects on bro"chocon~(llclion in dog%
  189

COPD mo~badrty rn smokers VI. 229
Iuyngul "caplaun~ m. relauonshq 10
  tobacco use. 583

lung neoplavnr m. ~cuo~ecove Itudlcr
of, 3s3

Bx:cna

cifcct of c~axltc smoie on axion of
   maccophagcs on. 191
pncumo*. mice rc~~s(;ulce following
   nguccta inhalation, 199
Bc"zfc)xcphcnanLhryhrylcnc
c.uElnogc"lc properws in cigarclIc
   smoke from. 290.291
l?cnz(a)a"tiace"c
alcoholic soluuon oi. pencaabihfy of
   mice crophagcal epahclium. 318
Bcn~bhnthracenc. 7.1 Zduncthyl
carcinoma inducuon in hamsters follow-
   ing innillauon of. 372
skin pamtmg wvrch, papdloma and
   rarcmoma induction in mxx by, 367
Benzcnc

as ruspccred contributor to health
   huudr of smokmg, 629
BcnzoO')fluoranthcne
c.ucinogenic propen,es in cigarc1tt
   smoke from. 291

Bcnzo(c)phcnanthre"e
carcmogcn~c properties in cigarette
   smoke from. 291
Bcnzofajpyrcnc

alcoholic x&~bon of. pcnetratio" of
mice csopha8eal cprthchum. 318
carcinogenic propcmer  in  cigaIc,le
smoke from. 290.291
caxmogcnialy of, m relation to asbestos
in hamsters. 283

in cyv. pope. and cigaretfc smoke, 491,
492

dctoxficatlo" by lung aryl hydroxylase.
283

effects during pregnancy in Laboratory
animafr, 431.432
errecLs of i"stdJation 0, implantaiion i"
?."lC".ll   tracheobronchiaI  UCC,
312.373

clTecls on awnal tissue and organ
cultures tn. 369.371
effecls with mfluenza virus on cigarette
inhalation by m~cc, 378
levels. effects of room six. amou*o(
tobacco burned, and ventilation.
487490,494

sarcoma induction in rats fouowing
   intidlation of, 372
skin painting with, papillama induction
   in mice by. 363.364
BcLel nut chewing
oral nwplarmr from, 392.395-396
Bicarbonare

in pancreatic sarctionr. effect of smoke
ing. 473.474

Bicycle crgomclcr performance
cudiovavulaz plramcrcrr m smokers vs.
   nonsmokers.612614

636


5u:h uc,ght

cffecf cl maternal rmokms. 417428.
433436

effect of matcrml smokmnp before and
durmg cunent prcrnancy by cqa~,tc
conrdnptlon.421423
effect  of maternal smokmg dunng
p,r"*our prrgna"ilc5.426418
efiect of paternal smokme. 424.4 25
effect of tobacco woke, n,co"nc. or
carbon  monoudc in  bboratory
ammalr. 428432

gestatton duar,on in smokcn VT. non-
rmokerr. 417420
mor,ality risk of low birth wqht ,nfxnts
of smok,ng vs. nonsmokmg morhers.
440-146

timing of influcnccof Smoking. 434.435
Bladder neoplasmr
frequency ,n smokers vs. nonmokcrs.
   264. 319-321

monal,ty rater. 319. 320
rebtlonsb,p of c,yuerte smokme to. 325
rcuospecwe stud,es of. and smokmg.
319.407410

and tryptophan metabohtcr in unnc.
  322-323

Blood cholexterol ICICIS
and coronay dwase. 17.18. 19-20. 39
effect of cabon monoxldc u1 rabb,tr.
   LSO

effect of smokme. 37. 39
eilect of smokmg m penpheral vascular
d,,ea>e. 68

and hyps:,ens,on. ,n smokers vs. non-
smoker,, 137

in p,pe and r,gx smokers, SSS. 586
m xmokerr vs. nommoker>, 94.98
Blood cucula,,on
eitec, of wnat~ons in hem%lobln and
   hemat. 62

Blood coagulation
etfect 0i smokmg. 32
Blood hpid,

ctfect of vnoking. 6142. 119-I 24
smoker, vs. nonsmokeri, 37
Blood platelet,

effccl of ,,,,oking, 62, 71
Blood preswre

coronz~y d,,eaw and smokmg. 39.43
du,toLLc. c,g.+~et,e r:nok,ng &ecu. 19
dlaxtohc. ,n smokers wrh CHD, 17-18.
20.38

effect of cxc,c,~c and smokmg. 611.
  614-616

cffrct of n,co*me. 32
effect of p,pe and c,gar rmokmg. 586
h,gh rash in mortahty from CVD.63
hypertenuve vs. nonhypertsnuvc. mor-
tabty rate, of CHD ,n. 38
rtsk _actorr m arter,o;clerons obhtcranr,
  68
in  rmohcrt.  nonsmokers.  and ex-
mokerr. 137-139
in smokers vs. nonsmokers. 37. 38.
99-100

systok. rnomhry from elevated. u,th
CHD. 38

Body wclghr

and hypcrtcnuon. ,n snokc,~. r.o"-
   rmokcrr. and cxsmokcrs. 137-l 39
Bxadycardra

dcvclopmcnt ,n dogs g,vcn n~oDne. 5 3
Bronchnl cplthclwm
h,r,olog,cal chlngcr ,n c.<ar. PiPC.
  c,pKrtc sloh~rr "I. r.onsr.oicrr.
   573.514.579
B,onchit,r

development ,n infants of maternal
   smokcrr. 499
inc,dcncc  in  children  of paJcnti
   rmokerr. 501.502
,nortal,ty rat,o~ ,n male p,pe and `WI
   smokers. 587.589
in pawve smokers, summary of rcccnt
   fmdmgs. 504
prcvalcncc in pipe and cigar unokcts.
   590.591
Bronchitis. chronic
delio,t!on of. 165
mortahty rn c,gare,te mokcrr. 201
mortahty rater. 165
smokers VI. nonsmokers. 221-231
Bronchopncumonia
development ,n dcgs follov!tie n8arctte
   sr,~okc ,nhalzr!on 297
Bronchopulmonary diseases. d~ron,c ob-
Stl"`IIY~
  all  pollution  relationship in.  178.
    242.343
characteruatlon of. 165
cpmrte smokmg effects on develop
   "lent. 201
grnctrc factors in pathoecncsls of. 174.
   176.178. 231
increased prevzdence of hetcrozygotes in.
    177-178
mortal,ty rates, 165-I 71
morta~rty rater in p,pe, c,:ar. and
   c,pare,te smokers, 201
morrahty ,~t,os ,n mr~le p'pe and crgar
   smokers. 586.587. S89
2.3.Butadione
  as  mspecled contributor  to health
   hazards of smoking. 629
Butylamme
  as  suspected contributor  to health
   hazards of smoking. 629
Butylaminc, N-methylnltroro
suspected cxcmogemc propenles in
   cqarrtlc woke from, 291

Cadmium

in cigarette smoke. relation to patho-
  genes~r of emphyrema. 180
Canada

COPD morb,d,ty of rmokcrs m. 230
mfectrous rerplratory &ease 111. rel3tiow
sh,p to smokin_e, 254
kidney  and bladder neoplasmr in
smokers ,n. 320

mortahty ra,es from COPD. 165-167.
  171

mortahty ratio\ from COPD. 169

637


rhrombovs in, rmokl"; rehtmnJl,p, 128
Ca"3d,ln veterans xtudy
lung  llCOpb,l"  nlon~l,ty ~.l"OS In.
   smokers vs. nonsmokers. 267
Cxbaole. 9i"c,hyl-
porrrble ,mpor,a"ce rn lobacco carcmo-
   gcner~~. 292
Carbon-14

Lbzled smoke parr,cul!e depo,,lion Ln
   hamster resplralory ,1x,.307-308
Carbon d,ox,de
as  suspected contnbutor to health
   hazards of smokmg. 629
Carbon monoxide

cholesterol levels i" rabb,ts. after ex-
**sure to. 150

and decrelw m exercise time before
claudlcatlon. 150

effect dur,ng pregnancy in laboratory
anmdr.430.431.446.447
effecr on aortas I" animals. IS0
effect on birth we,sht and neonatal
mortahty in 3nunals. 447
effect on cholerrerolird rabb,ts. 6 142
clfect on halthy m,okerr "I. "on-
smokers. 148

effect on human physmlogy. 56-58
effect on myocardrum. 151
rxposure to,  and human abwrpt,on,

143-150

as most bkely conrnbutor to hzllh
hazards of smoiamz. 627

su,,,mary of previous liindmfr on reh-
t,o"rh,p to pzs~,ve anoking. 483.
484.504

summary of recent lindmgr. lS5
from tobacco smoke. effects on psycho-
motor performance. ,ncludq aten-
tlYenes  and cogrut,on func~,on,
495497

Carbon monox,de levels
  m cigarette smoke. 55
effect of room size, amount of tobacco
   burned and vent,lat,on. 486.591
effect on exercise performance, 493
from smokers m burr and planes. 498
Carboxyhemoglobln
formawn in blood of smokers, 56.71
Carboxyhrmoglob,n levels
in oga~ette smokers. one hour after last
   clg"`etle, 147.148
and CO burden m m,okers vs. "on-
   smokers. 147, I48
effect on CO sbsorptlon. ,n paswe
   smokers. 591. 592
cffwt on exe*c,,e perfonn~"ce. 493.
   616.617

In re1u\es. 148. I49
in neonates of Ynok,ng mothers. 432,
433

I" ,mokerr vs. nonunokerr. by xx. race.
employment ~~10s or urban locrlmn.
  144-146

rummary of recent findmgr. IS5
L~I workers exposed to exhaur, gases. 143

eltea oi robacio cuing mcchodr. 582
CaIclnogc"r

lCt,On on or31 cavity. effect of salw3,
  314

c,pr. pipe. and cyarectc rmokc condcn-
sale. I" Sk!" palnllng cxpenmrnu In
anunals. 580-584

lirung of.,n `rg"e~te vnoke. 291.292
tobacco smoke const,tuc"tr IS. 580.584
Carc,"o,d tumor

prevalence in male and fern& unokcrr
   And nonsmokers. 276
CLlICillO"l3

fomlatlo" fouowing animal s!wl paintrIg
wlh smoke condensates, 363-368
induction in rats exposed to cigarette
tars. 374

und,fferentiated. relationship 10 ciga-
   re~tc snokmg, 274-175
Carcinoma. 2lveolx ceU
,nducuon ,n m,ce by cyarctte smoke
   ,nhak.r,on. 375

Carcinoma, anaplart,c
prevalence III male and female mokerr
   and nonsmokerr. 276
Carcinoma, bronchogenlc
development ," dogs following clflrette
   smoke mhslat,on. 295.298.2S?
morality irom. xelarionshipr to soak-
   I":, JLI pdlutjon and reudexc. 279
mortali,y UI rmok,ng vs. nc-mokmg
   asbestos workers. 283
Carcinoma. epldcrmoid
mortality from, reht,onsh~p to smoking.
   air poUu,,on and reudence, 250
prcvalencc u, male and female snokers
   and nonvnokers. 276
relat,ontiip of c,garettc rmoklng to.
   272-27s

Carcmoma, sp~rhchal
inductIon m m,ce by cigarette vnokc
   inhalx,on. 376

Carcinoma. oat cell
relationship of cigaette smohmg to. 173
Carcinoma. squamous cell
development I" mice drinking alcoholic
   benzo(a)pyrene. 3 18
in oral cw,~y. relationship to tobacco
   "se. 392-393

Carcinoma. tracheobronchial
induction ,n hamsters by cigarelte smoke
   inrtillar,on. 372-373
Cxdiac index

effect of cwxcke and smokmg, 6 124 14
Cardiovawuhr daeaser
atherosclerotic. effects of CO, 149. 150
morrabty ratios in male p,pe and cigar
   smokers. 58s. S86
pathogenests of, 1 SO. 15 I
summary of prorpeccive ep,dem,olog,cd
  stud,es for agar and p,pe unokers.
   586

ICC dso Artcrlosclerorir
Cudmvawuht ryrtem
cffccl of c,garettc rmoke on, 52.54.
   103-I 14

effect of ",cot,ne on. 52-54, 103.1 14

638


G:ciCohmLlrr
e!!ccx of nl`ollne orI rcIc3sc of. 32. 53.
    115

effect on blood clicnlar~on in coronary
   azzcr.er. 54
C3fS

cdury function in, effccl of cigarcrx
rrnokc on. 247

Ccnuai neT"O"S rystem
effect of carbon monoxldc in smoke on.
   56

Ccrcbro~xscular di,eascr
Ccfimllon of. 62
cp;dcmlologlcal studies. 149. 150
morlahty rates by rgc, sex and smokmg
   cll~rdicatlon. 151
moraitty rarcs, smokers VI. nongnokerr.
    6266
zlcrta!lry  ratlox in pipe and c:gar
   smokers. 585.586
Ccss.x!,on of smoking
cozpzred benefits in cipuctlc vs. pipel-

::<u smokers, 542.543
cEs:t on absolute aerobic oowcr. 613
c:Jeir on COPD dcvclopm~nt. 166
eYc:t on COPD development in British
yh~wclans. 168

cffrcr on COPD morbrdlzy and mor-

rallty. 201

effect on COPD morbidlty in smokers vs.
conrmokerr. I72

CIJCCI on coronary disease mortality
  rare. 28.4244, 102
cffccr on Infant bulb weighf. 421423,
  426428

inprowmcn!s in respnatory syslcm,
  174.175

rcht!on to incidence of CHD. 28.4244,
  102

prcvz!encc of. in pipe and cigar smokers,
  590.591

Chickcnr

diary funit~on m. effec: oi cigarctre
  rmoke on. 249

cffccl of cigarette smoke on embryos.
   370
ClxIdrcn

of smokcrr. incndence of pncumonla and
   bronrI+&& 502
of smokers. prevalence of rcsppuatory
   vmpiomr. 501.502
Chile

arherowlcrosis autopsy studier m.5 I. 52
ChOlCSICrOl

rabbm [cd.. -ubon monoxjde effects on.
6162

ryncrgxt~c rclationshrp of carbon mon-
oudc in coronary a[hctomatoGs. 59

deIini:lon and proccrrtn~.S4S
dcvclopmenr of crophqjul ncoplzrms.
  319

sirmlanr~cs wrth Irltlc c$wr. 594. 595
tar and nicoune content. 626.62;
tar levels of,  rclatmnrhlp to lury
   ncoplrrm dcvclopmcnt. 301,302
CigueIIc5, !ilter

summary oi prenour findings. 4
Cigars

definlrlonand procesring.545.546
Cigars. Illtlc

chcmlcal compontion of. 594, SYS. 5Y8
enluar~on oi potential pubbc health
impact. 592-598

shipment for domcrtlc consumption
   (1970.1972).592-594.597
simllarlry to ci~arctfes, 594.595
sugar and pti dilfcrences uith hrre
   crgxrr and c,~arcrres. 592.594
far and n~otinc co",cx.(. 594.596. 598
Cdiary actlvlly

effect of pipelc~qr ,moke vs. cigare~tc
   smoke m cats. 567.588
Clofibrate

and rcductlon in risk of sudden death in
   c~_earctfe rmokerx. 154
Cofiee dunkme

myocaldrsl rnfarction. smoking and. rn
   rmoke:i vs. nonsmokers. 141. I42
Comburrmn tempera!ure
cffcct on turnor~gcn~ actwity of p~pc
   and c~garerte robacco. 580,581
Congenital malformalmns
maternal smokmg and, JSO, 45 1
Connect:cuf Cancer Re31stry
figures on ageadJusted larynx neoplasm
   inadence, 303

figurer on mcidence of oral neoplarms.
310

Constitutional hypotheus
relationship to CHD and rmoking.4445.
   101-102
Cornsilk

smokmg. lack of arterial cpinephrinc
   lcvcl increase. 53
Coronary dlseaser
age-adjusted rater in smokers, 19
artcr~orclerolic, mortahty rater m U.S..
   17

arherorclerosls. effects of smokmg on.
59

blood prerrure of smokers Vs. "on-
smokers. 39.43

caboq dtoxide effects on oxygen upcake
in.58

death ratios of paired combinations of
high nrk. 21

cffccr of coffee drirzkmg and cigarcUe
rmokmg. I42

cprdemmlogul rludlcr. 136. 137

639


inadcncc and mortabty rates in former
smokcrr.42.4344
lnndcncc I" p:pc and c~gu rmokcn.585.
566

oral ncoplamr m. relauomhip of tobac-
   coua.390
Cyamde,

infarcuon in NYC pipe and cigar
  smokers. 28.3-1-35
infarction. rclat~onxhip to physical act-
ivlly, smokers vs. nonmrokers. 40
morbidily, relationship of rmoking to.
2X-31.33.35.8993
mortalrty and morbidity rctrospcct~ve
sludlcr, 36, 8993
mortabty rates in hypertcnrivcs vs.
nonhypcrtcnsivcs. 38
mortally rates in obcsc vs. nonobcr. 4 1
morlahty rates in snokcrs vs. "on-
smokers, 17-18. 20. 22-25
morrahry rater in. with i"cTcused carbon
monoxldc, 58

dctoticrtmn. m ~rcgnx" nokcrr "I.
nanmok~rs.433

in tobacco amblyopu etrology. 531.532
Crcchollonkm

Luyngcll "mplasmr m. relationship lo
tobacco use. 380.383
xcrum hpld dlffercnce tn smokers vs.
nolt~ 97

DDT
ar  ruqxcrcd contnbutor to hart"
   hazards of smokme. 629

Deaths. sudden

mortahy ra,cs of cigarette rmokers
from, AHA pooling project, 24, 26,
35

inadencc in p~pc and cigx rmokerr. 585
rcducuon  of risk of, in cigarette
   smokers. using clofibratc. 154
Denmark

mortzbly rates of pared combmatmns
of high rlrk. 2 I

athcrogenic effect of carbon monoxtdc
and hypoua. 60

mnrtahty rater of U.S. wtennr. 22. 34
mortahly rater. relationship to elcctro-
cardionaphx findmgr, 38
mortality ratios in p~pc and cigar
smokers. 585.586
n~otine effccl on coronary blood flow
I". 54
rchtiorlshlp  of blood pressure a"d
rmolmg.41.43

bladder ncoplarmr in. mctt&& and
rcwlts m retrospective fitudter of
smoking and. 407,409
carbon monoudc effects on human
blood tipxtr m. 12s
carbon mononldc effects on rabbit blood
!lpldr L". 12s

relationship of hext rate and smokmg,
41.43

~emm hpad dlflerenccs in smokers vs.
   nonsmokcrr in. 98
twins in. an_sna pcctoris in smokers vs.
   nonsmokers. 47
Delmarltis

relacmnshlp of physical actway and
smokmg. 37.39,40
relationshIp of Lrlglycendes to, 61
rclat~onsh~p to conrt~tut~,n~ makeup
and smoking.4445.101-102
rclatmnshlp to ECG abnormalities and
smokrng. 41.43

rclatmnrhrp to obcdIy and rmokmg.
  3941

among tobacro workers, 521
Diabetes mclhtus
effect on CHD i? smokers. 20
rclatronsh~p ullh crgarctte smoking I"
   pcnpheral rascular disease. 68
risk m mortahry from CVD, 67
Dibenz(a.h)acndmc
carclnogcmc properties in cigarette
   smoke from. 291

risk factors, 19.20. 36-37
smokers' age effects on development. 23.
35

in smokers with prcdtsposmg factors, 20
sudden death. and smoking,48
summary of previous findings, 4, 7
lee olzo Arleriosclerosis; hlyocardtal in-
   farct
CO!&

of paxnlal rmokerr. and rerpiratory
   symptoms in chJdrc". 499,501
p~evalcncc in pxpc and cigar onokcn.
   590.591
Crcsols

in cigar. pipe. and cigarette smoke. 547
as probable conlrtbufors to health
   hazards of smokm_e, 628
suspected caxinogenlc agent of c~garettc
   smoke, 292
Crolononitrdc
as  suspected conrrtbutor to health
   hazards of smoking. 629
Cuba

Dibcnz(aJ)airidme
  carclnoecruc properties  in  cigarette
    smoke from. 291
Diethylnltroomme
suspected cuclnogcnic properties in
   c~garetrc smoke from. 291
DimclhyLmmc                --
  as  suspected contrlburor to health
   hazards of smoking. 629
Dlmcthylnuxaamlne
suspected ~ar~~rag~nic propertrcs in
   ciperrc smoke from. 291
2,3-Diphosphoglycrnte
effects of carbon mo"ox,de OS. S6-U
DNA

inacaper m vnokcrs' oral cpithctial cells.
314

levels I" mouse lung exposed to cigaettc
   smoke. 187
Dogs

arhcropcnic clTectr of nicotine m. L k6
bladder "eopksmr in. fed 2-naphthy-
Imum. 322 .

laryngeal ncoplasms in. relation&p 10      bradycardu 2nd txhycardia in, TOIJOW-
`obacco use. 382                  mg mcotmc mjccuon. 53.54

640


641


cud,ac index, crfccr of smokmg. 612.
613

effect of smokzng znd tmokmg absu-
nencc.611.612.616.617
cffa,, of CO <.\po>urc Jnd lncrcsrcd
cubo\)hcl"oflobi" Icr*lx. 491, 493
influencing ixtorr.61 I. b16.617
summary ol tindIng, and mcchrnlrm of
ICUO". 616. 617 -

on trcadmti. cffat of smokmg. 613.

cffecls of ~rutton on body wcytht.
blood prc,,urc. and hypcncwon
development. 138-14 I
IOU- b,rth uaght ,nf*ntr of. 326428
mortlllty rate\ III. COPD. 201
tnorulny r~tc, in. coronary dl,ca*.
4244

NIIIWIY oi prwou, tindlngs o" hedlth
   ~~~nscqucncc~ oi CC~~I~IO". 6
Eye ,rr,t~t,o"

effects of exposure to c~pars~tc smoke.
I" p3uw rmokcr,. 495.496

cfTect of maternal imokmg.437449
cp!dcmioloncai rtud~er. I" u"oken v\.
   nonsmokcrr. 440446
I=lllCr?

advantages in reduction of part~culates.
   295. 301
Finland

blood pre<\urc drffercncer in rmoker5 vi.
nommoken. 99

COPD morhlday a" smokers. 226
lung ncopldw~ mon.ility in. rclatlnn+ip
   to tobacco uw. 271. 272
lunp ncopla$mr tn. rctrmpccttvc rtudy
   of. mahods. 351. 353
wrum llpld dlfferenwx in vnokcn vs.
   "on3mokcrx I". 94.95
\mokq ad "~cot~nc effect, on human
   blood h,wi\. I20
rltncrr texts

\mokcrr vs. nommoken. 6 IS
1 luoranthene

Formaldchydc
1,  wrpcrtcd conrr,butor to hul:h
   hsrardr of rmokmg, 6 29
F0rlX0Sd

ILUIC effect of cqarcttc vlokc on
   human pulmonvy functmn I". 195
rrnmm~hrm Study
cffcct of coficc drmklng on morrahty in
   Lmokcrs vs. "onrmokcrr. 142
FIl"CC

bkddcr ncoptumr m. mcthcdr and
rc,ultr in rctro,pectwe ,tudlrs of
rmohnp.407-409

CHD mortabty and morbjdrty I". 90. 93
ctgarettc smoke effects on animal tlrsuc
in. 369.370. 375

COPD mortabty of lmokerr I". 227
crophngcdl "roplaxmr I". rctrorpcctwc
   studzr of tobacco "szc. 404
laryngeal ncoplasmr I". rch\ionrhlp to
   tobacco u\e. 381.383
lung neoplasmr in. mcthodx of rctrospcc-
   we study of smokmg I". 352
oral ncopbrms I". rclalmn%hlp of tobac-
   couwa"d.389
Funqcadcs

concentration in cigarette bmokc. 291.

   292
FUIfUIA
15  surpccted contributor
   haurd, of smoking, 629

Gas phaw. cigarcttc xmokr
hdrmful con\t,tucnts I". 627
Gar1rtc xcretron

to health

effect of nlcotinc in laboratory dn~mxl\.
472,473

elfat of unukirq i" ul~cr pdtic"t\. 47 I
472

Gartroinrtwin~l disorders
prevalcncc tn ciparette and prpclcigar
   rmokrrr, 592
Genetic factor5

COPD pathogc"c+ and. 174. 176-I 78.
231

twin stud&. cl-feet\ of \mokm~. 4548.
   95
Germany

CHD morbidrty and mortality in. 91-92.
93

ciprcttc smoke inhaldrion cffcctr on
animal respiratory lract in. 376
lxynpeal ncoplarmr in. rclatiomhlp to
tobacco uy`. 381

lung ncoplasmr in, mclhodc of rctroqxc-
tivc xrudy of smokmp I". 349. 351.
3S2

polomum- IO k~clr in lungs of smokers
tn. 362

smoklnp and nicotme cffcctc on human
   blood hptds. I21
Gce3tl0n.4 ;rsr

eCTcc1 on pcrinrtal mortAty r;ltcs in
w"okinp YC. rmnsmokmg morhcr,.
440446

and lowhwth-wclphl infd"t\. cffccr of
mfcrnal \mokl"p. 4 I74 20

642


terms ured in smokmg and rentdatory
function. 241

Glucose mctabobsm
and insuhn revonw. sltcrption effects
   on myocarod response. 62
ClYCOgCll

lcvelr in mice lun_n e.vowd to ngarettc
   smakc. 187
Graphttc

    rcspmtory tract carcinoma m workers
      expoxd to. 282
Grip strength
    elfcct of smoking,611.612
   Cuanerhldrnc
    blockage of nicotine cardnc stimuLtian
       by. 53
  Gumea pigs
    lung neoplasm dcvelopmcnt followinp
       chronic  nickel carbonyl or dust
       inhalation. 282
    lungs of, cigarette smoke effects on
       sudactant activdy, 281
     rclpuatory  changes in, exposed to
      c,gxe:tc smoke. I88

H1mstcrs

bcnzo(a)pyrene inhalation by. cifect of
arbcrroy dust on carcinoma mduc-
tion. 188

bladder nroplas~~~r in, fed 2-naphthy-
laminc. 322

cigmtte smoke instillation or implsn-
   tation eifects on tncheobronchial
   tree of. 294,372.374
larynx of, efiect of cigarette smoke
   inhalation on, 307. 310
lung and embr/or. effects of cigarette
   smoke tarr on. 369-370
pulmonary changes from chronic nitro-
  gen dionde mhalat&. 246
rerpuatoty tract of, C-14 labeled particu-
   fates depositton in, 307-308
respiratory tract of. cigarette smoke
   inhalation effects on, 294, 377
ticalth Insurance Plan
myocardial infarction in pipe and cigar
   smokers under. 28.34-35
Heart

effect of nicotine, 32
Heart rate

cfiect of ~XCICW and smoking. 612616
cffec: cd rmokmg and coronary disease.
   41.43
Hematite
dust.  rcrplratory tract neoplasms in
   hamsters exposed to. 374
Hematocnt

un~tmns in. effect on coronary blood
   flow. 62
Hcmoglobm

aftinnty for oxygen. CO effects on
2.3dtphorphoglyceratc contxol of.
56-57

variations m. effect on coronary blood
now. 62

car`lrio?enK propenxs In clgarctte
   smukc. 290. 291
Hcxamcthomum
blockage of nic~ofme ard~lc >t~nuh':on
   by.53
Hook>hs

rmokcrr of, latyrgeal neoplasm induc-
   tmn in. 382
Humidity

and pathologic cffccts oi crporure to
   cprcnc smoke, 495
Hunguy

methods used for tcuospcctwc studier of
   lung ncopbrmr in. 354
Hydrocyanic 2nd
as probable contnbutor to hralth haz-
   ards of rmokmg. 628
Hydrogen cyamde
in clgarctte smoke. effects on body
   oxldatwe metabolism. 58
Hydrogen sulfide
as suspected contributor to health
   hazards of rmokmg. 629
Hydroqulnanc
a,  ruypcccled contr6utor to health
   hazards oi rmokmg. 629
3.Hydroxykynurcnmc
cxc:cmn of. smokmg effects on, 322
Hydroxyprotinc

level m m~cc lung exposed to cigaret!e
   smoke. 187
Hypertension

smokme eifcctr in. 137-141
summary of recent findmax. 15s
Hypoxemla

carbon dioxide effects on. 57. 7 I
Hypoxia

aortic arheromarosls development in
rabbits expored to. 60
portoperatwe. m smokers. 200. 256
postural, mechanism m asymptomatic
smokers vs. nonsmokers. 173
tissue. cxbon monoxtde effects on, 57

Iceland

lung neoplasms in. relationship to
   tobacco smoking. 270
Indeno(l,2,3<d)pyrene
carcinogenic properties in smoke. 291
India

esophageal neoplasms in. relrospectlve
srudles of tobacco use with. 404
laryngeal ncoplasms in. relatIonship to
tobacco "se. 381.382
oral neoplarmr in. trlationship of tobac-
co use. 388,392

relationshtp oi smoking to thrombosis
tn. 127

relationship of rmoklng to tuberculosis
tn. 253

smokmg and nicotine effects on human
   cardmvarcular rystem. 113
Indole. l-methyl-
posrlblr ~nitutor in tobacco carcmogenc-
   sis. 291

643


Sndurnlal hazards
effect ol dust on COPD dcvclopmcnt,
   201
cffcct on  COPD dcvclopncnt u1
   smokers. 179.150.244.245
Infant martahty
black vs. uh~tc nnokmg mothers. 443.
   446

effect of gcneoc differences and mnok-

ing. 446

effect of materrul vnohng. 437.449
effect of previous obstctncJ c~e"c"cc

and unokmg. 446
effect of saonocconomic background and
mmkina. 445.446

epidemrolopcal studier in snokcn vs.
nonsmokers. 440.446

factors othex th-m anoking. 445,446
risk of low-buth-weight mfants of
  smokmg v~ nonrmolclng mothers.
   440.446
Inrants

development of bro"ch!tis and pneum~.
  nu, and maternal rmokmg, 499
Influenza

rncidencc from aritlbody detici1 in
rmokmx. 5 19

prevalence m p,pe and cigar snoken.
490.491

Idlurnza "UUYI
effect on dogs mhaling ckarettc smoke.
   377

resistance of mice fouowing cIgarem
smoke mhaLxion. 199

Inhalation

efiect of previous smoking habits on
patterns of, 556.559
frcquencyper-puff in cigar and cigarette
smokers. 556.559
pipe. agas, and cigarette smokers, 554,
559

powble determiGng factors in patterns
of,553.554

summary oi previous fmdings on. 4
Intermittent cL?udicauoo
denease in c~erctse 1ime after exposure
   to co. 150

effects of coffee drinking and cigarette
smokiq. 142

rmokerrvs. nonsmoken, 144.148
Ireland

acute effect of cigarette smoke on
human pulmonvy function m. 194
CHD mortahty md morbidity m. 9 2
CHD mortahty and morbidW in.
smokcrr and "onrmokcn ip Q"

., _-

lung "eoplarms in. methods of rctrospcc-
tivc r,tudy of smokrng in, 354
maternal smoking and mfant weight in.
425

methods used in study of rmoking and
human pregnxwy. 420.422
Northern. monahty rater from COPD.
  170

occupar~onal exposure and smoking
rehtlonrhrpr to COPD in. 244
rclatwnlh~p of lung neopkvm to unok-
ing. a~ pollutron and rcudcnce m.
244

~crurn llpzd dliferencer in smokers Q.
   nonmokrrs I". 95
,mokmg and mcoune effects on human
  pcnphcral vascular system. 129
mokmg reLxt!onship to thrombau in.
   126
rure1

crgarc~rc smoke cffccts on animal cm-
bryor I". 369

monabty mtcs from COPD in. 166
Italy

strum lipid differcnocr in snokcn VS.
nonsmokers in, 96

txachcobronchial tree changes in smokers
and nonsmokers in. 289

lapa"

bladder neoplasm% in. methods and
results I" reuorpcctive srudJcr of
smokmg. 408.410
CHD monalrty and morbidity in.92
clgarctte smoke effects on human letal
lung t,v.uc J". 369

csophageA ncopLasms I" rcUorpcctwe
xtudles ol tobxcco use m, 404
kidney  and bladder neoplaonr of
smokers in, 321

lung neoplasmr, mortality of vnokcn
and nonsmokers in. 269
hmg neoplarms. retrospective smoking
study. methodsof. 352,354
mortality ratios. esophageal "eoplasms
in, 317

mortality ratios, pancreatic neoplarms I*
cigarette smokers. 324
rclatmnship of lung ncopksms to smok-
,ng, air polluuon, and residence in,
281

Kidney neoplxms
morrllity rates in U.S., 322
relationship of tobacco USA and. 325
in  rmakcrr and  nonsmoken.. 264,
   32&321

Korea

relation of human pulmonary histology
and smoking in, 281        -
tracheobronchel tree changes in mmkers
and nonvnokerr of. 285

Lactacmn

cff~ct of maternal smoking, 452455
cfkct of maternal smoking, sunmary of
fidingr. 455

cpldemialogical studies. 452
expertmental studlcr. 452.453
Lxtono

suspected carcmogenic agents in ciga-
   rette smoke. 291
Laparotomy

postopcratwe pulmonary compbcatio"s
followrng. in smokcrr VI. oon-
smokcrr. 200

644


Laryngeal ncoplasllu
devclopmcnt I" hamsters followmg qa-
   rctte smoke inhalacm". 265
development L" smokers. 307
inhdat~on parttmr and. 563
mortahty nrer.  in smokers \1. "on-
   smokers. 263-264
mortality r&s. 303.305
mortality ratios for pipe. cigu, and
   c~guettc smokers vs. nonunoken.
   563.566.561

rel3tlonship of tobacco use and develop-
mcnt of. 380-383
rehtlve risk for cigar. p,pe. and c,ga~~rtc
smokers. Ml-569
relawe risk rams from tobacco UY.
303.384

summary of retrospective studier. 568.
   569
L=Yn*

eplthelial changer in, clawfieafm" of,

307.309

hamster. C-14 labeled part~cuble depw-
r,on I". 307.308

halolo& chances I" cxgar. prl'r. and
   ctguerre smokers VI. "onmtokerr.
   567
IJp neoplarms

cigarette smoking m ecology of. S60.
561

ctgaar smokmg in eliolosy of. 560.5 61
p,pe mokmg m euology of. 315. 560.

561

r&twe nsk in p'pe. c+ir, and c~arctte
smokers vs. nonsmokers. 560.561



summary of ietmspcc~~ve stud,c,. 562
tobacco use rclat~on to. 387, 38X, 391.
   393
Lipoprotems

infdtratmn in arterial walls. carbon
   monoxide efiectr on. 59
III smokers vs. nonsmoker\. 95-98
Lummerccncc

tcchmques of, u,e in determining aro-
   matic hydrocarbons m urmc, 323
Lung ncoplasms

development I" dogs followmg cyareue
smoke inhalaoon. 265
cnnronmental and armaphetic factors,
278.28 I

group charactenstics of tobacco ore in
smoker, and nonsmokers, 266, 270,
355.359

groupmgs 272. 360
hatology of, and smokmg. 272-275
inhtlacmn patterns and. 573
mort~bty from chrommm compounds,
  283-284

morlalaty rafes expected I" U.S. m 1970.
  263.265
morfdhly  rates in \meller workers
expwed 10 arsen,c, 283
mortahty rater in smokers and non-
smokers. 266.269
mortahty rater in smokers m Norway
and I'mland. 271-272
mortahry rates m Unltcd Staler. 265
mortality rater. rmoklng dura"o" and,
266.270

mortallly rauos for cigar, pipe. and
c,&xrc,rc vnokcrr YI. nonpnokcn.
573-575

prcv;llcncc in mJlcr and females by
tumor type. 272. 276
reducuon m number uong filter-type
clglrercer. 301

relatmnrh~p of asbestos and smoking to.
283

reklivc nrk in cigar. pipe, and cigarette
smokers vs.  nonunokcrr,  573.
576.578

rctrorpcctwe study methods for smoking
relatmmhips. 266. 349-354
smoking m elmlo~y of. 263. 302
and smoking in women. 272,277
summary of prenour findings. 3.5-8
s"mmary of  retrospectwe  studier.
576-578

types lmpbcated in rmokmg. 263
Lungs

arterioles. effect of pipe/cigar smoking
vs. agarelte smoking on. 587
effect of clgarecre snake on tissue.
369-371

hamrfer. C-14 lab&d parbculales drp+
slllon in. 307-308

hufology of p!pc/agar smokers vs.
ag;lre,re mokerr. S8J

Macrophqcr. ~lveoL,r
effect of c~garccte smoke on. 191
hlamm3ls

rffect of cigarette smoke tars on cells.
  369

Maternal-fetal exchange
polycychc hydrocarbons and.433
hlethxrolcm
as  suspected contributor to  health
   hazard, of smokmg. 629
Methyl alcohol

as suspected contributor to health
   hazards of smoLmg, 629
3-hielhylcholanthrrne
effects during pregnancy in IJboralory
   animals, 43 I

N-Methylmrotmun~de
unnary excretron, effect of gnokmg.
   323
Mice

bladder ncoplasmr in. inductIon by
tryptophan metabohtes, 322
esophageal eprthchum of. alcohohc benr-
o(d)pyrene pcnetrdbdily of. 3 18
esophageal epithelium of, ml&swlved
benzo(a)pyrcne pcnctrability of. 318
lung neoplasm mcidence in. from chro-
mum oxide durr exposure. 284
lungs of. effects of cigarette smoke on.
  185. 369,370

pulmonary carcmoma induclmn in, fol-
lowng asbestos dust inhaldllon. 283
pulmonary changer from chrome nitro-
gen orlde mhalatlo". 187.246
pulmonary clearance I", clgsrette unoke
cffec[r on. 196

645


I"hALlllOll  cffcct on.  :94-195.
37s.379

,kin pzntmg of.  szokc cor.dcnutcs
   cficcts on. 295. 363-368
S~ouusks

clluuy runclmn 1". effect of cigarette
   smoke on. 249
.Honkcys

athcrogcnic effects of carbon monoxide
and hypoxu. 60

cdiary function "3. effccr of cigarctre
smoke on. 248

fetal bronchul tubes of. cffccts of
   cigxcttc smoke on, 371
rhesus. devclopmcnt of bladder nco-
   plssms from 2-naphthyLnunc. 322
squlrrcl.  muogen  o.udc effects on
   ICslS~P"cc to pncum"cocc"s. 199
Sforbldiry ra,,os

coronary dierws. smotcn with prcdu-
povng factors. 20
coronzry diseases, smokmg and. 28.31.
33.35

coronary diseases. rc~orpccuvc stwdicr.
36. 89-93

in Danuh twins. smokmg effects on.
45-17

development of COPD in smokers vs.
   nonsmokers. 171.221.231
Slorldlly rates

from blJddcr nsoplasms m L'.S. for
  1967.319
from  bronchopulmorary  d:seaw.
167.171

ccrcbrovawuLr dwxscs. cnokcn vs.
nommoker,. 62-63.6446
in chronx bronchopulmonary dircaw.
cigar/pLpc  smokers VI.  CI~arICllE
smokers and nonsmokers. 586. 587
compared rate< for cyarrttc VI. plpe/ci-
par er;+mokcrs. 542.543
coronary d!scaws, 17. 136
coronary d~,cdses. and age. 136
coronary dlscases. paxed combinations
of high rllk characten\tirs in. 21
coroxuy d&ass. retrospectwe studies.
36.8993

coronary diseases.  smokers vs. non-
smokers, 20.21-25
in Dnmrh twns. smokmp effects on. 47
csophagcal neoplasms. 3 I5
in former smokers, rclatton to CHD. 42.
4344

from kldncy neopksms m US. for 1967.
322

from lung ncoplasms expcctcd in 1970.
263.265

from I;ng ncoplasms for 1939 vs. 1967
in U.S.. 265

from lung nxplasms in uncltcr worken
cxpovd to aIscn,c. 233
from myocudul infarcrmn. 136
from oral ncopkrmr III 1967.3 I1
omrall mcs for ngu smokers VI. pipe
smokers. 54.9. 550

overall ,atcr for p.~+c'npa! srnoken and
dore-rcsaonsc ~~iaoons~zps. 550.559
ovcnu tata i0r p1pciclgar rmokcrs YS.
nonsmokcn. 549.550
overall raw from cancer in pipe and
cqa~ vmokcrr. 559
in SucOlsh rums. noksrs n. non-
smokers. 47

summary of prwious findtip, 36. 135
U.S. male vcwran, from CHD. 22. 34
Mortahty ratios

coronary deeaws. wth hiqh risk charac-
   tcristrcs. rsrlmawd. 24
esophageal neoplasmr. prospective and
   retrospective studies. 315.317
laryngeal ncoplasms. 303-30s
lung ncopllsms. tn male% by cigarette
   smoktng duntlon. 266.270
lung neoplasms in smokers in Norway
   and Fmland. 272
from pancrc~ric neophsms m nokcn
   and nonsmokers. 315-32s
in p~pc and cigar smokcrr by age and
   inhalation. 5S4.557
smokers ~5. nonsmokers. from lung
   ncoplams. 266.269
Mouth ncoplasms
frequency m smokers and nonsmokers.
   264

Mucopolysaccharidcs
funcuon as wrfactants m lung tissue.
   198
5!usscls

clliary functmn in. effects of cigaretlc
   smoke on. 247.248
hfyocardml infgc1
cofice drlnkinp. smokmg and, 141. I42
damare to rabbits after exposure to
   carbon monoxldc. 151
incidence in pipe and CI~X smokers. 585
martaht~-. in smokers vs. nonvnokers.
   136

. . .

sumrn~ry of previous tindings. 4. 135
in S,\edllh ~ornen smokers vs. non-

smokrrs. I36

se dro Coronary diwares
Xlyocardwm

cfrecrs oi hydrogen c);amde in smoke
on, 58

oxygen consumption in nicotine rtimula-
ted. 55

oxygen demand of nicotine effects, 34

2.Naphthylamme

development of bladder carcinomas and
paplllomas m dogs. hamsters. and
monkcyr. 322

suspcctcd bladder carcinogen in tobacco
smoke. 29 I

National Center ior Health Statistics
suwcy on rclaw~nsh~p of smokmg and
   incidence of rerpnatory disease. 199
Narmnal Coopcratwe Pooling Project
mortality statxstm from coronary dis-
   ease. 17-1 a
Natural gas

rcspuatory tracl carcinoma in workers
exposed to. 282

646


Ncoplzsms

adcnomalous, Ir:ducrmn m mice by c!ga-
ICI~E smoke ~nhaiaUon. 376
dcvclopmrnr m smokmg dogs. pcrcenr-
ages of. 300

rummary of previous tindmgs on rcla-
   uonrhlp to unokmg. 3-8
h'etherlands

cigarette smoke inhahlion cffxtr on
   mice Icxpxatory tract in. 315
lung nmplasms. methods oi relrospec-
   WC study oi smoking I", 349
serum lipid difference. m smokers vs.
   "onwnokersm.97
New York City

m)-ocardldl infarctions in cigar and pipe
smokers in, 28,34-35

Nickel
compounds,  surpcctcd  carcinogenic
   agcntr m c,garette smoke. 291. 629

antlpenlc propcrtlcs. 5 I4
atherogE"lc effects of. 116-l 18
m ctgx, pp. and cigarette smoke, 547
ch"~cal effects on ofispr~ng of smokmg
molherr. 454.455
I" duodenal ulca mduclion in cats. 472,
473

effect durmg prcgn~ncy in I3boratory
animals. 429,430
effect on blood lipldr. 119-l 24
effect on blood pressure. 32
effect on :ardlac rhythm. 32
effccc on cardiovascular system. 52-54.
  103-I 14

cffcct on cAtccholamme release. 32. 1 IS.
  151

effect on gartrw secretion in cats. 412.
  413

cffcct on gastr~ rccretion in ralr, 473
cffcc! on heart rate, 32
cffcct on ~mmunc response in man. 5 19
clfccr on lactation I" laboratory anlmalr.
4S2.453

cffcc: on lactauo" m smokers vs. non-
smokers. 453.454
cffcct on myocardium oxygen demand,
  34

cflcct on pancreat~ secretions in ani-
mllr.475.476

effect on pcrlpheral varculx system. 68.
  71.129-130

cffcct on p~pc/cigar smoke inhalatmn.
553.554

crncmn. by passwe smokers. 493
Inductlo" of necrorls rn .uterlal walls. 59
ncurogcmc cfkctr oi. 53
as potcnr,ator of duodenal ulcers m
  m1malr.475-477

sccrct~on. cflcct of cigar. pipe. and agu-
   me smoke an dogs. 586
Nlcollnc con!ent

effects of room IIZC. amount of tobacco
burned and \~cnuIac~on. 487-190.493

in htfle c~puur comyxrcd to CI~.~ICIICI and
   `L:UI. 593-596.598
I" mdk of Lborlrory xnlmalr. 4S2. 453
in milk of rmokmg morhcrr. 453
N~lric ox,dc

3% probable contributor 10 health hu-
   ads of rmokmg. 628
Nitrogen dtorzde
a, probable contributor to health bar-
   ardr of smokmg. 625
pulmonary chsnges in rodents chroni-
   cally Inhaling. 187.246
Nitrogen oxides

effects on resistance of squirrel monkeys
   10 pncumococcw, 196
4.N!troquinoh"c l-axrdc
alcoholic solutmn of. dcvclopmcnt of
   papdlomar in ma drmking. 318
Nitrorammes

effect on lactating hamsters. 4S3
N-N,trowmmcr

carclnogcnlclly  in  cigarette  smoke.
290-292

ewphagcal neoplasms Induced in annals
   by.318
Nonsmokers

allergrc rymptomr in. from robacco
   smoke exporurc. 520,521
carboxyhcmoglobm efieclr on oxygen
   uptake, 57
h'orcpmcphcne

effects of "acotine, I51
Norway

lung neop!asms I". for pope smokers. 270
lung neoplasms mortality I". relationship
to tobacco use. 271.212
tracheobronchlal tree changes in smokers
and nonsmokers of. 285

Obesity

relationship to smoking and CHD. 39-4 I
relationship to smoking L" peripheral
   arleriorclcroslr. 68
Occupational hazards
carboxyhemoglobm levels in workers ex-
   posed to exhaust gases. 143
Occupations

asbestos workers. lung ncoplarm mortal-
sty and smokmg. 283
asbestos workers. respnatory tract car-
cinoma, 282

bank employcer. smoking and COPD,
224

coal muters. impaired pulmonary func-
tmn in rmokmg, 189
coal miners, ropuatoty tract carcinoma.
282

coal mmerr. smoking and COPD. 179,
113.144-245
call mulcrr.  smoking and venillatory

I-uncrron. 233

flax mrll workers. smoking and COPD.

  22s
government employees. blood pressure
d~ffcrenccs  tn smokers vs. non-
smokers. 95

647


longrhorcmen, mortSry Gom rmoklng.
rclrcd ccrcbrovascular d&au. 66
lorqsholcmcn. momhry ram from CHD
:n, 24

longshorcmcn. smokmg and COPD. 24
longsnarcmcn. mokmg and rcnulatory
hmzuon. 234

mtdxxl srudcnts. xrum bpld d$fcrcnccs
  in sl"okcls vs. "onsmokcrr. 94
mcdul ,rudcnu. smokm~ and "lcotinc
effects on blood lipld icvclr. I20
mcdul students. xmokmg and thrombo-
ns rctat~onsh~ps. 126
mcdud students. rmoking and rent~la-
tory funcoon. 235-236
nickel workers. lung ncoplaons in. 282
phywanr. bladder and kidney "co-
piasmr m smoking. 319.320
phyuctanr. cersat,on of smoking effect
on COPD. 168

phyncrans. COPD mortahty rates. 17s
phyocuns. dcclmc m c~&~rttc smoking
I2lCS. 44

phywcians. mortahty from smoking-
rclawd ccrebrcvawular disease. 64
ph)-sxizns. morubty rates Gom CHD.
22

phyrrclans, mortality ratios from esopha-
gcal neoplarms. 316
physliixns. pulmonary funcr~on follow-
~n_e ccssauon of smokmg. 175
physxlans.  smoking and vent&tory
funcuon. 235.236, 739
plant wrkcrs.  occupauo"al exposure
and rmokmg relationshrps to COPD.
179.244.245

p!ant workers. xmoki"g and venlilatory
function. 232.2?-l

post oiticc workers. blood pressure dif-
fcrenccs in smokers vs. nonsmokers,
  100

post office workers. smokmg and venlila-
rary iuncuo". 235

post ofJicc workers, smoking and COPD.
  226.228
ptiners. YIUrn  lipid differences in
smokers vs. nonrmokers. 96
prisoners, smoking and njcotme effects
on peripheral vascular system. I29
railroad employees, mortahty and mor-
bu+ty. CHD and smokmg. 24, 30.93
smdtcs workers, lung neoplasm mortal-
ity from arsenic exposure. 283
soldiers. smoking and COPD. 223
steel rwrkers. COPD dcvclopmenl from
dust exposure. 119

stodcnts. carbon monoxide erieas on
blood Iiu,ds. 12s

studmts. mfcctious respiratory dlseaw in
smokers vs. nonsmokers. 254-255
students, morrahty from smoktng~elatcd
cexbrovascular disease. 64
students. monabty rarer from CHD. 24
rtudcnts. smoktng and COPD. 227
studcnrs. smokmg md mco~ne cflects
on blood hpld level, I21
students. &"okmg and thrombosis rcla-
uonsh:pr. 126

rrudcnts. rmoL.mg and vcntdaro~ iunc-
r~on. 237

tclcphonc company cmployccr. smoking
and COPD. 226

texrdc uorkccs. occupJtionll e\porure
and vnoking rclatlonril~p to COW.
244-24s

tranrportat,o" workers, XII poUuuon re-
laoon~!up to COPD. 22.l. 228
transportauo" workers. vnoking and
COPD. 224.228

trmsportatmn workers. smoking and
   vcrmlatory functson. 233,238
  uramum miners.  lung "cophxms I"
   smokers and nonsmokers. 282
uulity company employox. CHD mor-
   bidity in smokmg. 320-321
Oleic acid

suspected carcinogenic agent in cigarette
   smoke, 292
olive oil

pcnetrabllity of benzo(a)pyrene I" mlcc
   esophageal cpuhclium, 318
Oral neoplasms

alcohol consumption and smoking in
cuology of. 563
cstunatcd incldencc in U.S. for 1970.
310

inhalation patterns and. 561
mortality rates in, 31 I
mortabty rauos for pipe. ct_ear. and
cigarette smokers vs. nonunokcrs.
561-563

relal~onshrp of tobacco use. 311. 315.
387.393

rclat~vc nsk of development in pipe.
   cigar. and cigarette smokers vs. "on-
   smokers.561.564.565
smoking in etiology of. 315
summary of retrospective studies. 564,
   565
Organ CUltuIeS

agarette smoke effects on cell growth
   and reproduction in. 293.369-371
Orophxyngeal "eoplasms
frequency in smokers and nonsmokers.
   264
Oxygen

debt, effect of smokrng. 616.6 17
debt. exercise performance and. 616,
617

myocardial consumption of, folIowing
nicotme stzmulatio". 54, 7 1
transport in body. cubon monoxide
effects. 56.71

uptake in nonsmokers with specdic car-
boxyhemoglobl" levels. 57. 71

Palate

hamster. C-14 labeled smoke particul3t.x
   dcpovtm" in. 307.308
Pancreatic "eoplasms
rclallonshlp of smoking to mortality
   from, 324-325

smokmg and. 264.324-325

648


Pancreaclc sccrctions

brabonatc content. effect of smoking.
473.414

elfect oi ntcotmc in ammJlr.475.476
Papal"

pu!momy cflccts on rats expoxd to
   agarette smoke wrth, 189
Papdlomar

development in mtcc drinking alcohohc
bcnzopyrene. 318

formation followtng skin pintmg with
smoke tars. 363.365, 367
inducuon in hamsters exposed to bcnzo-
(alpyrenc, 372-373

Parents

incxdencc of pneumonia and bronchitis
in children of smokers. 501, SO2
prevalence of rerplratoty symptoms in
children of smokers. 498,499
smokers cough and phlegm producuon.
and respiratory symptoms in chil-
dren, 499

Particulate phase. cigarette smoke
  harmful conrtltuents I". 621
Parve smokers

patholo@c studies. 495
summary of prevtous findings. 483.484
summary of recent findIngs. 503,504
Passwe smokmg

CO, nicottnc. benro(a)pyrene. acrolein.
and aceraldehyde levels. 486-191
effects of carboxyhcmo$obin levels. in
permns wth angzna pectorlr. 491.
493

effects of carboxyhemo@obin levels on
CO absorption. 491,492
clfcLt> of CO in tobacco smoke on
pbychomotor performance. 495-191
eiiect\ of exposure to cigarette smoke.
in parive smokers. 495
effects of tobacco smoke constituents.
484494

effect, on bus and plane pa,se"gers. 498
c\cretlo" of "Kot"e, 493
cxpo,ure to clgarctte \mokc, and dcvcl-
opment oi eye dnd throat irrltauonr.
495.496

mcadcncc of pneumonia and bronchitis
I" chddrcn of parental smokers. 501,
502

matcrnrl unoking. and developmrnr of
bronch&s and pneun~onu I" mf~nls,
499.500

prrcnul cough and phlegm production,
2nd rcspnatory ,ymptoms in chil-
dren. 499

Peoples GA Light and Coke Co.
study of CHD. xer"m cholesterol and
   rmoLmg rclauomhlps, 39
Peptrc ulcer

cltn~cal studio. 469471
cpzdcmloloFwA studies, 469471
gdbtric secrctmn I" smokers M. "on-
~mokers.471.472

incrrasrd mottality m Japancrc rmokers
vs. nonsmokers. 469.470
matably tacos m Japancu adults by
age started ,mokmg. 469.470

momhty ratms I" mdc crgax and p,pc
rnokcrr. 592

predlspoung factors. 411
ICCU~C"EC t" smokers VI. nonsmokers.
471

smokmp and. 469
Pcrinatal stud,es
effect of maternal smoking on mortality,
   summary of findings. 448.449
Pcroxldcr

suspected carcinogenic agent tn crgucttc
smoke. 291

Personnhty charactcrislicx
iclatlonti!p to CHD and smoking. 4445.
   101-102
Pcaicldcs

content tn cigarette smoke, 291.292
PH

ptpclc~gat smoke inhalation and.553
of smoke m ciparcttes, cigars. and little
   crearr. 593.594.598
Phz~ocytostr

ciiect of c!$uctte wnoke i? rabbits. 5 19
pulmonary alveolarI. m smokers vs. "on-
rmokcrr. 191

Pharynced neoplarms
frequency I" smokers vs. nonrnokcrr.
   264

rclatmnrtxp to tobacco use. 388-390.
   392
Phenols

m ctcar. pope. and cigarette smoke. 547
ar probable. contrrbutorr to health haz-
rrdr of rmokm_e. 628
suspected carctnogenic agent of cigarette
smoke. 292

Phlecm productlo"
by parental smokers. and development
   of re,puatory symptoms m chiidren.
   499

by parent31 smokers. and incldenw of
   pneumonia and bronchitis in chil-
   drcn, 501.502
Phosphohprd,

function as surfactants in lung tissue.
198

smokers vs. nonsmokers. 95-96.98
Physxal actwiry

rcktronship lo myocardial infarction.
smokers "3. nonvnokers, 40
smollng 2nd tela(lonship to CHD. 37,
39.40

Piperidrne. nitrobo-
suspected rsranogenic properties in ciga-
   rette smoke from, 291
P"eUmO"la

inctdence in children of smokers. 501.
502

matern;ll smokme. and development in
infants. 499

m pawe rmokcrr. summary of recent
   l<ndi"gr. SO4
Poland

bltddm neoptasms in. methods and IC-
sultr in rctrospeclwc slud~er of unok-
ing and. 408.409

CHD mortahty and morbidity in.92
cwphagcal neoplasms in, retrospective
rtudles of tobacco UY with, 404


surpcrtcd c.ucmo~~n~ agent I" c@arclle
    smoke. 291-293.361-362
Port-ope~atrve comphcarxons
in duodenal ulcer removJ1. smokers vs.
    nonsmokers. 471
pulmonary.  smokers vs. nonsmokers.
    200-201
Potatium40

pre~nt I" tobacco leaf. 292
Preecl3npr1a

maternal rmokmg and. 456
I" rmokmg vs. nonxnokmg &omen, 456
Pregnancy

cuboxyhemoglobin levels in fetuses.

  IJK. 149
effccr  of smokmg durmg.  78-83.
417-156

effect of smoking dorm!, and develop-
ment of bronchltis and pneumon,a m
infanrs. 499.500

effect of lobacco smoke, n~cotme. and
carbon monoxide in laboratory an,-
mah. llS432

and prewous smokmg hoblts. effect on
rnfAnr burh ucqht. 426128
summary of prewour lindmes. 5.6
c!m~ng oi ~nllucnce of rmo&ng on birth
weight. 434,435

ree n/so Smokmg. maternal
Premalunly

rnd ma!ernal rmokmg. 426
PrOt"Z"J

cdlary function I", effect of cig.ircrte
   smoke on. 191.250
Psychomotor performance
cffecls ofC0 I" tobacco smoke. 495497
m pasivc unoker,. summary of recent
   hnding,. 504

Pubhc tranrportat,on
cffeclr of pawve smoking on bus and
   pIale pauengcrr, 498
F'ucrro RICO

erophdgral nroplrsms in. re~ro~pecwc
   audler of tobacco u,e wh, 404
rehtmnsh~p of tobacco use Jnd new
   pIam> of oral cwty in. 393
Pulmonq alvcoh

xuplurc. m p~pelc~r smokrn vs. cigu-
   e~te smokers and nommokerr. 587
F'ulmonay fibrow
in p~pclqar ,mokcrr VI. cqwette uno-
   kcrl and nonxmokcr,, 587
smoker, YJ. nonsmokers. 187
Pulmonary iunwon
effect on  exerted pcrformdnce in
   smokers 13. nonmoken.616
in p~pc/c~gar maker, vs. nonvnokcrr.
   587.591

Rabbits

arhrrogenic effects of carbon monoxrdc
and hypoxia. 60

atherogemc effects of nicotmc. 116-l 18
blood bpids in. rmokmg and mcotme
cffec:rr on. 123

cardlovarular function I". vnoking and
nicotine effeclr. 104. LOS
cholesterol fed. carbon monoxldc effects
on. 6162

cilmry function in. cig~rc~tc rmokc ef-
fect on. 247.248

pulmonary changes in cigarette >molung,

185

pulmonary clearance in. cigarette bmokc
effect on, 190. 196. 197

rkm painting. smoke condensate effects
   on. 293.364
Race

as a factor in perinatal mortahty in
rmokmg VI. nonsmoking molher,.
443446

ax a factor I" rtlllbirrh rater. 438,439
Rat5

blood hpids in.  nicotine and smoke
eliecu. I?4

cihary function m, cgarette smoke on,
247, 248

lung neopl.wns, from inuabronchial km-
plantkng of chromium compounds,
2R4

lung neoplasms, from nickel carbonyl
and dust inhalauon, 282
lungs. c~garctfe smoke effects on surfac-
tan, IC~IYI~Y. 198. 25 1

pulmonary ca&oma inducrmn follow-
ing asbestos dust mhalauon, 283
pulmonary changes from chronic mtro-
gen dioxide mhalation, 187, 246 _
respiratory tract, ci:arelte smoke inhale-
1x0" effeclr. 294. 375. 379

skin painting, smoke condensates effect,
293. 366

trachea; cigarette smoke effects on, 369
tracheal ligalion. agarette vnoke and
   pdpain effccls on. 189
tracheobronchul tree, cigarette smoke
   eifecls on. 294.312-375
Rewrpinc

n~cotmc cardiac rumulalion blockage by.
53

Rop~ra!ory function tests
vnokcrr. 172-i 73. 232.240
Rcrplrdlory symptoms
prcv;llrncc rn children of parcntd
   smokers. 498.499

650


anmd. ngarettc rmokc instrlla~~on or     S.5comas
impiantatio"  ellects on,  293.      formauon followmg ammal skm pannng
  372-374                         ulth smoke condenutcs. 364.366

a"imxI, effect of c;garette smoke tnhala-
t,on on, 294.295. 375-379
crfect of cigarette and qu smoke on
b:onchul reactw~ty. 190
dfect of cigarcttc smoke on human
cdiary luncuon. 191. 247-250
effect of cigarette rmokc on human
pulmonary clearance. 190.196
g~orrary of tcrmr used L" testing. 241
histological changes I" smokers, 180-183
,.mpro"eme"ts  in function followmg
rmokmg cersatlo". 174. 175
pathological  changer I"  clgmrte
smokers, 201

portoperatwe complicatlo" I". of
   srnokeir vs. nonsmokers. 200 202.
   256
pulmonary  alveolar phagocytorls I"
   rmokers VI. nonvnokerr. 19 1
pulmonary ,ntarcr,on I" dogs Inhaling
   c,gzuette smoke. 297
surface penman of. effect of cigaicrte
   smoke on. 198.25 I
surfacmnt actwty of. in smokers VI.
   nonsmokers. 198. 25 1
surLacta"rr I". definition. 198
Rcsprratory tract diseases
infecrmnr. prevJence UI smokers. 202
~"fecuons. smoking and, 202, 252-255
patholoelcal and cytological chaneer I".
   of smokers vs. nonsmokers. 284.269
vcntdatory function in. vnokeir VI "on-
   smokers. 201

Rctrospatwc studaes
lung neoplasms. and unokmg. methods.
   349.354
Rhodcsra

methods uwd in rewospective studxr of
   smoking in relatmn to lung neo-
   pLumr, 3S4
Rubtdlum-84

traOng Capdhry now in coronary blood
   now. 5s
RlJ""lJI~

effect of smoklnp. 613,614
Rural areas

lung neoplasm mctdcnce UI. in Switzcr-
Ilnd. 270

relatlonch#ps of lu": "eoplarm to vnok-
   ing. au pollution. and. 278-281
Rurxl populatmnr
lung "eoplasmr I". suspected ctlology of
   uweaxd. 302
RUWI

atherogcnlc effects of twotine on rabbrts
m. I lb

inductmn m rats by agarettc smoke
   in]ecuon. 372.373
sex

efiect of. I" alpha-1 antltrypr," defici-
ency emphysema, 177
effect of. in lung neoplasmr and tobacco
use, 270.355-359
efiect of.  in mortahty in cigarette
smokers. 302

cffcct of, on laryngeal neoplasm inci-
dence development, 303
rarm. eifect of maternal rmokmg on,

449.4so
I.allO.  m lung "eopL,m morullly u1
Sorway and Ftnland, 271.272

erTe:t oCtobacco e\tractr. 5 IS-517
tobacco anugcnr and. 5 14.5 IS
six lertr,g

chemrll co",t,tuc"ts I". 547-549
cd;oroxlcity. 588
eiiscr of curing methods. 558,589
effect of pH on mhdauo" of. 55 3
Ilrrlc, pH, compued to c!garttte and
   cigar smoke.S_4. 59X
tumongemc actiwty in laboratory a"~-
   mais. 580-584
S.xokc. cl<xette

alrerat~on of coronary blood flow, 54
bronchogenrc carcinoma lnductlon in

dog, mhahng, 295, 296
cadrnum levels I". 180
cubon monoxide levels in, 55
carclnogematy of components to ani-

mals. 303

cause of death in dogs from inhalation.
297

chemh-al constituents in. compared to
pqr/agai smoke. 547.548
ahan- mhlbltm". 293
effect of cunng methods, 588.589
efiect of nxkel on induction of lung xyl
h>dio\ylase. 282-283
effect on phqocytorir in rabbtts, 5 19
effect on rat and mouse fetus. site of
actKIn. 43s

effect on t,r,ue cultures. 293. 369-371
harmful cons~rtuents of. 625-630
~"hAwon by dogs. lung neoplasm dcvcl-
opmenr. 294-29s. 298.300
inhalahon cfCecls on ammal re~-puatory
trx,. 294-295.37s. 379
mhhuon effects on hamster Larynx.
307.310

651


hsting of Idcntrficd or surpcctrd turnon-
   eeruc qents. 290-293
2-"aphthylxn,nc tdcntlfied I". 291
"coplast~c chrngcr i" anun& mhzhng,
   261-26s
  tobacco  Jmblyopu  JelJtlonrhlp ,*
   cyanide mrtaballsm in.531.532
Smoke, pqlc

chcmtcal constituents I". 547.548
~~~~~~~~~~~~ of. 588
cffcct of pH on mhalatwn of, 553
turnongemc acuvity in laboratory ani-
   mals. 580-584
Smokers

COPD morbidity in. 172. 223.224.
221-228.230-231
effects of smoke on bronchul rcactivlty.
  190

esophageal ncoplxun mortahty ratio.
316

krdncy neoplasmr in. 320-321
lack of risk m CVD, 63
laryngeal neoplasm induction in.
380.383

laryngeal neoptasms I". 307
lung nsoplasms. lncldsnce in rural Swit-
zerland, 270

long neoplasms. mortahty in. 266.269
mortahty ratios from COPD in, 168-I 69.
  171

morlahty ratios from pancreat~ "eo-
plasms I". 324

myocardial mfa~ctron I". 28. 34-35
rcLtlonshlp of neopLsms of oral canty
with. 387-391.393-397
relatlonshlp to mfectious resplratoty dir-
CIYS. 253

rela!ive risk in laryngd neoplapn devel-
   opment. 302
Smokers. cigar

atypical nuclei in male esophageal epith-
clium. 405

bladder neoplasm, in, 3 19-3 20
cell rows and atyplcal cells in vocal cords
of, 306.385-386

Smokers, cigarefte
arterial occlusions in, 69
atherorclerosls in aortlc and coronary
   arteries, 48-52

atypical nucla in male esophageal epith-
clum. 405-106

bhdder neoplasms I". 319-321
cell tows and atypical cells tn vocal cords
of. 306.385-386

cessatmn of smokmg, effects on COPD
morbidrty, 172. 223. 225. 229-230
changes m ventllatory function and pub
monary histology. 201
comparattve nsk ior lung ncophsmr. 263
coronary diseases I". AIlA poolmg pro-
ject. 24, 26.35

coronary dwases usk by. 19-21
decline I". Brtttsh physrcians. 44
development of esophageal neopkuns.
319

dcvclopment of second pnmuy oral
ncoplasms r" conunumg. 313
effect of filters on emphysema develop
mcnt. 188

652

esophageal neopLxuns. murtably rlt~os
in, 316.317

h,staloqy and smokmg rclrt,o"shrp of
lung ncoplasnu in, 272-275
inhalatmn cifects on human pulmonary
functl"". 189.192-195
kldncy neoplasms in. 320-322
laryngeal  ncopLsm mductlo" I".
NO-383

lung "eophsmr. etiology. 265
lung neopbrms, mortality in, 266.
269.270

mortality from ccrebrovascular ducase,
6366

mortality ratios from COPD. 168.170
morta[lty *attos from +ncrcauc "eo-
plasms I". 324

postoperative pulmonary compbcatrons.
200.256

pulmonary surfactant actwity I", 198.
251

relationship in coronary and lower hmb
arter~osckros~s. 68
rclationshlp of asbestos in lung ncoplaun
mortabty, 283

rclationshlp lo mfectlous respiratory dis-
c.ues. 198. 252-25s
relatIonship to laryngeal neoplasm dcvrl-
opment Ml. 307

relatmnshlp to Ilp or oral c~v,ty "eo
olasms. 387-396

rela'tio"sh;p to lung neoplasms. 301.302
relatlonshlo with bladder "eoolasms in

mtn. 3i5

rclattonshlp with dult on COPD develop-
nlent, 179

risk of COPD in. 166
Smokers. pipe

atypical nuclei in male esophageal epith-
chum. 405

bladder neoplssms in. 319.320
cdl ~owsond alyptcal ceUr rn vocal cords
of. 306.385-386
COPD morbtdlty in. 172. 223-224,
22-i-231

development of esophageal neoplasms.
319

esophageal neoplarms, mortabty ratios,
316

kidney neopiarms in. 320.321
lack of risk in CVD. 63
laryngeal neoplasms. induction, 380.383
lung ncoplasms. incidence m Norway.
270

lung ncoplasmr. inctdence in rutal Switz-
erland. 270

lung neoplawns. mortaltty in, 350-353
mortahty tales from COPD, 168.169.
  171

mortalw ratios from pancreatic new
plarms. 324

myocardlal Infaxctm" I". 28.34-35
rclationshlp to k"f.xtious respiratory dis-
caYs. 253


rclat~onship to Iaryngcal ncoplavn dcvcl-
opmc"t, 307

relaconrn1p to lip ncoplms. 315
rclarlonrhlp to 01x1 cavrry ncopkrms.
337-390.393

rcLtivc rusk in laryngeal "eopiarm dcvel-
opmcnt. 63

relative nrk in lung ncopLwn dcvelop-
mcnt.302

;mokcrs ~3. nonsmokers
bladder "coplasms in, 319-321, 407310
cell rows and rtyp~cal cells in vocal cords
   of.306.385.386
ccrcbrovasakar disease mortality rates.
   6346

coronary disease morbidity ratios. 20
coronary dncare moitahty. 17-16. 20,
  22-25

coronary disease mortality. by sex.
  24-27

coronary drrcaw monahty. in Swdlrh
Wl"S.47

development of COPD in. 167. 171.
221-231

dJfcrenccr in emphysema Iypcs in. 180.
  IfI2

esophageal eplrhehal cells with alypicti
nuch in. 318

crophageal neoplasm morrality ratios,
  316-317

ericre"o" of tryptophan mc!abobter I".
  323

frequency of esophageal neoplasmr in.
  264

frequency of kidney neoplasms in. 264
frequency oimourh and phuyyngeal "co-
plssmr 1". 264

frequency of ""nary bladder ncoptauns.
264

group characteristxs in lung neophrms
and smoking in, 266, 270, 355-359
laryn_ecal ncopkrm mortality rates.
  263-264
laryngeal  neoplasm mortality ratios,
304-30s

laryngeal neoplasmr in. relationship to
tobacco "se. 380.383
lung fibrosis development m. 187
lung neoplasm mortality in uranium
miners.282

lung neoplasm mortality rater, for wo-
men.266-269

morrahty ratios from pancreatic "co-
plarmr I". 324

mortahry raftas al COPD in, 168-l 70
myocardul mfarctlo" relationshrpr to
phyrrcal actwity, 40
pathological and cytolo_eical changer in
rcsplratory tract of. 284.289
patoperative hypowmia I". 200. 256
portoperatwc pulmonary complications
1".200-201.256

Postural hypoxcmia mechanism in
rymptomauc. 173

ptdmonary alveolar phagocytorls in. 191
tcIa11on between CHD and rerum chol-
cm01 iA, 39

rclalmnrhip to mfectious respiratory dti-
CRY. 198.252-255

rcrum ltpldr I". 37.9498
surfacrant xuwty m !xng, of. 198. 251
type of lung ncoplamr m mdc and
   fcmdc. 276
Smoke r(rcams

CO lcvch ,n na~nsrcam cigar mokc.
486

c~nrtltucnts of tobacco smoke. 484494
rummay' oi previous findmg>, 483, 484
Smoke, tobacco

cffcct dunng pregnancy I" laboratory
anunalr. 428.429

CffCCI of conrutucnts on ptivt vno-
ken.484494

effect on stillbirth rate in l&xatory
animals.439

imtantsm.519.520
pH of, effect of leaf constituents. 594
summary of prcnour findmgs on rck-

llonship to parswe smokmg. 483.484
summsry of recent findings, 504
tumorigenic actwty. 580-584

Smoking

cficct of abstinence in cxercbe ocrfor-
mmcc.611.612.616.617 '
health hazards of, vmdaritwx of cigar-
cites wth little cigar. 594. 595
prevalence of m U.S. and Great Britain.
543.544

see also Passwe rmokmg
Smokmg. cpr

CO levels in mainstream smoke. 486
effect on morl&ly and morbldlty com-

pared to cigarette smoking. 541-543
in esophageal neoplasm developmenr.
567.570-572

garrromtertmal dlrorders and. 592
health consequences of. 549
histolo~al effects on bronchial eplth-

elw".573,574.579
histological effects on esophagus. S;O
histological effects on larynx. 5 67
histologtcal effects on lungs. 587
inhalation patterns and. 554-559
in laryngeal neoplasm development,

567-569

in lung neoplasm development. 553.516
and lung neoplasm mortalrty ratms,
573-57s

mortality ratios from cardiovarular dk
easer and. 585.586
mortality ratios from COPD and. 587.
589

mortality ratios from esophageal nc*
FkS"M and.567.570
mortality ratios from latyngcal nco
plarmr and. 563.566.567
mortahty ra:ior from oral ncoplarml
and.561.563
oral  neoplasm development and.
563-565
overall  mortality rater by amount
smoked. 550-552

overall mortality ratel from ncoplxsms.
559

pr.evaJcncc in Great Britain. 543,544
prevalence I" Umted States. 543,544
summary of previous Gndlngr on cffc~ti.
4.135              :


con~cnml rr-~!mimtmnr and. 450. 45 1
and derclopmcnr of bronchrrir and pncu-
monw I" mimu. 499.500
effect dunn~ pregnmcy. 417456
cffcctonbulh ucighl.4174`8.433436
cffccr on fetal mortahry. 438.439
effect on gcsut,o" dunuon. 417420
cfkct on tacuuon. 452455
effect on "cona~al caboxyhemoglobin
Icrclr.432.433

cffca on sex ratio. 449.450
precclampsu and. 456
sclccrivc acuon on fetus of CcItam wD
men vs. other. 445
timing of ~"flucncc on burh ueehl. 434,
435

SEC olro Prcgmncy
Smokmg. patcrnsl
efrect on Inisnt birth wclghr. 424, 425
Smokmp. pipe

cffei: on mortrhty and morbidity corn--
plrcd to c,~xc,,c rmokmg. 541-543
I" esoph~crJ neoplxm dcvrlopmcnr.
567.510-571

pstromtclliml dlrordcrs and.592
health consequencer of. 549
hi,lologtcal efirctc on bronchhl eplth-
ehurn.513.574.S79
h,srologml effects on ewnhqur. 570
hrrtoiogxal effects on Iu)`"x, 5 67
inhalalmn p&terns and. 554-559
in Ixyngcal ncoplasr~ development.
567-569

in lung neoplasm etiology by r"ou"t
smoked, 573-576

and lung neoplasm mortality rarior.
573-57s

mortzhry rattos from COPD and. 587.

589

mortality ratios from Lvyn@ "eo-
plarmr and. 563.566.567.570
mortahty rat101 from oral ncoplasms,
  561,563
orai  neoplarmr development and,
  563.565
overall  mortahty rates by amount
smoked. 5X-552
overall mortality rates fror" neoplasms
and, 559

pre%alencc m Great Brllain. 543.544
prevdlcnce I" UnIted States. 543.544
pu!momry hlstolopical changes and.587
summ.uy of prewous findmgs on cffecrs
   on smokers. 4.135
Snuff

ord lcslonr from, 313.387.390-391
Socioeconomxr

inCOPV. 178-179.242-243
South Afnca

csophqxal neoplasmr in, reuorpeclive
studier of tobacco "se.404
methods of retrorpeccwe sfudlcs of lung
neopl3rmr I". 354

occupational cxposurc and smoking I&-
tlonrhlr, 10 COPD in. 245

xruu~" l,pld dlffcrenccr 1" smoicrr vs.
   "onsmokers I". 95
SptlJ"l

prcv~lcnce I" pipe and cigu rmokcn.
   590.591
Steam acid

ruspccrcd cuc,nogcn,c agent of c$axrte
smoke, 292

Sttibirrhs

effects of maternal smoking. 438,439
ntts 1" blacks "I. uhltcs. 438.439
in smokers VI. nonrmokcrr. 438,439
Swcdcn

acute effect, of cigearctte smoke on
human pulmonary function. 194
blood pressure differences tn smokers YI.
nonsmokers. 100

CHD mortality and morbidity m. 93
CHD morbadiry in smokers in. 229. 231
effect of c~rcrtc smoke on 3nunals
ciliary function in. 247-250
genetic studies of twrns in. snokang
effcc(s on, 46. 95

laryngeal ncopl~rms in rslationshlp lo
tobacco "se, 382

relatmnrhlp of tobacco use and lip "KY
plasms I". 387

relatlonrhlp of tobacco "se and oral
   cav,ty neoplarms, 390
retrospective studies of esophageal "co-
   plarmr. by tobacco "se. 404
serum lipId dlffcrenccr I" smokers vs.
   nonsmokers of. 95
rmokwg and nicotine effects on human
   cardmvascula system, 11 I
rmohrng and nicotine effecrs on human
   per!phcral varcul~r system, 129
tracheobronchial wee changes I" smokers
   and nonsmokers in. 289
Swimming

effect of smoking, 612.614
Swrzerland

CHD morbidity and mortality I",
smokers vs. nonsmokers, 91
cigarette smoke effects on mice lung and
kidney [issue in, 370
cigarette smoke iohalation effects on
mice respiratory tract. 377
lung neoplasm incidence in cigar and
pipe smokers ofrural. 270
lung ncoplasmr. methods of retrospec-
twc study of smoking m. 351
serum lipld differences in smokers vs.
nonsmokers of. 96

Tachycardia

development in dogs induced by nice-
   tine, 53
Tars. c~garettc

carcmogenlc effect on animal oral cnvi-
tier. 314

carcmogen,cr,y. 290. 291
caranogentc properties on animal skin,
363-368.580-584
Cffect Of lnstlUallOn or implantation in
animal  lracheobronchral  tree.
372-374

effecl on "IIUC md organ cultures,
369-370

654


as hmful component of cigalcrtc
    rmokc. 626.427
summvy of prcvlous lindin3r on effects
   on smokers. 5
Tan. tobacco
dzfi",tlon. 627
in lrttic agus. compared to &~ctte~
   and cigars, 593-596. S98
sarcoma mducnon in mu following in-
    stdlation. 372
  skin  "~OphSl"  induction by, 264,
   363-368.580-584
Tctracthylammonium chloride
blockage of "icotinc cardiac slimu~tion
   by. 53
Throat

effect of cxpowrc to cigarette smokc.in

   pawvc rmoken. 495
ThromboanPut~ obliterans

ccssa~o~ of smoking. and remission. 70
dcfimtion. 69

fobacco allergy and. 521
mombosis

rmokmg znd, 62. 1X-128
ThIombus *oImatlOn
and smokxg. 154
Tlssuc ctiturer

effect of cigarette smoke on. 293.
   369-371
Tobacco

anr~gemuc properties of. 5 14
antigens, in smokers VI. nonsmokers, 5 17
curmg methods. and mcidence of respira-
tory infections in rats. 588, S89
effect on immune rcsponwr. 517-5 19
tluesued vs. air<ured. effect on rcspua-
tory system m animals, 587,588
pharmacolo@c. uritafive. and allergic ef-
fects, 5 19.521

Tobacco chewing
lip ncophsmr from. 387-3k9.391.392
oral ncoplasms from. 387-389.391-392
Tobacco extracts
anugenic properties, 5 14.5 IS
effect on skm. 5 IS-5 17
irr1tantsm.514.515
thromboan@tls obhterann and. 521
Tobacco Icafcomponcnts
anugcn1c properucr, 514.515
prcwnce of potassium, 292
Tobacco. pipe
dcfmttion and proccuing, 546
Tongue
hamster. C-14 ldbcled particulate dcposr-
   Lion m. 307-308

Trachu

hamncr. C-14 Lbelcd part~cuL~.c dcpos,.
tmn L". 307.308

Trcadmdl poformancc
clrdrovluutax puamctcrs in smokers VI.
   nonrmoicrr, 269-21 I
effect of \,camm C. 271
oxygen mtakc in smokcn vs. "OR
   smokers. 27 I
Tiiglyccndcr

coronary dlwaw relationship to. 61
smokers vs. nonsmokers, 95-96. 98
Twptophan mcubolirm
altcratio~~ by smoking, 323

carcmogc:cruc,ty i" nuce bladders. 322
rcl.al~on of CXCICEO,, ,n mokzr, and
   nanrmokcrs. 323
Tubcrculor,,
in  smokers VI.  nonsmokrn.  198.
   252-254
T-A-i",

nngma pcctoris development in. rmoklng
cflccu on, 46-47
gcnctrc studies of xmoldng cffccts on,
4S48

monality from CHD. in mokcn vs.
nonsmokers, 136.137
smoking effect% on morttity and morbi-
dity in, 41

United Kingdom

bhdder ncoplasms in. mcthods i? rcuo-
spawc studies of smokmg and.
408-410

blood prcrsurc differcnccr in Ynokcn VI.
nonsmokers in. 99, 100
cicrette smoke effects on animal cdtarv

ciguette smoke effects on huma" fetal
lung and mlcc trachea. 370
ciguettc smoke effects on human pul-
monaxy funcuon, 194.195
cipre!re smoke eifccts on mice respira-
tory tract. 378

cigarette smoke implantation effects on
rat t:achcobro"chwl ucc in. 372-373
COPD morbtdlly r" smokers m. 221-223.

229. 230

kidney and bladder ncoplasms in

smokers in, 320

lury "eoplasms mortality in males in
England and Wales. 266
methods of rcuorpcctivc study of lung
neoplasms and smokmg I", 350, 352
mortality from cerebrovawular disease
related to snokmg in. 64
mortality rates from COPD in. kck of
increaw, 166

mortality ratios from esophageal nc*
pkrmr in, 316

mortality ratios rrom laryngeal "co-
pLsms in. 304

occupational exposure and smokingrek-
tlonships to COPD in, 244-245
physicians m. decline in cigarette smok-
ing rater, 44

physiaans in. mortality from lung new
pksms in smokers and nonsmoken,
267

pulmonary function in. c$arette smoke
effects on, 194

relauonshlp of lung neopksms to smok-
ins. au poiluuon, and rcudencc in,
279-2HO

rel~bonshrp of smoking and tuberculosis
in, 252

scmm bpld diffcrenccr in smokers vs.
nonrmokcrs I". 91.98
rmokmg and "lcotmc elfccts on animal
cardlovarcular funcho" in, 103
rmokmg and "~cotmc &ecu on human
blood hplds m. 122

655


acute cffcct of clguette smoke on hu-
rn." pulmonary funcuon m.
  192.193.195

blood prcl,urc diffcrcnccr in nnokcrs n.
nonsmokers in, 99.100
CHD mortnhty and morbidity in
smokers vs. nonmokcrr in, 26-31.
33,89-91

cigarcue smoke effccu on antial diary
funcnon in. 247-250

crgarene smoke cffccts on animal tiwucl
in. X69-371

cigarette smoke cffect~ on pulmonary
surfaaanu and surface tension, 198.
251

ciparcttc smoke implantation effects on
animal  tracheobronchial txc,

372.374

cigarrtrc rmokc inhalaiion effects on
animal msptia1ory tract,, 375-376.
378.380

COPD morbidity in smokers. 221. 222,
224-226.227-228,231

esophageal neopksrns in, retrospective
studier of tobacco use. 404

csophqeal oeoplasmr mortity in. in
  1967.315

human pulmonary function following
ccssaoon of smoking in. 175
kidney and bladder neopksms in
smokers in. 319-321

laryngeal neoplasms incidence in 1967,
303

laryngeal ncopksms in, rclationshipr to
  tobacco "se. 304-305.380-381
lung neopkumr mortality rates in,
smokers and nonsmokers in. 266269
methods of retrospective study of lung
neoplasm, and smoking in. 349.354
mortality from sonic aneurysm r&ted
to rmokulg in, 67

mmtdity from cercbrovnwular d&s
related to smoking. 6466
mortality rater for bladder neoplamrs in

1967.319

mortiiy rates for COPD, 165-l 66
mortiity rater for kidney neophrms in
  1967.322

mortality raics for lung ncoplarms ex-
pested in 1970,263,265
mortahty rates for lung neoplarmr in
1939 vs. 1961.2b.S

mortality ratios for COPD, 166-l 71
mortality ratios for elophagcal nce
plzmr in. 3 16-320

mondiry ratbar for laryngcd neopbm~,
  304-305

mortality ratios for pancreatic nropksmr
in rmokur md nonrmokerr rn. 324

,,o~on,um-210 `svcb in lung of nokas
in. 361-362

r&co&up of human pul~oruy hitcl-
ogy and smoking in. 181-153
relationxhip of lung neoplamu to mok-
ing. au poUution. and rctidcnce i%
279-280

rck3tionship of noking to i-Jccuow
rcspuatory disca.ws in. 253-25s
rclatiodup of tobacco use md lip nc*
plzsml. 387-391,393
relationship of tobacco use and MC-
phsmr of oral awn. 387-391. 393
ICN~ hpid dlffercnca in anoken v).
nonrmokcn in. 94.96,97
smokmg and nrcotinc effects on anlnll
cudiovauu~ function ~1. 103.lC8
smoking and mcotmc effects on humln
blood lipids, 119-122
smoking and nicotmc cffccts on human
cardiovawukr system. 109-110. 112,
  113-115

,mokmg and nicoti,c effects on human
catccholammc levch, IIS
smoking and nrcofix effects on hurra
pcnpheral varulx system, 129-135
smokmg relationshIp to rhrombosir LT.
126. I27

trachcobronchial tree change3 in mokcn
   and nonsmokers in. 205-289
Uramum miners
lung neophsms in, 282
Urban =rcu

lung neoplasm raies in. 302
relationship of lung neoplasms. smoking,
   air pollution to, 278-281
Urban populat]onx
lung neoplarmr in. suspected etiology of
   innewd. 302

periphcr& rmoking and nicotine effect
   on.6849, 71.129-130
VCtltildtiO~

effectl on constituents of tobwxl
smoke, 486-lPl

Ventilatory function
effect of exercise and smoking. 614.6 15
Ventricular fibrillation
death from. nicotme effects on, 32
Venticular premature beats
effect of cigarctle smoking. 142
ViruSCS

hflucnza. cigarcrte rmokc effects on
   resistance of mtce wth. 199
innucnra,  niti~e:en oxide effects on
   squlnel monkey resxtance to. 199
Vitamin B 12

in pregnant smoken VL nonsmoker,, 433
Vitamin C

cffcct on treadmill pafomw,ce i,,
smokers YI. nonanokcn. 615


in milk of smokmmq mothcrr. 455          sumrn~~y of prcrious fiidings on effects
in prqmnt smokers VI. mnvnoiers, 433        of smokmg. 5-7

657