Yudin N, Potapova T, Naykova T, Ivanov S, Kobzev V, Romaschenko A, Voevoda M; Keystone Symposia on Molecular and Cellular Biology: 1998 HIV Pathogenesis and Treatment.
Keyst Symp Mol Cell Biol Keyst Symp Mol Cell Biol. 1998 Mar 13-19; 80 (abstract no. 3086).
Institute of Cytology and Genetics of the Russian Academy of Sciences, Siberian Branch, Novosibirsk, Russia.
A 32-base pair inactivating deletion in the beta-chemokine receptor 5 (CCR5) gene, common for Northern European populations, is associated with reduced HIV-1 transmission risk and delayed desease progression. We used a PCR approach to study deletion distribution among 531 individuals representing mainly West and East Siberian. Central Asian and Far Eastern parts of Russia. The distribution of the deletion in populations of these regions remained to be done and is the subject of much current interest of epidemiologists and population geneticists due to their crucial role in the origin and spread of this mutation. The frequency of the deltaccr5 allele in Siberian Russians is similar to that reported for West European countries. The most interesting finding is the high frequency of the deleted variant in natives of West Siberia, of the Finno-Ugrian decent (11.1%). Among them Komi, Mordvinian and Mari represent Finnic speakers branch which originally resided primarily in Europe between the Volga river and Ural Mountains. Khanty and Mansi are representatives of the Ugric branch, which resided in the West Siberia roughly from Ural Mountains in the west to the Enisei river basin in the east. The very high value of the deltaccr5 (17.9%) in the finnic group of Komi, Mordvinian, and Mari exceeds that for North European populations and approaches the value for European Ashkenazi Jews (Martinson et al., 1997). It is unclear at present whether it may be attributed to population history or is a consequence of small sample size. Nevertheless, the fact that the deltaccr5 is relatively widespread in the natives of the North-East boundary between Europe and Asia is obvious. In contrast, further to the east among indigenous populations of Central Asia, East Siberia, Russian Far East and Canada negligible frequencies of the CCR5 gene deletion were found. Sporadic occurrence throughout the entire region apparently may be attributed to gene flow from European descendants as supported by study of mixed populations. In conclusion, our study shows that the deltaccr5 distribution in native populations is limited primarily to Europe with a sharp negative gradient towards the east along the territory of Russian Eurasia.
Publication Types:
Keywords:
- Alleles
- Asia
- Asia, Central
- Base Pairing
- Canada
- Ethnic Groups
- Europe
- European Continental Ancestry Group
- Far East
- Gene Deletion
- Genetics, Population
- HIV-1
- Polymerase Chain Reaction
- Population
- Receptors, CCR5
- Receptors, Chemokine
- Russia
- Siberia
- genetics
Other ID:
UI: 102236849
From Meeting Abstracts