Energy Citations Database

Bibliographic Citation

 
Document
For copies of Journal Articles, please contact the Publisher or your local public or university library and refer to the information in the Resource Relation field.
For copies of other documents, please see the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or Document Availability.
Title EARLY EFFECTS OF X IRRADIATION ON THE PERMEABILITY OF EXCISED AND LIVING AORTA WALL
Creator/Author Brinkman, R. ; Lamberts, H.B. ; Bottema, J.K.
Publication Date1960 Jan 01
OSTI IdentifierOSTI ID: 4679842
Resource TypeJournal Article
Resource RelationKoninkl. Ned. Akad. Wetenschap., Proc., Ser. C; Vol: 64
Research OrgUniv. of Groningen, Netherlands
SubjectBIOLOGY AND MEDICINE; AMINES; BIOCHEMISTRY; BLOOD VESSELS; BODY; CHEMICALS; CONGO RED; DIFFUSION; DYES; ITALY; QUANTITY RATIO; RADIATION DOSES; RADIATION EFFECTS; RADIATION PROTECTION; RATS; SODIUM SULFATES; SULFATES; THIOSULFATES; X RADIATION
Description/Abstract Experiments are reported that demonstrate an increase of permeability of aortic tissue after irradiation, presumably as a result of the depolymerization of mucopolysaccharides (MPS). A drop in injection pressure of the aorta followed irradiation with 500 r. The increased permeability of irradiated aorta could also be demonstrated by a dye technique in which infiltration of trypan blue into the intima was demonstrated. Penetration of dye following irradiation was diminished if physiologic pressure in the lumen was maintained. In rats the increased aortic infiltration could be demonstrated readily. If the rat received 1000 to 3000 r whole-body x irradiation, was injected 10 min later intravenously with 0.4 ml/100 g of a 1% solution of Congo red in 5% glucose, and was killed after 30 min, the aorta of the irradiated rat was distinctly more stained than that of nonirradiated animals, indicating increased macromolecular infiltration through the mucopolysaccharide barrier. If 1 mg/g sodium thiosulfate was given subcutaneously just before irradiation, the aorta was completely protected. No consistent protective effect was demonstrated with aminoethylisothiuronium, cysteamine, cystamine, or serotonin. (TCO)
LanguageEnglish
FormatPages: 449-53
System Entry Date2001 Jun 03

Top