From: Tatusov, Roman (NIH/NLM/NCBI)
Sent: Monday, March 01, 2004 8:14 PM
To: ncbi-seminar@ncbi.nlm.nih.gov
Subject: NCBI Seminar - Tuesday, March 2, 11 am

Tuesday, March 2, 11 AM,
Building 38A, 5th floor conference room

COGs: Hierarchical approach
Roman Tatusov, NCBI

The avalanche of finished complete genomes calls for novel approach to collect orthologous genes and visualize clusters.
The tight monophyletic subset of proteins (MIG - mini group) are central in modern COGs arrangement. MIGs are constructed automatically using efficient algorithm for closely related species. The procedure was employed in updating unicellular and eukaryotic C/KOGs. In KOGs the most significant additions are Mus musculus and Rattus norvegicus genomes. They underline the magnitude of mammalian presence in current version of KOGs.

Fungi (Ascomycota) genomes play important role in connecting two COG partitions (unicellular and eukaryotic clusters).
The availability of Neurospora crassa, a representative of the 3rd subphylum of Ascomycota phylum makes this link more presentable. The MIG procedure was employed to assemble FUGs (Fungi groups) associated with COGs and KOGs.