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Title Uptake and distribution of (/sup 3/H)benzo(a)pyrene in the Northern pike (Esox lucius). Examination by whole-body autoradiography and scintillation counting
Creator/Author Balk, L. ; Meijer, J. ; DePierre, J.W. ; Appelgren, L.E.
Publication Date1984 Jul 01
OSTI IdentifierOSTI ID: 6303933
Other Number(s)CODEN: TXAPA
Resource TypeJournal Article
Resource RelationToxicol. Appl. Pharmacol. ; Vol/Issue: 74:3
Research OrgUniv. of Stockholm, Sweden
Subject560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987) ;550501 -- Metabolism-- Tracer Techniques; ;BENZOPYRENE-- METABOLISM;BENZOPYRENE-- TISSUE DISTRIBUTION;BENZOPYRENE-- UPTAKE;TRITIUM COMPOUNDS-- AUTORADIOGRAPHY; BILE;FISHES;KIDNEYS;LIVER;SCINTILLATION COUNTING;SKIN;TRACER TECHNIQUES;URINE
Related SubjectANIMALS;AQUATIC ORGANISMS;AROMATICS;BIOLOGICAL MATERIALS;BIOLOGICAL WASTES;BODY;BODY FLUIDS;CONDENSED AROMATICS;COUNTING TECHNIQUES;DIGESTIVE SYSTEM;DISTRIBUTION;GLANDS;HYDROCARBONS;ISOTOPE APPLICATIONS;LABELLED COMPOUNDS;MATERIALS;ORGANIC COMPOUNDS;ORGANS;VERTEBRATES;WASTES
Description/Abstract The uptake and distribution of the polyaromatic hydrocarbon benzo(a)pyrene in Northern pike (Esox lucius) were investigated by whole body autoradiography and scintillation counting.^(/sup 3/H)Benzo(a)pyrene was administered either in the diet or in the water.^The uptake and distribution of this compound and its metabolites were followed from 10 hr to 21 days after the initial exposure.^The autoradiography patterns observed here with both routes of administration suggest, as expected, that benzo(a)pyrene is taken up through the gastrointestinal system and the gills, metabolized in the liver, and excreted in the urine and bile.^Other findings indicate that the gills may not be a major route of excretion for benzo(a)pyrene and its metabolites in the Northern pike; that benzo(a)pyrene may be taken up from the water directly into the skin of this fish; that benzo(a)pyrene and its metabolites are heterogeneously distributed in the kidney of the Northern pike; and that very little radioactivity accumulates in the adipose tissue.^With scintillation counting, uptake of radioactivity from the water was found to occur rapidly in all organs, reaching a plateau in most cases after about 0.8 days.^The concentrations of radioactivity in different organs ranged between 50 (many organs) and 80,000 (gallbladder + bile) times that found in the surrounding water.
Country of PublicationUnited States
LanguageEnglish
FormatPages: 430-449
System Entry Date2001 May 13

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