JONES RN, PFALLER MA, ERWIN ME, BEACH ML; Interscience Conference on Antimicrobial Agents and Chemotherapy.
Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 1999 Sep 26-29; 39: 264 (abstract no. 1263).
C.A.S.T., Inc., Iowa City, IA.
Linezolid, formerly U-100766, is a novel 4-morpholinyl-substituted oxazolidinone with a spectrum against gram-positive species and a few fastidious gram-negative organisms. Earliest reports (Iowa, 1996) demonstrated consistent potency against stock collections of susceptible and multi-resistant staphylococci, streptococci and Enterococcus spp. This investigation used 7,599 recent clinical strains (1998-99), isolated from documented clinical infections from >50 hospital laboratories in North and South America. Organisms were tested by NCCLS (1997) reference broth microdilution procedures and in media appropriate for the species processed. All quality control results were within NCCLS published ranges. Selected comparison drugs were quinupristin/dalfopristin (Q/D), vancomycin (VANCO) and some penicillins or fluoroquinolones. The linezolid activity (no. tested/MIC[90] in microg/ml/%
Publication Types:
Keywords:
- Acetamides
- Enterococcus
- Iowa
- Microbial Sensitivity Tests
- Oxazolidinones
- Research Design
- South America
- Staphylococcus
- Streptococcus
- Virginiamycin
- dalfopristin
- linezolid
- quinupristin
Other ID:
UI: 102245293
From Meeting Abstracts