1.0 Submitter/Company Information
Submitting Company: PROCTOR & GAMBLE CO

Submitter Comments


2.0 Submission Information

EPA Receipt Date: 08/31/92

8(e)/FYI ID Number: 8EHQ-0892-08818 A

Submission Stage: INI

Document Control Number: 88920007231

Microfiche Number: OTS0545540

3.0 Chemical Information
CAS Number: 68131-39-5

TSCA Chemical Inventory Name: Alcohols, C12-15, ethoxylated

Synonyms: ETHOXYLATED ALCOHOLS (C12-C15)

Other Chemicals in Submission:

4.0 Study Information
Study Title:
INITIAL SUBMISSION: IRWIN DOSE RANGE STUDY-SUMMARY REPORT WITH COVER LETTER DATED 081092

Study Information:
Acute/Subacute Toxicity
Unknown Environmental Effects

Summary/Abstract:
ACUTE INTRAPERITONEAL (IP) TOXICITY IS MODERATE BASED ON 75% (3/4) MORTALITY AT
100 MG/KG. DOSES (MG/KG) AND CORRESPONDING MORTALITY WERE 32 (0/4), 100 (3/4),
316 (4/4), AND 3160 (4/4). SIGNS OF NEUROTOXICITY 15 MINUTES POST-DOSING
INCLUDED MARKED RESPIRATORY DEPRESSION, LOSS OF RIGHTING REFLEX, AND PARALYSIS
(ALL DOSES); CONVULSING (100, 316); TWITCHING (100, 316, 1000); AND ABNORMAL
CARRIAGE AND GAIT (AT OR ABOVE 100). MARKED INFLAMMATION OF THE SMALL
INTESTINE AND PALENESS OF THE LIVER AND KIDNEYS WAS SEEN.