NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08 LAB: Southern Research Inst RHODAMINE 6G DATE: 09/07/94 EXPERIMENT: 05048 TEST: 01 TIME: 00:08:31 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1 CONT: N01-ES-28024 ROUTE: DOSED FEED NTP C#: 56122 PATHOLOGIST: H. GILES CAS: 989-38-8 ------------------------------------------------------------------------------------------------------------------------------------ REASONS FOR REMOVAL: ALL REMOVAL DATE RANGE: ALL TREATMENT GROUPS: INCLUDE ALL NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08 LAB: Southern Research Inst RHODAMINE 6G DATE: 09/07/94 EXPERIMENT: 05048 TEST: 01 TIME: 00:08:31 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE CONT: N01-ES-28024 ROUTE: DOSED FEED NTP C#: 56122 PATHOLOGIST: H. GILES CAS: 989-38-8 RATS(FISCHER344) ---------------------------- FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED. IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED. ---------------- Adrenal Gland Bone Marrow Brain Clitoral Gland Epididymis Heart Islets, Pancreatic Kidney Liver Lung Nose Ovary Pancreas Parathyroid Gland Pituitary Gland Preputial Gland Prostate Salivary Glands Spleen Testes Thymus Thyroid Gland Urinary Bladder NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08 LAB: Southern Research Inst RHODAMINE 6G DATE: 09/07/94 EXPERIMENT: 05048 TEST: 01 TIME: 00:08:31 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE CONT: N01-ES-28024 ROUTE: DOSED FEED NTP C#: 56122 PATHOLOGIST: H. GILES CAS: 989-38-8 SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS IN THE ANALYSIS OF THE STUDY OF RHODAMINE 6G ==================================================================================================== MALE RATS ------------- ORGAN MORPHOLOGY ------- ------------ Liver Hepatocellular Carcinoma or Hepatocellular Adenoma Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma Skin Keratoacanthoma Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma Thyroid Gland: C-Cell Carcinoma or Adenoma All Organs Malignant Tumors ==================================================================================================== FEMALE RATS ------------- ORGAN MORPHOLOGY ------- ------------ Adrenal Medulla Pheochromocytoma Benign Pheochromocytoma: Benign, Complex, Malignant, NOS Uterus Sarcoma Stromal ==================================================================================================== DATE: 09/07/94 EXPERIMENT: 05048 TEST: 01 PAGE 1 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- RHODAMINE 6G TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | UNTREATD 0.012% 0.025% | UNTREATD 0.012% 0.025% | | | CONTROL | CONTROL | |=================================================================================================================================| | | |Adrenal Cortex | | Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/50 (2%) 0/49 (0%) 0/50 (0%) | 1/50 (2%) 3/50 (6%) 0/50 (0%) | |ADJUSTED (b) | 2.2% 0.0% 0.0% | 3.4% 7.6% 0.0% | |TERMINAL (d) | 0/22 (0%) 0/21 (0%) 0/27 (0%) | 1/29 (3%) 1/30 (3%) 0/30 (0%) | |FIRST INCIDENCE (DAYS) | 603 --- --- | 734 (T) 638 --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.287N P=0.500N P=0.504N | P=0.376N P=0.324 P=0.493N | |INCIDENTAL TUMOR | P=0.428N P=0.581N P=0.718N | P=0.347N P=0.349 P=0.493N | |LOGISTIC REGRESSION | P=0.188N P=0.438N P=0.412N | P=0.363N P=0.289 P=0.493N | |COCHRAN-ARMITAGE | P=0.284N | P=0.367N | |FISHER EXACT | P=0.505N P=0.500N | P=0.309 P=0.500N | |=================================================================================================================================| | | |Adrenal Medulla | | Pheochromocytoma Benign | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 18/50 (36%) 25/49 (51%) 23/50 (46%) | 3/50 (6%) 3/50 (6%) 8/50 (16%) | |ADJUSTED (b) | 55.0% 72.0% 61.3% | 10.3% 8.1% 22.7% | |TERMINAL (d) | 9/22 (41%) 12/21 (57%) 13/27 (48%) | 3/29 (10%) 1/30 (3%) 4/30 (13%) | |FIRST INCIDENCE (DAYS) | 585 639 629 | 734 (T) 638 531 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.435 P=0.101 P=0.435 | P=0.070 P=0.639N P=0.120 | |INCIDENTAL TUMOR | P=0.160 P=0.086 P=0.167 | P=0.048 * P=0.620N P=0.067 | |LOGISTIC REGRESSION | P=0.185 P=0.081 P=0.203 | P=0.053 P=0.644N P=0.092 | |COCHRAN-ARMITAGE | P=0.191 | P=0.059 | |FISHER EXACT | P=0.096 P=0.208 | P=0.661N P=0.100 | |=================================================================================================================================| DATE: 09/07/94 EXPERIMENT: 05048 TEST: 01 PAGE 2 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- RHODAMINE 6G TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | UNTREATD 0.012% 0.025% | UNTREATD 0.012% 0.025% | | | CONTROL | CONTROL | |=================================================================================================================================| | | |Adrenal Medulla | | Pheochromocytoma Malignant | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 10/50 (20%) 8/49 (16%) 5/50 (10%) | 0/50 (0%) 0/50 (0%) 2/50 (4%) | |ADJUSTED (b) | 34.8% 27.3% 18.5% | 0.0% 0.0% 6.7% | |TERMINAL (d) | 5/22 (23%) 3/21 (14%) 5/27 (19%) | 0/29 (0%) 0/30 (0%) 2/30 (7%) | |FIRST INCIDENCE (DAYS) | 694 643 733 (T) | --- --- 734 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.065N P=0.459N P=0.072N | P=0.097 (e) P=0.245 | |INCIDENTAL TUMOR | P=0.100N P=0.413N P=0.096N | P=0.097 (e) P=0.245 | |LOGISTIC REGRESSION | P=0.091N P=0.432N P=0.097N | P=0.097 (e) P=0.245 | |COCHRAN-ARMITAGE | P=0.107N | P=0.095 | |FISHER EXACT | P=0.416N P=0.131N | (e) P=0.247 | |=================================================================================================================================| | | |Adrenal Medulla | | Pheochromocytoma: Benign, Complex, Malignant, NOS | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 23/50 (46%) 27/49 (55%) 26/50 (52%) | 3/50 (6%) 3/50 (6%) 10/50 (20%) | |ADJUSTED (b) | 67.8% 75.7% 69.6% | 10.3% 8.1% 28.6% | |TERMINAL (d) | 12/22 (55%) 13/21 (62%) 16/27 (59%) | 3/29 (10%) 1/30 (3%) 6/30 (20%) | |FIRST INCIDENCE (DAYS) | 585 639 629 | 734 (T) 638 531 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.463N P=0.228 P=0.513N | P=0.021 * P=0.639N P=0.047 * | |INCIDENTAL TUMOR | P=0.281 P=0.215 P=0.324 | P=0.013 * P=0.620N P=0.024 * | |LOGISTIC REGRESSION | P=0.315 P=0.209 P=0.352 | P=0.014 * P=0.644N P=0.032 * | |COCHRAN-ARMITAGE | P=0.316 | P=0.017 * | |FISHER EXACT | P=0.241 P=0.345 | P=0.661N P=0.036 * | |=================================================================================================================================| DATE: 09/07/94 EXPERIMENT: 05048 TEST: 01 PAGE 3 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- RHODAMINE 6G TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | UNTREATD 0.012% 0.025% | UNTREATD 0.012% 0.025% | | | CONTROL | CONTROL | |=================================================================================================================================| | | |Bone | | Osteosarcoma or Osteoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) | 1/50 (2%) 1/50 (2%) 0/50 (0%) | |ADJUSTED (b) | 0.0% 0.0% 5.9% | 2.3% 2.0% 0.0% | |TERMINAL (d) | 0/22 (0%) 0/21 (0%) 0/27 (0%) | 0/29 (0%) 0/30 (0%) 0/30 (0%) | |FIRST INCIDENCE (DAYS) | --- --- 657 | 626 569 --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.113 (e) P=0.266 | P=0.342N P=0.748N P=0.509N | |INCIDENTAL TUMOR | P=0.073 (e) P=0.199 | P=0.193N P=0.677N P=0.362N | |LOGISTIC REGRESSION | P=0.094 (e) P=0.237 | P=0.255N P=0.647 P=0.467N | |COCHRAN-ARMITAGE | P=0.095 | P=0.334N | |FISHER EXACT | (e) P=0.247 | P=0.753N P=0.500N | |=================================================================================================================================| | | |Clitoral/Preputial Gland | | Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/49 (4%) 3/48 (6%) 2/43 (5%) | 5/42 (12%) 4/40 (10%) 2/39 (5%) | |ADJUSTED (b) | 6.8% 14.3% 4.4% | 17.0% 12.5% 5.0% | |TERMINAL (d) | 1/22 (5%) 3/21 (14%) 0/25 (0%) | 4/27 (15%) 2/24 (8%) 0/25 (0%) | |FIRST INCIDENCE (DAYS) | 620 733 (T) 468 | 667 657 623 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.554N P=0.487 P=0.676N | P=0.199N P=0.537N P=0.245N | |INCIDENTAL TUMOR | P=0.554N P=0.460 P=0.660N | P=0.201N P=0.549N P=0.238N | |LOGISTIC REGRESSION | P=0.515 P=0.485 P=0.636 | P=0.196N P=0.535N P=0.247N | |COCHRAN-ARMITAGE | P=0.547 | P=0.195N | |FISHER EXACT | P=0.490 P=0.641 | P=0.532N P=0.248N | |=================================================================================================================================| DATE: 09/07/94 EXPERIMENT: 05048 TEST: 01 PAGE 4 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- RHODAMINE 6G TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | UNTREATD 0.012% 0.025% | UNTREATD 0.012% 0.025% | | | CONTROL | CONTROL | |=================================================================================================================================| | | |Clitoral/Preputial Gland | | Carcinoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/49 (4%) 4/48 (8%) 4/43 (9%) | 1/42 (2%) 4/40 (10%) 3/39 (8%) | |ADJUSTED (b) | 4.9% 10.8% 13.1% | 2.4% 12.7% 10.3% | |TERMINAL (d) | 0/22 (0%) 0/21 (0%) 2/25 (8%) | 0/27 (0%) 2/24 (8%) 2/25 (8%) | |FIRST INCIDENCE (DAYS) | 661 619 667 | 661 603 635 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.310 P=0.298 P=0.367 | P=0.242 P=0.179 P=0.279 | |INCIDENTAL TUMOR | P=0.182 P=0.335 P=0.300 | P=0.262 P=0.191 P=0.309 | |LOGISTIC REGRESSION | P=0.191 P=0.337 P=0.265 | P=0.229 P=0.167 P=0.273 | |COCHRAN-ARMITAGE | P=0.222 | P=0.234 | |FISHER EXACT | P=0.329 P=0.278 | P=0.165 P=0.280 | |=================================================================================================================================| | | |Clitoral/Preputial Gland | | Carcinoma or Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 4/49 (8%) 7/48 (15%) 6/43 (14%) | 6/42 (14%) 8/40 (20%) 5/39 (13%) | |ADJUSTED (b) | 11.3% 23.5% 16.8% | 19.0% 24.3% 14.8% | |TERMINAL (d) | 1/22 (5%) 3/21 (14%) 2/25 (8%) | 4/27 (15%) 4/24 (17%) 2/25 (8%) | |FIRST INCIDENCE (DAYS) | 620 619 468 | 661 603 623 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.375 P=0.235 P=0.407 | P=0.485N P=0.357 P=0.546N | |INCIDENTAL TUMOR | P=0.265 P=0.242 P=0.374 | P=0.472N P=0.356 P=0.521N | |LOGISTIC REGRESSION | P=0.198 P=0.253 P=0.217 | P=0.496N P=0.349 P=0.558N | |COCHRAN-ARMITAGE | P=0.245 | P=0.491N | |FISHER EXACT | P=0.250 P=0.289 | P=0.347 P=0.553N | |=================================================================================================================================| DATE: 09/07/94 EXPERIMENT: 05048 TEST: 01 PAGE 5 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- RHODAMINE 6G TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | UNTREATD 0.012% 0.025% | UNTREATD 0.012% 0.025% | | | CONTROL | CONTROL | |=================================================================================================================================| | | |Islets, Pancreatic | | Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/50 (2%) 3/49 (6%) 4/50 (8%) | 2/48 (4%) 0/49 (0%) 0/50 (0%) | |ADJUSTED (b) | 4.5% 13.1% 13.1% | 6.3% 0.0% 0.0% | |TERMINAL (d) | 1/22 (5%) 2/21 (10%) 3/27 (11%) | 1/28 (4%) 0/30 (0%) 0/30 (0%) | |FIRST INCIDENCE (DAYS) | 733 (T) 720 643 | 695 --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.196 P=0.293 P=0.237 | P=0.100N P=0.224N P=0.235N | |INCIDENTAL TUMOR | P=0.141 P=0.297 P=0.161 | P=0.120N P=0.232N P=0.291N | |LOGISTIC REGRESSION | P=0.155 P=0.289 P=0.187 | P=0.099N P=0.224N P=0.235N | |COCHRAN-ARMITAGE | P=0.137 | P=0.098N | |FISHER EXACT | P=0.301 P=0.181 | P=0.242N P=0.237N | |=================================================================================================================================| | | |Islets, Pancreatic | | Carcinoma or Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/50 (4%) 4/49 (8%) 5/50 (10%) | 3/48 (6%) 0/49 (0%) 1/50 (2%) | |ADJUSTED (b) | 9.1% 17.7% 15.9% | 9.7% 0.0% 3.3% | |TERMINAL (d) | 2/22 (9%) 3/21 (14%) 3/27 (11%) | 2/28 (7%) 0/30 (0%) 1/30 (3%) | |FIRST INCIDENCE (DAYS) | 733 (T) 720 643 | 695 --- 734 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.255 P=0.317 P=0.296 | P=0.178N P=0.110N P=0.290N | |INCIDENTAL TUMOR | P=0.186 P=0.321 P=0.204 | P=0.202N P=0.115N P=0.335N | |LOGISTIC REGRESSION | P=0.200 P=0.318 P=0.230 | P=0.181N P=0.106N P=0.298N | |COCHRAN-ARMITAGE | P=0.173 | P=0.179N | |FISHER EXACT | P=0.329 P=0.218 | P=0.117N P=0.293N | |=================================================================================================================================| DATE: 09/07/94 EXPERIMENT: 05048 TEST: 01 PAGE 6 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- RHODAMINE 6G TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | UNTREATD 0.012% 0.025% | UNTREATD 0.012% 0.025% | | | CONTROL | CONTROL | |=================================================================================================================================| | | |Liver | | Hepatocellular Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 4/50 (8%) 0/50 (0%) 6/50 (12%) | 0/50 (0%) 1/49 (2%) 0/50 (0%) | |ADJUSTED (b) | 18.2% 0.0% 20.7% | 0.0% 2.7% 0.0% | |TERMINAL (d) | 4/22 (18%) 0/21 (0%) 5/27 (19%) | 0/29 (0%) 0/29 (0%) 0/30 (0%) | |FIRST INCIDENCE (DAYS) | 733 (T) --- 680 | --- 700 --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.352 P=0.066N P=0.491 | P=0.730N P=0.517 (e) | |INCIDENTAL TUMOR | P=0.342 P=0.066N P=0.477 | P=0.690 P=0.500 (e) | |LOGISTIC REGRESSION | P=0.315 P=0.066N P=0.443 | P=0.729N P=0.495 (e) | |COCHRAN-ARMITAGE | P=0.259 | P=0.727N | |FISHER EXACT | P=0.059N P=0.370 | P=0.495 (e) | |=================================================================================================================================| | | |Liver | | Hepatocellular Carcinoma or Hepatocellular Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 5/50 (10%) 0/50 (0%) 6/50 (12%) | 0/50 (0%) 1/49 (2%) 0/50 (0%) | |ADJUSTED (b) | 22.7% 0.0% 20.7% | 0.0% 2.7% 0.0% | |TERMINAL (d) | 5/22 (23%) 0/21 (0%) 5/27 (19%) | 0/29 (0%) 0/29 (0%) 0/30 (0%) | |FIRST INCIDENCE (DAYS) | 733 (T) --- 680 | --- 700 --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.517 P=0.034N* P=0.626N | P=0.730N P=0.517 (e) | |INCIDENTAL TUMOR | P=0.507 P=0.034N* P=0.622 | P=0.690 P=0.500 (e) | |LOGISTIC REGRESSION | P=0.477 P=0.034N* P=0.588 | P=0.729N P=0.495 (e) | |COCHRAN-ARMITAGE | P=0.405 | P=0.727N | |FISHER EXACT | P=0.028N* P=0.500 | P=0.495 (e) | |=================================================================================================================================| DATE: 09/07/94 EXPERIMENT: 05048 TEST: 01 PAGE 7 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- RHODAMINE 6G TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | UNTREATD 0.012% 0.025% | UNTREATD 0.012% 0.025% | | | CONTROL | CONTROL | |=================================================================================================================================| | | |Liver | | Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 5/50 (10%) 0/50 (0%) 6/50 (12%) | 0/50 (0%) 1/49 (2%) 0/50 (0%) | |ADJUSTED (b) | 22.7% 0.0% 20.7% | 0.0% 2.7% 0.0% | |TERMINAL (d) | 5/22 (23%) 0/21 (0%) 5/27 (19%) | 0/29 (0%) 0/29 (0%) 0/30 (0%) | |FIRST INCIDENCE (DAYS) | 733 (T) --- 680 | --- 700 --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.517 P=0.034N* P=0.626N | P=0.730N P=0.517 (e) | |INCIDENTAL TUMOR | P=0.507 P=0.034N* P=0.622 | P=0.690 P=0.500 (e) | |LOGISTIC REGRESSION | P=0.477 P=0.034N* P=0.588 | P=0.729N P=0.495 (e) | |COCHRAN-ARMITAGE | P=0.405 | P=0.727N | |FISHER EXACT | P=0.028N* P=0.500 | P=0.495 (e) | |=================================================================================================================================| | | |Lung | | Alveolar/Bronchiolar Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/50 (4%) 0/50 (0%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | |ADJUSTED (b) | 5.3% 0.0% 3.7% | 0.0% 0.0% 0.0% | |TERMINAL (d) | 0/22 (0%) 0/21 (0%) 1/27 (4%) | 0/29 (0%) 0/30 (0%) 0/30 (0%) | |FIRST INCIDENCE (DAYS) | 618 --- 733 (T) | --- --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.350N P=0.246N P=0.464N | (e) (e) (e) | |INCIDENTAL TUMOR | P=0.459N P=0.261N P=0.615N | (e) (e) (e) | |LOGISTIC REGRESSION | P=0.372N P=0.214N P=0.494N | (e) (e) (e) | |COCHRAN-ARMITAGE | P=0.377N | (e) | |FISHER EXACT | P=0.247N P=0.500N | (e) (e) | |=================================================================================================================================| DATE: 09/07/94 EXPERIMENT: 05048 TEST: 01 PAGE 8 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- RHODAMINE 6G TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | UNTREATD 0.012% 0.025% | UNTREATD 0.012% 0.025% | | | CONTROL | CONTROL | |=================================================================================================================================| | | |Lung | | Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/50 (4%) 1/50 (2%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | |ADJUSTED (b) | 5.3% 3.0% 3.7% | 0.0% 0.0% 0.0% | |TERMINAL (d) | 0/22 (0%) 0/21 (0%) 1/27 (4%) | 0/29 (0%) 0/30 (0%) 0/30 (0%) | |FIRST INCIDENCE (DAYS) | 618 668 733 (T) | --- --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.365N P=0.522N P=0.464N | (e) (e) (e) | |INCIDENTAL TUMOR | P=0.472N P=0.517N P=0.615N | (e) (e) (e) | |LOGISTIC REGRESSION | P=0.376N P=0.471N P=0.494N | (e) (e) (e) | |COCHRAN-ARMITAGE | P=0.386N | (e) | |FISHER EXACT | P=0.500N P=0.500N | (e) (e) | |=================================================================================================================================| | | |Lung | | Sarcoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 2/50 (4%) | |ADJUSTED (b) | 0.0% 0.0% 0.0% | 0.0% 0.0% 4.1% | |TERMINAL (d) | 0/22 (0%) 0/21 (0%) 0/27 (0%) | 0/29 (0%) 0/30 (0%) 0/30 (0%) | |FIRST INCIDENCE (DAYS) | --- --- --- | --- --- 405 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | (e) (e) (e) | P=0.093 (e) P=0.235 | |INCIDENTAL TUMOR | (e) (e) (e) | P=0.121 (e) P=0.215 | |LOGISTIC REGRESSION | (e) (e) (e) | P=0.300 (e) P=0.496 | |COCHRAN-ARMITAGE | (e) | P=0.095 | |FISHER EXACT | (e) (e) | (e) P=0.247 | |=================================================================================================================================| DATE: 09/07/94 EXPERIMENT: 05048 TEST: 01 PAGE 9 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- RHODAMINE 6G TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | UNTREATD 0.012% 0.025% | UNTREATD 0.012% 0.025% | | | CONTROL | CONTROL | |=================================================================================================================================| | | |Mammary Gland | | Carcinoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 3/50 (6%) 1/50 (2%) 2/50 (4%) | |ADJUSTED (b) | 0.0% 0.0% 0.0% | 10.3% 3.3% 6.7% | |TERMINAL (d) | 0/22 (0%) 0/21 (0%) 0/27 (0%) | 3/29 (10%) 1/30 (3%) 2/30 (7%) | |FIRST INCIDENCE (DAYS) | --- --- --- | 734 (T) 734 (T) 734 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | (e) (e) (e) | P=0.397N P=0.292N P=0.484N | |INCIDENTAL TUMOR | (e) (e) (e) | P=0.397N P=0.292N P=0.484N | |LOGISTIC REGRESSION | (e) (e) (e) | P=0.397N P=0.292N P=0.484N | |COCHRAN-ARMITAGE | (e) | P=0.411N | |FISHER EXACT | (e) (e) | P=0.309N P=0.500N | |=================================================================================================================================| | | |Mammary Gland | | Carcinoma or Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 4/50 (8%) 1/50 (2%) 2/50 (4%) | |ADJUSTED (b) | 0.0% 0.0% 0.0% | 13.8% 3.3% 6.7% | |TERMINAL (d) | 0/22 (0%) 0/21 (0%) 0/27 (0%) | 4/29 (14%) 1/30 (3%) 2/30 (7%) | |FIRST INCIDENCE (DAYS) | --- --- --- | 734 (T) 734 (T) 734 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | (e) (e) (e) | P=0.235N P=0.167N P=0.319N | |INCIDENTAL TUMOR | (e) (e) (e) | P=0.235N P=0.167N P=0.319N | |LOGISTIC REGRESSION | (e) (e) (e) | P=0.235N P=0.167N P=0.319N | |COCHRAN-ARMITAGE | (e) | P=0.249N | |FISHER EXACT | (e) (e) | P=0.181N P=0.339N | |=================================================================================================================================| DATE: 09/07/94 EXPERIMENT: 05048 TEST: 01 PAGE 10 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- RHODAMINE 6G TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | UNTREATD 0.012% 0.025% | UNTREATD 0.012% 0.025% | | | CONTROL | CONTROL | |=================================================================================================================================| | | |Mammary Gland | | Fibroadenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 6/50 (12%) 1/50 (2%) 4/50 (8%) | 19/50 (38%) 15/50 (30%) 17/50 (34%) | |ADJUSTED (b) | 25.1% 4.8% 13.5% | 51.8% 46.0% 46.0% | |TERMINAL (d) | 5/22 (23%) 1/21 (5%) 3/27 (11%) | 12/29 (41%) 13/30 (43%) 11/30 (37%) | |FIRST INCIDENCE (DAYS) | 695 733 (T) 680 | 602 572 629 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.216N P=0.064N P=0.263N | P=0.367N P=0.223N P=0.407N | |INCIDENTAL TUMOR | P=0.231N P=0.061N P=0.288N | P=0.395N P=0.206N P=0.477N | |LOGISTIC REGRESSION | P=0.251N P=0.061N P=0.314N | P=0.421N P=0.208N P=0.457N | |COCHRAN-ARMITAGE | P=0.299N | P=0.384N | |FISHER EXACT | P=0.056N P=0.370N | P=0.263N P=0.418N | |=================================================================================================================================| | | |Mammary Gland | | Fibroma, Fibroadenoma or Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 6/50 (12%) 1/50 (2%) 4/50 (8%) | 20/50 (40%) 15/50 (30%) 17/50 (34%) | |ADJUSTED (b) | 25.1% 4.8% 13.5% | 54.6% 46.0% 46.0% | |TERMINAL (d) | 5/22 (23%) 1/21 (5%) 3/27 (11%) | 13/29 (45%) 13/30 (43%) 11/30 (37%) | |FIRST INCIDENCE (DAYS) | 695 733 (T) 680 | 602 572 629 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.216N P=0.064N P=0.263N | P=0.294N P=0.166N P=0.335N | |INCIDENTAL TUMOR | P=0.231N P=0.061N P=0.288N | P=0.315N P=0.151N P=0.393N | |LOGISTIC REGRESSION | P=0.251N P=0.061N P=0.314N | P=0.342N P=0.150N P=0.376N | |COCHRAN-ARMITAGE | P=0.299N | P=0.308N | |FISHER EXACT | P=0.056N P=0.370N | P=0.201N P=0.339N | |=================================================================================================================================| DATE: 09/07/94 EXPERIMENT: 05048 TEST: 01 PAGE 11 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- RHODAMINE 6G TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | UNTREATD 0.012% 0.025% | UNTREATD 0.012% 0.025% | | | CONTROL | CONTROL | |=================================================================================================================================| | | |Mammary Gland | | Fibroma, Fibroadenoma, Carcinoma, or Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 6/50 (12%) 1/50 (2%) 4/50 (8%) | 23/50 (46%) 16/50 (32%) 18/50 (36%) | |ADJUSTED (b) | 25.1% 4.8% 13.5% | 63.1% 49.2% 48.8% | |TERMINAL (d) | 5/22 (23%) 1/21 (5%) 3/27 (11%) | 16/29 (55%) 14/30 (47%) 12/30 (40%) | |FIRST INCIDENCE (DAYS) | 695 733 (T) 680 | 602 572 629 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.216N P=0.064N P=0.263N | P=0.172N P=0.083N P=0.208N | |INCIDENTAL TUMOR | P=0.231N P=0.061N P=0.288N | P=0.180N P=0.071N P=0.241N | |LOGISTIC REGRESSION | P=0.251N P=0.061N P=0.314N | P=0.209N P=0.069N P=0.237N | |COCHRAN-ARMITAGE | P=0.299N | P=0.185N | |FISHER EXACT | P=0.056N P=0.370N | P=0.109N P=0.208N | |=================================================================================================================================| | | |Nose | | Carcinoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/45 (0%) | 0/49 (0%) 0/50 (0%) 0/47 (0%) | |ADJUSTED (b) | 4.1% 0.0% 0.0% | 0.0% 0.0% 0.0% | |TERMINAL (d) | 0/22 (0%) 0/21 (0%) 0/26 (0%) | 0/29 (0%) 0/30 (0%) 0/30 (0%) | |FIRST INCIDENCE (DAYS) | 576 --- --- | --- --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.110N P=0.247N P=0.252N | (e) (e) (e) | |INCIDENTAL TUMOR | P=0.205N P=0.290N P=0.500N | (e) (e) (e) | |LOGISTIC REGRESSION | P=0.108N P=0.113N P=0.540N | (e) (e) (e) | |COCHRAN-ARMITAGE | P=0.111N | (e) | |FISHER EXACT | P=0.247N P=0.274N | (e) (e) | |=================================================================================================================================| DATE: 09/07/94 EXPERIMENT: 05048 TEST: 01 PAGE 12 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- RHODAMINE 6G TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | UNTREATD 0.012% 0.025% | UNTREATD 0.012% 0.025% | | | CONTROL | CONTROL | |=================================================================================================================================| | | |Pancreas | | Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/50 (4%) 6/49 (12%) 0/50 (0%) | 1/48 (2%) 0/49 (0%) 0/50 (0%) | |ADJUSTED (b) | 7.5% 26.2% 0.0% | 3.6% 0.0% 0.0% | |TERMINAL (d) | 1/22 (5%) 5/21 (24%) 0/27 (0%) | 1/28 (4%) 0/30 (0%) 0/30 (0%) | |FIRST INCIDENCE (DAYS) | 695 692 --- | 734 (T) --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.182N P=0.114 P=0.208N | P=0.274N P=0.486N P=0.486N | |INCIDENTAL TUMOR | P=0.196N P=0.125 P=0.235N | P=0.274N P=0.486N P=0.486N | |LOGISTIC REGRESSION | P=0.206N P=0.114 P=0.231N | P=0.274N P=0.486N P=0.486N | |COCHRAN-ARMITAGE | P=0.237N | P=0.278N | |FISHER EXACT | P=0.128 P=0.247N | P=0.495N P=0.490N | |=================================================================================================================================| | | |Pituitary Gland: Pars Distalis or Unspecified Site | | Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 9/49 (18%) 8/49 (16%) 12/49 (24%) | 31/49 (63%) 29/49 (59%) 28/50 (56%) | |ADJUSTED (b) | 31.8% 27.4% 36.9% | 73.4% 68.1% 65.6% | |TERMINAL (d) | 5/22 (23%) 4/21 (19%) 8/27 (30%) | 18/29 (62%) 17/30 (57%) 16/30 (53%) | |FIRST INCIDENCE (DAYS) | 574 522 482 | 405 572 405 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.381 P=0.553N P=0.446 | P=0.320N P=0.352N P=0.346N | |INCIDENTAL TUMOR | P=0.386 P=0.429N P=0.387 | P=0.260N P=0.430N P=0.258N | |LOGISTIC REGRESSION | P=0.254 P=0.434N P=0.303 | P=0.273N P=0.413N P=0.308N | |COCHRAN-ARMITAGE | P=0.259 | P=0.265N | |FISHER EXACT | P=0.500N P=0.312 | P=0.418N P=0.298N | |=================================================================================================================================| DATE: 09/07/94 EXPERIMENT: 05048 TEST: 01 PAGE 13 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- RHODAMINE 6G TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | UNTREATD 0.012% 0.025% | UNTREATD 0.012% 0.025% | | | CONTROL | CONTROL | |=================================================================================================================================| | | |Skin | | Basal Cell Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 0/50 (0%) 1/50 (2%) 2/50 (4%) | 1/50 (2%) 0/50 (0%) 1/50 (2%) | |ADJUSTED (b) | 0.0% 4.8% 6.5% | 3.4% 0.0% 3.3% | |TERMINAL (d) | 0/22 (0%) 1/21 (5%) 1/27 (4%) | 1/29 (3%) 0/30 (0%) 1/30 (3%) | |FIRST INCIDENCE (DAYS) | --- 733 (T) 698 | 734 (T) --- 734 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.190 P=0.491 P=0.285 | P=0.674 P=0.493N P=0.755N | |INCIDENTAL TUMOR | P=0.163 P=0.491 P=0.242 | P=0.674 P=0.493N P=0.755N | |LOGISTIC REGRESSION | P=0.160 P=0.491 P=0.244 | P=0.674 P=0.493N P=0.755N | |COCHRAN-ARMITAGE | P=0.145 | P=0.666 | |FISHER EXACT | P=0.500 P=0.247 | P=0.500N P=0.753N | |=================================================================================================================================| | | |Skin | | Keratoacanthoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 1/50 (2%) 2/50 (4%) 8/50 (16%) | 1/50 (2%) 1/50 (2%) 0/50 (0%) | |ADJUSTED (b) | 2.6% 7.5% 24.3% | 3.4% 3.3% 0.0% | |TERMINAL (d) | 0/22 (0%) 1/21 (5%) 4/27 (15%) | 1/29 (3%) 1/30 (3%) 0/30 (0%) | |FIRST INCIDENCE (DAYS) | 667 662 667 | 734 (T) 734 (T) --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.013 * P=0.460 P=0.033 * | P=0.326N P=0.755N P=0.493N | |INCIDENTAL TUMOR | P=0.006 ** P=0.507 P=0.017 * | P=0.326N P=0.755N P=0.493N | |LOGISTIC REGRESSION | P=0.006 ** P=0.503 P=0.018 * | P=0.326N P=0.755N P=0.493N | |COCHRAN-ARMITAGE | P=0.006 ** | P=0.334N | |FISHER EXACT | P=0.500 P=0.015 * | P=0.753N P=0.500N | |=================================================================================================================================| DATE: 09/07/94 EXPERIMENT: 05048 TEST: 01 PAGE 14 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- RHODAMINE 6G TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | UNTREATD 0.012% 0.025% | UNTREATD 0.012% 0.025% | | | CONTROL | CONTROL | |=================================================================================================================================| | | |Skin | | Squamous Cell Papilloma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 2/50 (4%) 0/50 (0%) 3/50 (6%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) | |ADJUSTED (b) | 6.6% 0.0% 9.5% | 0.0% 0.0% 3.3% | |TERMINAL (d) | 0/22 (0%) 0/21 (0%) 2/27 (7%) | 0/29 (0%) 0/30 (0%) 1/30 (3%) | |FIRST INCIDENCE (DAYS) | 695 --- 629 | --- --- 734 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.443 P=0.259N P=0.570 | P=0.277 (e) P=0.507 | |INCIDENTAL TUMOR | P=0.320 P=0.226N P=0.414 | P=0.277 (e) P=0.507 | |LOGISTIC REGRESSION | P=0.379 P=0.240N P=0.498 | P=0.277 (e) P=0.507 | |COCHRAN-ARMITAGE | P=0.380 | P=0.272 | |FISHER EXACT | P=0.247N P=0.500 | (e) P=0.500 | |=================================================================================================================================| | | |Skin | | Trichoepithelioma, Basal Cell Carcinoma, or Basal Cell Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 0/50 (0%) 2/50 (4%) 3/50 (6%) | 1/50 (2%) 0/50 (0%) 1/50 (2%) | |ADJUSTED (b) | 0.0% 9.5% 9.4% | 3.4% 0.0% 3.3% | |TERMINAL (d) | 0/22 (0%) 2/21 (10%) 1/27 (4%) | 1/29 (3%) 0/30 (0%) 1/30 (3%) | |FIRST INCIDENCE (DAYS) | --- 733 (T) 698 | 734 (T) --- 734 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.127 P=0.227 P=0.160 | P=0.674 P=0.493N P=0.755N | |INCIDENTAL TUMOR | P=0.096 P=0.227 P=0.113 | P=0.674 P=0.493N P=0.755N | |LOGISTIC REGRESSION | P=0.095 P=0.224 P=0.122 | P=0.674 P=0.493N P=0.755N | |COCHRAN-ARMITAGE | P=0.085 | P=0.666 | |FISHER EXACT | P=0.247 P=0.121 | P=0.500N P=0.753N | |=================================================================================================================================| DATE: 09/07/94 EXPERIMENT: 05048 TEST: 01 PAGE 15 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- RHODAMINE 6G TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | UNTREATD 0.012% 0.025% | UNTREATD 0.012% 0.025% | | | CONTROL | CONTROL | |=================================================================================================================================| | | |Skin | | Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, | | Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 3/50 (6%) 4/50 (8%) 14/50 (28%) | 2/50 (4%) 1/50 (2%) 2/50 (4%) | |ADJUSTED (b) | 9.0% 16.7% 39.5% | 6.9% 3.3% 6.7% | |TERMINAL (d) | 0/22 (0%) 3/21 (14%) 7/27 (26%) | 2/29 (7%) 1/30 (3%) 2/30 (7%) | |FIRST INCIDENCE (DAYS) | 667 662 629 | 734 (T) 734 (T) 734 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.005 ** P=0.453 P=0.014 * | P=0.609N P=0.488N P=0.684N | |INCIDENTAL TUMOR | P<0.001 ** P=0.505 P=0.002 ** | P=0.609N P=0.488N P=0.684N | |LOGISTIC REGRESSION | P=0.001 ** P=0.487 P=0.004 ** | P=0.609N P=0.488N P=0.684N | |COCHRAN-ARMITAGE | P=0.001 ** | P=0.608 | |FISHER EXACT | P=0.500 P=0.003 ** | P=0.500N P=0.691N | |=================================================================================================================================| | | |Skin: Subcutaneous Tissue | | Fibroma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 4/50 (8%) 6/50 (12%) 4/50 (8%) | 0/50 (0%) 2/50 (4%) 0/50 (0%) | |ADJUSTED (b) | 13.8% 23.9% 14.8% | 0.0% 6.7% 0.0% | |TERMINAL (d) | 2/22 (9%) 4/21 (19%) 4/27 (15%) | 0/29 (0%) 2/30 (7%) 0/30 (0%) | |FIRST INCIDENCE (DAYS) | 662 620 733 (T) | --- 734 (T) --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.456N P=0.338 P=0.559N | P=0.651N P=0.245 (e) | |INCIDENTAL TUMOR | P=0.531N P=0.347 P=0.582N | P=0.651N P=0.245 (e) | |LOGISTIC REGRESSION | P=0.538N P=0.349 P=0.616N | P=0.651N P=0.245 (e) | |COCHRAN-ARMITAGE | P=0.564N | P=0.658N | |FISHER EXACT | P=0.370 P=0.643N | P=0.247 (e) | |=================================================================================================================================| DATE: 09/07/94 EXPERIMENT: 05048 TEST: 01 PAGE 16 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- RHODAMINE 6G TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | UNTREATD 0.012% 0.025% | UNTREATD 0.012% 0.025% | | | CONTROL | CONTROL | |=================================================================================================================================| | | |Skin: Subcutaneous Tissue | | Neurofibrosarcoma, Fibrosarcoma, Sarcoma, | | Neurofibroma, or Fibroma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 4/50 (8%) 8/50 (16%) 5/50 (10%) | 0/50 (0%) 2/50 (4%) 1/50 (2%) | |ADJUSTED (b) | 13.8% 28.3% 16.8% | 0.0% 6.7% 3.3% | |TERMINAL (d) | 2/22 (9%) 4/21 (19%) 4/27 (15%) | 0/29 (0%) 2/30 (7%) 1/30 (3%) | |FIRST INCIDENCE (DAYS) | 662 583 643 | --- 734 (T) 734 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.557 P=0.161 P=0.587 | P=0.385 P=0.245 P=0.507 | |INCIDENTAL TUMOR | P=0.395 P=0.159 P=0.492 | P=0.385 P=0.245 P=0.507 | |LOGISTIC REGRESSION | P=0.450 P=0.172 P=0.508 | P=0.385 P=0.245 P=0.507 | |COCHRAN-ARMITAGE | P=0.451 | P=0.377 | |FISHER EXACT | P=0.178 P=0.500 | P=0.247 P=0.500 | |=================================================================================================================================| | | |Skin: Subcutaneous Tissue | | Neurofibrosarcoma, Fibrosarcoma, or Sarcoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 0/50 (0%) 2/50 (4%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) | |ADJUSTED (b) | 0.0% 5.8% 2.3% | 0.0% 0.0% 3.3% | |TERMINAL (d) | 0/22 (0%) 0/21 (0%) 0/27 (0%) | 0/29 (0%) 0/30 (0%) 1/30 (3%) | |FIRST INCIDENCE (DAYS) | --- 583 643 | --- --- 734 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.395 P=0.230 P=0.514 | P=0.277 (e) P=0.507 | |INCIDENTAL TUMOR | P=0.187 P=0.218 P=0.282 | P=0.277 (e) P=0.507 | |LOGISTIC REGRESSION | P=0.439 P=0.270 P=0.536 | P=0.277 (e) P=0.507 | |COCHRAN-ARMITAGE | P=0.377 | P=0.272 | |FISHER EXACT | P=0.247 P=0.500 | (e) P=0.500 | |=================================================================================================================================| DATE: 09/07/94 EXPERIMENT: 05048 TEST: 01 PAGE 17 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- RHODAMINE 6G TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | UNTREATD 0.012% 0.025% | UNTREATD 0.012% 0.025% | | | CONTROL | CONTROL | |=================================================================================================================================| | | |Testes | | Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 46/49 (94%) 49/50 (98%) 44/50 (88%) | | |ADJUSTED (b) | 100.0% 100.0% 97.8% | | |TERMINAL (d) | 22/22 (100%) 21/21 (100%) 26/27 (96%) | | |FIRST INCIDENCE (DAYS) | 574 522 468 | | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.126N P=0.267 P=0.137N | | |INCIDENTAL TUMOR | P=0.151N P=0.298 P=0.254N | | |LOGISTIC REGRESSION | P=0.302N P=0.250 P=0.423N | | |COCHRAN-ARMITAGE | P=0.157N | | |FISHER EXACT | P=0.301 P=0.254N | | |=================================================================================================================================| | | |Thyroid Gland: C-Cell | | Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 5/50 (10%) 6/48 (13%) 1/50 (2%) | 4/50 (8%) 3/50 (6%) 4/50 (8%) | |ADJUSTED (b) | 16.7% 23.9% 3.7% | 13.8% 9.5% 13.3% | |TERMINAL (d) | 1/22 (5%) 4/21 (19%) 1/27 (4%) | 4/29 (14%) 2/30 (7%) 4/30 (13%) | |FIRST INCIDENCE (DAYS) | 662 583 733 (T) | 734 (T) 728 734 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.071N P=0.463 P=0.083N | P=0.563N P=0.477N P=0.628N | |INCIDENTAL TUMOR | P=0.107N P=0.460 P=0.112N | P=0.568 P=0.484N P=0.628N | |LOGISTIC REGRESSION | P=0.094N P=0.462 P=0.101N | P=0.561N P=0.463N P=0.628N | |COCHRAN-ARMITAGE | P=0.096N | P=0.575 | |FISHER EXACT | P=0.471 P=0.102N | P=0.500N P=0.643N | |=================================================================================================================================| DATE: 09/07/94 EXPERIMENT: 05048 TEST: 01 PAGE 18 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- RHODAMINE 6G TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | UNTREATD 0.012% 0.025% | UNTREATD 0.012% 0.025% | | | CONTROL | CONTROL | |=================================================================================================================================| | | |Thyroid Gland: C-Cell | | Carcinoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/50 (6%) 1/48 (2%) 1/50 (2%) | 0/50 (0%) 1/50 (2%) 2/50 (4%) | |ADJUSTED (b) | 10.7% 4.5% 3.7% | 0.0% 3.3% 4.7% | |TERMINAL (d) | 1/22 (5%) 0/21 (0%) 1/27 (4%) | 0/29 (0%) 1/30 (3%) 0/30 (0%) | |FIRST INCIDENCE (DAYS) | 662 729 733 (T) | --- 734 (T) 531 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.180N P=0.332N P=0.265N | P=0.141 P=0.507 P=0.227 | |INCIDENTAL TUMOR | P=0.213N P=0.309N P=0.300N | P=0.139 P=0.507 P=0.180 | |LOGISTIC REGRESSION | P=0.199N P=0.326N P=0.296N | P=0.180 P=0.507 P=0.288 | |COCHRAN-ARMITAGE | P=0.210N | P=0.145 | |FISHER EXACT | P=0.324N P=0.309N | P=0.500 P=0.247 | |=================================================================================================================================| | | |Thyroid Gland: C-Cell | | Carcinoma or Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 7/50 (14%) 7/48 (15%) 2/50 (4%) | 4/50 (8%) 4/50 (8%) 6/50 (12%) | |ADJUSTED (b) | 23.9% 27.4% 7.4% | 13.8% 12.7% 17.4% | |TERMINAL (d) | 2/22 (9%) 4/21 (19%) 2/27 (7%) | 4/29 (14%) 3/30 (10%) 4/30 (13%) | |FIRST INCIDENCE (DAYS) | 662 583 733 (T) | 734 (T) 728 531 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.048N* P=0.569 P=0.057N | P=0.316 P=0.621N P=0.379 | |INCIDENTAL TUMOR | P=0.077N P=0.575 P=0.081N | P=0.280 P=0.628N P=0.352 | |LOGISTIC REGRESSION | P=0.065N P=0.568 P=0.072N | P=0.286 P=0.610N P=0.356 | |COCHRAN-ARMITAGE | P=0.071N | P=0.302 | |FISHER EXACT | P=0.581 P=0.080N | P=0.643N P=0.370 | |=================================================================================================================================| DATE: 09/07/94 EXPERIMENT: 05048 TEST: 01 PAGE 19 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- RHODAMINE 6G TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | UNTREATD 0.012% 0.025% | UNTREATD 0.012% 0.025% | | | CONTROL | CONTROL | |=================================================================================================================================| | | |Thyroid Gland: Follicular Cell | | Carcinoma or Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/50 (4%) 0/48 (0%) 0/50 (0%) | 1/50 (2%) 0/50 (0%) 1/50 (2%) | |ADJUSTED (b) | 9.1% 0.0% 0.0% | 3.4% 0.0% 3.3% | |TERMINAL (d) | 2/22 (9%) 0/21 (0%) 0/27 (0%) | 1/29 (3%) 0/30 (0%) 1/30 (3%) | |FIRST INCIDENCE (DAYS) | 733 (T) --- --- | 734 (T) --- 734 (T) | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.086N P=0.247N P=0.194N | P=0.674 P=0.493N P=0.755N | |INCIDENTAL TUMOR | P=0.086N P=0.247N P=0.194N | P=0.674 P=0.493N P=0.755N | |LOGISTIC REGRESSION | P=0.086N P=0.247N P=0.194N | P=0.674 P=0.493N P=0.755N | |COCHRAN-ARMITAGE | P=0.104N | P=0.666 | |FISHER EXACT | P=0.258N P=0.247N | P=0.500N P=0.753N | |=================================================================================================================================| | | |Uterus | | Polyp Stromal | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | # # # | |----------- | | | |OVERALL (a) | | 7/50 (14%) 12/50 (24%) 13/50 (26%) | |ADJUSTED (b) | | 21.2% 32.9% 35.9% | |TERMINAL (d) | | 4/29 (14%) 7/30 (23%) 8/30 (27%) | |FIRST INCIDENCE (DAYS) | | 661 643 575 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | | P=0.111 P=0.196 P=0.124 | |INCIDENTAL TUMOR | | P=0.059 P=0.179 P=0.072 | |LOGISTIC REGRESSION | | P=0.079 P=0.179 P=0.093 | |COCHRAN-ARMITAGE | | P=0.093 | |FISHER EXACT | | P=0.154 P=0.105 | |=================================================================================================================================| DATE: 09/07/94 EXPERIMENT: 05048 TEST: 01 PAGE 20 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- RHODAMINE 6G TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | UNTREATD 0.012% 0.025% | UNTREATD 0.012% 0.025% | | | CONTROL | CONTROL | |=================================================================================================================================| | | |Uterus | | Sarcoma Stromal | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | # # # | |----------- | | | |OVERALL (a) | | 3/50 (6%) 1/50 (2%) 0/50 (0%) | |ADJUSTED (b) | | 6.6% 3.3% 0.0% | |TERMINAL (d) | | 0/29 (0%) 1/30 (3%) 0/30 (0%) | |FIRST INCIDENCE (DAYS) | | 531 734 (T) --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | | P=0.067N P=0.296N P=0.132N | |INCIDENTAL TUMOR | | P=0.083N P=0.757N P=0.139N | |LOGISTIC REGRESSION | | P=0.037N* P=0.456N P=0.060N | |COCHRAN-ARMITAGE | | P=0.063N | |FISHER EXACT | | P=0.309N P=0.121N | |=================================================================================================================================| | | |Uterus | | Sarcoma Stromal or Polyp Stromal | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | # # # | |----------- | | | |OVERALL (a) | | 10/50 (20%) 13/50 (26%) 13/50 (26%) | |ADJUSTED (b) | | 26.4% 35.9% 35.9% | |TERMINAL (d) | | 4/29 (14%) 8/30 (27%) 8/30 (27%) | |FIRST INCIDENCE (DAYS) | | 531 643 575 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | | P=0.307 P=0.374 P=0.335 | |INCIDENTAL TUMOR | | P=0.214 P=0.189 P=0.234 | |LOGISTIC REGRESSION | | P=0.272 P=0.310 P=0.313 | |COCHRAN-ARMITAGE | | P=0.284 | |FISHER EXACT | | P=0.318 P=0.318 | |=================================================================================================================================| DATE: 09/07/94 EXPERIMENT: 05048 TEST: 01 PAGE 21 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- RHODAMINE 6G TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | UNTREATD 0.012% 0.025% | UNTREATD 0.012% 0.025% | | | CONTROL | CONTROL | |=================================================================================================================================| | | |All Organs | | Leukemia: Lymphocytic, Monocytic, Mononuclear, | | or Undifferentiated | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 27/50 (54%) 21/50 (42%) 19/50 (38%) | 11/50 (22%) 11/50 (22%) 10/50 (20%) | |ADJUSTED (b) | 68.3% 53.1% 47.1% | 28.2% 26.3% 25.5% | |TERMINAL (d) | 11/22 (50%) 5/21 (24%) 8/27 (30%) | 3/29 (10%) 3/30 (10%) 4/30 (13%) | |FIRST INCIDENCE (DAYS) | 574 559 453 | 646 575 361 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.061N P=0.290N P=0.065N | P=0.461N P=0.536N P=0.500N | |INCIDENTAL TUMOR | P=0.121N P=0.193N P=0.110N | P=0.519N P=0.531N P=0.549 | |LOGISTIC REGRESSION | P=0.060N P=0.161N P=0.072N | P=0.395N P=0.568 P=0.458N | |COCHRAN-ARMITAGE | P=0.068N | P=0.452N | |FISHER EXACT | P=0.158N P=0.080N | P=0.595N P=0.500N | |=================================================================================================================================| | | |All Organs | | Mesothelioma Benign, Malignant, NOS | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 1/50 (2%) 2/50 (4%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | |ADJUSTED (b) | 4.5% 4.0% 3.7% | 0.0% 0.0% 0.0% | |TERMINAL (d) | 1/22 (5%) 0/21 (0%) 1/27 (4%) | 0/29 (0%) 0/30 (0%) 0/30 (0%) | |FIRST INCIDENCE (DAYS) | 733 (T) 522 733 (T) | --- --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.597N P=0.492 P=0.716N | (e) (e) (e) | |INCIDENTAL TUMOR | P=0.229N P=0.509N P=0.716N | (e) (e) (e) | |LOGISTIC REGRESSION | P=0.527N P=0.647 P=0.716N | (e) (e) (e) | |COCHRAN-ARMITAGE | P=0.620N | (e) | |FISHER EXACT | P=0.500 P=0.753N | (e) (e) | |=================================================================================================================================| DATE: 09/07/94 EXPERIMENT: 05048 TEST: 01 PAGE 22 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- RHODAMINE 6G TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | UNTREATD 0.012% 0.025% | UNTREATD 0.012% 0.025% | | | CONTROL | CONTROL | |=================================================================================================================================| | | |All Organs | | Osteosarcoma or Osteoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) | 1/50 (2%) 1/50 (2%) 0/50 (0%) | |ADJUSTED (b) | 0.0% 0.0% 5.9% | 2.3% 2.0% 0.0% | |TERMINAL (d) | 0/22 (0%) 0/21 (0%) 0/27 (0%) | 0/29 (0%) 0/30 (0%) 0/30 (0%) | |FIRST INCIDENCE (DAYS) | --- --- 657 | 626 569 --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.113 (e) P=0.266 | P=0.342N P=0.748N P=0.509N | |INCIDENTAL TUMOR | P=0.073 (e) P=0.199 | P=0.193N P=0.677N P=0.362N | |LOGISTIC REGRESSION | P=0.094 (e) P=0.237 | P=0.255N P=0.647 P=0.467N | |COCHRAN-ARMITAGE | P=0.095 | P=0.334N | |FISHER EXACT | (e) P=0.247 | P=0.753N P=0.500N | |=================================================================================================================================| | | |All Organs | | Benign Tumors | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 49/50 (98%) 50/50 (100%) 48/50 (96%) | 43/50 (86%) 41/50 (82%) 46/50 (92%) | |ADJUSTED (b) | 100.0% 100.0% 100.0% | 95.5% 93.0% 97.9% | |TERMINAL (d) | 22/22 (100%) 21/21 (100%) 27/27 (100%) | 27/29 (93%) 27/30 (90%) 29/30 (97%) | |FIRST INCIDENCE (DAYS) | 574 522 468 | 405 572 405 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.167N P=0.357 P=0.181N | P=0.374 P=0.315N P=0.415 | |INCIDENTAL TUMOR | P=0.610 P=0.490 P=0.534 | P=0.151 P=0.374N P=0.217 | |LOGISTIC REGRESSION | P=0.437 P=0.484 P=0.586 | P=0.130 P=0.276N P=0.153 | |COCHRAN-ARMITAGE | P=0.355N | P=0.225 | |FISHER EXACT | P=0.500 P=0.500N | P=0.393N P=0.262 | |=================================================================================================================================| DATE: 09/07/94 EXPERIMENT: 05048 TEST: 01 PAGE 23 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- RHODAMINE 6G TERMINAL SACRIFICE AT 105 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | UNTREATD 0.012% 0.025% | UNTREATD 0.012% 0.025% | | | CONTROL | CONTROL | |=================================================================================================================================| | | |All Organs | | Malignant Tumors | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 39/50 (78%) 33/50 (66%) 30/50 (60%) | 21/50 (42%) 22/50 (44%) 20/50 (40%) | |ADJUSTED (b) | 86.0% 69.4% 68.0% | 47.5% 50.2% 49.1% | |TERMINAL (d) | 16/22 (73%) 7/21 (33%) 14/27 (52%) | 7/29 (24%) 10/30 (33%) 11/30 (37%) | |FIRST INCIDENCE (DAYS) | 574 522 453 | 531 569 361 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.054N P=0.352N P=0.049N* | P=0.465N P=0.564 P=0.497N | |INCIDENTAL TUMOR | P=0.059N P=0.089N P=0.063N | P=0.455N P=0.473 P=0.578N | |LOGISTIC REGRESSION | P=0.075N P=0.097N P=0.078N | P=0.387N P=0.468 P=0.438N | |COCHRAN-ARMITAGE | P=0.035N* | P=0.458N | |FISHER EXACT | P=0.133N P=0.041N* | P=0.500 P=0.500N | |=================================================================================================================================| | | |All Organs | | Malignant and Benign Tumors | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 50/50 (100%) 50/50 (100%) 49/50 (98%) | 48/50 (96%) 47/50 (94%) 49/50 (98%) | |ADJUSTED (b) | 100.0% 100.0% 100.0% | 98.0% 95.9% 98.0% | |TERMINAL (d) | 22/22 (100%) 21/21 (100%) 27/27 (100%) | 28/29 (97%) 28/30 (93%) 29/30 (97%) | |FIRST INCIDENCE (DAYS) | 574 522 453 | 405 569 361 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.171N P=0.405 P=0.188N | P=0.501 P=0.372N P=0.533 | |INCIDENTAL TUMOR | P=0.638N (e) (e) | P=0.375 P=0.545N P=0.414 | |LOGISTIC REGRESSION | P=0.638N (e) (e) | P=0.404 P=0.508N P=0.501 | |COCHRAN-ARMITAGE | P=0.272N | P=0.395 | |FISHER EXACT | P=1.000N P=0.500N | P=0.500N P=0.500 | |=================================================================================================================================| DATE: 09/07/94 EXPERIMENT: 05048 TEST: 01 PAGE 24 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- RHODAMINE 6G TERMINAL SACRIFICE AT 105 WEEKS (a) Number of tumor-bearing animals / number of animals examined at site. (b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for intercurrent mortality. (d) Observed incidence at terminal kill. (f) Beneath the control incidence are the P-values associated with the trend test. Beneath the dosed group incidence are the P-values corresponding to pairwise comparisons between the controls and that dosed group. The life table analysis regards tumors in animals dying prior to terminal kill as being (directly or indirectly) the cause of death. The incidental tumor test regards these lesions as non-fatal. Logistic regression is an alternative method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage and Fisher's exact tests compare directly the overall incidence rates. For all tests, a negative trend is indicated by "N". (e) Value of Statistic cannot be computed. (I) Interim sacrifice (T) Terminal sacrifice # Tumor rates based on number of animals necropsied. * To the right of any statistical result, indicates significance at (P<=0.05). ** To the right of any statistical result, indicates significance at (P<=0.01).