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DOI 10.1016/j.taap.2003.12.026
Title The kinin system in the envenomation caused by the Tityus serrulatus scorpion sting
Creator/Author Fukuhara, Y.D.M. ; Dellalibera-Joviliano, R. ; Cunha, F.Q.C. ; Reis, M.L. ; Donadi, E.A. E-mail: eadonadi@fmrp.usp.br
Publication Date2004 May 01
OSTI IdentifierOSTI ID: 20493822
Other Number(s)Journal ID: ISSN 0041-008X; TXAPA9; TRN: US04R3358065989
Resource TypeJournal Article
Resource RelationJournal: Toxicology and Applied Pharmacology; Journal Volume: 196; Journal Issue: 3; Other Information: DOI: 10.1016/j.taap.2003.12.026; PII: S0041008X04000419; Copyright (c) 2004 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); PBD: 1 May 2004
Subject60 APPLIED LIFE SCIENCES; ELDERLY PEOPLE; ENZYME IMMUNOASSAY; KININS; PATHOGENESIS; SCORPIONS; VENOMS
Description/Abstract Several lines of evidence in experimental animals indicate that the kinin system may participate in the pathogenesis of envenomation by the Tityus serrulatus (Ts) scorpion sting, but there are no studies in humans with regard to this system. In this study, we evaluated the plasma levels of high-molecular (HKg) and low-molecular (LKg) weight kininogens (detected by ELISA), the activities of plasma or tissue kallikreins and kininase II (enzymatic action upon selective substrates), and the Ts plasma venom levels (ELISA). A total of 27 patients (12 males) aged 12-72 were evaluated immediately at hospital admittance. According to the severity of envenomation, patients were classified as mild (n = 15), moderate (n = 8), and severe cases (n = 4). Controls were paired for age and sex. Plasma venom levels were associated with the severity of envenomation. Severe cases presented lower levels of LKg in relation to mild and controls. Inverse correlations were seen between LKg levels and the venom concentration. The results of this study suggested that the kinin system may participate in the pathogenesis of human Ts envenomation and knowledge about this system may be useful to develop new strategies to reduce the damage caused by scorpion envenomation.
Country of PublicationUnited States
LanguageEnglish
FormatSize: page(s) 390-395
System Entry Date2004 Jul 13

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