Bibliographic Citation
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DOI | 10.1016/j.taap.2003.12.026 |
Title | The kinin system in the envenomation caused by the Tityus serrulatus scorpion sting |
Creator/Author | Fukuhara, Y.D.M. ; Dellalibera-Joviliano, R. ; Cunha, F.Q.C. ; Reis, M.L. ; Donadi, E.A. E-mail: eadonadi@fmrp.usp.br |
Publication Date | 2004 May 01 |
OSTI Identifier | OSTI ID: 20493822 |
Other Number(s) | Journal ID: ISSN 0041-008X; TXAPA9; TRN: US04R3358065989 |
Resource Type | Journal Article |
Resource Relation | Journal: Toxicology and Applied Pharmacology; Journal Volume: 196; Journal Issue: 3; Other Information: DOI: 10.1016/j.taap.2003.12.026; PII: S0041008X04000419; Copyright (c) 2004 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); PBD: 1 May 2004 |
Subject | 60 APPLIED LIFE SCIENCES; ELDERLY PEOPLE; ENZYME IMMUNOASSAY; KININS; PATHOGENESIS; SCORPIONS; VENOMS |
Description/Abstract | Several lines of evidence in experimental animals indicate that the kinin system may participate in the pathogenesis of envenomation by the Tityus serrulatus (Ts) scorpion sting, but there are no studies in humans with regard to this system. In this study, we evaluated the plasma levels of high-molecular (HKg) and low-molecular (LKg) weight kininogens (detected by ELISA), the activities of plasma or tissue kallikreins and kininase II (enzymatic action upon selective substrates), and the Ts plasma venom levels (ELISA). A total of 27 patients (12 males) aged 12-72 were evaluated immediately at hospital admittance. According to the severity of envenomation, patients were classified as mild (n = 15), moderate (n = 8), and severe cases (n = 4). Controls were paired for age and sex. Plasma venom levels were associated with the severity of envenomation. Severe cases presented lower levels of LKg in relation to mild and controls. Inverse correlations were seen between LKg levels and the venom concentration. The results of this study suggested that the kinin system may participate in the pathogenesis of human Ts envenomation and knowledge about this system may be useful to develop new strategies to reduce the damage caused by scorpion envenomation. |
Country of Publication | United States |
Language | English |
Format | Size: page(s) 390-395 |
System Entry Date | 2004 Jul 13 |
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