JB6 Highlights 2001 and References                              Return to Home Page

(a current JB6 Bibliography is also listed after the Highlights References)

The mouse Balb/C JB6 model (1) is the only well characterized model of genetic variants for a neoplastic transformation response to tumor promoters.  These cells are not differentially sensitive to tumor promoter induced mitogenesis or differentiation (2), thus increasing the likelihood that molecular response differences will be transformation-relevant.  These cells are also not differential at the level of tumor promoter receptors such as protein kinase C or epidermal growth factor receptor, thus indicating that these are post-receptor signaling variants (3).  Moreover the JB6 response variants are stably free of spontaneous transformation (a property found to be mouse strain dependent) and stably responsive (P+) or nonresponsive (P-) to tumor promoter induced transformation.  Thus molecular events that occur only in the P+ cells are candidates for mediating tumor promotion while those that occur only in the P- cells are candidate inhibitors.  The JB6 model is not suitable for studying epidermal differentiation or keratin synthesis.  The JB6 model is uniquely suited for studying tumor promotion and promotion-relevant molecular events.  Research using the Balb/C mouse JB6 model of transformation response variants has yielded milestones that propelled research in several areas.

Mechanistic Insights
The JB6 model was among the first (along with those reported by M. Oren and his colleagues (4) in which expression of a mutant of the tumor suppressor p53 was shown to produce a gain of oncogenic response (5).  The first cloning of mouse TIMP-3 was done as part of a differential display analysis of JB6 cells (6). The demonstration that TIMP-3 functions as a tumor suppressor in human colon carcinoma cells (7) was supported by others who isolated TIMP-3 by gene trapping (8).  The first observation of a requirement for active oxygen generation in tumor promotion was made with JB6 cells  (9) and has been followed up extensively (10-15). The ubiquitous secreted cell adhesion glycophosphoprotein osteopontin was first cloned in 1987 from JB6 cells by subtractive hybridization (16).  Osteopontin expression plays important roles in tumor promotion and tumor progression, inflammation, bone remodeling and other processes (17-19).  The 1989 discovery (20) and subsequent reports (21, 22) that the JB6 transformation variants are also AP-1 response variants stimulated the demonstration that  AP-1 activation is causal for progression/ invasion (23, 24), maintenance (25), and induction (26) of tumor phenotype in mouse cell culture models. These findings stimulated in vivo investigations that implicated cFos in papilloma-to- carcinoma progression but not in tumor promotion (papilloma induction) (27).  That tumor promotion in vivo requires AP-1 activation was first established using dominant negative jun(TAM67) expressing transgenic mice (28).   Transformation relevant pathways to AP-1 activation have been elucidated in JB6 cells, implicating MAP kinase ERK activation (29, 30).  The ERK requirement for AP-1 activation has been extended to AP-1 activation by UVB (31) and by arsenite (32).  The observation that UVB activates AP-1 has been extended from JB6 cells to human keratinocytes (33, 34) and to mouse skin in vivo (35, 36).  NF B-dependent gene expression is also required for transformation in the JB6 model (14).  P- cells are nonresponsive for NF B activation (14).  Inducible nitric oxide synthase (iNOS) is induced in P+ but not in P- JB6 cells cocultured with an interferon- -stimulated macrophage cell line (37).  INOS induction is NF B-dependent.  iNOS is one of a small set of genes that appears to be targeted in mice expressing AP-1/NF B inhibitor (TAM67) (Young et al., unpublished).

Cancer Prevention
In addition to propelling mechanistic insights, studies with the JB6 model have impacted research in cancer prevention.  A number of tumor promotion inhibitors studied in the JB6 model have been discovered to owe their transformation inhibiting activity at least in part to their AP-1 repressing activity. Among these inhibitors are turmeric-derived curcumin (38), aspirin (39), the tea polyphenol EGCG (40-42), potato proteinase inhibitors (43, 44), gingerol (45), citrifolin A (46), Omega 3 fatty acids (47), and novel glycosides (48).   Some of these inhibitors have been shown to target AP-1 also in mouse skin (35). Recently Birt and colleagues have discovered that the basis for caloric restriction inhibiting tumor promotion lies at least in part, in its inhibition of ERK and AP-1 activation (49, 50).  Other molecular targets of cancer prevention agents have been identified using the JB6 model.  The grape skin inhibitor resveratrol activates p53 (51).

Cancer Risk Assessment
Finally, the JB6 model has also been valuable for cancer risk assessment.   The sensitivity of the JB6 model has made it possible to convincingly conclude that exposure to electric and magnetic fields around power lines poses little or no human risk (52, 53).  Environmental metals such as arsenic and vanadium have been shown to act as tumor promoters in the JB6 model (32, 54).

In summary the use of the mouse JB6 model has spawned a number of advances not only in basic cell biology but also in understanding the molecular mechanism of tumor promotion.  Moreover these studies have contributed to progress in cancer prevention and risk assessment research.  Many of these advances have been extended from the JB6 model to human epithelial cell (solid tumor) progression models or to in vivo mouse multistage carcinogenesis models.  This progress reflects a response of many laboratories to the unique opportunities for discovery presented by the mouse JB6 model.

References:

 1. Colburn N. H., Former B. F., Nelson K. A., Yuspa S. H.: Tumour promoter induces anchorage independence irreversibly. Nature 281: 589-591, 1979.
 2. Colburn N. H., Wendel E. J., Abruzzo G.: Dissociation of mitogenesis and late-stage promotion of tumor cell phenotype by phorbol esters: mitogen-resistant variants are sensitive to promotion. Proc Natl Acad Sci U S A 78: 6912-6916, 1981.
 3. Colburn N. H., Gindhart T. D., Hegamyer G. A., Blumberg P. M., Delclos K. B., Magun B. E., Lockyer J.: Phorbol diester and epidermal growth factor receptors in 12-O- tetradecanoylphorbol-13-acetate-resistant and -sensitive mouse epidermal cells. Cancer Res 42: 3093-3097, 1982.
 4. Shaulian E., Zauberman A., Ginsberg D., Oren M.: Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence- specific DNA binding. Mol Cell Biol 12: 5581-5592, 1992.
 5. Sun Y., Nakamura K., Wendel E., Colburn N.: Progression toward tumor cell phenotype is enhanced by overexpression of a mutant p53 tumor-suppressor gene isolated from nasopharyngeal carcinoma. Proc Natl Acad Sci U S A 90: 2827-2831, 1993.
 6. Sun Y., Hegamyer G., Colburn N. H.: Molecular cloning of five messenger RNAs differentially expressed in preneoplastic or neoplastic JB6 mouse epidermal cells: one is homologous to human tissue inhibitor of metalloproteinases-3. Cancer Res 54: 1139-1144, 1994.
 7. Bian J., Wang Y., Smith M. R., Kim H., Jacobs C., Jackman J., Kung H. F., Colburn N. H., Sun Y.: Suppression of in vivo tumor growth and induction of suspension cell death by tissue inhibitor of metalloproteinases (TIMP)-3. Carcinogenesis 17: 1805- 1811, 1996.
 8. Andreu T., Beckers T., Thoenes E., Hilgard P., von Melchner H.: Gene trapping identifies inhibitors of oncogenic transformation. The tissue inhibitor of metalloproteinases-3 (TIMP3) and collagen type I alpha2 (COL1A2) are epidermal growth factor-regulated growth repressors. J Biol Chem 273: 13848-13854, 1998.
 9. Nakamura Y., Colburn N. H., Gindhart T. D.: Role of reactive oxygen in tumor promotion: implication of superoxide anion in promotion of neoplastic transformation in JB-6 cells by TPA. Carcinogenesis 6: 229-235, 1985.
 10. Crawford D., Zbinden I., Amstad P., Cerutti P.: Oxidant stress induces the protooncogenes c-fos and c-myc in mouse epidermal cells. Oncogene 3: 27-32, 1988.
 11. Ghosh R., Amstad P., Cerutti P.: UVB-induced DNA breaks interfere with transcriptional induction of c- fos. Mol Cell Biol 13: 6992-6999, 1993.
 12. Amstad P. A., Liu H., Ichimiya M., Chang S., Berezesky I. K., Trump B. F.: bcl-2 enhancement of malignant transformation in mouse epidermal JB6 cells. Mol Carcinog 20: 231-239, 1997.
 13. Gupta A., Rosenberger S. F., Bowden G. T.: Increased ROS levels contribute to elevated transcription factor and MAP kinase activities in malignantly progressed mouse keratinocyte cell lines. Carcinogenesis 20: 2063-2073, 1999.
 14. Hsu T.-C., Nair R., Tulsian P., Hegamyer G., Young M. R., Colburn N. H.: Transformation non-responsive cells owe their resistance to lack of NF- B activation. Cancer Res 61: 4160-4168, 2001.
 15. Hsu T. C., Young M. R., Cmarik J., Colburn N. H.: Activator protein 1 (AP-1)- and nuclear factor kappaB (NF-kappaB)- dependent transcriptional events in carcinogenesis. Free Radic Biol Med 28: 1338-48., 2000.
 16. Craig A. M., Smith J. H., Denhardt D. T.: Osteopontin, a transformation-associated cell adhesion phosphoprotein, is induced by 12-O-tetradecanoylphorbol 13-acetate in mouse epidermis. J Biol Chem 264: 9682-9689, 1989.
 17. Denhardt D. T., Giachelli C. M., Rittling S. R.: Role of osteopontin in cellular signaling and toxicant injury. Annu Rev Pharmacol Toxicol 41: 723-749, 2001.
 18. Chang P. L., Prince C. W.: 1 alpha,25-dihydroxyvitamin D3 stimulates synthesis and secretion of nonphosphorylated osteopontin (secreted phosphoprotein 1) in mouse JB6 epidermal cells. Cancer Res 51: 2144-2150, 1991.
 19. Chang P. L., Chambers A. F.: Transforming JB6 cells exhibit enhanced integrin- mediated adhesion to osteopontin. J Cell Biochem 78: 8-23, 2000.
 20. Bernstein L. R., Colburn N. H.: AP1/jun function is differentially induced in promotion-sensitive and resistant JB6 cells. Science 244: 566-569, 1989.
 21. Ben-Ari E. T., Bernstein L. R., Colburn N. H.: Differential c-jun expression in response to tumor promoters in JB6 cells sensitive or resistant to neoplastic transformation. Mol Carcinog 5: 62-74, 1992.
 22. Bernstein L. R., Bravo R., Colburn N. H.: 12-O-tetradecanoylphorbol-13-acetate-- induced levels of AP-1 proteins: a 46-kDa protein immunoprecipitated by anti-fra-1 and induced in promotion-resistant but not promotion-sensitive JB6 cells. Mol Carcinog 6: 221-229, 1992.
 23. Hennigan R. F., Hawker K. L., Ozanne B. W.: Fos-transformation activates genes associated with invasion. Oncogene 9: 3591-3600, 1994.
 24. Lamb R. F., Hennigan R. F., Turnbull K., Katsanakis K. D., MacKenzie E. D., Birnie G. D., Ozanne B. W.: AP-1-mediated invasion requires increased expression of the hyaluronan receptor CD44. Mol Cell Biol 17: 963-976, 1997.
 25. Domann F. E., Levy J. P., Birrer M. J., Bowden G. T.: Stable expression of a c-JUN deletion mutant in two malignant mouse epidermal cell lines blocks tumor formation in nude mice. Cell Growth Differ 5: 9-16, 1994.
 26. Dong Z., Birrer M. J., Watts R. G., Matrisian L. M., Colburn N. H.: Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells. Proc Natl Acad Sci U S A 91: 609-613, 1994.
 27. Saez E., Rutberg S. E., Mueller E., Oppenheim H., Smoluk J., Yuspa S. H., Spiegelman B. M.: c-fos is required for malignant progression of skin tumors. Cell 82: 721-732, 1995.
 28. Young M. R., Li J. J., Rincon M., Flavell R. A., Sathyanarayana B. K., Hunziker R., Colburn N.: Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion. Proc Natl Acad Sci U S A 96: 9827-9832, 1999.
 29. Watts R. G., Huang C., Young M. R., Li J. J., Dong Z., Pennie W. D., Colburn N. H.: Expression of dominant negative Erk2 inhibits AP-1 transactivation and neoplastic transformation. Oncogene 17: 3493-3498, 1998.
 30. Huang C., Ma W. Y., Young M. R., Colburn N., Dong Z.: Shortage of mitogen- activated protein kinase is responsible for resistance to AP-1 transactivation and transformation in mouse JB6 cells. Proc Natl Acad Sci U S A 95: 156-161, 1998.
 31. Huang C., Ma W. Y., Dong Z.: The extracellular-signal-regulated protein kinases (Erks) are required for UV-induced AP-1 activation in JB6 cells. Oncogene 18: 2828- 2835, 1999.
 32. Huang C., Ma W. Y., Li J., Goranson A., Dong Z.: Requirement of Erk, but not JNK, for arsenite-induced cell transformation. J Biol Chem 274: 14595-14601, 1999.
 33. Chen W., Borchers A. H., Dong Z., Powell M. B., Bowden G. T.: UVB irradiation- induced activator protein-1 activation correlates with increased c-fos gene expression in a human keratinocyte cell line. J Biol Chem 273: 32176-32181, 1998.
 34. Barthelman M., Bair W. B., 3rd, Stickland K. K., Chen W., Timmermann B. N., Valcic S., Dong Z., Bowden G. T.: (-)-Epigallocatechin-3-gallate inhibition of ultraviolet B-induced AP-1 activity. Carcinogenesis 19: 2201-2204, 1998.
 35. Huang C., Ma W. Y., Hanenberger D., Cleary M. P., Bowden G. T., Dong Z.: Inhibition of ultraviolet B-induced activator protein-1 (AP-1) activity by aspirin in AP-1-luciferase transgenic mice. J Biol Chem 272: 26325-26331, 1997.
 36. Barthelman M., Chen W., Gensler H. L., Huang C., Dong Z., Bowden G. T.: Inhibitory effects of perillyl alcohol on UVB-induced murine skin cancer and AP-1 transactivation. Cancer Res 58: 711-716, 1998.
 37. Murakami A., Kawabata K., Koshiba T., Gao G., Nakamura Y., Koshimizu K., Ohigashi H.: Nitric oxide synthase is induced in tumor promoter-sensitive, but not tumor promoter-resistant, JB6 mouse epidermal cells cocultured with interferon- gamma-stimulated RAW 264.7 cells: the role of tumor necrosis factor-alpha. Cancer Res 60: 6326-6331, 2000.
 38. Lu Y. P., Chang R. L., Lou Y. R., Huang M. T., Newmark H. L., Reuhl K. R., Conney A. H.: Effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate- and ultraviolet B light-induced expression of c-Jun and c-Fos in JB6 cells and in mouse epidermis. Carcinogenesis 15: 2363-2370, 1994.
 39. Dong Z., Huang C., Brown R. E., Ma W. Y.: Inhibition of activator protein 1 activity and neoplastic transformation by aspirin. J Biol Chem 272: 9962-9970, 1997.
 40. Dong Z., Ma W., Huang C., Yang C. S.: Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, (-)- epigallocatechin gallate, and theaflavins. Cancer Res 57: 4414-4419, 1997.
 41. Nomura M., Ma W. Y., Huang C., Yang C. S., Bowden G. T., Miyamoto K., Dong Z.: Inhibition of ultraviolet B-induced AP-1 activation by theaflavins from black tea. Mol Carcinog 28: 148-155, 2000.
 42. Nomura M., Ma W., Chen N., Bode A. M., Dong Z.: Inhibition of 12-O- tetradecanoylphorbol-13-acetate-induced NF-kappaB activation by tea polyphenols, (-)-epigallocatechin gallate and theaflavins. Carcinogenesis 21: 1885-1890, 2000.
 43. Huang C., Ma W. Y., Ryan C. A., Dong Z.: Proteinase inhibitors I and II from potatoes specifically block UV- induced activator protein-1 activation through a pathway that is independent of extracellular signal-regulated kinases, c-Jun N-terminal kinases, and P38 kinase. Proc Natl Acad Sci U S A 94: 11957-11962, 1997.
 44. Liu G., Chen N., Kaji A., Bode A. M., Ryan C. A., Dong Z.: Proteinase inhibitors I and II from potatoes block UVB-induced AP-1 activity by regulating the AP-1 protein compositional patterns in JB6 cells. Proc Natl Acad Sci U S A 98: 5786-5791, 2001.
 45. Bode A. M., Ma W. Y., Surh Y. J., Dong Z.: Inhibition of epidermal growth factor- induced cell transformation and activator protein 1 activation by. Cancer Res 61: 850- 853, 2001.
 46. Sang S., He K., Liu G., Zhu N., Cheng X., Wang M., Zheng Q., Dong Z., Ghai G., Rosen R. T., Ho C. T.: A new unusual iridoid with inhibition of activator protein-1 (AP-1) from the leaves of Morinda citrifolia L. Org Lett 3: 1307-1309, 2001.
 47. Liu G., Bibus D. M., Bode A. M., Ma W. Y., Holman R. T., Dong Z.: Omega 3 but not omega 6 fatty acids inhibit AP-1 activity and cell transformation in JB6 cells. Proc Natl Acad Sci U S A 98: 7510-7515, 2001.
 48. Liu G., Bode A., Ma W. Y., Sang S., Ho C. T., Dong Z.: Two novel glycosides from the fruits of morinda citrifolia (noni) inhibit ap-1 transactivation and cell transformation in the mouse epidermal jb6 cell line. Cancer Res 61: 5749-5756, 2001.
 49. Liu Y., Duysen E., Yaktine A. L., Au A., Wang W., Birt D. F.: Dietary energy restriction inhibits ERK but not JNK or p38 activity in the epidermis of SENCAR mice. Carcinogenesis 22: 607-612, 2001.
 50. Birt D. F., Yaktine A., Duysen E.: Glucocorticoid mediation of dietary energy restriction inhibition of mouse skin carcinogenesis. J Nutr 129: 571S-574S, 1999.
 51. She Q. B., Bode A. M., Ma W. Y., Chen N. Y., Dong Z.: Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase. Cancer Res 61: 1604-10., 2001.
 52. Saffer J. D., Chen G., Colburn N. H., Thurston S. J.: Power frequency magnetic fields do not contribute to transformation of JB6 cells. Carcinogenesis 18: 1365-1370, 1997.
 53. West R. W., Hinson W. G., Swicord M. L.: Anchorage-independent growth with JB6 cells exposed to 60 HZ magnetic fields at several flux densities. Bioelectrochemistry & Bioenergetics 39: 175-179, 1996.
 54. Ding M., Li, J.-J., Leonard, S.S., Ye, J.-P., Shi, X., Colburn, N.H., Castranova, V. andVallyathan, V.: Vanadate-induced activation of activator protein-1: Role of reactiveoxygen species. Carcinogenesis 20: 663-668, 1999.


JB6 Bibliography (1978-date)

1978

  1. Colburn, N.H., Vorder Bruegge, W.F., Bates, J.R., Gray, R.H., Rossen, J.D., Kelsey, W.H., and Shimada, T.  Correlation of anchorage independent growth with tumorigenicity of chemically transformed mouse epidermal cells.  Cancer Res. 38:  624-634, 1978.
  2. Colburn, N.H.  Chemical transformation of epidermal cell cultures.  In Saffiotti, U. and Autrup, H. (Eds.):  In Vitro Carcinogenesis.  National Cancer Institute.  Technical Report Series 44, 1978, pp. 69-94.
  3. Colburn, N.H., Vorder Bruegge, W.F., Bates, J., and Yuspa, S.H.  Epidermal cell transformation in vitro.  In Slaga, T.J., Sivak, A., and Boutwell, R.K. (Eds.):  Mechanisms of Tumor Promotion and Cocarcinogenesis.  New York, Raven Press, 1978, pp. 257-271.
1979
  1. Colburn, N.H., Former, B.F., Nelson K.A., and Yuspa, S.H.  Tumor promoter induces anchorage independence irreversibly.  Nature 281:  589-591, 1979.
  2. Colburn N.H.  The use of tumor promoter responsive epidermal cell lines to study preneoplastic progression.  In Franks, L.M. and Wigley, C.B. (Eds.):  Neoplastic Transformation in Differentiated Epithelial Cell Systems in vitro.  New York, Academic Press, 1979, pp. 113-134.
1980
  1. Colburn, N.H.  Tumor promotion and preneoplastic progression.  In Slaga, T.J. (Ed.):  Carcinogenesis; Modifiers of Carcinogenesis, Vol. 5.  New York, Raven Press, 1980, pp. 33-56.
  2. Colburn, N.H., Koehler, B., and Nelson, K.A.  A cell culture assay for tumor promoter dependent progression toward neoplastic phenotype:  detection of tumor promoters and promotion inhibitors.  Teratogenesis, Carcinog. Mutagen. 1:  87-96, 1980.
  3. Colburn, N.H.  Tumor promoter produces anchorage independence in mouse epidermal cells by an induction mechanism.  Carcinogenesis 1:  951-954, 1980.
1981
  1. Colburn, N.H. and Gindhart, T.  Specific binding of transforming growth factor correlates with promotion of anchorage independence in EGF receptorless JB6 cells.  Biochem. Biophys. Res. Commun. 102:  799-807, 1981.
  2. Colburn, N.H., Wendel, E., and Abruzzo, G.  Dissociation of mitogenesis and late-stage promotion of tumor cell phenotype by phorbol esters:  mitogen resistant variants are sensitive to promotion.  Proc. Natl. Acad. Sci. USA 78:  6912-6916, 1981.
  3. Dion, L.D., DeLuca, L., and Colburn, N.H.  Phorbol ester-induced anchorage independence and its antagonism by retinoic acid correlates with altered expression of specific glycoproteins.  Carcinogenesis 2:  951-958, 1981.
1982
  1. Colburn, N.H., Dion, L.D., and Wendel, E.J.  The role of mitogenic stimulation and specific glycoprotein changes in the mechanism of late-stage promotion in JB-6 epidermal cell lines.  In Hecker, E., Fusening, N. E., Kunz, W., Marks, F., and Thielmann, H.W. (Eds.):  Carcinogenesis: A Comprehensive Survey.  New York, Raven Press, 1982, pp. 231-235.
  2. Colburn, N. and Huberman, E.  Tumor promotion:  workshop report.  In Haris, C.C. and Cerutti, P.A. (Eds.):  Mechanisms of Chemical Carcinogenesis.  New York, Alan R. Liss, 1982, pp. 499-501.
  3. Colburn, N.H., Wendel, E. and Srinivas, L.  Responses of preneoplastic epidermal cells to tumor promoters and growth factors:  use of promoter resistant variants for mechanism studies.  J. Cell. Biochem. 18:  261-270, 1982.
  4. Srinivas, L. and Colburn, N.H.  Tumor promoter induced ganglioside changes in promotable mouse epidermal cells:  antagonism by an antipromoter.  J. Natl. Cancer Inst. 68:  469-473, 1982.
  5. Colburn, N.H., Gindhart, T., Hegamyer, G., Blumberg, P.M., Delclos, K.B., Magun, B.E., and Lockyer, L.  Phorbol diester and EGF receptors in TPA-resistant and TPA-sensitive mouse epidermal cells.  Cancer Res. 42:  3093-3097, 1982.
  6. Srinivas, L., Gindhart, T.D., and Colburn, N.H.  TPA resistant cells lack trisialoganglioside (GT) response.  Proc. Natl. Acad. Sci. USA 79:  4988-4991, 1982.
  7. Dion, L.D., Bear, J., Bateman, J., Deluca, L.M., and Colburn, N.H.  Tumor promoting phorbol ester inhibits procollagen synthesis in promotable JB6 mouse epidermal cells.  J. Natl. Cancer Inst. 69:  1147-1154, 1982.
1983
  1. Bondy G. P., Denhardt D. T.: Exposure of JB6 mouse epidermal cells to 12-0-tetradecanoyl- phorbol-13-acetate is not accompanied by a significant change in total DNA-cytosine methylation. Carcinogenesis 4: 1599-1603, 1983.
  2. Colburn, N.H., Talmadge, C.B., and Gindhart, T.D.  Transfer of sensitivity to tumor promoters by transfection of DNA from sensitive into insensitive mouse JB6 epidermal cells.  Mol. Cell. Biol. 3:  1182-1186, 1983.
  3. Colburn, N.H., Gindhart, T.D., Dalal, B., and Hegamyer, G.A.  The role of phorbol ester receptor binding in responses to promoters by mouse and human cells.  In Langenbach, R., Nesnow, S., and Rice, J. (Eds.):  Organ and Species Specificity in Chemical Carcinogenesis.  New York, Plenum Publishing Corp., 1983, pp. 189-200.
  4. Colburn, N.H., Talmadge, C.B., and Gindhart, T.D.  Transfer of phorbol ester promotability by transfection of DNA from promotable into nonpromotable cells.  In Cohn W.E. (Ed.):  Progress in Nucleic Acid Research and Molecular Biology.  New York, Academic Press, 1983, pp. 107-110.
  5. Copley, M., Gindhart, T., and Colburn, N.  Hexose uptake as an indicator of JB6 mouse epidermal cell resistance to the mitogenic activity of TPA.  J. Cell. Physiol. 114:  173-178, 1983.
  6. Gensler H. L., Bowden G. T.: Evidence suggesting a dissociation of DNA strand scissions and late- stage promotion of tumor cell phenotype. Carcinogenesis 4: 1507-1511, 1983.
  7. Sobel, M.E., Dion, L.D., Vuust, Jens, and Colburn, N.H.  Tumor promoting phorbol esters inhibit procollagen synthesis at a pretranslational level in JB6 mouse epidermal cells.  Mol. Cell. Biol. 3:  1527-1532, 1983.
1984
  1. Srinivas, L. and Colburn, N.H.  Preferential oxidation of cell surface sialic acid by periodate leads to promotion of transformation in JB6 cells.  Carcinogenesis 5:  515-519, 1984.
  2. Srinivas, L. and Colburn, N.H.  Reduced trisialoganglioside synthesis in chemically but not mos-transformed mouse epidermal cells.  Cancer Res. 44:  1510-1514, 1984.
  3. Colburn, N.H., Lerman, M.I., Srinivas, L., Nakamura, Y., Hegamyer, G.A., and Gindhart, T.D.  Membrane and genetic events in tumor promotion:  studies with promoter resistant variants of JB6 cells.  In Fujiki, H. (Ed.):  Cellular Interactions by Environmental Tumor Promoters.  Tokyo, Japan Sci. Soc. Press, 1984, pp. 155-166.
  4. Colburn, N.H., Lerman, M.I., Srinivas, L., Nakamura, Y., Hegamyer, G.A., and Gindhart, T.D.  Genetic determinants of tumor promotion:  studies with promoter resistant variants of JB6 cells. In Bishop, M., Graves, M., and Rowley, T. (Eds.):  Genes and Cancer, Vol. 17.  New York, Alan R. Liss, 1984, pp. 137-155.
  5. Colburn, N.H., Srinivas, L., Hegamyer, G.A., Dion, L.D., and Wendel, E.J.  Role of specific membrane and genetic changes in the mechanism of tumor promotion.  Studies with promoter-resistant variants.  In Borsonyi, M. (Ed.):  The Role of CoCarcinogens and Promoters in Human and Experimental Carcinogenesis.  Lyon, France, IARC Publication, 1984, pp. 205-215.
  6. Feuerstein N., Sahai A., Anderson W. B., Salomon D., Cooper H. L.: Differential phosphorylation events associated with phorbol ester effects on acceleration versus inhibition of cell growth. Cancer Res 44: 5227-5233, 1984.
  7. Fleischmann, W.R., Jr., Newton, R.C., Fleischmann, C.M., Colburn, N.H., and Brysk, M.M.  Discrimination between nonmalignant and malignant cells by combinations of IFN-  plus IFN- /ß.  J. Bio. Response Mod. 3:  397-405, 1984.
  8. Gindhart T. D., Stevens L., Copley M. P.: Transformation and tumor promoter sensitive phosphoproteins in JB6 mouse epidermal cells:  one is also sensitive to heat stress. Carcinogenesis 5: 1115-1121, 1984.
1985
  1. Colburn, N.H., Lerman, M.I., Hegamyer, G.A., and Gindhart, T.D.  A transforming activity not detectable by DNA transfection to NIH 3T3 cells is detected by JB6 mouse epidermal cells.  Mol. Cell. Biol. 5:  890-893, 1985.
  2. Colburn, N.H.  Genes and membrane signals involved in neoplastic transformation.  In Huberman, E. and Barr, S. H. (Eds.):  Carcinogenesis: A Comprehensive Survey.  The Role of Chemicals and Radiation in the Etiology of Cancer.  New York, Raven Press, 1985, Vol. 10, pp. 235-248.
  3. Diwan, B.A., Ward, J.M., Rice, J.M., Colburn, N.H., and Spangler, E.F.  Tumor-promoting effects of di(2-ethylhexyl)phthalate in JB6 mouse epidermal cells and mouse skin.  Carcinogenesis 6:  343-347, 1985.
  4. Gensler H. L., Matrisian L. M., Bowden G. T.: Effect of retinoic acid on the late-stage promotion of transformation in JB6 mouse epidermal cells in culture. Cancer Res 45: 1922-1925, 1985.
  5. Gindhart T.D., Srinivas, L., and Colburn, N.H.  Benzoyl peroxide promotion of transformation of JB6 mouse epidermal cells:  inhibition by ganglioside GT but not retinoic acid.  Carcinogenesis 6:  309-311, 1985.
  6. Gindhart, T.D., Nakamura, Y., Stevens, L.A., Hegamyer, G.A., West, M.W., Smith, B.M., and Colburn, N.H.  Genes and signal transduction in tumor promotion:  conclusion from studies with promoter resistant variants of JB6 mouse epidermal cells.  In Mass, M. (Ed.):  Carcinogenesis: A Comprehensive Survey.  Tumor Promotion and Enhancement in the Etiology of Human and Experimental Respiratory Tract Carcinogenesis.  New York, Raven Press, 1985, Vol.  8, pp. 341-368.
  7. Nakamura, Y., Colburn, N.H., and Gindhart, T.D.  Role of reactive oxygen in tumor promotion:  implication of superoxide anion in promotion of neoplastic transformation in JB- 6 cells by TPA.  Carcinogenesis 6:  229-235, 1985.
  8. Zerlauth G., Wolf G.: Release of fibronectin is linked to tumor promotion:  response of promotable and non-promotable clones of a mouse epidermal cell line. Carcinogenesis 6: 73-78, 1985.
1986
  1. Greenfield A. R., Taffet S. M., Haddox M. K.: Immunocytochemical localization of ornithine decarboxylase in cultured murine cells. Cell Tissue Res 243: 33-40, 1986.
  2. Hosoi, J., Abe, E., Suda, T., Colburn, N.H., and Kuroki, T.  Induction of anchorage- independent growth of JB6 mouse epidermal cells by 1, 25-Dihydroxy vitamin D31.  Cancer Res. 46:  5582-5586, 1986.
  3. Lerman, M.I., Hegamyer, G.A., and Colburn, N.H.  Cloning and characterization of putative genes that specify sensitivity to induction of neoplastic transformation by tumor promoters.  Int. J. Cancer 37:  293-302, 1986.
  4. Smith, B.M., Gindhart, T.D., and Colburn, N.H.   Extracellular calcium requirement for promotion of transformation in JB6 cells.  Cancer Res. 46:  701-706, 1986.
  5. Smith, B.M., Gindhart, T.D., and Colburn, N.H.  Possible involvement of a lanthanide sensitive protein kinase C substrate in lanthanide promotion of neoplastic transformation.  Carcinogenesis 7:  1949-1956, 1986.
  6. Takahashi, K., Heine, U.I., Junker, J.L., Colburn, N.H., and Rice, J.M.  The role of cytoskeleton changes and expression of the H-ras oncogene during promotion of neoplastic transformation in mouse epidermal JB6 cells.  Cancer Res. 46:  5923-5932, 1986.
  7. Ward J. M., Diwan B. A., Ohshima M., Hu H., Schuller H. M., Rice J. M.: Tumor-initiating and promoting activities of di(2-ethylhexyl) phthalate in vivo and in vitro. Environ Health Perspect 65: 279-291, 1986.
1987
  1. Colburn, N.H.  The genetics of tumor promotion.  In Barrett, J. C. (Ed.):  Mechanisms of Environmental Carcinogenesis, Vol. 1.  Boca Raton, CRC Press, Inc., 1987, pp. 81-95.
  2. Colburn, N.H., Farber, E., Weinstein, I.B., Diamond, L., and Slaga, T.J.  Meeting Report:  American Cancer Society workshop conference on tumor promotion and antipromotion.  Cancer Res. 47: 5509-5513, 1987.
  3. Colburn, N.H., Moses, H.L. and Stanbridge, E.J. (Eds.):  Growth Factors, Tumor Promoters, and Cancer Genes, Vol. 58.  New York, A. R. Liss, 1987, pp. 410.
  4. Crawford D., Cerutti P.: Expression of oxidant stress-related genes in tumor promotion of mouse epidermal cells JB6, in Cerutti P, Nygaard OF, Simic MD (eds): Anticarcinogenesis and Radiation Protection. New York, Plenum Press, 1987, pp 183-190.
  5. Hosoi J., Kato K., Kuroki T.: Induction of anchorage-independent growth of mouse JB6 cells by cholera toxin. Carcinogenesis 8: 377-380, 1987.
  6. Smith J. H., Denhardt D. T.: Molecular cloning of a tumor promoter-inducible mRNA found in JB6 mouse epidermal cells: induction is stable at high, but not at low, cell densities. J Cell Biochem 34: 13-22, 1987.
  7. Lerman, M.I., Sakai, A., Yao, K-T., and Colburn, N.H.  DNA sequences in human nasopharyngeal carcinoma cells that specify susceptibility to tumor promoter-induced neoplastic transformation.  Carcinogenesis 8:  121-127, 1987.
  8. Colburn, N.H. and Smith, B.M.  Genes that cooperate with tumor promoters in transformation.  J. Cell. Biochem. 34:  129-142, 1987.
  9. Seed, J.L., Nakamura, Y., and Colburn, N.H.  Implication of superoxide radical anion in promotion of neoplastic transformation in mouse JB6 cells by TPA.  In Cerutti, P. A., Nygaard, O. F., and Simic, M. G. (Eds.):  Anticarcinogenesis and Radiation Protection.  New York, Plenum Press, 1987, pp. 175-181.
1988
  1. Cerutti P., Krupitza G., Larsson R., Muehlematter D., Crawford D., Amstad P.: Physiological and pathologic effects of oxidants in mouse epidermal cells. Ann NY Acad Sci 551: 75-82, 1988.
  2. Cerutti P.: Commentary -- Response modification creates promotability in multistage carcinogenesis. Carcinogenesis 9: 519-562, 1988.
  3. Colburn, N.H., Smith, B.M., Wendel, E.J., Nakamura, Y., and Winterstein, D.  Comparison of mouse pro-1 and pro-2 transfectants for responses to tumor promoters and antipromoters.  Cancer Res. 48:  6076-6080, 1988.
  4. Colburn, N.H., Smith, B.M., Wendel, E.J., Dowjat, W.K., and Shimada, T.  Transfer by progene transfection of tumor promoter-sensitive phenotype to promotion-insensitive JB6 cells.  Cancer Res. 48:  1195-1200, 1988.
  5. Craig A. M., Nemir M., Mukherjee B. B., Chambers A. F., Denhardt D. T.: Identification of the major phosphoprotein secreted by many rodent cell lines as 2ar/osteopontin: enhanced expression in H-ras-transformed 3T3 cells. Biochem Biophys Res Commun 157: 166-173, 1988.
  6. Crawford D., Zbinden I., Amstad P., Cerutti P.: Oxidant stress induces the proto-oncogenes c-fos and c-myc in mouse epidermal cells. Oncogene 3: 27-32, 1988.
  7. Dion, L.D., Gindhart, T.D., and Colburn, N.H.  Fours days duration of tumor promoter exposure required to transform JB6 P+ cells to anchorage independence.  Cancer Res. 49:  7126-7131, 1988.
  8. Dowjat, K.W., Cao, Y., Nagashima, K., Sakai, A., and Colburn, N.H.  Comparison of P+active and inactive pro-1 homologs from human nasopharyngeal carcinoma cells.  Mol. Carcinog. 1:  33-40, 1988.
  9. Garrity, R.R., Seed, J.L., Young, H.A., Winterstein, D., and Colburn, N.H.  Evidence that mouse promotion-sensitivity gene pro-1 is transcribed by RNA  polymerase III.  Gene 68:  63-72, 1988.
  10. Kraft A. S., Reeves J. A., Ashendel C. L.: Differing modulation of protein kinase C by bryostatin 1 and phorbol esters in JB6 mouse epidermal cells. J Biol Chem 263: 8437-8442, 1988.
  11. Larsson R., Cerutti P.: Oxidants induce phosphorylation of ribosomal protein S6. J Biol Chem 263: 17452-17458, 1988.
  12. Lerman, M.I. and Colburn, N.H.  Pro genes, a novel class of genes that specify sensitivity to induction of neoplastic transformation by tumor promoters.  In Langenbach, R., Barrett, J. C., and Elmore, E. (Eds.):  Tumor Promoters:  Biological Approaches for Mechanistic Studies and Assay Systems.  New York, Raven Press, 1988, pp. 357-385.
  13. Muehlematter D., Larsson R., Cerutti P.: Active oxygen induced DNA strand breakage and poly ADP-ribosylation in promotable and non-promotable JB6 mouse epidermal cells. Carcinogenesis 9: 239-245, 1988.
  14. Nadler S. A., Honigberg B. M.: Genetic differentiation and biochemical polymorphism among trichomonads. J Parasitol 74: 797-804, 1988.
  15. Nakamura, T., Gindhart, T.D., Winterstein, D., Tomita, I., Seed, J.L.,  and Colburn, N. H.  Early superoxide dismutase-sensitive event promotes neoplastic transformation in mouse epidermal JB6 cells.  Carcinogenesis 9:  203-207, 1988.
  16. Smith, B.M. and Colburn, N.H.  Protein kinase C and its substrates in tumor promoter- sensitive and -resistant cells. J. Biol. Chem. 263:  6424-6431, 1988.
1989
  1. Bernstein, L.R. and Colburn, N.H.  AP-1/jun function is differentially induced in promotion sensitive and resistant JB6 cells.  Science 244:  566-569, 1989.
  2. Cerutti P., Larsson R., Krupitza G., Muehlematter D., Crawford D., Amstad P.: Pathophysiological mechanisms of active oxygen. Mutat Res 214: 81-88, 1989.
  3. Cerutti P.: Response modification in carcinogenesis. Environmental Health Perspective 81: 39-43, 1989.Colburn, N.H., Raab-Traub, N., Becker, Y., Cao, Y., and Winterstein, D.  Transforming activity of nasopharyngeal carcinoma DNA detectable in mouse JB6 cells.  Int. J. Cancer44:  1012-1016, 1989.
  4. Colburn, N.H. (Ed.):  Genes and Signal Transduction in Multistage Carcinogenesis.  New York, Marcel Dekker, 1989, 461 pages.
  5. Craig A. M., Smith J. H., Denhardt D. T.: Osteopontin, a transformation-associated cell adhesion phosphoprotein, is induced by 12-O-tetradecanoylphorbol 13-acetate in mouse epidermis. J Biol Chem 264: 9682-9689, 1989.
  6. Crawford D. R., Amstad P. A., Foo D. D., Cerutti P. A.: Constitutive and phorbol-myristate- acetate regulated antioxidant defense of mouse epidermal JB6 cells. Mol Carcinog 2: 136-143, 1989.
  7. Denhardt D. T., Craig A. M., Smith J. H.: Regulation of gene expression by the tumor promoter 12-0-tetradecanoylphorbol-13-acetate, in Colburn NH (ed): Genes and Signal Transduction in Multistage Carcinogenesis. New York, Marcell Dekker, 1989, pp 167-189.
  8. Garrity, R.R., Smith, B.M., and Colburn, N.H.  Genes and signals involved in tumor promoter induced transformation.  In Colburn, N.H. (Ed.):  Genes and Signal Transduction in Multistage Carcinogenesis.  New York, Marcel Dekker, 1989, pp. 139-166.Jain A. K., Shimoi K., Nakamura Y., Sano M., Tomita I.: Effect of tea on 12-O tetradecanoyl- phorbol-13 acetate (TPA) induced promotion of transformation in JB6 mouse epidermal cells. Indian J Cancer 26: 92-98, 1989.
  9. Kischel T., Harbers M., Stabel S., Borowski P., Muller K., Hilz H.: Tumor promotion and depletion of protein kinase C in epidermal JB6 cells. Biochem Biophys Res Commun 165: 981-987, 1989.
  10. Krupitza G., Cerutti P.: ADP-ribosylation of ADPR-transferase and topoisomerase I in intact mouse epidermal cells JB6. Biochemistry 28: 2034-2040, 1989.
  11. Larsson R., Cerutti P.: Translocation and enhancement of phosphotransferase activity of protein kinase C following exposure in mouse epidermal cells to oxidants [published erratum appears in Cancer Res 1990 Jan 1;50(1):212]. Cancer Res 49: 5627-5632, 1989.
  12. Muehlematter D., Ochi T., Cerutti P.: Effects of tert-butyl hydroperoxide on promotable and non-promotable JB6 mouse epidermal cells. Chem Biol Interact 71: 339-352, 1989.
  13. Simek, S.L., Kligman, D., Patel, J., and Colburn, N.H.  Differential synthesis of an 80-kDa PKC substrate in preneoplastic and neoplastic mouse JB6 cells.  Proc. Natl. Acad. Sci. USA86:  7410-7414, 1989.
  14. Smith J. H., Denhardt D. T.: Evidence for two pathways of protein kinase C induction of 2ar expression: correlation with mitogenesis. J Cell Physiol 139: 189-195, 1989.
1990
  1. Amstad P., Cerutti P.: Genetic modulation of the cellular antioxidant defense capacity. Environ Health Perspect 88: 77-82, 1990.
  2. DeBenedetti F., Colburn N. H., Oppeneheim J. J., Faltynek C. R.: Tumor necrosis factor induces anchorage independent growth of two murine non-transformed cell lines, Molecular and Cellular Biology of Cytokines, Wiley-Liss, 1990, pp 275-280.
  3. Garrity, R.R., Hegamyer, G.C., Seed, J.L.,  and Colburn, N.H.  Deletion mapping of tumor promotion susceptibility gene pro-1 implicates an RNA polymerase III transcription unit.  Mol. Carcinog. 3:  243-250. 1990.
  4. Ludwig A., Dietel M., Schafer G., Muller K., Hilz H.: Nicotinamide and nicotinamide analogues as antitumor promoters in mouse skin. Cancer Res 50: 2470-2475, 1990.
  5. Miki H., Yamadori I., Heine U. I., Kenney S., Riggs C. W., Rice J. M.: Effect of 12-O- tetradecanoylphorbol-13-acetate on intercellular communication in various clones of mouse epidermal JB6 cells. Cancer Res 50: 1324-1329, 1990.
  6. Miyagi T., Sagawa J., Kuroki T., Matsuya Y., Tsuiki S.: Tumor-promoting phorbol ester induces alterations of sialidase and sialyltransferase activities of JB6 cells. Jpn J Cancer Res 81: 1286-1292, 1990.
  7. Yamadori I., Heine U. I., Kenney S., Riggs C. W., Rice J. M.: Effect of 12-O- tetradecanoylphorbol-13-acetate on colony formation and intercellular communication in a coculture system of JB6 clones. Cancer Res 50: 5567-5573, 1990.
1991
  1. Amstad P., Peskin A., Shah G., Mirault M. E., Moret R., Zbinden I., Cerutti P.: The balance between Cu,Zn-superoxide dismutase and catalase affects the sensitivity of mouse epidermal cells to oxidative stress. Biochemistry 30: 9305-9313, 1991.
  2. Bernstein, L., Ben-Ari, E., Simek, S., and Colburn, N.H.  Gene regulation during promotion of neoplastic transformation in mouse JB6 cells.  Environ. Health Perspect. 93:  111-119, 1991.
  3. Cao, Y., Sun, Y., Poirier, S., Winterstein, D., Hegamyer, G., Seed, J., Malin, S. and Colburn, N.H.  Isolation and partial characterization of a transformation-associated sequence from human nasopharyngeal carcinoma.  Mol. Carcinog. 4:  297-307, 1991.
  4. Cerutti P., Trump B. F.: Inflammation and oxidative stress in carcinogenesis. Cancer Cells 3: 1-7, 1991.
  5. Cerutti P.: Oxidant stress and carcinogenesis. Eur J Clin Invest 21: 1-5, 1991.
  6. Chang P. L., Prince C. W.: 1 alpha,25-dihydroxyvitamin D3 stimulates synthesis and secretion of nonphosphorylated osteopontin (secreted phosphoprotein 1) in mouse JB6 epidermal cells. Cancer Res 51: 2144-2150, 1991.
  7. Craig A. M., Denhardt D. T.: The murine gene encoding secreted phosphoprotein 1 (osteopontin): promoter structure, activity, and induction in vivo by estrogen and progesterone. Gene 100: 163-171, 1991.
  8. De Benedetti F., Falk L., Ruscetti F. W., Colburn N. H., Faltynek C. R., Oppenheim J. J.: Synergistic inhibition of phorbol ester-induced transformation of JB6 cells by transforming growth factor-beta and retinoic acid. Cancer Res 51: 1158-1164, 1991.
  9. Harbers M., Hilz H.: Suppression of c-fos precursor RNA splicing by the protein kinase C inhibitor H7 [1-(5-isoquinolinesulphonyl)-2-methylpiperazine]. Biochem J 278: 305-308, 1991.
  10. Nose K., Shibanuma M., Kikuchi K., Kageyama H., Sakiyama S., Kuroki T.: Transcriptional activation of early-response genes by hydrogen peroxide in a mouse osteoblastic cell line. Eur J Biochem 201: 99-106, 1991.
  11. Sun, Y., Poirier, S., Hegamyer, G. and Colburn, N.H.  Isolation and characterization of a transformation associated gene from human nasopharyngeal carcinoma cells.  In Rhim, J.S. and Dritschilo, A. (Eds.):  Neoplastic Transformation in Human Cell Systems in vitro.  Clifton, NJ, The Humana Press Inc., 1991, pp. 203-212.
  12. Wilder P. J., Rizzino A.: Effects of transforming growth factor beta on the anchorage- independent growth of murine epithelial JB6 cells. Cancer Res 51: 5898-5902, 1991.
1992
  1. Amstad P. A., Krupitza G., Cerutti P. A.: Mechanism of c-fos induction by active oxygen. Cancer Res 52: 3952-3960, 1992.
  2. Ben-Ari, E.T., Bernstein, L.R., and Colburn, N.H.  Differential c-jun expression in response to tumor promoters in JB6 cells sensitive or resistant to neoplastic transformation.  Mol. Carcinog.  5:  62-74, 1992.51.     Cerutti P., Shah G., Peskin A., Amstad P.: Oxidant carcinogenesis and antioxidant defense, vol 663, Annals of the New York Academy of Sciences, 1992.
  3. Colburn, N.H.  Gene regulation by active oxygen and other stress inducers:  role in tumor promotion and progression.  In Spatz, L. and Bloom, A. (Eds.):  Biological Consequences of Oxidative Stress:  Implications for Cardiovascular Disease and Carcinogenesis.  Oxford, England, Oxford University Press, 1992, pp. 121-137.
  4. Harbers M., Borowski P., Fanick W., Lengyel H., Buck F., Hinsch K. D., Hilz H.: Epigenetic activation of Gi-2 protein, the product of a putative protooncogene, mediates tumor promotion in vitro. Carcinogenesis 13: 2403-2406, 1992.
  5. Hirano, K., Smith, B.M., and Colburn, N.H.  Differential induction of 15 and 16 kDa nuclear proteins in promotion sensitive and promotion resistant mouse JB6 cells.  Oncology Res. 4:  17-21, 1992.
  6. Jain P. T., Fitzpatrick M. J., Phelps P. C., Berezesky I. K., Trump B. F.: Studies of skin toxicity in vitro: dose-response studies on JB6 cells. Toxicol Pathol 20: 394-404, 1992.
  7. Miyagi T., Hata K., Konno K., Tsuiki S.: Multiple forms of mammalian sialidase: altered expression in carcinogenesis. Tohoku J Exp Med 168: 223-229, 1992.
  8. Simek S. L., Fields A. P., Colburn N. H., Winkler-Pickett R., Young H. A.: The presence in a mouse T cell line of a 97-kDa protein kinase C (PKC) with characteristics similar to known members of the novel PKC subgroup and its possible role in lymphocyte gene expression. J Immunol 149: 3542-3549, 1992.
  9. Smith J. S., Jr., Wey H. E., Leikauf G. D., Baxter C. S.: Carba-prostacyclin inhibits 12-O- tetradecanoylphorbol-13-acetate (TPA)- induced transformation in sensitive murine epidermal JB6 cells. Carcinogenesis 13: 1859-1862, 1992.
  10. Smith J. S., Jr., Wey H. E., Leikauf G. D., Baxter C. S.: JB6 murine epidermal cell lines sensitive and resistant to 12-O- tetradecanoylphorbol-13-acetate (TPA)-induced transformation exhibit differential arachidonic acid metabolism in response to TPA and the calcium ionophore A23187. Carcinogenesis 13: 189-192, 1992.
  11. Sun, Y., Pommier, Y., and Colburn, N.H.  Acquisition of a growth inhibitory response to phorbol ester involves DNA damage.  Cancer Res. 52:  1907-1915, 1992.
  12.  Sun, Y., Hegamyer, G., Cheng, Y.-J., Hildesheim, A., Chen, J.-Y., Chen,  I.-H., Cao, Y., Yao, K.-T., and Colburn, N.H.  An infrequent point mutation of the p53 gene in human nasopharyngeal carcinoma.  Proc. Natl. Acad. Sci. USA 89:  6516-6520, 1992.
  13. Wilder P. J., Rizzino A.: TGF-beta does not appear to mediate all effects of 12-O- tetradecanoylphorbol-13-acetate on the anchorage-independent growth of murine epithelial JB6 cells [letter]. In Vitro Cell Dev Biol 28A: 581-582, 1992.
1993
  1. Chang P. L., Prince C. W.: 1 alpha,25-Dihydroxyvitamin D3 enhances 12-O- tetradecanoylphorbol-13- acetate- induced tumorigenic transformation and osteopontin expression in mouse JB6 epidermal cells. Cancer Res 53: 2217-2220, 1993.
  2. Garrett L. R., Ackland-Berglund C. E., Jones C. J., Cuchens M. A.: Differential effects of TPA and pristane on gene expression and transformation in mouse epidermal cells. Exp Cell Res 205: 416-421, 1993.
  3. Ghosh R., Amstad P., Cerutti P.: UVB-induced DNA breaks interfere with transcriptional induction of c- fos. Mol Cell Biol 13: 6992-6999, 1993.
  4. Rudd C. J., Mansbridge J. N., Suing K. D., Dawson M. I.: Correlation of the ability of retinoids to inhibit promoter-induced anchorage-independent growth of JB6 mouse epidermal cells with their activation of retinoic acid receptor gamma. Cancer Lett 73: 41-49, 1993.
  5. Shah G., Ghosh R., Amstad P. A., Cerutti P. A.: Mechanism of induction of c-fos by ultraviolet B (290-320 nm) in mouse JB6 epidermal cells. Cancer Res 53: 38-45, 1993.
  6. Simek, S.L., Kozak, C.A., Winterstein, D., Hegamyer, G., and Colburn, N.H.  Sequence and localization of a novel FK 506 binding protein to mouse chromosome 11.  Genomics 18:  407-409, 1993.
  7. Singh K., Deonarine D., Shanmugam V., Senger D. R., Mukherjee A. B., Chang P. L., Prince C. W., Mukherjee B. B.: Calcium-binding properties of osteopontin derived from non-osteogenic sources. J Biochem (Tokyo) 114: 702-707, 1993.
  8. Sun, Y., Nakamura, K., Wendel, E., and Colburn, N.H.  Progression toward tumor cell phenotype is enhanced by overexpression of a mutant p53 tumor suppressor gene isolated from nasopharyngeal carcinoma.  Proc. Natl. Acad. Sci. 90:  2827-2831, 1993.
  9. Sun, Y., Dong, Z., Nakamura, K., Colburn, N.H.  Dosage-dependent dominance over wild- type p53 of a mutant p53 isolated from nasopharyngeal carcinoma.  FASEB J. 7:  944-950, 1993.
  10. Sun, Y., Nakamura K., Hegamyer, G., Dong Z., and Colburn, N.H.  No point mutation of H-ras or p53 genes expressed in preneoplastic-to-neoplastic progression as modeled in mouse JB6 cell variants.  Mol. Carcinog. 8:  49-57, 1993.
  11. Sun, Y., Hegamyer, G., and Colburn, N.  PCR-direct sequencing of a GC-rich region by inclusion of 10% DMSO:  Application to mouse c-jun.  BioTechniques 15:  372-374, 1993.
1994
  1. Amstad P., Moret R., Cerutti P.: Glutathione peroxidase compensates for the hypersensitivity of Cu,Zn- superoxide dismutase overproducers to oxidant stress. J Biol Chem 269: 1606-1609, 1994.
  2. Banbura M., Ackland-Berglund C., Lee S. H., Hamernik D., Jones C.: Analysis of transcriptional activation of a cyclic AMP response element by 2,6,10,14-tetramethylpentadecane (pristane) in JB6 mouse epidermal cells. Mol Carcinog 11: 204-214, 1994.
  3. Bernstein L. R., Ferris D. K., Colburn N. H., Sobel M. E.: A family of mitogen-activated protein kinase-related proteins interacts in vivo with activator protein-1 transcription factor. J Biol Chem 269: 9401-4, 1994.
  4. Chang P. L., Ridall A. L., Prince C. W.: Calcitriol regulation of osteopontin expression in mouse epidermal cells. Endocrinology 135: 863-869, 1994.
  5. Claudio, P.P, Howard, C.M., Baldi, A., De Luca, A., Condorelli, G., Sun, Y., Colburn, N, Calabretta, B., and Giordano, A.  p130/pRb2 has similar yet distinctive growth suppresive proterties as retinoblastoma family members, pRb and p1071.  Cancer Res. 54:  5556-60, 1994.
  6. Cmarik, J.L., Herschman, H., and Colburn, N.H.  Preferential primary response gene expression in promotion-resistant vs. promotion-sensitive JB6 cells.  Mol. Carcinog. 11:  115-124, 1994.
  7. Dong, Z. and Colburn, N.  AP-1:  A molecular target for prevention of carcinogenesis.  In Srivastava, S. (Ed.):  Molecular Markers of Early Detection of Cancer.  Futura Publishing Corp., 1994, pp. 123-130.
  8. Dong, Z., Birrer, M., Watts, R., Matrisian, L., and Colburn, N.H.  Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells.  Proc. Natl. Acad. Sci. USA 91:  609-613, 1994.
  9. Dong, Z., Cmarik,, J., Wendel, E.J., and Colburn, N.H.  Differential transformation efficiency but not AP-1 induction under anchorage dependent and independent conditions.  Carcinogenesis 15:  1001-1004, 1994.
  10. Jain P. T., Chang S. H., Berezesky I. K., Amstad P., Cerutti P. A., Trump B. F.: Differential cytotoxicity in mouse epidermal JB6 cells: a potential mechanism for oxidant tumor promotion. Mol Carcinog 11: 164-169, 1994.
  11. Lu Y. P., Chang R. L., Lou Y. R., Huang M. T., Newmark H. L., Reuhl K. R., Conney A. H.: Effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate- and ultraviolet B light-induced expression of c-Jun and c-Fos in JB6 cells and in mouse epidermis. Carcinogenesis 15: 2363-2370, 1994.
  12. Sun, Y., Hegamyer, G, and Colburn, N.H.  Molecular cloning of five mRNAs differentially expressed in preneoplastic or neoplastic JB6 mouse epidermal cells:  One is homologous to human tissue inhibitor of metalloproteinase-3.  Cancer Res. 54:  1139-1144, 1994.
  13. West R. W., Hinson W. G., Lyle D. B., Swicord M. L.: Enhancement of anchorage- independent growth in JB6 cells exposed to 60 hertz magnetic fields. Bioelectrochemistry and Bioenergetics 34: 39-43, 1994.
1995
  1. Chang P. L., Yang W. C., Prince C. W.: Effects of okadaic acid on calcitriol- and phorbol ester-induced expression and phosphorylation of osteopontin in mouse JB6 epidermal cells. Ann N Y Acad Sci 760: 24-34, 1995.
  2. Dong, Z., Lavrovsky, V., and Colburn, N.  Transformation reversion induced in JB6 RT101 cells by AP-1 inhibitors.  Carcinogenesis 16: 749-756, 1995.
  3. Dong, Z., Watts, R.G., Sun, Y., Zhan, S.-N., and Colburn, N.H.  Progressive elevation of AP-1 activity during preneoplastic-to-neoplastic progression as modeled in JB6 cell variants.  Int. J. Oncol. 7:  359-364, 1995.
  4. Huang M. T., Ma W., Lu Y. P., Chang R. L., Fisher C., Manchand P. S., Newmark H. L., Conney A. H.: Effects of curcumin, demethoxycurcumin, bisdemethoxycurcumin and tetrahydrocurcumin on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion. Carcinogenesis 16: 2493-2497, 1995.
  5. Lagarrigue S., Chaumontet C., Heberden C., Martel P., Gaillardsanches I.: Suppression of oncogene-induced transformation by quercetin and retinoic acid in rat liver epithelial cells. Cellular and Molecular Biology Res 41: 551-560, 1995.
  6. Pasqualucci L., Wasik M., Teicher B. A., Flenghi L., Bolognesi A., Stirpe F., Polito L., Falini B., Kadin M. E.: Antitumor activity of anti-CD30 immunotoxin (Ber-H2/saporin) in vitro and in severe combined immunodeficiency disease mice xenografted with human CD30+ anaplastic large-cell lymphoma. Blood 85: 2139-2146, 1995.
  7. Singh N., Aggarwal S.: The effect of active oxygen generated by xanthine/xanthine oxidase on genes and signal transduction in mouse epidermal JB6 cells. Int J Cancer 62: 107-114, 1995.
  8. Singh, N., Sun, Y., Nakamura, K., Smith, M.R., and Colburn, N.H.  c-Jun/AP-1 as possible mediators of tumor necrosis factor- -induced apoptotic response in mouse JB6 tumor cells.  Oncology Res. 7:  353-362, 1995.
  9. Su L., Mukherjee A. B., Mukherjee B. B.: Expression of antisense osteopontin RNA inhibits tumor promoter-induced neoplastic transformation of mouse JB6 epidermal cells. Oncogene 10: 2163-2169, 1995.
  10. Sun, Y., Dong, Z., Jackman, J., Hegamyer, G., Kim, H., Sithanandam, K., and Colburn, N.H.  Status of the MDM-2 and WAF-1 genes in mouse epidermal JB6 variants harboring wild-type p53:  A p53-independent induction of  WAF-1.  Int. J. Oncology 6:  465-471, 1995.
  11. Sun, Y., Hegamyer, G., Kim, H., Sithanandam, Li, H., Watts, R., and Colburn, N.H.  Molecular cloning of mouse tissue inhibitor of metalloproteinases-3 (mTIMP-3) and its promoter:  Specific lack of expression in neoplastic JB6 cells may reflect altered gene methylation.  J. Biol. Chem. 270:  19312-19319, 1995.
  12. Watts, R., Ben-Ari, E.T., Bernstein, L.R., Birrer, M.J., Winterstein, D., Wendel, E., and Colburn, N.H.  c-jun and multistage carcinogenesis:  Overexpression of introduced c-jun is associated with progression toward a neoplastic endpoint in mouse JB6 cells sensitive but not resistant to tumor promoter induced transformation.  Mol. Carcinog. 13:  27-36, 1995.
1996
  1. Bian J., Wang Y., Smith M. R., Kim H., Jacobs C., Jackman J., Kung H. F., Colburn N. H., Sun Y.: Suppression of in vivo tumor growth and induction of suspension cell death by tissue inhibitor of metalloproteinases (TIMP)-3. Carcinogenesis 17: 1805-1811, 1996.
  2. Cockerill F., 3rd, Beebakhee G., Soni R., Sherman P.: Polysaccharide side chains are not required for attaching and effacing adhesion of Escherichia coli O157:H7. Infect Immun 64: 3196- 3200, 1996.
  3. FitzGerald C. T., Fernandez-Salguero P., Gonzalez F. J., Nebert D. W., Puga A.: Differential regulation of mouse Ah receptor gene expression in cell lines of different tissue origins. Arch Biochem Biophys 333: 170-178, 1996.
  4. Huang C., Ma W. Y., Dong Z.: Requirement for phosphatidylinositol 3-kinase in epidermal growth factor-induced AP-1 transactivation and transformation in JB6 P+ cells. Mol Cell Biol 16: 6427-6435, 1996.
  5. Huang C., Ma W. Y., Bowden R., Dong Z.: UVB-induced AP-1 activation does not require EGF receptor, but is blocked by a dominant negative PKClamba/iota. J Biol Chem 271: 31262- 31268, 1996.
  6. Li, J.-J., Dong, Z., Dawson, M.I., and Colburn, N.H.  Inhibition of tumor promoter-induced transformation by retinoids that transrepress AP-1 without transactivating retinoic acid response element.  Cancer Res. 56:  483-489, 1996.
  7. Lavrovsky, V., Dong, Z., and Colburn, N.  Drug induced reversion of progression phenotype is accompanied by reversion of AP-1 phenotype in JB6 cells.  In Vitro Cell. Dev. Biol.  32:  234-237,  1996.
  8. Schmidt K. N., Amstad P., Cerutti P., Baeuerle P. A.: Identification of hydrogen peroxide as the relevant messenger in the activation of pathway of transcription factor NF-kappaB, in Snyder R (ed): Biological Reactive Intermediates. New York, Plenum Press, 1996, pp 63-68.
  9. Singh N., Aggarwal S.: Benzoyl peroxide modulates gene expression by epigenetic mechanism in mouse epidermal JB6 cells. Indian J Exp Biol 34: 647-651, 1996.
  10. Steele V. E., Sharma S., Mehta R., Elmore E., Redpath L., Rudd C., Bagheri D., Sigman C. C., Kelloff G. J.: Use of in vitro assays to predict the efficacy of chemopreventive agents in whole animals. J Cell Biochem Suppl 26: 29-53, 1996.
  11. Sun, Y., Kim, H., Parker, M., Stetler-Stevenson, W.G., and Colburn, N.H.  Lack of suppression of tumor cell phenotype by overexpression of TIMP-3 in mouse JB6 tumor cells:  Identification of a transfectant with increased tumorigenicity and invasiveness.  Anticancer Res. 16:  1-8, 1996.
  12. West R. W., Hinson W. G., Swicord M. L.: Anchorage-independent growth with JB6 cells exposed to 60 HZ magnetic fields at several flux densities. Bioelectrochemistry and Bioenergetics 39: 175-179, 1996.
  13. Wroblewski J. M., Lay L. T., Van Zant G., Phillips G., Seth P., Curiel D., Meeker T. C.: Selective elimination (purging) of contaminating malignant cells from hematopoietic stem cell autografts using recombinant adenovirus. Cancer Gene Ther 3: 257-264, 1996.
1997
  1. Amstad P. A., Liu H., Ichimiya M., Chang S., Berezesky I. K., Trump B. F.: bcl-2 enhancement of malignant transformation in mouse epidermal JB6 cells. Mol Carcinog 20: 231-239, 1997.
  2. Amstad P. A., Liu H., Ichimiya M., Berezesky I. K., Trump B. F.: Manganese superoxide dismutase expression inhibits soft agar growth in JB6 clone41 mouse epidermal cells. Carcinogenesis 18: 479-484, 1997.
  3. Chang P. L., Lee T. F., Garretson K., Prince C. W.: Calcitriol enhancement of TPA-induced tumorigenic transformation is mediated through vitamin D receptor-dependent and -independent pathways. Clin Exp Metastasis 15: 580-592, 1997.
  4. Cmarik, J.L. and Colburn, N.H.  Use of mouse JB6 cells to identify molecular targets and novel agents for prevention of carcinogenesis.  Proc. International Conf. on Food Factors:  Chemistry and Cancer Prevention. H. Ohigashi et al., (eds.), Springer-Verlag, Tokyo, 67- 76, 1997.
  5. Deng X., Cao Y., Hu W., Gu H., Yao K.: [No point mutation of the 2.8 kb EcORI fragment of the nasopharyngeal carcinoma transforming gene TX in nasopharyngeal carcinoma]. Hunan I Ko Ta Hsueh Hsueh Pao 22: 102-104, 1997.
  6. Dong, Z., Ding, M., Ma, W.-Y., and Colburn, N.H. Inhibition of tumor promoter induced transformation by expression of the small GTP-binding protein rac in JB6 cells.  Int.  J. Oncology 11: 157-161, 1997.
  7. Dong,  Z., Crawford, H.C., Lavrovsky, V., Taub, D., Watts, R., Matrisian, L.M., and Colburn, N.H.  A dominant negative mutant of Jun blocking 12-0-Tetradecanoylphorbol-13- acetate-Induced invasion in mouse keratinocytes.  Mol. Carcinog. 19: 204-212, 1997.
  8. Dong Z., Ma W., Huang C., Yang C. S.: Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, (-)-epigallocatechin gallate, and theaflavins. Cancer Res 57: 4414-4419, 1997.
  9. Dong Z., Huang C., Brown R. E., Ma W. Y.: Inhibition of activator protein 1 activity and neoplastic transformation by aspirin. J Biol Chem 272: 9962-9970, 1997.
  10. Gopalakrishna R., Chen Z. H., Gundimeda U.: Selenocompounds induce a redox modulation of protein kinase C in the cell, compartmentally independent from cytosolic glutathione: its role in inhibition of tumor promotion. Arch Biochem Biophys 348: 37-48, 1997.
  11. Huang C., Ma W. Y., Ryan C. A., Dong Z.: Proteinase inhibitors I and II from potatoes specifically block UV- induced activator protein-1 activation through a pathway that is independent of extracellular signal-regulated kinases, c-Jun N-terminal kinases, and P38 kinase. Proc Natl Acad Sci U S A 94: 11957-11962, 1997.
  12. Huang C., Ma W. Y., Hanenberger D., Cleary M. P., Bowden G. T., Dong Z.: Inhibition of ultraviolet B-induced activator protein-1 (AP-1) activity by aspirin in AP-1-luciferase transgenic mice. J Biol Chem 272: 26325-26331, 1997.
  13. Huang C., Ma W. Y., Hecht S. S., Dong Z.: Inositol hexaphosphate inhibits cell transformation and activator protein 1 activation by targeting phosphatidylinositol-3' kinase [published erratum appears in Cancer Res 1997 Nov 15;57(22):5198]. Cancer Res 57: 2873-2878, 1997.
  14. Huang C., Ma W., Dong Z.: Signal transduction through atypical PKCs, but not the EGF receptor, is necessary for UVC-induced AP-1 activation in immortal murine cells. Oncogene 14: 1945-1954, 1997.
  15. Huang C., Schmid P. C., Ma W. Y., Schmid H. H., Dong Z.: Phosphatidylinositol-3 kinase is necessary for 12-O- tetradecanoylphorbol-13-acetate-induced cell transformation and activated protein 1 activation. J Biol Chem 272: 4187-4194, 1997.
  16. Huang C., Ma W. Y., Ding M., Bowden G. T., Dong Z.: Direct evidence for an important role of sphingomyelinase in ultraviolet-induced activation of c-Jun N-terminall kinase. J Biol Chem 272: 27753-27757, 1997.
  17. Huang C., Ma W. Y., Dawson M. I., Rincon M., Flavell R. A., Dong Z.: Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid. Proc Natl Acad Sci USA 94: 5826-5830, 1997.
  18. Kim, H., Pennie, W.D., Sun, Y., and Colburn, N.H. Differential functional significance  of AP-1 binding sites in the promoter of gene encoding mouse tissue inhibitor of metalloproteinases-3.  Biochem. J. 324: 547-553, 1997.
  19. Kiss Z., Mukherjee J. J.: Phosphocholine and sphingosine-1-phosphate synergistically stimulate DNA synthesis by a MAP kinase-dependent mechanism. FEBS Lett 412: 197-200, 1997.
  20. Kiss Z., Guyer B., Dong Z.: Promotion-resistant JB6 mouse epidermal cells exhibit defects in phosphatidylethanolamine synthesis and phorbol ester-induced phosphatidylcholine hydrolysis. Biochem J 323: 489-495, 1997.
  21. Li, J.J., Westergaard, C., Ghosh, P. and Colburn, N.H. Inhibitors of both NF B and AP-1 activation block neoplastic transformation response.  Cancer Res. 57: 3569-3576,1997.
  22. Nakamura Y., Kawase I., Harada S., Matsuda M., Honma T., Tomita I.: Antitumor- promoting effects of tea aqueous nondialysates in mouse epidermal JB6 cells., in Ohigashi H, Osawa T, Terao T, Watanabe S, Yoshikawa T (eds): Food Factors for Cancer Prevention. Tokyo, Springer- Verlaag, 1997, pp 138-141.
  23. Pennie,  W.D., Sun, Y., Kim, H., and Colburn, N.H.  Differential expression of TIMP-3 during neoplastic progression in the mouse JB6 model system.  In Liang, P. and Pardee, A.B.  (Eds):  Differential Display, Methods, and Protocols.  Totowa, NJ, Humana Press, 85: 249-261, 1997.
  24. Saffer J. D., Chen G., Colburn N. H., Thurston S. J.: Power frequency magnetic fields do not contribute to transformation of JB6 cells. Carcinogenesis 18: 1365-1370, 1997.
  25. Strickland, J., Sun, Y., Dong, Z. and Colburn, N.H. Grafting assay distinguishes promotion  sensitive from promotion resistant JB6 cells.  Carcinogenesis 18: 1135-1138, 1997.
1998
  1. Cmarik, J.L., Li, Y., Ogram, S.A., Reeves, R. and Colburn, N.H. Tumor promoter induces high mobility group HMG-Y protein expression in transformation-sensitive but not resistant cells.  Oncogene 16: 3387-3396, 1998.
  2. Dong Z., Huang C., Ma W. Y., Malewicz B., Baumann W. J., Kiss Z.: Increased synthesis of phosphocholine is required for UV-induced AP-1 activation. Oncogene 17: 1845-1853, 1998.
  3. Eto I.: Promotion-sensitive epidermal and mammary epithelial cells maintained in suspension over agarose. Cell Prolif 31: 71-92, 1998.
  4. Huang C., Ma W. Y., Li J., Hecht S. S., Dong Z.: Essential role of p53 in phenethyl isothiocyanate-induced apoptosis. Cancer Res 58: 4102-4106, 1998.
  5. Huang C., Chen N., Ma W. Y., Dong Z.: Vanadium induces AP-1- and NFkappB-dependent transcription activity. Int J Oncol 13: 711-715, 1998.
  6. Huang C., Ma W. Y., Dong Z.: Potentiation of insulin-induced phosphatidylinositol-3 kinase activity by phorbol ester is mediated by protein kinase C epsilon. Cell Signal 10: 185-190, 1998.
  7. Huang C., Ma W. Y., Young M. R., Colburn N., Dong Z.: Shortage of mitogen-activated protein kinase is responsible for resistance to AP-1 transactivation and transformation in mouse JB6 cells. Proc Natl Acad Sci U S A 95: 156-161, 1998.
  8. Kiss Z., Anderson W. H., Mukherjee J. J.: Ethanol potentiates the stimulatory effects of insulin and phosphocholine on mitogenesis by a zinc-dependent and rapamycin- sensitive mechanism in fibroblasts and JB6 cells. Biochem J 330: 819-826, 1998.
  9. Lavrovskii V. A., Subkhankulova T. N.: [Spontaneous reversion of tumor cells as a source of dormant metastases]. Tsitologiia 40: 291-301, 1998.
  10. Ma W. Y., Huang C., Dong Z.: Inhibition of ultraviolet C irradiation-induced AP-1 activity by aspirin is through inhibition of JNKs but not erks or P38 MAP kinase. Int J Oncol 12: 565-568, 1998.
  11. Smalley M. J., Titley J., O'Hare M. J.: Clonal characterization of mouse mammary luminal epithelial and myoepithelial cells separated by fluorescence-activated cell sorting. In Vitro Cell Dev Biol Anim 34: 711-721, 1998.
  12. Watts, R.G., Huang, C., Young, M.R., Li, J.J., Dong, Z., Pennie, W.D. and Colburn, N.H.  Expression of Dominant Negative Erk2 Inhibits AP-1 Transactivation and Neoplastic Transformation.  Oncogene 17: 3493-3498, 1998.
1999
  1. Bae G. U., Seo D. W., Kwon H. K., Lee H. Y., Hong S., Lee Z. W., Ha K. S., Lee H. W., Han J. W.: Hydrogen peroxide activates p70(S6k) signaling pathway. J Biol Chem 274: 32596- 32602, 1999.
  2. Bernstein LR, Walker SE.  Tumor promotion resistant cells are deficient in AP-1 DNA binding, JunD DNA binding and JunD expression and form different  AP-1-DNA complexes than promotion sensitive cells.  Biochim Biophys Acta. 1999 Dec 23;1489(2-3):263-80.
  3. Chen N., Ma W., Huang C., Dong Z.: Translocation of protein kinase Cepsilon and protein kinase Cdelta to membrane is required for ultraviolet B-induced activation of mitogen- activated protein kinases and apoptosis. J Biol Chem 274: 15389-15394, 1999.
  4. Chung J. Y., Huang C., Meng X., Dong Z., Yang C. S.: Inhibition of activator protein 1 activity and cell growth by purified green tea and black tea polyphenols in H-ras-transformed cells: structure-activity relationship and mechanisms involved [In Process Citation]. Cancer Res 59: 4610- 4617, 1999.
  5. Chung J. Y., Huang C., Meng X., Dong Z., Yang C. S.: Inhibition of activator protein 1 activity and cell growth by purified green tea and black tea polyphenols in H-ras-transformed cells: structure-activity relationship and mechanisms involved. Cancer Res 59: 4610-4617, 1999.
  6. Cmarik, J.L., Min, H., Hegamyer, G., Zhan, S., Matsuhashi, S., Yoshinaga, H. and Colburn, N.H.  Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation.  Proc. Natl. Acad. Sci. USA 96: 14037-14042, 1999.
  7. Ding M., Li J. J., Leonard S. S., Ye J. P., Shi X., Colburn N. H., Castranova V., Vallyathan V.: Vanadate-induced activation of activator protein-1: role of reactive oxygen species. Carcinogenesis 20: 663-668, 1999.
  8. Ding M., Dong Z., Chen F., Pack D., Ma W. Y., Ye J., Shi X., Castranova V., Vallyathan V.: Asbestos induces activator protein-1 transactivation in transgenic mice. Cancer Res 59: 1884-1889, 1999.
  9. Ding M., Shi X., Dong Z., Chen F., Lu Y., Castranova V., Vallyathan V.: Freshly fractured crystalline silica induces activator protein-1 activation through ERKs and p38 MAPK. J Biol Chem 274: 30611-30616, 1999.
  10. Dong Z., Huang C., Ma W. Y.: PI-3 kinase in signal transduction, cell transformation, and as a target for chemoprevention of cancer. Anticancer Res 19: 3743-3747, 1999.
  11. Gopalakrishna R., Gundimeda U., Anderson W. B., Colburn N. H., Slaga T. J.: Tumor promoter benzoyl peroxide induces sulfhydryl oxidation in protein kinase C: its reversibility is related to the cellular resistance to peroxide-induced cytotoxicity. Arch Biochem Biophys 363: 246-258, 1999.
  12. Huang C., Ma W. Y., Li J., Dong Z.: Arsenic induces apoptosis through a c-Jun NH2- terminal kinase- dependent, p53-independent pathway. Cancer Res 59: 3053-3058, 1999.
  13. Huang C., Ma W. Y., Dong Z.: The extracellular-signal-regulated protein kinases (Erks) are required for UV-induced AP-1 activation in JB6 cells. Oncogene 18: 2828-2835, 1999.
  14. Huang C., Li J., Ma W. Y., Dong Z.: JNK activation is required for JB6 cell transformation induced by tumor necrosis factor-alpha but not by 12-O-tetradecanoylphorbol-13-acetate. J Biol Chem 274: 29672-29676, 1999.
  15. Jansen, A.P., Colburn, N.H. and Verma, A.K.: Tumor promoter-induced ornithine decarboxylase gene espression occurs independently of AP-1 activation.  Oncogene18:5806-13, 1999.
  16. Kagoura M., Matsui C., Morohashi M.: Phytol is a novel tumor promoter on ICR mouse skin. Jpn J Cancer Res 90: 377-384, 1999.
  17. Li B., Gutierrez P. L., Amstad P., Blough N. V.: Hydroxyl radical production by mouse epidermal cell lines in the presence of quinone anti-cancer compounds. Chem Res Toxicol 12: 1042- 1049, 1999.
  18. Pennie, W.D., Hegamyer, G.A., Young, M.R. and Colburn, N.H.: Specific methylation events contribute to the transcriptional repression of the mouse tissue inhibitor of metalloproteinases-3 gene (TIMP-3) in neoplastic cells.  Cell Growth & Diff.  10:279-286, 1999.
  19. Rajesh D., Schell K., Verma A. K.: Ras mutation, irrespective of cell type and p53 status, determines a cell's destiny to undergo apoptosis by okadaic acid, an inhibitor of protein phosphatase 1 and 2A. Mol Pharmacol 56: 515-525, 1999.
  20. Shi X., Dong Z., Huang C., Ma W., Liu K., Ye J., Chen F., Leonard S. S., Ding M., Castranova V., Vallyathan V.: The role of hydroxyl radical as a messenger in the activation of nuclear transcription factor NF-kappaB. Mol Cell Biochem 194: 63-70, 1999.
  21. Snawder J. E.: Effect of magnetic field exposure on anchorage-independent growth of a promoter-sensitive mouse epidermal cell line (JB6). Environ Health Perspect 107: 195-198, 1999.
  22. Young, M.R., Li, J.-J., Rincon, M., Flavell, R.A., Sathyanarayana, B.K., Hunziker, R. and Colburn, N.H.  Transgenic mice demonstrate AP-1 transactivation is required for tumor promotion.  Proc. Natl. Acad. Sci. USA 96: 9827-9832, 1999.
2000
  1. Berdyshev E. V., Schmid P. C., Dong Z., Schmid H. H.: Stress-induced generation of N- acylethanolamines in mouse epidermal JB6 P+ cells. Biochem J 346 Pt 2: 369-74., 2000.
  2. Borowski P., Resch K., Schmitz H., Heiland M.: A synthetic peptide derived from the non- structural protein 3 of hepatitis C virus serves as a specific substrate for PKC. Biol Chem 381: 19- 27., 2000.
  3. Chang P.-L., Chambers A. F.: Transforming JB6 cells exhibit enhanced integrin-mediated adhesion to osteopontin. J Cell Biochem 78: 8-23, 2000.
  4. Chang L. C., Song L. L., Park E. J., Luyengi L., Lee K. J., Farnsworth N. R., Pezzuto J. M., Kinghorn A. D.: Bioactive constituents of Thuja occidentalis. J Nat Prod 63: 1235-8., 2000.
  5. Chen N. Y., Ma W. Y., Yang C. S., Dong Z.: Inhibition of arsenite-induced apoptosis and AP-1 activity by epigallocatechin-3-gallate and theaflavins. J Environ Pathol Toxicol Oncol 19: 287-95, 2000.
  6. Cmarik, J., Hegamyer, G., Gerrard, B., Dean, M. and Colburn, N.H.  cDNA cloning and mapping of mouse pleckstrin (Plek), a gene upregulated in transformation-resistant cells.  Genomics 66:204-212, 2000.
  7. Davis, M.A., Flaws, J.A., Young, M. and Colburn, N.H. Effect of ceramide analog C2 on intracellular glutathione determines apoptotic or necrotic cell death of JB6 tumor cells.  Tox. Sci. 53: 48-55, 2000.
  8. Dong Z.: Effects of food factors on signal transduction pathways. Biofactors 12: 17-28, 2000.
  9. Eto I.: Molecular cloning and sequence analysis of the promoter region of mouse cyclin D1 gene: implication in phorbol ester-induced tumour promotion. Cell Prolif 33: 167-87., 2000.
  10. Gannett P. M., Ye J., Ding M., Powell J., Zhang Y., Darian E., Daft J., Shi X.: Activation of AP-1 through the MAP kinase pathway: A potential mechanism of the carcinogenic effect of arenediazonium ions [In Process Citation]. Chem Res Toxicol 13: 1020-7, 2000.
  11. Hsu, T-C., Young, M.R., Cmarik, J. and Colburn, N.H.  Activator protein-1 (AP-1)- and nuclear factor- B (NF- B)-dependent transcriptional events in carcinogenesis.  FORUM Free Radical Biology & Medicine 28: 1338-1348, 2000.
  12. Huang C., Zhang Z., Ding M., Li J., Ye J., Leonard S. S., Shen H. M., Butterworth L., Lu Y., Costa M., Rojanasakul Y., Castranova V., Vallyathan V., Shi X.: Vanadate induces p53 transactivation through hydrogen peroxide and causes apoptosis. J Biol Chem 275: 32516-22., 2000.
  13. Huang C., Mattjus P., Ma W. Y., Rincon M., Chen N. Y., Brown R. E., Dong Z.: Involvement of nuclear factor of activated T cells activation in UV response. Evidence from cell culture and transgenic mice. J Biol Chem 275: 9143-9., 2000.
  14. Huang C., Li J., Chen N., Ma W., Bowden G. T., Dong Z.: Inhibition of atypical PKC blocks ultraviolet-induced AP-1 activation by specifically inhibiting ERKs activation. Mol Carcinog 27: 65-75., 2000.
  15. Li, J-J., Cao, Y., Young, M.R., and Colburn, N.H.  Induced expression of dominant negative cJun down regulates NF B and AP-1 target genes and suppresses tumor phenotype in human keratinocytes.  Molec. Carcinogenesis 29:159-169, 2000.
  16. Murakami A., Kawabata K., Koshiba T., Gao G., Nakamura Y., Koshimizu K., Ohigashi H.: Nitric oxide synthase is induced in tumor promoter-sensitive, but not tumor promoter-resistant, JB6 mouse epidermal cells cocultured with interferon-gamma-stimulated RAW 264.7 cells: the role of tumor necrosis factor-alpha. Cancer Res 60: 6326-31., 2000.
  17. Nakamura K., Shinozuka K., Kunitomo M.: [Suppressive effect of protein kinase C inhibitors on tumor cell function via phosphorylation of p53 protein in mice]. Yakugaku Zasshi 120: 1387-94., 2000.
  18. Nakamura, K., Sun, Y., Yokoyama, Y., Ferris, D., Singh, N., Ichikawa, T., Shinozuka, K., Kunitomo, M., and Colburn, N.H.  Phosphorylation status and function of P53 are inversely related to protein Kinase C activation.  Anticancer Research 20:1-6, 2000.
  19. Nomura M., Ma W., Chen N., Bode A. M., Dong Z.: Inhibition of 12-O-tetradecanoylphorbol- 13-acetate-induced NF-kappaB activation by tea polyphenols, (-)-epigallocatechin gallate and theaflavins. Carcinogenesis 21: 1885-90., 2000.
  20. Nomura M., Ma W. Y., Huang C., Yang C. S., Bowden G. T., Miyamoto K., Dong Z.: Inhibition of ultraviolet B-induced AP-1 activation by theaflavins from black tea. Mol Carcinog 28: 148-55., 2000.
  21. Schmid P. C., Schwartz K. D., Smith C. N., Krebsbach R. J., Berdyshev E. V., Schmid H. H.: A sensitive endocannabinoid assay. The simultaneous analysis of N- acylethanolamines and 2- monoacylglycerols. Chem Phys Lipids 104: 185-91., 2000.
  22. She Q. B., Chen N., Dong Z.: ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation. J Biol Chem 275: 20444-9., 2000.
  23. Sun, Y., Kim, H., Bian, J., Wang, Y., Pennie, W. and Colburn, N.H. Regulation of expression of the mouse tissue inhibitor of metalloproteinases-3 (TIMP-3) gene.  In Edward, D. Khokha, R. and Howkes, S. (Eds): Inhibitors of Metalloproteinases in Development and Disease: TIMPs', pp.  25-23, 2000.
2001
 
  1. Berdyshev EV, Schmid PC, Krebsbach RJ, et al.  Cannabinoid-receptor-independent cell signalling by N-acylethanolamines.  Biochem J 360: 67-75, 2001.
  2. Chung J. Y., Park J. O., Phyu H., Dong Z., Yang C. S.: Mechanisms of inhibition of the Ras- MAP kinase signaling pathway in 30.7b Ras 12 cells by tea polyphenols (-)-epigallocatechin-3-gallate and theaflavin-3,3'-digallate. Faseb J 15: 2022-4, 2001.
  3. Ding M., Shi X., Lu Y., Huang C., Leonard S., Roberts J., Antonini J., Castranova V., Vallyathan V.: Induction of Activator Protein-1 through Reactive Oxygen Species by Crystalline Silica in JB6 Cells. J Biol Chem 276: 9108-14, 2001.
  4. Hsu, T-C., Nair, R., Tulsian, P., Hegamyer, G., Young, M.R. and Colburn, N.H.  Transformation non-responsive cells owe their resistance to lack of P65/NF- B activation.  Cancer Res.  61: 4160-4168, 2001.
  5. Huang C., Bode A. M., Chen N. Y., Ma W. Y., Li J., Nomura M., Dong Z.: Transactivation of AP-1 in AP-1-luciferase reporter transgenic mice by arsenite and arsenate. Anticancer Res 21: 261-7, 2001.
  6. Huang, C., Li, J., Ding, M., Leonard, S.S., Wang, L., Castranova, V., Vallyathan, V., and Shi, X.  UV induces phosphorylation of protein kinase B (Akt) at Ser-473 and Thr-308 in mouse epidermal Cl 41 cells through hydrogen peroxide.  J. Biol. Chem. 276: 40234-40240, 2001.
  7. Kumar NV, Bernstein LR.  Ten ERK-related proteins in three distinct classes associate with AP-1 proteins and/or AP-1 DNA.  J Biol Chem. 2001 Aug 24;276(34):32362-72.
  8. Liu G., Bode A., Ma W. Y., Sang S., Ho C. T., Dong Z.: Two novel glycosides from the fruits of Morinda citrifolia (noni) inhibit AP-1 transactivation and cell transformation in the mouse epidermal JB6 cell line. Cancer Res 61: 5749-56, 2001.
  9. Liu G., Chen N., Kaji A., Bode A. M., Ryan C. A., Dong Z.: Proteinase inhibitors I and II from potatoes block UVB-induced AP-1 activity by regulating the AP-1 protein compositional patterns in JB6 cells. Proc Natl Acad Sci U S A 98: 5786-91, 2001.
  10. Nomura M., Kaji A., Ma W. Y., Zhong S., Liu G., Bowden G. T., Miyamoto K., Dong Z.: Mitogen- and stress-activated protein kinase 1 mediates activation of akt by ultraviolet b irradiation. J Biol Chem 276: 25558-67, 2001.
  11. Nomura M., Kaji A., Ma W., Miyamoto K., Dong Z.: Suppression of cell transformation and induction of apoptosis by caffeic acid phenethyl ester. Mol Carcinog 31: 83-9, 2001.
  12. Nomura, M., Kaji, A., He, Z., Ma, W-Y., M, K-i., Yang, C.S., and Dong, Z.  Inhibitory mechanisms of tea polyphenols on the ultraviolet B-activated phosphatidylinositol 3-kinase-dependent pathway.  J. Biol. Chem. 276: 46624-46631, 2001.
  13. Pisha E., Lui X., Constantinou A. I., Bolton J. L.: Evidence that a metabolite of equine estrogens, 4-hydroxyequilenin, induces cellular transformation in vitro. Chem Res Toxicol 14: 82- 90, 2001.
  14. Przybyszewski J., Yaktine A. L., Duysen E., Blackwood D., Wang W., Au A., Birt D. F.: Inhibition of phorbol ester-induced AP-1-DNA binding, c-Jun protein and c-jun mRNA by dietary energy restriction is reversed by adrenalectomy in SENCAR mouse epidermis. Carcinogenesis 22: 1421-7, 2001.
  15. Tapanadechopone P., Tumova S., Jiang X., Couchman J. R.: Epidermal transformation leads to increased perlecan synthesis with heparin-binding-growth-factor affinity. Biochem J 355: 517-27, 2001.
  16. Weber T. J., Huang Q., Monks T. J., Lau S. S.: Differential regulation of redox responsive transcription factors by the nephrocarcinogen 2,3,5-tris(glutathion-S-yl)hydroquinone. Chem Res Toxicol 14: 814-21, 2001.
  17. Yang, H-S., Jansen, A.P., Nair, R., Shibahara, K., Verma, A.K., Cmarik, J.L. and Colburn, N.H.  A novel transformation suppressor, Pdcd4, inhibits AP-1 transactivation but not NF B or ODC transactivation.  Oncogene 20: 669-676, 2001.
  18. Young, M.R., Nair, R., Bucheimer, N., Tulsian, P., Hsu, T-C., and Colburn, N.H.  FRA-1, a pivotal player in the map kinase dependent activation of AP-1 and neoplastic transformation.  MCB, in press.
  19. Zhang YG, Liu GM, Dong ZG.  MSK1 and JNKs mediate phosphorylation of STAT3 in UVA-irradiated mouse epidermal JB6 cells.   J Biol Chem 276: (45) 42534-42542, 2001.
  20. Zhong S., Zhang Y., Jansen C., Goto H., Inagaki M., Dong Z.: MAP Kinases Mediate UVB-induced Phosphorylation of Histone H3 at Serine 28. J Biol Chem 276: 12932-7, 2001.
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