DAVID Gene Report
2867328
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) Related Genes Homo sapiens
SP_COMMENT
PTM:Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occur.,
PTM:Phosphorylation of Ser-695 is partial and occurs only if Thr-693 is phosphorylated.,
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,
disease:Defects in EGFR are associated with lung cancer [MIM:211980].,
function:Isoform 2/truncated isoform may act as an antagonist.,
function:Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation.,
miscellaneous:Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis, and cell proliferation.,
similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,
similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.,
similarity:Contains 1 protein kinase domain.,
subcellular location:Cell membrane; Single-pass type I membrane protein.,
subcellular location:Isoform 2: Secreted.,
subunit:Binds RIPK1. CBL interacts with the autophosphorylated C-terminal tail of the EGF receptor. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. The autophosphorylated form interacts with PIK3C2B, maybe indirectly. Interacts with PELP1.,
tissue specificity:Expressed in placenta. Isoform 2 is also expressed in ovarian cancers.,
OMIM_DISEASE
Adenocarcinoma of lung, response to tyrosine kinase inhibitor in ,
Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in ,
Nonsmall cell lung cancer, susceptibility to ,
REFSEQ_PROTEIN
NP_005219 ,
NP_958439 ,
NP_958440 ,
NP_958441 ,
REFSEQ_MRNA
NM_005228 ,
NM_201282 ,
NM_201283 ,
NM_201284 ,
GENPEPT_ACCESSION
AAA52370 ,
AAA52371 ,
AAA63171 ,
AAB53063 ,
AAC50796 ,
AAC50797 ,
AAC50798 ,
AAC50799 ,
AAC50800 ,
AAC50801 ,
AAC50802 ,
AAC50803 ,
AAC50804 ,
AAG35786 ,
AAG35787 ,
AAG35788 ,
AAG35789 ,
AAG35790 ,
AAG43240 ,
AAG43243 ,
AAG43244 ,
AAH94761 ,
AAI18666 ,
AAI28420 ,
AAK01080 ,
AAS07524 ,
AAS83109 ,
AAT52212 ,
AAT97978 ,
AAT97979 ,
AAZ66620 ,
BAD92679 ,
BAF83041 ,
CAA25240 ,
CAA25282 ,
CAA29668 ,
CAJ55813 ,
CAM91181 ,
EAW50962 ,
EAW50963 ,
EAW50964 ,
EAW50965 ,
Genomic_DNA ,
Genomic_RNA ,
JOINED ,
mRNA ,
GENE_SYMBOL
EGFR ,
GENE_NAME
EGFR protein,
Epidermal growth factor receptor,
Epidermal growth factor receptor (Fragment),
Epidermal growth factor receptor isoform a variant,
Epidermal growth factor receptor isoform a variant (Fragment),
Epidermal growth factor receptor precursor,
Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1),
Epidermal growth factor receptor short isoform,
Putative uncharacterized protein EGFR,
Putative uncharacterized protein EGFR (Fragment),
Receptor tyrosine-protein kinase ErbB-1,
Truncated epidermal growth factor receptor,
Truncated epidermal growth factor receptor (Fragment),
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian),
GENERIF_SUMMARY
A truncated form of the hEGFR ectodomain comprising residues 1-501, unlike the full-length hEGFR ectodomain (residues 1-621), binds hEGF and hTGF-alpha with high affinity and is a competitive inhibitor of EGF-stimulated mitogenesis. ,
Chemical/biological model for EGFR activation. ,
EGFR has been detected in the nucleus and might function as a transcription factor to activate gene transcription. ,
The data presented here demonstrate that, in contrast to activation by the cytokine, growth hormone (GH), the activation of STAT5b by the growth factor, epidermal growth factor (EGF), requires overexpression of the EGF receptor (EGFR). ,
effects of receptor-selective retinoid ligands on EGFR-associated signal transduction ,
Interaction of the extracellular domain of the epidermal growth factor receptor with gangliosides ,
this study, 11 analogs of a fragment of the B-loop of EGF-related peptides from several species were synthesized to study binding to A431 human epidermoid carcinoma using both 125I-EGF and [3'4'-3H-Tyr(22,29), Abu(20,31)]EGF(20-31)-NH(2). ,
CsA affects EGF-r metabolism in gingival keratinocytes resulting in an increased number of cell surface receptors ,
Calmodulin binds to the EGFR ,
data demonstrate that prostaglandin E2 transactivates EGFR and triggers mitogenic signaling in gastric epithelial and colon cancer cells as well as in rat gastric mucosa in vivo ,
sequestration in non-caveolar lipid rafts inhibits lipid binding ,
Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors ,
estrogen transactivates the epidermal growth factor receptor (EGFR) to MAP K signaling axis via GPR30;implications for breast cancer biology ,
Identification of epidermal growth factor receptor as a target of Cdc25A protein phosphatase ,
contig map for the EGFR region and markers positioned on its associated physical map to the analysis of 7p11.2 amplifications in a series of glioblastomas. ,
EGFR is often strongly expressed and is a potential therapeutic target in patients with malignant thymic tumors ,
Antisense epidermal growth factor receptor RNA transfection in human glioblastoma cells down-regulates telomerase activity and telomere length. ,
epidermal growth factor receptor activity on fertilization capacity of testicular harvested spermatozoa ,
results suggest a potential mechanism by which maintenance of low levels of EGFR expression and subsequent EGFR upregulation may be attributed to the loss of transcriptional repression of EGFR gene expression in hormone-dependent breast cancer cells ,
Src-dependent phosphorylation of the EGFR at Tyr-845 is required for EGFR transactivation and zinc-induced Ras activation ,
Effects of pharmacologic antagonists of epidermal growth factor receptor, PI3K and MEK signal kinases on NF-kappaB and AP-1 activation and IL-8 and VEGF expression in human head and neck squamous cell carcinoma lines. ,
blocking of ubiquitination by inhibiting Src family kinases ,
novel mechanism of EGFR internalization that does not require ligand binding, receptor kinase activity, or ubiquitylation and does not direct the receptor into a degradative pathway ,
Dephosphorylation of the EGFR and the consequent suppression of EGFR signalling. Review. ,
second cysteine-rich region contains targeting information for caveolae/rafts ,
Helicobacter pylori-stimulated EGF receptor transactivation requires metalloprotease cleavage of HB-EGF ,
determination of decorin binding site ,
Expression of this molecule and its correlation with prognostic markers in patients with head and neck tumors ,
Detection of serum epidermal growth factor receptor in the diagnosis of proliferation of pituitary adenomas ,
These data demonstrate a distinct radiation response profile at the transcriptional level that is dependent on enhanced EGFR/Ras/MAPK signaling. ,
These results indicate that epidermal growth factor (EGF) receptors can form a ligand-independent inactive dimer and that receptor dimerization and activation are mechanistically distinct and separable events. ,
ErbB1 and ErbB2 employ different mechanisms of plasma membrane targeting during keratinocyte differentiation; cytoskeletal association may facilitate the coupling of activated ErbB1 and ERK. ,
Rac activation upon cell-cell contact formation is dependent on signaling from here ,
Differential EGFR patterns by interphase cytogenetics in malignant peripheral nerve sheath tumor and morphologically similar spindle cell neoplasms. ,
Results show that the juxtamembrane region of the epidermal growth factor receptor is necessary for accurate polarized expression of the native molecule. ,
The results of this study indicate that dual inhibition of focal adhesion kinase (FAK) and epidermal growth factor receptor (EGFR) signaling pathways can cooperatively enhance apoptosis in breast cancers. ,
Stimulation of cells with EGF rapidly leads to phosphorylation of Hrs, raising the question whether the EGF receptor tyrosine kinase phosphorylates Hrs directly. Several downstream kinases, rather than the active receptor kinase are responsible. ,
These results demonstrate that 1,25(OH)(2)D(3) alters EGFR membrane trafficking and down-regulates EGFR growth signaling. ,
EGF receptor expression was elevated in the prefrontal cortex in schizophrenic ,
Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors. ,
findings suggest an increase in functional TGF-alpha and activation of the EGFr in response to IFN-gamma ,
Data show that human sprouty2 potentiates epidermal growth factor receptor signalling by specifically intercepting c-Cbl-mediated effects on receptor down-regulation. ,
Data indicate that phospholipase A2 downregulates the EGF receptor-mediated intracellular signal transduction that may be mediated by arachidonic acid and/or ceramide. ,
Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha. ,
Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains ,
caveolin-1/EGFR association and is critical for the EGF-induced tyrosine phosphorylation of caveolin-1 that is associated with its inhibition of EGFR activation. ,
determination of whether G protein-coupled receptor kinase-2 can phosphorylate and desensitize epidermal growth factor receptor ,
Human cytomegalovirus infection inhibits epidermal growth factor (EGF) signalling by targeting EGF receptors ,
ligand-independent activation of the epidermal growth factor receptor is triggered by cholesterol depletion from the plasma membrane ,
Endocytosis is regulated by Grb2-mediated recruitment of the Rab5 GTPase-activating protein RN-tre. ,
Cell proliferation, nuclear ploidy, and EGFr and HER2/neu tyrosine kinase oncoproteins in infiltrating ductal breast carcinoma. ,
epidermal growth factor receptor may have a role in disease relapse and progression to androgen-independence in human prostate cancer ,
mediation of synergism with c-src by STAT5b ,
mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivo ,
hydrogen peroxide increases cPLA(2) activity through its phosphorylation utilizing an epithelial growth factor/Ras/extracellular signal-regulated kinase and p38 pathway. ,
EGF receptor is activated in a pathway that requires ARF4 to induce phospholipase D2 ,
Mutual interaction of EGFR with c-Src is required for many EGFR-mediated cellular functions including proliferation, migration, survival and EGFR endocytosis, as discussed in this review. ,
EGFR, DI, and the diploid are valuable targets for judging metastasis and recurrence of gastric cancer before and after operation. ,
Expression of the invasive phenotype in breast epithelial cells requires increased EGF receptor signaling, involving both PI 3-kinase and Erk 1,2 activities, which leads to enhanced secretion of MMP-9 and transcription of invasion-related genes. ,
Levels of this receptor are lowered in cryptorchism. ,
targeting in cancer, involved in apoptosis (REVIEW) ,
activation regulates mutation and epidermal growth factor receptor activation regulates vascular endothelial growth factor mRNA expression in human glioblastoma cells by transactivating the proximal VEGF promoter. ,
TPA-induced AP-1 activation requires EGFR protein, but not EGFR tyrosine kinase and EGFR autophosphorylation at tyrosine(1173), whereas both EGFR tyrosine kinase and EGFR autophosphorylation at Y(1173) play a critical role in EGF-induced AP-1 activation. ,
SKMG-3 cells produced high levels of EGFR protein. Signals from overexpressed EGFRs contribute to the constitutive phosphorylation of Erk, but these signals may not be required for the constitutive activation of PI3K or AKT1. ,
role in mediating thromboxane A2-dependent -signal-regulated kinase activation ,
the mechanism of attenuated ERK signaling in EGFR-overexpressing cells is a sequestration of ERKs at the cell membrane in EGFR-containing complexes. ,
Review. Mucin transcription in response to both gram-positive bacteria and tobacco smoke is mediated through activation of the epidermal growth factor receptor (EGFR). ,
Expression of EGFR seems to play an important role in metastasis, especially liver metastasis and recurrence of pancreatic cancer. ,
in glioblastoma multiforme patients a complex relationship exists between epidermal growth factor receptor expression and age ,
results demonstrate that tamoxifen resistant MCF-7 cell growth is mediated by the autocrine release and action of an epidermal growth factor receptor-specific ligand inducing preferential epidermal growth factor receptor/c-erbB2 dimerization ,
Inhibition of erbB receptor family members protects HaCaT keratinocytes from ultraviolet-B-induced apoptosis. This inhibition was specific for the erbB receptor family and specific for ultraviolet-B-induced apoptosis. ,
EGFR binds to c-src and has a role in oncogenesis ,
Exogenous OPN increased EGFR mRNA expression, as well as EGFR kinase activity. Inhibition of EGFR significantly impaired the cell migration response to OPN. ,
Comparative study in the expression of p53, EGFR, TGF-alpha, and cyclin D1 in verrucous carcinoma, verrucous hyperplasia, and squamous cell carcinoma of head and neck region. ,
Five autophosphorylation sites in the extra-kinase C-terminal domain of EGFR are not required for the ability of EGFR to induce morphological differentiation of PC12 cells. ,
data indicate that growth hormone, by activating extracellular signal related kinases, can modulate epidermal growth factor-induced epidermal growth factor receptor trafficking and signaling ,
Epidermal growth factor and ionizing radiation up-regulate the DNA repair genes XRCC1 & ERCC1 in DU145 & LNCaP prostate carcinoma through MAPK signaling indicating a capacity of the EGFR-ERK signaling to modulate DNA repair in cancer cells. ,
EGFR microsatellite polymorphism is associated with autosomal dominant polycystic kidney disease. ,
Expression of EGF and EGFR is involved in the gallbladder carcinogenesis, and is related to high activity of cell proliferation. ,
propose a role of Ent-1 in the trafficking of EGFR to down-regulate intestinal mitogenic signals, highlighting the mechanisms of cell growth arrest associated with enterocytic differentiation ,
Human colon carcinoma cells that overexpress cyclooxygenase exhibit growth stimulation and induction of this protein. ,
Overexpression of an introduced EGFR, under an E1A-insensitive heterologous promoter, blocked E1A induction of apoptosis in SCC cells. E1A-mediated EGFR downregulation appears to be the cause not consequence of E1A-induced apoptosis in these cells. ,
Data show that by using RNA interference , the expression of endogenous erbB1 can be specifically and extensively suppressed in A431 human epidermoid carcinoma cells. ,
The study found that over-expression of EGFR occurred more often in cases of cervical cancer (50%) compared to breast cancer cases (36%), while in breast cancer EGFR expression correlated significantly with metastasis of the lymph nodes. ,
EGFR/HER2 heterodimers traffic as single entities; levels of HER2 in normal cells are barely at the threshold necessary to drive efficient heterodimerization ,
Nitric oxide and nitric oxide donors induce EGF receptor phosphorylations, in A431 tumor cells. ,
deltaEGFR may contribute to glioblastoma development ,
EGFRvIII expressed in human tumors is phosphorylated and hence activated; sustained activation of EGFRvIII is implicated in the pathogenesis of non-small cell lung cancers ,
ZO-1 bound to EGFR irrespective of the phosphorylation status of EGFR. EGFR associated ZO-1 was highly tyrosine-phosphorylated only in primary colorectal cancers but was dephosphorylated in the liver-metastasized cancers. ,
The expression of this protein was not different in the clone cell variants or the A431 parental line. ,
Results suggest that epidermal growth factor receptor and protein kinase C activation are involved in 12- O-tetradecanoylphorbol-13-acetate-induced cell signaling for modulation of cadherin-dependent cell-cell adhesion and cell shape in Caco-2 cells. ,
signaling intensity determines intracellular protein interactions, ubiquitination, and internalization ,
Loss of PTEN/MMAC1/TEP in tumor cells expression this protein counteracts the antitumor action of EGFR tyrosine kinase inhibitors. ,
carboxyl-terminal mutation of the epidermal growth factor receptor alters tyrosine kinase activity and substrate specificity ,
androgens promote an increase in the activity of the epidermal growth factor (EGF)-network by increasing ErbB1 levels, and this activity of is essential for androgen-induced proliferation and survival of the prostate cancer LNCaP cell line. ,
findings establish Cbl protein as the major endogenous ubiquitin ligase responsible for epidermal growth factor receptor degradation ,
EGFR gene expression is identified in recurrent glioblastoma multiforme ,
Seasonal allergic rhinitis subject showed significant elevation in EGFR expression, consistent with the observation of mucus hypersecretion in allergic rhinitis. ,
Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system. ,
HEGFR was expressed in the subventricular zone embryologically ,
Epidermal growth factor receptor negatively regulates intracellular kinase activation in the absence of ligand ,
Characterization and expression of novel 60-kDa and 110-kDa EGFR isoforms in human placenta. ,
Data show that stimulation of epidermal growth factor receptors differentially regulates chemokine expression in keratinocytes. ,
PGE2 regulates cell migration via the EGFR, and affects cell division and neoplasm invasiveneess. ,
Data support that EGFR and HER-2/neu play an important role in cell cycle control in ductal carcinoma in situ. ,
The results suggest that activation and nuclear localization of EGFR may be needed for induction of NOS-2 in response to elevated intraocular pressure in glaucomatous optic neuropathy. ,
Ligand-induced EGFR degradation is preceded by proteasome-dependent EGFR de-ubiquitination. ,
Data show that detachment-induced expression of Bim requires a lack of beta(1)-integrin engagement, downregulation of EGF receptor (EGFR) expression and inhibition of Erk signalling. ,
PLSCR1, through its interaction with Shc, promotes Src kinase activation through the EGF receptor. ,
EGFR is a necessary component for HCMV-triggered signalling and viral entry ,
endosomal epidermal growth factor receptor stimulates cell growth ,
EGFR has a role in beta2 tyrosine phosphorylation of AP-2 by interacting at receptor 974YRAL and di-leucine motifs ,
Results demonstrate that mice humanised for epidermal growth factor receptor (EGFR) display tissue-specific hypomorphic phenotypes and describe a novel function for EGFR in bone development. ,
EGF receptor down-regulation by UVA may play an important role in the execution of the cell suicide program by attenuating its anti-apoptotic function ,
EGFR is an aldosterone-induced protein and is involved in the manifold (patho)biological actions of aldosterone ,
EGFR overexpression is frequent in NSCLC, is most prominent in SCC, and correlates with increased gene copy number per cell. High gene copy numbers per cell showed a trend toward poor prognosis. ,
identification of ligand-induced site-specific phosphorylation of epidermal growth factor receptor ,
depending on their localization, oxytocin receptors transactivate EGFR and activate ERK1/2 using different signalling intermediates. The final outcome is a different temporal pattern of EGFR and ERK1/2 phosphorylation ,
These results indicate that the EGFR signaling pathway is involved in urothelial regeneration. ,
Mitogenic effects of gastrin-releasing peptide in head and neck squamous cells are mediated by activation of EGFR. ,
ERBB1 is overexpressed and may play a role in high-grade diffusely infiltrative pediatric brain stem glioma ,
Infection of primary cells with adenoviruses carrying the relevant point mutations confirmed the crucial role of putative YXX Phi and dileucine (LL) transport motifs within Ad2 10.4-14.5 for down-regulation of Fas, TRAIL-R1, TRAIL-R2, and EGFR. ,
Epidermal growth factor receptor (a potential therapeutic target) and SALL2 stained most cases of synovial sarcoma; staining was significantly less common among other tested sarcomas. ,
ganglioside GM3 inhibits integrin-induced, ligand-independent epidermal growth factor receptor phosphorylation (cross-talk) through suppression of Src family kinase and phosphatidylinositol 3-kinase signaling ,
Up-regulation of EGFR is associated with renal cell carcinoma ,
cholesterol depletion with cyclodextrin induced an increase in both basal and EGF-stimulated EGF receptor phosphorylation, at specific tyrosine sites, that was associated with an increase in the intrinsic kinase activity of the EGF receptor kinase. ,
the EGF receptor is abundantly expressed in epithelioid vascular smooth muscle cells and the activation of this receptor results in cell cycle arrest through activation of the mitogen-activated protein kinase pathway ,
lysosomal degradation by adenovirus E3 RIDalpha protein dependent on specific domains ,
findings suggest that the coexpression of c-erbB-2 oncogene protein, epidermal growth factor receptor, and TGF-beta1 in pancreatic ductal adenocarcinoma is related to the histopathological grades and clinical stages of tumors ,
heregulin/EGFR system as a possible important physiologic growth regulatory system in melanocytes in which multiple deregulations may occur during progression toward melanoma, all resulting in, or indicating, growth factor independence. ,
demonstration that metalloproteinase-mediated transactivation of the EGFR is a key mechanism of the cellular signalling network that promotes MAPK activation as well as tumour cell migration and invasion ,
transactivation of the EGFr is required for the full expression of cAMP-dependent Cl- secretory responses ,
data suggest that agonist-induced binding of Src kinase to the Src homology 3 binding sites in the P2Y(2) purinergic receptor facilitates Src activation and allows Src to efficiently phosphorylate the epidermal growth factor receptor ,
E-cadherin and epidermal growth factor receptor (EGFR) are associated in mammary epithelial cells and that E-cadherin engagement in these cells induces transient activation of EGFR, as previously seen in keratinocytes. ,
The Id-1-induced androgen-independent prostate cancer cell growth was correlated with up-regulation of EGF-R. ,
results support a structural model for oligomerization of EGF receptors in which dimers are positioned head-to-head with respect to the ligand-binding site ,
SHP-2/Gab1 association is critical for linking EGFR to NF-kappaB transcriptional activity via the PI3-kinase/Akt signaling axis in glioblastoma cells ,
sorting of endocytosed epidermal growth factor receptor into the degradation pathway requires both its kinase activity and actin-binding domain ,
involvement urokinase plasminogen activator secretion and cell motility in breast cancer cells ,
EGFR and ErbB-2 have roles in ligand-dependent apoptosis that could be a natural mechanism to protect tissues from unrestricted proliferation ,
the adhesion-dependent activation of EGF receptor signaling is promoted by L1-type CAMs in vitro and in vivo ,
the relationship between the egfr polymorphism and breast cancer risk ,
Overexpression of EGFR is associated with recurrent non-small cell lung cancer ,
PGF(2 alpha)-FP receptor may promote endometrial tumorigenesis via phospholipase C-mediated phosphorylation of EGF receptor and MAPK signaling pathways. ,
CaM co-immunoprecipitates with EGF-activated and non-activated receptors ,
EGFR and c-Src-mediated Stat-3 activation is facilitated by Pyk2 ,
A significantly higher frequency of EGFR expression occurred in PC than in AC glottic cancer. ,
EGFR and COX-2 cooperate to promote cervical neoplasm progression ,
a novel and important role for metalloprotease activation and EGFR transmodulation in mediating the cellular response to TNF ,
Sustained hyaluronan depolymerization is expected to cause tissue kallikrein activation, EGF release, and EGFR signaling. ,
Trypsin exerts robust trophic action on colon cancer cells and underline the critical role of EGF-R transactivation. ,
Cell surface expression of EGFR is associated with osteosarcoma pathogenesis ,
whole gene amplifications of egfr are rare in invasive breast cancer and explain protein overexpression in only about 12.5% of invasive breast cancer cases ,
epidermal growth factor receptor and CD95 activation are triggered by Src family kinase Yes ,
The EGFR pathway may be a specific, signal transduction pathway that regulates reactive astrocytes to form cavernous spaces in the glial scars following CNS injury and in the compressed optic nerve in glaucomatous optic nerve neuropathy. ,
PPARgamma and EGFR signalling have roles in urothelial terminal differentiation ,
EGFR regulation by E-cadherin was associated with complex formation between EGFR and E-cadherin that depended on the extracellular domain of E-cadherin but was independent of beta-catenin binding or p120-catenin binding ,
Intensive staining of EGF-R is associated with invasive tumours of bladder ,
Data show that epidermal growth factor receptor signaling results in phosphorylation of CUG-BP1, and leads to increased binding of CUG-BP1 to CCAAT/enhancer binding protein beta (C/EBP beta) mRNA and elevated expression of the C/EBPbeta LIP isoform. ,
misfolding of the LDLR epidermal growth factor-AB pair results from low density lipoprotein receptor familial hypercholesterolemia mutations ,
A subgroup of patients with non-small-cell lung cancer have specific mutations in the EGFR gene, which correlate with clinical responsiveness to the tyrosine kinase inhibitor gefitinib. ,
somatic mutations of EGFR were found in 15 of 58 non-small cell lung cancer tumors from Japan and 1 of 61 from the United States; EGFR mutations may predict sensitivity to gefitinib ,
Results provide an explanation for cell surface receptor cross-talk involving the Met receptor and link G protein-coupled receptors and the epidermal growth factor receptor to the oncogenic potential of Met signaling in human carcinoma cells. ,
P. 445 ,
Overexpression of EGFR was observed in only a small fraction of colorectal carcinomas, but were frequently accompanied by gene amplification. ,
the epidermal growth factor receptor has a role in activating ERK with extracellular oxidation by taurine chloramine ,
Endothelial cell vessel assembly requires EGFR signaling transduction pathways. ,
Data demonstrate that at least four different sets of endogenously expressed gangliosides, including GD3, did not have a significant effect on epidermal growth factor receptor distribution in the plasma membrane. ,
Statistically significant relation existed between the ovarian cancer metastatic potential and EGFR expression level. ,
The overall time-dependent activation of EGFR autophosphorylation was identical in cells treated with 1 nm BTC or 1.5 nm EGF. ,
EGFR inhibition promotes desmosome assembly in oral squamous cell carcinoma cells, resulting in increased cell-cell adhesion ,
The cytoplasmic overexpression of EGFr plays a significant role in the progression of pancreatic ductal adenocarcinoma, especially in the invasion and acquisition of aggressive clinical behavior. ,
EGFR, PYK2, Yes, and SHP-2 are involved in transduction of the TF/FVIIa signal possibly via transactivation of the EGF receptor. ,
epidermal growth factor receptor is dephosphorylated at endomembranes after ligand-mediated endocytosis ,
transactivation through CCR3 is a critical pathway that elicits mitogen-activated protein kinase activation and cytokine production in bronchial epithelial cells ,
trans-activation by calcium-sensing receptor ,
The tumor-specific mutation of epidermal growth factor receptor promotes cells survival and dimerization with the wild-type EGFR. ,
EGF receptor traffic is disrupted by farnesyltransferase inhibitors through modulation of the RhoB GTPase ,
c-erbB-2 and EGF-R are overexpressed in breast neoplasms and have an inverse association with Estrogen Receptor expression ,
Human leukocyte elastase induces keratinocyte proliferation by proteolytic activation of an EGFR signaling cascade involving TGF-alpha. ,
betacellulin may play a role as a local growth factor in promoting the differentiated villous trophoblastic function via ErbB-1 in early placentas and in contributing to placental growth through EVT cell function via ErbB-4 in term placentas. ,
The epidermal growth factor receptor (EGFR) is one of signalling pathways activated during premalignant proliferative changes in the airway epithelium. ,
an interrelationship is now known to exist between the IGF and EGF receptors [review] ,
amphiregulin- and ErbB1-dependent mechanism by which autocrine ERK activation is maintained in normal keratinocytes ,
EGFR, c-erbB-2, VEGF and MMP-2 and MMP-9 play an important role in tumor growth, invasion and metastasis in squamous cell carcinoma of the head and neck ,
In each of these gliomas, the founding molecule was generated by a simple event that circularizes a chromosome fragment overlapping the epidermal growth factor receptor gene. ,
novel mechanism by which IGF-I induces ERK activation in a manner that is dependent on the basal level of EGFR-TK activity, but is independent of receptor transactivation. ,
Upregulation of leucine-rich repeats and immunoglobulin-like domains 1 is followed by enhanced ubiquitylation and degradation of EGFR ,
mutant EGFRs selectively transduce survival signals on which nonsmall cell lung cancers become dependent ,
Carbon black causes oxidative stress-mediated proliferation of airway epithelium, involving activation of EGF-R. ,
IL-1beta-dependent prolonged EGFR transactivation involves multiple pathways, including an IL-8-dependent pathway. ,
EGFR signaling involves reinforcing altered gene expression of uPAR,thus further inducing cell motility. ,
In patients with breast cancer, most CNS metastatic tumor deposits showed expression for either EGFR or HER-2/neu, and less often for both. ,
Syk acts a negative control element of EGFR signalling. ,
Data show that activation of ADAM-17 results in discrete cellular responses, while G protein-coupled receptor agonists promote activation of the Ras/MAPK pathway and cell proliferation via the epidermal growth factor receptor. ,
The timing of lethality caused by homozygosity for a null allele of the epidermal growth factor receptor in mice is strongly dependent on genetic background. ,
Data report that antagonism of the type 1 insulin-like growth factor receptor in combination with inhibitors of the epidermal growth factor receptor synergistically sensitizes human malignant glioma cells to CD95L-induced apoptosis. ,
Results describe the role of epidermal growth factor receptor regulation in antiapoptosis, cell migration, and cell proliferation. ,
Egfr Wa5 is a novel ENU-induced antimorphic allele caused by a kinase-dead receptor acting as a dominant negative ,
data explain how thrombin exerts robust trophic action on colon cancer cells and underline the critical role of EGFR transactivation ,
GqPCR-induced FAK activation is mediated by via a pathway involving transactivation of the EGFr and alterations in the actin cytoskeleton. ,
serum epidermal growth factor receptor and HER2 have roles in response of advanced non-small cell lung cancer to chemotherapy ,
a novel regulatory role for Galphas in EGF receptor degradation and provide mechanistic insights into the function of Galphas in endocytic sorting ,
NHERF stabilizes EGFR at the cell surface and slows the rate of endocytosis without affecting recycling ,
EGF signalling amplification is induced by dynamic clustering of EGFR ,
analysis of conformations of the epidermal growth factor receptor and antibody binding [review] ,
cholangiocarcinoma cells exhibit sustained EGFR activation due to defective receptor internalization ,
Data demonstrate that the alpha-hemolysin elevates the activity of receptor-like protein tyrosine phosphatase sigma (rPTPsigma). ,
regulation of LMP1 on the nuclear translocation of EGFR is critical for the process of nasopharyngeal carcinoma ,
For genotype of EGFR gene Bsr I polymorphism, there was statistically significant differences between systemic lupus erythematosus and controls. In addition, there was significant association between the two groups in allelic frequency of the T allele. ,
Our results suggest a novel role for the juxtamembrane domain (JM) of EGFR in mediating intracellular dimerization and thus receptor kinase activation and function. ,
role for EGFR activity in the lifespan and inflammatory potential of RSV-infected epithelial cells ,
protein kinase B/Akt phosphorylation is stimulated by mechanical stretch in epidermal cells via angiotensin II type 1 receptor and epidermal growth factor receptor ,
S1P transactivates c-Met and EGFR in gastric cancer cells. ,
Gene 33 is a physiological feedback inhibitor of the EGFR, functioning to inhibit EGFR phosphorylation and all events induced by EGFR activation ,
EGFR is increased by cAMP, a potent inducer of decidualization of the endometrial stroma. ,
HER2-mediated effects on EGFR dimerization and trafficking were sufficient to explain the observed HER2-mediated amplification of epidermal growth factor-induced ERK signaling ,
therapeutic potential of siRNA to impact DeltaEGFR as a glioma-specific target ,
The reduction in EGFR levels and EGF-induced signaling in SOCS5-expressing cells requires both the Src homology-2 and SOCS box domains of SOCS5. ,
These results suggest that EGFR amplification is a relatively rare event in larynx carcinogenesis that obviously does not predispose to tumor progression. ,
PMA transactivates the EGFR and increases cell proliferation by activating the PKCdelta/c-Src pathway in glioblastoma cells ,
epidermal growth factor receptor interacts with gastrointestinal peptide hormone receptors to regulate mitogenic signaling and cell migration [review] ,
High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness ,
Grb2-mediated recruitment of the functional RING domain of Cbl to the EGFR is essential and sufficient to support receptor endocytosis ,
the acceleration of EBV LMP1 on the G1/S transition via the nuclear accumulation of EGFR was critical in the process of nasopharyngeal carcinoma ,
Data show that expression of epidermal growth factor receptors (EGFR) in transgenic mouse Schwann cells elicited features of neurofibromas, supporting the relevance of EGFR to peripheral nerve tumor formation. ,
An inhibitor of this and of the mTOR pathwway inhibits growth of glioma in a xenograft mousse model. ,
A common polymorphism in the EGFR promoter was associated with altered promoter activity and gene expression both in vitro and in vivo. ,
In addition to EGFR mutations, other factors in non-small cell lung carcinoma cells, such as high expression of ErbB family members, may constitutively activate AKT and sensitize cells to EGFR inhibitors. ,
Expression of nuclear EGFR correlated positively with increased levels of cyclin D1 and Ki-67, both are indicators for cell proliferation for prognosis of breast cancer. ,
Cpd 5-caused ERK phosphorylation is probably regulated by both EGFR-dependent and EGFR-independent pathways. ,
Epidermal growth factor receptor gene polymorphisms have higher risk of pelvic recurrence in patients with rectal cancer treated with chemoradiation ,
stimulation of the EGFR pathway is one mechanism by which the bone marrow microenvironment may contribute to the growth and survival of B-cell acute leukemia ,
Data suggest the possibility of a mechanically activated epidermal growth factor receptor (EGFR) autocrine feedback loop involving selected EGFR ligands. ,
Tyr-992 and Tyr-1173 are required for phosphorylation of the epidermal growth factor receptor by ionizing radiation and modulation by SHP2 ,
EGFR mutations were significantly related to histology and smoke exposure and were a strong predictive factor for gefitinib responsiveness in non-small cell lung cancers. ,
YB-1 overexpression can induce EGF independence in human mammary epithelial cells via activation of the EGFR pathway ,
HDL blocks neuroblastoma differentiation by inhibition of EGFR ,
Findings provide evidence that STAT 3 signal activity in head and neck carcinomas, which is partially responsible for proliferative activity, can be controlled via the EGFR. ,
Mutations in either the EGFR TK domain or the KRAS gene can lead to lung cancer pathogenesis. EGFR TK domain mutations are the first molecular change known to occur specifically in never smokers. ,
Findings suggest that a distinct minority of colorectal adenocarcinomas exhibit somatic mutations of EGFR, and these tumors may be susceptible to gefitinib treatment. ,
The optimization and specification of therapeutic approaches based on erbB-receptor targeting requires to account for EGFR coexpression as well as the potential presence of erbB-receptor relevant growth factors. ,
EGFR gene 2073*T-related genotypes and allele are associated with higher susceptibilities to endometriosis and leiomyoma ,
HB-EGF/HER-1 signaling is relevant to mesenchymal stem cell biology, by regulating both proliferation and differentiation ,
EGFR-related protein (ERRP) is a 53 to 55 kDa protein that is a natural inhibitor of EGFRs in human but not in mouse or rat cells. ,
Increased levels of EGFR were significantly associated with adult soft tissue sarcomas ,
decreased EGF receptor tyrosine phosphorylation and aberrant recruitment of the adaptor proteins ShcA and Grb2 to the EGF receptor in cells harbouring the hepatitis C virus subgenomic replicon ,
Mutations in the tyrosine kinase domain of the epidermal growth factor receptor is associated with non-small cell lung cancer ,
data indicate that altered expression of beta-catenin may play an important role in oral cancer progression through increased proliferation and invasiveness under epidermal growth factor receptor (EGFR) activation but not mutation or cyclin D1 expression ,
p38 mediates EGF receptor activation after oxidant injury; Src activates MMK3, which, in turn, activates p38; and the EGF receptor signaling pathway plays a critical role in renal epithelial cell dedifferentiation ,
regulation of phosphorylation of ER-alpha and EGFR may play critical roles in EGF-induced transcriptional activation of WISP-2 gene in breast tumor cells ,
data suggest that mutations of epidermal growth factor receptor (EGFR) and K-RAS genes might separately, but not cooperatively, contribute to lung adenocarcinoma pathogenesis ,
Analysis with phospho-specific antibodies indicates that 3 kinases generate a signal-specific, combinatorial phosphorylation profile of the Hrs-STAM complex, with the potential of diversifying tyrosine kinase receptor signalling through a common element. ,
The membrane-anchoring domain of EGFR ligands dictates their ability to operate in juxtacrine mode. ,
the EGF receptor plays a central role in the signaling pathway that links albumin to the activation of ERK1/ERK2 and increased expression of IL-8 ,
Using the LightCycler PCR assay, the EGFR L858R mutation status might correlate with gender, pathologic subtypes, and gefitinib sensitivity of lung cancers. ,
epidermal growth factor receptor is activated by imatinib mesylate, resulting in cyclooxygenase-2 induction and prostaglandin E2 accumulation ,
study reveals a novel cross-talk between the EP1 receptor and EGFR signaling that synergistically promotes cancer cell growth and invasion ,
High EGFR gene copy number identified by FISH may be an effective molecular predictor for gefitinib efficacy in advanced NSCLC. ,
heterogeneity in the density of EGFR due to localization in certain regions of the plasma membrane, which has been experimentally reported, can also lead to concave up shape of the Scatchard plot of the EGF binding on EGFR ,
autocrine and/or paracrine NRG-1/erbB signaling promotes neoplastic Schwann cell proliferation ,
analysis of EGFR mutations in malignant pleural effusion of non-small cell lung cancer (case report) ,
Approximately 6% of breast carcinomas show EGFR amplification with EGFR protein overexpression and may be candidates for trials of EGFR-targeted antibodies or small inhibitory molecules. ,
These results suggest a possible important "cross-talk" between SDF-1/CXCR4 and EGFR intracellular pathways that may link signals of cell proliferation in ovarian cancer. ,
EGFR physically interacts with signal transducers and activators of transcription 3 in the nucleus, leading to transcriptional activation of inducible nitric oxide synthase. ,
Active mutation of the EGFR kinase domain was strongly associated with response to gefitinib ,
EGFR downregulation is inhibited by Sprouty2 targeting both the Cbl and CIN85 pathways. ,
overexpression of the active form of the small GTPase RhoA induces the activation of Epidermal Growth Factor Receptor and promotes cell motility ,
EGFR may have a role in recurrence of rectal cancer after radiotherapy and surgery ,
Gastrin-releasing peptide receptor mediates activation of the epidermal growth factor receptor in lung cancer cells ,
Our findings suggest that extracellular H(2)O(2) generated by EGFR-ligand interaction permeates the plasma membrane and inhibits EGFR-associated tyrosine phosphatase activity. ,
PTEN protein could inhibit cell invasion even in the presence of the constitutively active epidermal growth factor receptor(EGFR) ,
Decorin causes EGFR internalization via caveolae ,
analysis of ligand-induced dimer-tetramer transition during the epidermal growth factor receptor activation of the cell surface ,
Data show that blockade of epidermal growth factor receptor import into the nucleus also blocks radiation-induced activation of DNA-PK, inhibits DNA repair, and increases radiosensitivity of treated cells. ,
EGFR expression was associated with improved survival. ,
Chromogenic in situ hybridization analysis and morphology identified 22 small cell (SCGBM) and 22 non-small cell glioblastoma (NSCGBM), and 12 cases of a mixed phenotype. ,
Existence of unidirectional IGF-IR/EGFR cross-talk mechanism whereby IGF-II, acting through IGF-IR, regulates basal and ligand-activated EGFR signaling and cell proliferation in a c-SRC-dependent manner in tamoxifen-resistant breast cancer. ,
analysis of activating mutations in catalytic domain of EGFR in 3.5% (2 of 57) of ovarian cancers ,
Overall, these data suggest that GRK2 has a regulatory role in EGF-induced ERK/MAPK activation. ,
fibrin can support the wound healing process of the epidermis via the TGF-alpha/EGF-R pathway ,
results show that EGFR are present on normal human melanocytes ,
Gene polymorphisms active in the EGFR pathway may be associated with the sensitivity of colorectal cancer patients to platinum-based chemotherapy. ,
These findings suggest a mechanism by which filopodia detect the presence and concentration of effector molecules far from the cell body and mediate cellular responses via directed transport of activated receptors. ,
This study suggests that coexpression of LN-5 gamma2 and EGFR is closely related to the progression and poor prognosis of esophageal SCC. ,
The effects of high glucose on proximal tubular cells proliferation, reduced apoptosis and increased NHE3 mRNA levels are mediated by EGFR-dependent up-regulation of SGK-1. ,
Data show that epidermal growth factor receptor dileucine motif 679-LL is an alpha-helical stabilizing motif that regulates a predominant step during lysosomal sorting, involving intracellular retention under both sub-saturating and saturating conditions. ,
EGFR antisense-odn can significantly inhibit proliferation of human hepatoma cells, indicating that EGFR may play important role in development of hepatoma and will be new target for its treatment. ,
EGFR signaling has a role in regulating host defense and immune response by tightly controlling TLR2 induction during bacterial infections ,
thrombomodulin induces Ca2+ signals and nitric oxide synthesis through EGFR and calmodulin kinase II ,
Two tyrosine residues in the C terminus of human TRPC4 phosphorylated following epidermal growth factor (EGF) receptor stimulation of COS-7 cells. ,
findings suggest that overexpression of EGFR in glioblastomas in Chinese patients may be associated closely with the patients age but not with the tumors' pathological pathway. ,
Overexpression of EGFR was significantly correlated with depth of invasion of the tumor ,
simulation results show the formation of a channel under Thr766 following the movement of the side chain of Gln767 away from the hinge in EGFR ,
The patients with mutations of EGFR to have a more favorable prognosis than those with wild type (p=0.033). ,
Intratumoral variation of epidermal growth factor receptor (EGFR) expression in glioblastoma multiforme was examined, and radionuclide labelled substances that bind specifically to EGFR were considered for intracavitary therapy. ,
EGFR mutation plays an important role in pathogenesis of lung adenocarcinoma ,
The mechanism of deoxycholic acid-induced EGFR activation is ligand-dependent and is controlled, at least in part, at the level of amphiregulin release from the basolateral cell membrane. ,
EGFR expression status in lung cancer correlates with its mutation. ,
LPA acts upstream of various receptor tyrosine kinases and COX-2, and thus may act as a potent stimulator of colorectal cancer. ,
the effect of interleukin-8 (IL-8) induced by H. pylori infection on EGFR transactivation and epithelial cell growth ,
The frequency of CA allele combinations was assessed in healthy women from Poland; results provide new data on EGFR microsatellite instability and may contribute to the understanding of EGFR gene expression regulation. ,
the inhibition of EGFR and mTOR has distinct as well as common signaling consequences in glioblastoma multiforme cells ,
EGF-R fate is controlled by a checkpoint downstream of receptor ubiquitination whose regulation by the Cbl RF tail may require Sprouty2 degradation. ,
Acquisition of resistance to tyrosine kinase inhibitors in non-small cell lung cancer is linked to a specific secondary somatic mutation, EGFR T790M. ,
These results identify CKLFSF8 as a novel regulator of EGF-induced signaling and indicate that the association of EGFR with four transmembrane proteins is critical for EGFR desensitization. ,
RPTP-kappa is a key regulator of EGFR tyrosine phosphorylation and function in human keratinocytes ,
Breast carcinomas with squamous differentiation are a distinct subgroup of breast tumors with a very high frequency of EGFR expression ,
Ubiquitination of EGFR at late stages of endocytosis was significantly lower than that in control cells. Highly ubiquitinated forms of EGFR demonstrated more sensitivity to MG132 treatment. ,
RhoB is essential in regulating keratinocyte cell survival after UVB exposure through epidermal growth factor receptor signaling ,
EGFR expression and signaling does not seeme to be affected by treatment with erlotinib or gefitinib ,
rab7 regulates the endocytic trafficking of the EGF.EGFR complex by regulating its lysosomal degradation ,
Activation of erbB1 leads to phosphorylation of protein phosphatase 2A, inhibiting its activity, which provides a rapid means of sensing the loss of epithelial integrity and subsequently restoring barrier function. ,
EGFR, in addition to E2F1, target sites induce B-Myb promoter ,
data suggest that the EGFR immunopositivity can be considered as reliable predictors of disease stage in urine ThinPrep (TP) specimens. ,
data describe percentage of bone marrow cells expressing receptors for interleukin-1, platelet-derived growth factor, fibroblast growth factor, transforming growth factor-beta, epidermal growth factor and c-Fos and c-Myc in untreated lung & breast cancer ,
In contrast, although present at comparable plasma levels, desmethyl-gefitinib had little effect on tumour growth and is, therefore, considered unlikely to contribute significantly to the therapeutic activity of gefitinib in the clinical situation. ,
spatially distributed Monte Carlo based simulation framework to enable the simulation of in vivo receptor diffusion and dimerization ,
These findings reveal a new role for EGFR in the postnatal brain and open new avenues to optimize cell engraftment for brain repair. ,
Activated epidermal growth factor receptor-Stat-3 signaling promotes tumor survival in non-small cell lung cancer ,
Findings disclose a cross-talk between the COX-2/PGE(2)/EP(1) and EGFR/c-Met signaling pathways that coordinately regulate human hepatocellular carcinoma cell invasion. ,
EGFR mutations may contribute to the development of bronchioloaveolar carcinoma and are one of the early genetic alterations in multistage carcinogenic processes of lung adenocarcinoma ,
Theaflavin-3, 3'-digallate may exert chemopreventive effects through the downregulation of the EGFR. ,
An EGFR mutant with four amino acid changes exhibited binding to the conformationally-specific monoclonal antibodies. and human epidermal growth factor ,
PGI-IP interaction within glandular epithelial cells can promote the expression of proangiogenic genes in human endometrium via cross talk with the EGFR. ,
EGFR-induced signaling and Grb2 are essential for formation of clathrin-coated pits accommodating the EGFR, while activation of MAPK and PI3K is not required. ,
Antibodies from naive human scFv (single-chain Fv) phage display libraries provide a valuable and potentially clinically relevant panel of agents to target the members of the EGFR family. ,
ERBB3 is the pivotal element of the Erbb pathway promoting tumorigenesis by heterodimerization with NEU or EGFR, but the NEU/EGFR dimer does not appear to play a significant role in prostate cancer ,
Epidermal growth factor receptor exposed to oxidative stress undergoes Src- and caveolin-1-dependent perinuclear trafficking ,
IR-induced ERK1/2 activation involves EGFR through a Src-dependent pathway that is distinct from EGFR ligand activation ,
study provides a new insight into oncogenic signaling by EGFRvIII and improves our understanding of how autocrine loops are generated in glioma ,
Reactive Oxygen Species-induced Goblet Cell metaplasia in normal human bronchial epithelial cells is associated with Hyaluronan depolymerization and Epidermal Growth Factor (EGF) processing by Tissue Kallikrein followed by EGF Receptor signaling. ,
phosphatidylinositol 4-kinase IIalpha is necessary for the correct endocytic traffic and downregulation of activated epidermal growth factor receptor. ,
Mutations in the EGFR ligand-binding domain in tumours may permit signaling stimulation by ligands that are not normally potent EGFR agonists. EGFR mutations & new signalling activities may allow deregulated EGFR signalling in tumour cells. ,
Data show that long-term ciliated cell hyperplasia and activation of epidermal growth factor receptor signaling coincide with mucous cell metaplasia after respiratory viral clearance in airways. ,
EGFR signaling pathway negatively regulates prostate specific antigen expression which may be induced by the alteration of androgen expression via the PI3K-Akt pathway in LNCaP C-81 cells ,
Results identify a protein tyrosine phosphatase as a potential substrate of TACE and describe proteolytic processing of PTP-LAR as a means of regulating phosphatase activity downstream and thus under the control of EGFR-mediated signaling pathways. ,
N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) can induce the clustering of epidermal growth factor receptor (EGFR) in human amnion FL cells. ,
Data show that c-erbB-1 and c-erbB-2 are differentially regulated in cancers of the papilla of Vater and pancreas, suggesting that the two types of cancer are biologically different. ,
Epidermal growth factor receptor gene mutation is associated with adenocarcinomas of the lung ,
In contrast, although present at comparable plasma levels, desmethyl-gefitinib had little effect on tumour growth and is, therefore, considered unlikely to contribute significantly to the therapeutic activity of gefitinib in the clinical situation. ,
The existence of mutations in the tyrosine kinase domain of the EGFR gene in a small subset of synovial sarcomas suggests that only few patients may profit from the tyrosine kinase inhibitor therapy. ,
COX-2 and EGFR may be cooperative in the stepwise progression from Barrett's esophagus to adenocarcinoma, thereby leading to carcinogenesis. ,
EGFR expression is not stable during metastatic progression in a significant proportion of non-small-cell-lung cancer patients. ,
Understanding of EGFR identity in colorectal cancer which could be useful in reconsidering the predictive tools for the identification of tumors putatively responsive to EGFR targeted therapy. ,
EGFR expression in bladder cancer cells was associated with up-regulation of ID-1 and cancer staging. ,
The steric hindrance created by the antibody near the EGFR dimer interface interferes with receptor dimerization, and we postulate this as the structural origin for the antitumor effect of mAb 806. ,
Epidermal growth factor receptor and KRAS mutation patterns is associated with non-small cell lung cancer patients ,
Taken together, these data provide direct evidence for the role of EGFR ubiquitination in receptor targeting to the lysosome and implicate Lys63-linked polyubiquitin chains in this sorting process. ,
The study shows that tyrosine 192 of CARP-1 is a target of apoptosis signaling, and CARP-1, in turn, promotes apoptosis by activating p38 MAPK and caspase-9. ,
Mutations in the EGFR ligand-binding domain in tumours may permit signaling stimulation by ligands that are not normally potent EGFR agonists. EGFR mutations & new signalling activities may allow deregulated EGFR signalling in tumour cells. ,
Data provide the first evidence of somatic mutations of the EGFR gene in bile duct carcinoma. ,
Our work sheds light into the nature and regulation of the nuclear EGFR pathway and provides a plausible mechanism by which cells shuttle cell-surface EGFR and potentially other RTKs through the nuclear pore complex and into the nuclear compartment. ,
EGFR mutation and gene amplification potentially have impact on the responsiveness to EGFR targeting agents in ovarian cancer. ,
Mutations in EGFR is associated with Non-Small-Cell Lung Carcinoma ,
CD44 interaction with LARG and EGFR plays a pivotal role in Rho/Ras co-activation, PLC epsilon-Ca2+ signaling, and Raf/ERK up-regulation required for CaMKII-mediated cytoskeleton function and in head and neck squamous cell carcinoma progression ,
a wide spectrum of somatic EGFR TK mutations reporting a relatively high incidence (15%) in NSCLC patients of Greek and Czech origin. ,
Healing of wounds in sheets of corneal epithelial cells is absolutely dependent on epidermal growth factor receptor signaling, and the present data suggest that its activation is a result of wound-induced phospholipase D activation. ,
Salient features of the structural model for EGFR regulation and argue that the intramolecular tether provides only limited autoinhibitory control of EGFR activity. ,
the trophic properties of gastrin in colorectal cancer may be mediated in part by transactivation of the EGFR and phosphorylation of ERK1/2, leading to degradation of PPARgamma protein and a decrease in PPARgamma activation ,
seminal plasma and PGE(2) can promote the expression of tumorigenic and angiogenic factors, in cervical adenocarcinoma cells via the EP4 receptor, EGFR, and ERK1/2 signaling pathways ,
An EGF mutant, designated WVR/EGF/IADIQ, gained high affinity for ErbB3 & showed concomitant ErbB3 activation through ErbB2.ErbB3 heterodimers similar to the natural ErbB3 ligand NRG1beta, while the capacity to bind & activate ErbB1 was fully maintained. ,
overexpression of epidermal growth factor receptor due to missense mutation and single nucleotide polymorphisms is associated with gastrointestinal tract tumor ,
Significant higher expression of alternatively spliced mRNA forms of the insulin-like growth factor 1 receptor are associated with neuroendocrine tumors ,
Circular dichroism spectroscopy indicated that the EGFR C-terminal domain possessed a significant level of secondary structure in the form of alpha-helices and beta-sheets, with a marginal change in beta-sheet content occurring upon phosphorylation. ,
The Epidermal Growth Factor Receptor represent independents prognostic marker for intracranial ependymomas to identify patient subgroups with different risk profiles in further clinical investigations. ,
The Increased expression of erbB-1 was associated with increased levels of Ki-67 and MCM2 expression, and combined overexpression of these receptors was associated with the highest levels of proliferation, suggesting a synergistic effect. ,
High epidermal growth factor receptor is associated with disease recurrence in colon cancer patients ,
PLD functions as a GTPase activating protein (GAP) through its phox homology domain (PX), which directly activates the GTPase domain of dynamin and increased epidermal growth factor receptor (EGFR) endocytosis at physiological EGF concentrations. ,
96% of tumor samples were positive for EGFR expression; 63% were positive for activated EGFR; 76% were positive for activated Akt; and 96% were positive for activated ERK1/2. ,
The aim of this review is the biology of the EGFR and its use as a target for a new class of anticancer agents for colorectal cancer.Results available so far demonstrated a manageable and acceptable toxicity profile and a promising level of activity. ,
results show that TACE undergoes phosphorylation that regulates release of amphiregulin upon GRP treatment; a signaling cascade of GRP-Src-PI3-K-PDK1-TACE-amphiregulin-EGFR with multiple points of interaction, translocation & phosphorylation is suggested ,
Frequent EGFR mutations is associated with brain metastases of lung adenocarcinoma ,
patients with mutant-type EGFR might be treated with EGFR-TKIs before any other drugs ,
the versican G3 domain regulates neuronal attachment, neurite outgrowth, and synaptic function of hippocampal neurons via EGFR-dependent and -independent signaling pathways ,
role for p38 MAP kinase in the regulation of EGFR endocytosis ,
Final outcome of bladder cancer patients with high HER1- and HER2-expressing tumors depends on the expression of HER3 AND HER4. ,
RNa silencing had no inhibitory effect on cell proliferation, migration and activation status of EGFR-coupled signaling cascades in glioma cells. ,
lysophosphatidic acid-induced IL-8 secretion is partly dependent on EGFR transactivation regulated by PKCdelta-dependent activation of Lyn kinase and MMPs and proHB-EGF ,
periostin has an active role in the epithelial-mesenchymal transformation and metastasis that requires cross-talk between integrin and EGFR signaling pathways ,
No change in expression levels of EGFR was seen in the histologic progression to esophageal adenocarcinoma. ,
Gefitinib-sensitizing mutations in the EGFR gene were found in human esophageal tumors. ,
EGF receptor trafficking and signaling occur through a subset of signaling molecules including p44/42 MAPK and Gab1. ,
EGFR functions as control center & integration site for signaling processes, involving stimulation with EGF. It has 6 docking sites for Grb2 and is a direct binding partner of STAT5. ,
EGF stimulates receptor neddylation, which enhances subsequent ubiquitylation, as well as sorting of EGFR for degradation ,
analysis of proteins that bind to and interact with EGFR ,
These findings are consistent with a model in which ErbB1 expression increases during development of the androgen-independent state. Drugs targeted toward ErbB signaling could be of therapeutic relevance in the management of advanced prostatic carcinoma. ,
Results describe a relationship between the effects of epidermal growth factor (EGF) on cell proliferation and levels of EGF receptor expression in a cell line expressing different levels of EGFR caused by different concentrations of EGF treatment. ,
The CDK/cyclin-like complex formed by two kinase domains thus explains the activation of EGFR-family receptors by homo- or heterodimerization. ,
These data demonstrate that sterile wounding initiates an innate immune response through activation of the epidermal growth factor receptor that increases resistance to overt infection and microbial colonization. ,
The data suggest that prolactin synergistically augments epidermal growth factor signaling in T47D breast cancer cells at least in part by lessening EGF-induced epidermal growth factor receptor downregulation. ,
These results demonstrated that cell surface beta1,4GT1 may negatively regulate cell survival possibly through inhibiting and modulating EGFR signaling pathway. ,
EGFRvIII expression may regulate phenotypic plasticity in ovarian cancer and thereby contribute to more aggressive disease ,
A subset of pancreatic ductal adenocarcinomas is characterized by EGFR gene numerical alterations including sporadic cases of amplification or absence of one allele (maybe due to gene deletion or intragenic point mutation and allelic silence). ,
The majority of oral squamous cell carcinomas highly express EGFR and p-EGFR, and a statistically significant correlation was identified between high EGFR expression and the pathologic factor tumor invasion. ,
Ymer functions as a novel inhibitor for the down-regulation of the EGF receptor and plays a crucial role for regulating the amount of the EGF receptor on the cell surface membrane ,
Induction of keratinocyte migration is conveyed through EGFR, promoted by endogenous HB-EGF and requires GSK-3alpha activity. ,
ERBB-1 amplification is uncommon and appears to be late event in the development of ethmoid sinus adenocarcinoma. ,
the production of TGF-alpha by HRCC cells leads to the activation of EGFR on tumor-associated endothelial cells that serve as an essential target for therapy with tyrosine kinase inhibitors ,
Data show that decorin protein core inhibits tumor xenograft growth and metabolism by hindering epidermal growth factor receptor function and triggering apoptosis via caspase-3 activation. ,
the disulfide-bonded structure of the membrane-proximal portion of the EGF receptor, rather than its primary sequence, is important for EGF binding and signaling but is not involved in localizing the receptor to lipid rafts ,
Significantly elevated epidermal growth factor receptor is associated with metastatic malignant melanoma patients with an inverse correlation between EGF-R and IL-6 levels. ,
Data show that activation of survivin gene expression is mediated by oxygen-independent hypoxia-inducible factor-1alpha up-regulation, mediated by epidermal growth factor (EGF) receptor signaling in EGF-treated cancer cells. ,
EGF receptor is activated in human keratinocytes by oxidative inhibition of receptor-type protein-tyrosine phosphatase kappa by ultraviolet irradiation ,
analysis of activating mutations within EGFR in both esophageal and pancreatic adenocarcinomas and a model of the role of EGFR signaling in neoplasms ,
These results demonstrate that both clathrin-positive and clathrin-negative electron dense coats exist on endosomes and are involved in endosomal sorting of the EGFR. ,
epidermal growth factor receptor has a role in response to gefitinib treatment in patients with non-small cell lung cancer ,
The -216T allele was more frequent in the patients compared with the control population (224/376 = 59.6% vs 165/352 = 46.8%; p = 0.0006) corresponding to an odd ratio of 1.67 (1.24; 2.25). ,
Data show that treatment of tumor cell lines with the epidermal growth factor receptor-specific inhibitor cetuximab results in paradox phosphorylation of tyrosine 1173 in the receptor. ,
T790M mutation is sometimes present in a minor population of tumor cells during the development of non-small cell lung cancer. ,
EGFR somatic mutations directly influence both erlotinib cancer cell sensitivity and cellular transformation. ,
ITSN forms a complex with Cbl in vivo mediated by the Src homology (SH) 3 domains binding to the Pro-rich COOH terminus of Cbl. This interaction stimulates the ubiquitylation and degradation of the activated EGFR. ,
These results suggest that vinexin beta plays a role in maintaining the phosphorylation of EGFR on the plasma membrane through the regulation of c-Cbl. ,
EGFR is required for UVB-mediated induction of multiple signaling pathways that are known to mediate tumor formation in skin. ,
analysis of the mechanisms of action of EGFR-TK-inhibition in hepatocellular cancer cells by erlotinib ,
EGFR and TrkB crosstalk each other in response to EGF and BDNF, leading to cell survival pathway activation in ovarian cancer cells. ,
somatic mutations in EGFR quantitatively differ in pharmacology and signaling properties ,
different EGF receptor mutations exert various negative mechanisms that have the potential to modify receptor internalization and may involve resistance to tyrosine kinase inhibitors in cancers [EGFRvIII, EGF Receptor VIII] ,
transactivation of EGFR by IGF-1 requires basal intracellular H(2)O(2) ,
The findings of EGFR abnormalities in lung cancer have supported the notion that different molecular mechanisms and pathways are involved in the pathogenesis of lung cancer arising in never and ever smokers. ,
IL-13 and EGFR pathways make critical but quite distinct contributions to gene regulation in airway epithelial cells, and that both pathways affect expression of the key transcription factor, FOXA2, a known regulator of mucus production. ,
receptor stability is regulated by MUC1 expression ,
cells surviving an attack by alpha toxin can be induced to proliferate via recruitment of an EGFR-dependent signalling pathway ,
The phosphorylation sites that are most strongly correlated with migration & proliferation were identified, eg. EGFR Y1173 correlates with proliferation. ,
The effects of house dust mite allergen and the cytokines IL-4 and TGF-beta on TARC expression in 16HBE cells and primary bronchial asthma epithelium, was examined. ,
In midgut carcinoid tumor stroma PDGFRalpha was expressed in 35%, PDGFRbeta in 94% and EGFR in 9%. ,
In this article, we review efforts that have been undertaken to identify genomic determinants of drug susceptibility to EGFR tyrosine kinase inhibitors, with particular focus on the role of gene mutations. ,
fine-tuning mechanism of Par3 in epithelial tight junction assembly controlled by the EGF receptor-SFK signaling pathway. ,
the impacts of smoking and sex on the risk of EGFRmut non-small-cell lung cancers (NSCLC) are different from those for EGFRwt NSCLC ,
Serum-independent growth of 5637 cells involves the transmembrane signaling cascade via EGFR ligand(s) (but not HGF), EGFR, Src and p145(met)[p145met] ,
EGFR on the cell surface of cancer cells must exist as an untethered dimer that adopts a previously unreported conformation that is inactive which may provide synergy between monoclonal antibodies and AG1478 in a xenograft model. ,
EGFR intron 1 polymorphism may influence response to treatment with tyrosine kinase inhibitors in breast cancer. ,
The expression of EGFR in postmitotic, terminally differentiated adult retinal neurons suggests that EGFR has pleiotropic functions. ,
UBPY-mediated EGFR de-ubiquitination promotes EGFR degradation ,
These results suggest that the secreted Hsp70 mediates the cross-communication of Toll like receptor and epidermal growth factor receptor signaling systems in A431 cells. ,
Even a modest attenuation of EGF-R signaling leads to a severe defect in postnatal growth of the beta-cells, which leads to the development of diabetes in transgenic mice. ,
EGFR mutations in esophageal carcinoma are rare but do exist, and thus gefitinib could be included in esophageal cancer treatment regimens by selecting those patients who possess such mutations. ,
N-linked glycan with GlcNAc termini linked to EGFR is the target to interact with ganglioside GM3, causing inhibition of EGF-induced EGFR tyrosine kinase ,
Since the EGF receptor is often overexpressed in skin cancers, it might be possible to significantly reduce the proliferative potential of these cells making them good targets for laser-pulsed UV light treatment. ,
Mutations and amplification/overdose in the EGFR gene are present in low-grade oligodendroglial tumours, and may contribute to the development of these brain neoplasms. ,
S100beta-v-erbB transgenic rats may serve as a useful animal model for the identification of EGFR-related molecular targets and as a tool for the assessment of novel therapeutic approaches. ,
An inflammation-dependent EGF-R cascade causes overproduction of the gel-forming mucin MUC5AC, which accumulates in cholesterol gallstone disease. The ability to interrupt this cascade is of potential interest in the prevention of cholesterol gallstones. ,
Inhibition of EGFR activity decreases cell migration involved in insulin-induced wound repair. Insulin stimulates wound healing in corneal epithelium by activating EGFR. This points to novel insulin signaling pathway during corneal wound healing. ,
These findings unmask an EGF-sensitive checkpoint, helping to understand the link between sustained EGFR signalling, proliferation and the acquisition of a radioresistant phenotype in cancer cells. ,
Review. Excessive EGFR signalling plays a critical role in NSCLC tumorigenesis in patients harbouring an EGFR mutation. Mutant EGFRs drive the growth of cancer cells & maintain their malignant phenotype by selective activation of Akt & STAT pathways. ,
The EGFR protein was carried out in 71 of these cases, nonproliferative benign breast disease, proliferative BBD without atypia, proliferative BBD with atypia, carcinoma in situ (n=15) or invasive carcinoma. ,
Immunohistochemical analysis was performed with antibodies to VEGF, EGFR, MMP-2, and COX-2 in relation to human papilloma viral load and persistence of human papillomavirus after conization with negative margins ,
Combined blockade of both epidermal growth factor receptors and G protein coupled recaptors (GPCRs) may be a strategy to treat cancers, including head and neck squamous cell carcinoma that shows cross-talk between GPCR and EGFR signaling pathways. ,
These studies suggest that ACK1 senses signal of epidermal growth factor (EGF) and regulates ligand-induced degradation of EGFR. ,
EGFR positivity was observed in all the cases (100%) of benign prostatic hypertrophy (BPH) and prostatic intraepithelial neoplasia (PIN) and in only 10 cases (28.5%) of prostatic carcinoma. ,
Epidermal growth factor receptor mutations are associated with adenosquamous carcinoma of the lung ,
EGFR gene amplification is frequently present in prostatic phyllodes tumors in humans. ,
Motogenetic activation by EGF requires the concomitant functionality of EGFR and the hyaluronan receptor CD44, whereas activation by TGF-alpha requires EGFR and integrin alphavbeta3. ,
somatic alterations in p53 and EGFR have roles in progression of primary lung cancer ,
EGFR gene mutation does not change the effect of gefitinib in non-small cell lung cancer cells ,
EGFRvIII mutation in lung cancer is correlated with increased expression of EGFR ,
Detailed pharmacokinetic characterization of this bioprobe could assist in the development of a kinetic model that would afford accurate measurement of EGFR content in tumors. ,
Overexpression of epidermal growth factor receptor is associated with esophageal and esophagogastric junction adenocarcinomas ,
These results suggest that in AGS cells, DC transactivates EGFR through M-BAR- and ADAM/HB-EGF-dependent mechanisms. ,
This indicates that EGF receptors are trafficked from the endoplasmic reticulum to the nucleus by a novel pathway that involves the Sec61 translocon. ,
The number of dinucleotide repeats in this receptor identifies a possible susceptible population to lung cancer. ,
no evidence to support the hypothesis that the +61 A-G polymorphism of EGFR is involved in the non-melanocytic skin tumor development in transplanted subjects undergoing immunosuppressive treatment ,
long term treatment with epidermal growth factor (EGF) leads to a marked increase in the levels of ADAM17, which also increases the shedding of several substrates of ADAM17, including the desmosomal cadherin Dsg-2 ,
W-13 calmodulin inhibitor has a role in epidermal growth factor receptor activation ,
EGFR targeted strategies for pancreatic cancer ,
The EGFR/Vav2/Rac1 axis is a crucial pathway for the acquisition of motile and invasive properties of most head and neck squamous cell carcinoma cells. ,
Directed trafficking of plasma membrane EGFR is an essential element of signal transduction leading to p42/p44 MAP kinase activation. ,
Mutations in epidermal growth factor receptor is associated with lung squamous-cell carcinomas, adenosquamous carcinomas, and large-cell carcinomas ,
PTEN tumor-suppressor protein has a role in response to epidermal growth factor receptor tyrosine kinase inhibitors in glioblastoma ,
Estradiol receptor alpha and androgen receptor upregulate EGFR phosphorylation. ,
Targeting of EGFR to determine molecular alterations of this gene may be useful in the management of patients with brain metastases. ,
Overexpression of the EGFR is associated with astrocytomas ,
EGFR overexpression in small cell carcinoma of the urinary bladder does not seem to be caused by gene amplification ,
Our results show EGFR mutations did not occur in these patients suggesting that gefitinib is unlikely to be effective in patients with tumors not harboring specific EGFR TK domain. ,
EGFR depletion induced enhancement of IGF1R ubiquitylation and degradation. ,
Conventional PKC isoforms, especially PKCalpha, mediate feedback inhibition of G-protein-coupled receptor -induced EGFR transactivation. ,
No siatistically significant value in assocation with survival or event-free survival in head and neck squamous cell carcinoma. ,
Tenascin C repeat Ten14 in monomeric form does not bind EGFR with sufficient stability so as to induce degradation of receptor, or undergo EGFR-mediated internalization over either the short (20 min) or long (48 h) term ,
Aldosterone leads to enhanced EGFR expression via interaction with EGFR promoter, which is mineralocorticoid receptor specific and could contribute to the aldosterone-induced increase in fibronectin abundance. ,
EGFR signaling is controlled by a novel mechanism involving trafficking-dependent alterations in receptor compartmentalization. ,
EGFR cannot compensate for IGF1R depletion. ,
Findings suggest that the EGFR mutation is frequent in Korean lung cancer patients. ,
Alterations in PTEN and amplification of EGFR are uncommon in pediatric malignant gliomas, in contrast to adult malignant gliomas. ,
overexpression of spartin results in a prominent decrease in EGFR degradation ,
In a novel culture system normal human adult melanocytes expressed both EGF receptor (EGFR) mRNA and protein and EGF showed a dose dependent mitogenic effect on the cells ,
decorin is taken up by more than one endocytic pathway; uptake depends on EGFR signaling rather than trafficking along the same pathway ,
The presence of EGFR mutations had no effect on survival. ,
protein-tyrosine phosphatase 1B governs differential recruitment of signaling pathways involved in EGFR regulation of epithelial ion transport. ,
integrin alpha1beta1-EGFR cross talk is a key step in negatively regulating Rac1 activation, reactive oxygen species production, and excessive collagen synthesis ,
GRP appears to rescue NSCLC cells exposed to gefitinib through release of amphiregulin and activation of the Akt pathway, suggesting GRPR and/or EGFR autocrine pathways in NSCLC cells may modulate therapeutic response to EGFR inhibitors. ,
incidence of somatic mutations in the tyrosine kinase domains of EGFR was very low and the increased gene copy number of EGFR did not significantly influence survival of pancreatic adenocarcinoma patients ,
This study is the first to demonstrate that EGFR is implicated in IFNgamma-dependent signaling pathways. ,
Analysis of tumor EGFR mutations in patients with NSCLC could be used to identify patients suitable for treatment with gefitinib to obtain optimum response and disease control rates. ,
EGFR is hypermethylated and silenced in a subset of solid tumor cell lines and primary tumor specimens, and cotreatment with decitabine and gefitinib has an additive effect only in EGFR methylated breast cancer cell lines. ,
the long lifetime of EGFRvIII, mutant variant of EGFR is caused by inefficient internalization and impaired sorting to lysosomes due to lack of effective ubiquitinylation. ,
REVIEW ,
Results show epidermal growth factor receptor forms higher order oligomers within microclusters on A431 cells that are sensitive to tyrosine kinase inhibitor binding. ,
Comparative genomic hybridization and immunohistochemical assessment of EGFR, PTEN, p53, and MIB-1 expression in 13 oligodendrogliomas, one oligoastrocytoma and 23 high-grade astrocytomas is reported. ,
analysis of specimens from patients with cancer of unknown primary for EGFR gene mutation, gene amplification, transcriptional regulation as well as protein expression ,
Rin1 regulates EGFR degradation in cooperation with STAM ,
There is a distinct clinical profile for NSCLC patients with the EGFR mutation ,
Our findings suggest that the balance between hepsin and its inhibitor, HAI-2, may have prognostic value in RCC. ,
propose that the non-incidental coamplification of Myc and either ERBB2 or EGFR occurred through translocation and subsequent rearrangement ,
Inhibition of the EGFR signaling pathway reduces ductal carcinoma in situ mammosphere-forming efficiency. ,
present results suggest that it is not a useful indicator of prognosis in oral squamous cell carcinoma ,
Potentially interesting value of the serum levels of sEGFR and EGF, especially when combined, as markers for non-small cell lung cancer and head and neck cancer. ,
Shorter EGFR intron 1 CA repeat length is associated with worse pancreatic cancer clinical prognosis and in vitro response to erlotinib. ,
Role of lipid rafts in EGFR-mediated cancer cell chemotaxis. ,
Mutations in the EGFR tyrosine kinase domain correlate with the clinical response to Gefitinib in lung cancer patients. ,
examinination of distributions of three polymorphisms and their relationships to each other and to EGFR gene mutations and allelic imbalance (AI) in non-small cell lung cancers ,
Frequencies of EGFR mutations were similar in both the alveolar and bronchial types of lung cancer ,
These results suggest that Rabring7 is involved in the endocytic trafficking of EGFR through its E3 ligase activity. ,
Lipid raft cholesterol regulates apoptotic cell death in prostate cancer cells through EGFR-mediated Akt and ERK pathways. ,
These results suggest that PEA3 is regulated by EGFR and that the elevated PEA3 expression detected in human ovarian cancer may divert cells to a more invasive phenotype by regulating MMP-9 and MMP-14. ,
Integrin-mediated adhesion via alpha3beta1, but not alpha6beta4 integrin, supports cell survival through EGFR by signaling downstream to Erk. ,
Targeting EGFR is a novel strategy against neuroblastoma. ,
Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling ,
EGFR pathway, EGFR mutation and/or amplification, may be involved in lung carcinogenesis. ,
Results show a a significant correlation between the EGFR L858R mutation and the expression of p-Akt and suggest that the activation of Akt is dependent on EGFR mutation pattern. ,
Frequent osteopontin expression is typical of, but not specific for malignant pleural mesothelioma, whereas it appears to select pulmonary adenocarcinoma cases with p65 and MMP-9 expression, suggesting a link with EGFR signalling pathways. ,
EGFR/Akt pathway mitigated G2/M arrest in human HaCaT keratinocytes and normal human keratinocytes treated with low doses of UVA irradiation. ,
EGFR mutations in exon 21 are early events in small bronchiolalveolar carcinomas, while exon 19 mutations are later events occurring in adenocarcinomas of various types. ,
Association of epidermal growth factor receptor mutations in lung cancer with chemosensitivity to gefitinib in isolated cancer cells from male and female Japanese patients. ,
Two somatic alterations (E829E and R831C) were identified in the cytoplasmic domain of the EGFR gene in 1 of 10 osteosarcoma samples. ,
observations show that EGFR-T790M provides a proliferative advantage with respect to WT EGFR and suggest that the enhanced kinase activity of this mutant is the basis for rare cases of inherited susceptibility to lung cancer ,
In kidney disease, increased parathyroid hyperplasia cell growth driven by enhanced EGFR could be further aggravated through elevations in integrin beta1 and FAK expression. ,
EGFR expression was shown to be a significant predictor of poor prognosis among gastric cancer patients having the same stage according to the current TNM staging system. ,
E2 can activate a linear pathway involving the sequential activation of IGF-IR, MMP, HB-EGF, EGFR, and MAPK in MCF-7 breast cancer cells ,
Results demonstrate that ErbB1 signaling is hyperactive in squamous cell carcinoma cells, but not basal cell carcinoma cells. ,
it is suggested that atypical adenomatous hyperplasia (AAH) could develop by either KRAS or EGFR gene mutation, but AAH harbouring a KRAS gene mutation might not progress further to an invasive cancer ,
Infection of AGS cells by H. pylori significantly increased EGFR mRNA and protein levels. ,
EGF-stimulated receptor ubiquitination and trafficking are mediated via GAPex-5 ,
epidermal growth factor receptor D761Y mutation has a role in response to tyrosine kinase inhibitors ,
Study has identified a subset of naturally occurring EGFR mutations that lack a critical radioprotective function of EGFR, providing valuable insights on how the EGFR mediates cell survival in response to radiation in NSCLC cell lines. ,
Gbetagamma mediates UVB-induced human keratinocyte apoptosis by augmenting the ectodomain shedding of HB-EGF, which sequentially activates EGFR and p38 ,
Downregulation of E-cadhedrin expression is associataed with increased EGFR downstream signalling and a subsequent increase in expression of Th2-attracting chemokine TARC. ,
MIP-3alpha-mediated ERK1/2 activation in Caco-2 cells appeared to require metalloproteinase-dependent release of the endogenous EGFR ligand amphiregulin and transactivation of the EGFR. ,
Overexpression of EGFR and HER-2 is associated with pancreatic ductal adenocarcinoma ,
Our data suggest that erbB-1/erbB-2 overexpression is a direct effect of higher than normal transcriptional activity of the encoding genes in a subset of human endometrial carcinomas ,
Shiga toxin trafficking to the Golgi is controlled by several Rab GAPs and their target Rabs and this process is discrete from ligand-induced EGFR trafficking. RabGAP-5 was unique among the GAPs tested and reduced the uptake of EGF but not Shiga toxin ,
It seems that continued EGFR tyrosine kinase inhibition may be beneficial to EGFR-mutant lung cancers. ,
EGFR mutation can easily be detected in metastatic lymph nodes sampled by EBUS-TBNA. ,
study of EGFR, HER2, TP53& KRAS mutations of p14arf expression of non-small cell lung cancers in relation to smoking ,
the R497K polymorphism of the EGFR could be a key determinant for reduced tumor recurrence and a longer survival of patients with stage II/III as well as metastatic colorectal carcinoma ,
among adenocarcinomas, nonmucinous and mucinous bronchioloalveolar carcinoma components were significantly associated with EGFR and K-ras gene mutations, respectively ,
Data support that there are significant differences between EGFR and COX-2 expressions in the 3 different histogenetic types of cervical cancer. ,
In bronchioalveolar carcinoma/adenocarcinoma with bronchioalveolar features mucinous differentiation was significantly correlated with the absence of EGFR mutation and presence of KRAS mutation. ,
Amplification of the EGFR gene and polysomy 7 are frequent alterations in primary melanomas and are associated with bad prognosis ,
OSU-03012 prevents YBX1 from inducing EGFR. ,
EGFR and K-ras mutations may have a role in progression of resected non-small-cell lung cancer ,
In Chinese lung cancer patients, a low number of CA repeats in intron 1 of the EGF receptor gene is associated with a better clinical outcome during therapy with gefitinib. ,
EGFR signalling plays a central role in cyclooxygenase-2 induction by transforming growth factor-beta 1 in human bronchial epithelial cells. ,
EGFR mutations were therefore significantly associated with a better PFS in the first-line cytotoxic chemotherapy regimens. ,
In NSCLC cases with wt- or mutant KRAS, downregulation of EGFR expression was a rare event although upregulation in bone metastases was observed more frequently in wt K-RAS cases. ,
Decreased intratumoral EGFR expression and the absence of activated EGFR suggests that EGFR inhibition might not be an ideal target for antibody therapy. ,
EGFR activation in malignant gliomas can transcriptionally activate COX-2 expression in a process that requires p38-MAPK and Sp1/Sp3 ,
endothelin A receptor and epidermal growth factor receptor are targeted by the combination of ZD4054 and gefitinib in ovarian carcinoma ,
EGCG inhibits the binding of EGF to the EGFR and the subsequent dimerization and activation of the EGFR by altering membrane organization ,
EGFR-mutated atypical adenomatous hyperplasias, but not atypical adenomatous hyperplasias with wild-type EGFR, are likely to progress to nonmucinous bronchioloalveolar carcinomas. ,
The combination of cetuximab and trastuzumab could induce synergistic antiproliferative effects in several oesophageal Squamous cell carcinoma cell lines with EGFR and HER-2 expression. ,
Neither mutation of EGFR nor increased copy number of EGFR or HER2 was diagnostic of response to gefitinib. ,
ZD6474 treatment inhibited EGFR phosphorylation and led to a dose- and time-dependent decrease in nasopharyngeal carcinoma cell ,
Fluorescence in situ hybridization/immunohistochemistry analysis of EGFR may be a useful ancillary tool to classify difficult cytology cases and inform clinicians arranging targeted chemotherapy. ,
No correlation between epidermal growth factor receptor protein overexpression and epidermal growth factor receptor gene amplification in gastrointestinal stromal tumors. ,
HGF induces transactivation of the EGFR in epithelial cells, and this is a prerequisite for induction of full motility. ,
Adenin/guanine polymorphisms are not associated with endometrial cancer in a Japanese population. ,
EGFR mutation and gene amplification is asociated with clear cell sarcoma of the kidney ,
activating phosphorylation site on the c-Met receptor was found to be highly responsive to EGFRvIII levels, indicating cross-activation of the c-Met receptor tyrosine kinase by EGFRvIII ,
acquired resistance against both erlotinib, as well as gefitinib was most likely a result of tumor cells acquiring the T790M mutations ,
CK5/6 and/or EGFR expressing tumor types have a persistently poorer prognosis over the longer term. ,
These data suggest that the distinct topography of receptors and their docking partners modulates signaling activities. ,
When combining thymidylate synthase and epidermal growth factor A61G genotype analysis, a small subgroup with a complete pathologic response rate of 100 percent was identified. ,
Oncogenic activity of epidermal growth factor receptor kinase mutant alleles is enhanced by the T790M drug resistance mutation ,
study investigated EGFR protein expression & gene mutations in exons 18, 19 and 21 in 40 renal angiomyolipomas (AML); no EGFR gene mutations of TK domain were detected and strong immunostaining was found in 5% of the renal AML cases ,
study found that EGFR down-regulation was impaired in two non-small cell lung cancers with EGFR tyrosine kinase domain mutations; the mutant receptors were poorly ubiquitylated and exhibited decreased association with the ubiquitin ligase Cbl ,
Reduction of sperm motility by tryptase through the PAR-2 receptor involves epidermal growth factor receptor pathways. ,
EGFR mutation status influenced the effect of adjuvant chemotherapy with uracil-tegafur. ,
Epidermal growth factor receptor (EGFR) ubiquitination as a mechanism of acquired resistance. ,
Overexpression of EGFR is associated with astrocytic tumor pathogenesis and progression ,
The mitogenic signaling for schwannomas is unlikely to be related to overexpression or amplification of EGFR. ,
upregulation of EGFR expression in a few warty and basaloid HG-VIN cases and in many SCCs of the vulva. ,
We report the histological and genetic study of two glioblastomas, one case arising de novo and the other case arising 3 years after a previously diagnosed anaplastic astrocytoma, with concurrent EGFR amplification and TP-53 mutation ,
Phosphorylated-GSK3beta-ser9 and EGFR are involved in the histogenesis of different lung carcinomas. ,
CHROMOSOME
7,
ENTREZ_GENE_ID
1956 ,
EC_NUMBER
2.7.10.1 ,
UNIGENE
Hs.488293 ,
PIR_NREF_ID
NF00074113,
NF00075591,
NF00082661,
NF00082846,
NF00086767,
NF00088851,
NF00091344,
NF00091806,
NF00091999,
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NF00128502,
NF00139463,
NF01684466,
NF02029559,
NF02396892,
NF03284198,
UNIREF100_ID
UniRef100_P00533 ,
UniRef100_P55245 ,
UniRef100_Q504U8 ,
UniRef100_Q68GS5 ,
UniRef100_Q68GS6 ,
UniRef100_Q9H3C8 ,
UNIPROT_ID
EGFR_HUMAN ,
Q504U8_HUMAN ,
Q59FL8_HUMAN ,
Q68GS5_HUMAN ,
Q68GS6_HUMAN ,
Q75MF2_HUMAN ,
Q8WZA5_HUMAN ,
Q9H3C8_HUMAN ,
CYTOBAND
7p12,
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