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Our Science – Wlodawer Website

Alexander Wlodawer, Ph.D.

Selected Publications
1)  Pletnev S, Shcherbo D, Chudakov D, Pletneva N, Merzlyak E, Wlodawer A, Dauter Z, Pletnev V.
A crystallographic study of bright far-red fluorescent protein mKate reveals pH-induced cis-trans isomerization of the chromophore.
J. Biol. Chem. 2008. In Press. [Journal]
2)  Davis J, Wang J, Tropea JE, Zhang D, Dauter Z, Waugh DS, Wlodawer A.
Novel fold of VirA, a type III secretion system effector protein from Shigella flexneri.
Protein Sci. 2008. In Press. [Journal]
3)  Miller M.
The importance of being flexible: The case of basic region leucine Zipper per transcriptional regulators.
Current Protein and Peptide Science. 9: In press, 2008. In Press. [Journal]
4)  Zdanov A, Wlodawer A.
A new look at cytokine signaling.
Cell. 132: 179-81, 2008. [Journal]
5)  Li M, Gustchina A, Alexandratos J, Wlodawer A, Wunschmann S, Kepley CL, Chapman MD, Pomes A.
Crystal structure of a dimerized cockroach allergen Bla g 2 complexed with a monoclonal antibody.
J. Biol. Chem. 283: 2806-2814, 2008. [Journal]
6)  Chruszcz M, Wlodawer A, Minor W.
Determination of protein structures--a series of fortunate events.
Biophys. J. 95: 1-9, 2008. [Journal]
7)  Melnikov EE, Andrianova AG, Morozkin AD, Stepnov AA, Makhovskaya OV, Botos I, Gustchina A, Wlodawer A, Rotanova TV.
Limited proteolysis of E. coli ATP-dependent protease Lon - a unified view of the subunit architecture and characterization of isolated enzyme fragments.
Acta Biochim. Pol. 55: 281-96, 2008. [Journal]
8)  Wlodawer A, Minor W, Dauter Z, Jaskolski M.
Protein crystallography for non-crystallographers, or how to get the best (but not more) from published macromolecular structures.
FEBS J. 275: 1-21, 2008. [Journal]
9)  Nascimento AS, Krauchenco S, Golubev AM, Gustchina A, Wlodawer A, Polikarpov I.
Statistical coupling analysis of aspartic proteinases based on crystal structures of the Trichoderma reesei enzyme and its complex with pepstatin A.
J. Mol. Biol. 382: 763-78, 2008. [Journal]
10)  Zdanov A. Zdanov A, eds.
Classification and known structures of class II cytokines. In: Class II Cytokines. Volume .
Kerala, India: Transworld Research Network; 2007. p. 1-14 [Book Chapter]
11)  Ziolkowska NE, Shenoy SR, O'Keefe BR, McMahon JB, Palmer KE, Dwek RA, Wormald MR, Wlodawer A.
Crystallographic, thermodynamic, and molecular modeling studies of the mode of binding of oligosaccharides to the potent antiviral protein griffithsin.
Proteins. 67: 661-70, 2007. [Journal]
12)  Jaskolski M, Gilski M, Dauter Z, Wlodawer A.
Numerology versus reality: a voice in a recent dispute.
Acta Crystallogr. D Biol. Crystallogr. 63: 1282-3, 2007. [Journal]
13)  Botos I, Wlodawer A.
The expanding diversity of serine hydrolases.
Curr. Opin. Struct. Biol. 17: 683-90, 2007. [Journal]
14)  Moulaei T, Botos I, Ziolkowska NE, Bokesch HR, Krumpe LR, McKee TC, O'Keefe BR, Dauter Z, Wlodawer A.
Atomic-resolution crystal structure of the antiviral lectin scytovirin.
Protein Sci. 16: 2756-60, 2007. [Journal]
15)  Wlodawer A, Li M, Gustchina A, Tsuruoka N, Ashida M, Minakata H, Oyama H, Oda K, Nishino T, Nakayama T.
Crystallographic and biochemical investigations of kumamolisin-As, a serine-carboxyl peptidase with collagenase activity.
J Biol Chem. 279: 21500-21510, 2004. [Journal]
16)  Wang J, Wlodawer A, Dauter Z.
What happens when the signs of anomalous differences or the handedness of substructure are inverted?.
Acta Crystallogr. D Biol. Crystallogr. 63: 751-8, 2007. [Journal]
17)  Chang C, Magracheva E, Kozlov S, Fong S, Tobin G, Kotenko S, Wlodawer A, Zdanov A.
Crystal structure of interleukin-19 defines a new subfamily of helical cytokines.
J Biol Chem. 278: 3308-13, 2003. [Journal]
18)  Ziolkowska NE, Shenoy SR, O'Keefe BR, Wlodawer A.
Crystallographic studies of the complexes of antiviral protein griffithsin with glucose and N-acetylglucosamine.
Protein Sci. 16: 1485-9, 2007. [Journal]
19)  LaRonde-LeBlanc N, Santhanam AN, Baker AR, Wlodawer A, Colburn NH.
Structural basis for inhibition of translation by the tumor suppressor Pdcd4.
Mol. Cell. Biol. 27: 147-56, 2007. [Journal]
20)  Xu Q, Guo HB, Wlodawer A, Nakayama T, Guo H.
The QM/MM Molecular Dynamics and Free Energy Simulations of the Acylation Reaction Catalyzed by the Serine-Carboxyl Peptidase Kumamolisin-As.
Biochemistry. 2007. [Journal]
21)  Wlodawer A.
Deposition of structural data redux.
Acta Crystallogr. D Biol. Crystallogr. 63: 421-3, 2007. [Journal]
22)  Wlodawer A.
Natalia Sergeevna Andreeva 1922-2006.
Nat Struct Mol Biol. 14: 2, 2007. [Journal]
23)  Demartini DR, Wlodawer A, Carlini CR.
A comparative study of the expression of serine proteinases in quiescent seeds and in developing Canavalia ensiformis plants.
J. Exp. Bot. 58: 521-32, 2007. [Journal]
24)  Sanches M, Krauchenco S, Martins NH, Gustchina A, Wlodawer A, Polikarpov I.
Structural Characterization of B and non-B Subtypes of HIV-Protease: Insights into the Natural Susceptibility to Drug Resistance Development.
J. Mol. Biol. 369: 1029-40, 2007. [Journal]
25)  Jaskolski M, Gilski M, Dauter Z, Wlodawer A.
Stereochemical restraints revisited: how accurate are refinement targets and how much should protein structures be allowed to deviate from them?.
Acta Crystallogr. D Biol. Crystallogr. 63: 611-20, 2007. [Journal]
26)  Pletneva N, Pletnev V, Tikhonova T, Pakhomov AA, Popov V, Martynov VI, Wlodawer A, Dauter Z, Pletnev S.
Refined crystal structures of red and green fluorescent proteins from the button polyp Zoanthus.
Acta Crystallogr. D Biol. Crystallogr. 63: 1082-93, 2007. [Journal]
27)  Pletneva NV, Pletnev SV, Chudakov DM, Tikhonova TV, Popov VO, Martynov VI, Wlodawer A, Dauter Z, Pletnev VZ.
[Three-dimensional structure of yellow fluorescent protein zYFP538 from Zoanthus sp. at the resolution 1.8 angstrom].
Bioorg. Khim. 33: 421-30, , ,. [Journal]
28)  Guo H, Wlodawer A, Nakayama T, Xu Q, Guo H.
Catalytic Role of Proton Transfers in the Formation of a Tetrahedral Adduct in a Serine Carboxyl Peptidase.
Biochemistry. 45: 9129-9137, 2006. [Journal]
29)  Prasanna MD, Vondrasek J, Wlodawer A, Rodriguez H, Bhat TN.
Chemical compound navigator: a web-based chem-BLAST, chemical taxonomy-based search engine for browsing compounds.
Proteins. 63: 907-17, 2006. [Journal]
30)  Ziólkowska NE, O'Keefe BR, Mori T, Zhu C, Giomarelli B, Vojdani F, Palmer KE, McMahon JB, Wlodawer A.
Domain-swapped structure of the potent antiviral protein griffithsin and its mode of carbohydrate binding.
Structure. 14: 1127-35, 2006. [Journal]
31)  Gustchina A, Jaskólski M, Wlodawer A.
Lessons learned fighting HIV can be applied to anti-cancer drug design.
Cell Cycle. 5: 463-4, 2006. [Journal]
32)  Zdanov A.
Membrane-bound receptors of the interleukin-10 family of cytokines.
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. 5: 207-214, 2006. [Journal]
33)  Jaskólski M, Li M, Laco G, Gustchina A, Wlodawer A.
Molecular replacement with pseudosymmetry and model dissimilarity: a case study.
Acta Crystallogr. D Biol. Crystallogr. 62: 208-15, 2006. [Journal]
34)  Xiong C, O'Keefe BR, Botos I, Wlodawer A, McMahon JB.
Overexpression and purification of scytovirin, a potent, novel anti-HIV protein from the cultured cyanobacterium Scytonema varium.
Protein Expr. Purif. 46: 233-9, 2006. [Journal]
35)  Okubo A, Li M, Ashida M, Oyama H, Gustchina A, Oda K, Dunn BM, Wlodawer A, Nakayama T.
Processing, catalytic activity and crystal structures of kumamolisin-As with an engineered active site.
FEBS J. 273: 2563-76, 2006. [Journal]
36)  Rotanova TV, Botos I, Melnikov EE, Rasulova F, Gustchina A, Maurizi MR, Wlodawer A.
Slicing a protease: structural features of the ATP-dependent Lon proteases gleaned from investigations of isolated domains.
Protein Sci. 15: 1815-28, 2006. [Journal]
37)  Ziólkowska NE, Wlodawer A.
Structural studies of algal lectins with anti-HIV activity.
Acta Biochim. Pol. 53: 617-26, 2006. [Journal]
38)  Xu Q, Guo H, Wlodawer A, Guo H.
The importance of dynamics in substrate-assisted catalysis and specificity.
J. Am. Chem. Soc. 128: 5994-5, 2006. [Journal]
39)  Brik A, Alexandratos J, Lin YC, Elder JH, Olson AJ, Wlodawer A, Goodsell DS, Wong CH.
1,2,3-Triazole as a Peptide Surrogate in the Rapid Synthesis of HIV-1 Protease Inhibitors.
Chembiochem. 6: 1167-1169, 2005. [Journal]
40)  LaRonde-LeBlanc N, Wlodawer A.
A Family Portrait of the RIO Kinases.
J Biol Chem. 280: 37297-300, 2005. [Journal]
41)  Guo H, Wlodawer A, Guo H.
A General Acid-Base Mechanism for the Stabilization of a Tetrahedral Adduct in a Serine-Carboxyl Peptidase: A Computational Study.
J Am Chem Soc. 127: 15662-15663, 2005. [Journal]
42)  Pletnev S, Magracheva E, Wlodawer A, Zdanov A.
A model of the ternary complex of interleukin-10 with its soluble receptors.
BMC Struct Biol. 5: 10, 2005. [Journal]
43)  Pletnev S, Magracheva E, Wlodawer A, Zdanov A.
A model of the ternary complex of interleukin-10 with its soluble receptors.
BMC Struct Biol. 5: 10, 2005. [Journal]
44)  Prasanna MD, Vondrasek J, Wlodawer A, Bhat TN.
Application of InChI to curate, index, and query 3-D structures.
Proteins. 60: 1-4, 2005. [Journal]
45)  Botos I, Melnikov EE, Cherry S, Kozlov S, Makhovskaya OV, Tropea JE, Gustchina A, Rotanova TV, Wlodawer A.
Atomic-resolution Crystal Structure of the Proteolytic Domain of Archaeoglobus fulgidus Lon Reveals the Conformational Variability in the Active Sites of Lon Proteases.
J Mol Biol. 351: 144-57, 2005. [Journal]
46)  LaRonde-LeBlanc N, Guszczynski T, Copeland T, Wlodawer A.
Autophosphorylation of Archaeoglobus fulgidus Rio2 and crystal structures of its nucleotide-metal ion complexes.
FEBS J. 272: 2800-10, 2005. [Journal]
47)  Oyama H, Fujisawa T, Suzuki T, Dunn BM, Wlodawer A, Oda K.
Catalytic residues and substrate specificity of recombinant human tripeptidyl peptidase I (CLN2).
J Biochem (Tokyo). 138: 127-34, 2005. [Journal]
48)  Wünschmann S, Gustchina A, Chapman MD, Pomés A.
Cockroach allergen Bla g 2: an unusual aspartic proteinase.
J. Allergy Clin. Immunol. 116: 140-5, 2005. [Journal]
49)  Tözsér J, Tropea JE, Cherry S, Bagossi P, Copeland TD, Wlodawer A, Waugh DS.
Comparison of the substrate specificity of two potyvirus proteases.
FEBS J. 272: 514-23, 2005. [Journal]
50)  Gustchina A, Li M, Wünschmann S, Chapman MD, Pomés A, Wlodawer A.
Crystal structure of cockroach allergen Bla g 2, an unusual zinc binding aspartic protease with a novel mode of self-inhibition.
J Mol Biol. 348: 433-44, 2005. [Journal]
51)  Li M, Laco GS, Jaskolski M, Rozycki J, Alexandratos J, Wlodawer A, Gustchina A.
Crystal structure of human T cell leukemia virus protease, a novel target for anticancer drug design.
Proc. Natl. Acad. Sci. U.S.A. 102: 18332-7, 2005. [Journal]
52)  Li M, Rasulova F, Melnikov EE, Rotanova TV, Gustchina A, Maurizi MR, Wlodawer A.
Crystal structure of the N-terminal domain of E. coli Lon protease.
Protein Sci. 14: 2895-900, 2005. [Journal]
53)  Wlodawer A.
Giving credit where credit is due.
Nat Struct Mol Biol. 12: 634; discussion 634, 2005. [Journal]
54)  Snásel J, Krejcík Z, Jencová V, Rosenberg I, Ruml T, Alexandratos J, Gustchina A, Pichová I.
Integrase of Mason-Pfizer monkey virus.
FEBS J. 272: 203-16, 2005. [Journal]
55)  Zakowicz H, Yang HS, Stark C, Wlodawer A, Laronde-Leblanc N, Colburn NH.
Mutational analysis of the DEAD-box RNA helicase eIF4AII characterizes its interaction with transformation suppressor Pdcd4 and eIF4GI.
RNA. 11: 261-74, 2005. [Journal]
56)  Dauter Z, Botos I, LaRonde-LeBlanc N, Wlodawer A.
Pathological crystallography: case studies of several unusual macromolecular crystals.
Acta Crystallogr D Biol Crystallogr. 61: 967-75, 2005. [Journal]
57)  Botos I, Wlodawer A.
Proteins that bind high-mannose sugars of the HIV envelope.
Prog Biophys Mol Biol. 88: 233-82, 2005. [Journal]
58)  Yusof AM, Hu NJ, Wlodawer A, Hofmann A.
Structural evidence for variable oligomerization of the N-terminal domain of cyclase-associated protein (CAP).
Proteins. 58: 255-62, 2005. [Journal]
59)  Laronde-Leblanc N, Guszczynski T, Copeland T, Wlodawer A.
Structure and activity of the atypical serine kinase Rio1.
FEBS J. 272: 3698-713, 2005. [Journal]
60)  Laronde-Leblanc N, Guszczynski T, Copeland T, Wlodawer A.
Structure and activity of the atypical serine kinase Rio1.
FEBS J. 272: 3698-713, 2005. [Journal]
61)  LaRonde-LeBlanc N, Wlodawer A.
The RIO kinases: An atypical protein kinase family required for ribosome biogenesis and cell cycle progression.
Biochim Biophys Acta. 1754: 14-24, 2005. [Journal]
62)  Rotanova TV, Melnikov EE, Khalatova AG, Makhovskaya OV, Botos I, Wlodawer A, Gustchina A.
Classification of ATP-dependent proteases Lon and comparison of the active sites of their proteolytic domains.
Eur J Biochem. 271: 4865-71, 2004. [Journal]
63)  Chang C, Plückthun A, Wlodawer A.
Crystal structure of a truncated version of the phage lambda protein gpD.
Proteins. 57: 866-8, 2004. [Journal]
64)  LaRonde-LeBlanc N, Wlodawer A.
Crystal structure of A. fulgidus Rio2 defines a new family of serine protein kinases.
Structure (Camb). 12: 1585-94, 2004. [Journal]
65)  Botos I, Melnikov EE, Cherry S, Khalatova AG, Rasulova FS, Tropea JE, Maurizi MR, Rotanova TV, Gustchina A, Wlodawer A.
Crystal structure of the AAA+ alpha domain of E. coli Lon protease at 1.9A resolution.
J Struct Biol. 146: 113-22, 2004. [Journal]
66)  Wlodawer A.
How to kill an enzyme (in more ways than one).
Structure (Camb). 12: 1117-9, 2004. [Journal]
67)  Forrer P, Chang C, Ott D, Wlodawer A, Plückthun A.
Kinetic stability and crystal structure of the viral capsid protein SHP.
J Mol Biol. 344: 179-93, 2004. [Journal]
68)  Zdanov A.
Structural features of the interleukin-10 family of cytokines.
Curr. Pharm. Des. 10: 3873-84, 2004. [Journal]
69)  Botos I, Melnikov EE, Cherry S, Tropea JE, Khalatova AG, Rasulova F, Dauter Z, Maurizi MR, Rotanova TV, Wlodawer A, Gustchina A.
The catalytic domain of Escherichia coli Lon protease has a unique fold and a Ser-Lys dyad in the active site.
J Biol Chem. 279: 8140-8, 2004. [Journal]
70)  Wlodawer A, Li M, Gustchina A, Oyama H, Oda K, Beyer BB, Clemente J, Dunn BM.
Two inhibitor molecules bound in the active site of Pseudomonas sedolisin: a model for the bi-product complex following cleavage of a peptide substrate.
Biochem Biophys Res Commun. 314: 638-45, 2004. [Journal]
71)  Wlodawer A, Durell SR, Li M, Oyama H, Oda K, Dunn BM.
A model of tripeptidyl-peptidase I (CLN2), a ubiquitous and highly conserved member of the sedolisin family of serine-carboxyl peptidases.
BMC Struct Biol. 3: 8, 2003. [Journal]
72)  Lubkowski J, Dauter M, Aghaiypour K, Wlodawer A, Dauter Z.
Atomic resolution structure of Erwinia chrysanthemi L-asparaginase.
Acta Crystallogr D Biol Crystallogr. 59: 84-92, 2003. [Journal]
73)  Botos I, Wlodawer A.
Cyanovirin-N: a sugar-binding antiviral protein with a new twist.
Cell Mol Life Sci. 60: 277-87, 2003. [Journal]
74)  Wlodawer A, Li M, Gustchina A, Oyama H, Dunn BM, Oda K.
Structural and enzymatic properties of the sedolisin family of serine-carboxyl peptidases.
Acta Biochim Pol. 50: 81-102, 2003. [Journal]
75)  Maurady A, Zdanov A, de Moissac D, Beaudry D, Sygusch J.
A conserved glutamate residue exhibits multifunctional catalytic roles in D-fructose-1,6-bisphosphate aldolases.
J. Biol. Chem. 277: 9474-83, 2002. [Journal]
76)  Gustchina A, Li M, Phylip LH, Lees WE, Kay J, Wlodawer A.
An unusual orientation for Tyr75 in the active site of the aspartic proteinase from Saccharomyces cerevisiae.
Biochem Biophys Res Commun. 295: 1020-6, 2002. [Journal]
77)  Hofmann A, Tarasov S, Grella M, Ruvinov S, Nasr F, Filipowicz W, Wlodawer A.
Biophysical characterization of cyclic nucleotide phosphodiesterases.
Biochem Biophys Res Commun. 291: 875-83, 2002. [Journal]
78)  Chang C, Magracheva E, Kozlov S, Fong S, Tobin G, Kotenko S, Wlodawer A, Zdanov A.
Crystal structure of interleukin-19 defines a new subfamily of helical cytokines.
J Biol Chem. 2002. [Journal]
79)  Hofmann A, Grella M, Botos I, Filipowicz W, Wlodawer A.
Crystal structures of the semireduced and inhibitor-bound forms of cyclic nucleotide phosphodiesterase from Arabidopsis thaliana.
J Biol Chem. 277: 1419-25, 2002. [Journal]
80)  Hofmann A, Hess S, Noegel AA, Schleicher M, Wlodawer A.
Crystallization of cyclase-associated protein from Dictyostelium discoideum.
Acta Crystallogr D Biol Crystallogr. 58: 1858-61, 2002. [Journal]
81)  Chang C, Newton DL, Rybak SM, Wlodawer A.
Crystallographic and functional studies of a modified form of eosinophil-derived neurotoxin (EDN) with novel biological activities.
J Mol Biol. 317: 119-30, 2002. [Journal]
82)  Botos I, Mori T, Cartner LK, Boyd MR, Wlodawer A.
Domain-swapped structure of a mutant of cyanovirin-N.
Biochem Biophys Res Commun. 294: 184-90, 2002. [Journal]
83)  Vondrasek J, Wlodawer A.
HIVdb: a database of the structures of human immunodeficiency virus protease.
Proteins. 49: 429-31, 2002. [Journal]
84)  Hofmann A, Wlodawer A.
PCSB--a program collection for structural biology and biophysical chemistry.
Bioinformatics. 18: 209-10, 2002. [Journal]
85)  Hofmann A, Ruvinov S, Hess S, Schantz R, Delmer DP, Wlodawer A.
Plant annexins form calcium-independent oligomers in solution.
Protein Sci. 11: 2033-40, 2002. [Journal]
86)  Wlodawer A.
Rational approach to AIDS drug design through structural biology.
Annu Rev Med. 53: 595-614, 2002. [Journal]
87)  Dunn BM, Goodenow MM, Gustchina A, Wlodawer A.
Retroviral proteases.
Genome Biol. 3: REVIEWS3006, 2002. [Journal]
88)  Jaffe EK, Kervinen J, Martins J, Stauffer F, Neier R, Wlodawer A, Zdanov A.
Species-specific inhibition of porphobilinogen synthase by 4-oxosebacic acid.
J Biol Chem. 277: 19792-9, 2002. [Journal]
89)  Phan J, Zdanov A, Evdokimov AG, Tropea JE, Peters HK, Kapust RB, Li M, Wlodawer A, Waugh DS.
Structural basis for the substrate specificity of tobacco etch virus protease.
J Biol Chem. 277: 50564-72, 2002. [Journal]
90)  Hofmann A, Iwai H, Hess S, Plückthun A, Wlodawer A.
Structure of cyclized green fluorescent protein.
Acta Crystallogr D Biol Crystallogr. 58: 1400-6, 2002. [Journal]
91)  Botos I, O'Keefe BR, Shenoy SR, Cartner LK, Ratner DM, Seeberger PH, Boyd MR, Wlodawer A.
Structures of the complexes of a potent anti-HIV protein cyanovirin-N and high mannose oligosaccharides.
J Biol Chem. 277: 34336-42, 2002. [Journal]
92)  Barrientos LG, Louis JM, Botos I, Mori T, Han Z, O'Keefe BR, Boyd MR, Wlodawer A, Gronenborn AM.
The domain-swapped dimer of cyanovirin-N is in a metastable folded state: reconciliation of X-ray and NMR structures.
Structure (Camb). 10: 673-86, 2002. [Journal]
93)  Wlodawer A, Li M, Dauter Z, Gustchina A, Uchida K, Oyama H, Dunn BM, Oda K.
Carboxyl proteinase from Pseudomonas defines a novel family of subtilisin-like enzymes.
Nat Struct Biol. 8: 442-6, 2001. [Journal]
94)  Botos I, Wu Z, Lu W, Wlodawer A.
Crystal structure of a cyclic form of bovine pancreatic trypsin inhibitor.
FEBS Lett. 509: 90-4, 2001. [Journal]
95)  Chang C, Mooser A, Plückthun A, Wlodawer A.
Crystal structure of the dimeric C-terminal domain of TonB reveals a novel fold.
J Biol Chem. 276: 27535-40, 2001. [Journal]
96)  Aghaiypour K, Wlodawer A, Lubkowski J.
Do bacterial L-asparaginases utilize a catalytic triad Thr-Tyr-Glu.
Biochim Biophys Acta. 1550: 117-28, 2001. [Journal]
97)  Wlodawer A, Li M, Gustchina A, Dauter Z, Uchida K, Oyama H, Goldfarb NE, Dunn BM, Oda K.
Inhibitor complexes of the Pseudomonas serine-carboxyl proteinase.
Biochemistry. 40: 15602-11, 2001. [Journal]
98)  Kervinen J, Jaffe EK, Stauffer F, Neier R, Wlodawer A, Zdanov A.
Mechanistic basis for suicide inactivation of porphobilinogen synthase by 4,7-dioxosebacic acid, an inhibitor that shows dramatic species selectivity.
Biochemistry. 40: 8227-36, 2001. [Journal]
99)  Dauter Z, Li M, Wlodawer A.
Practical experience with the use of halides for phasing macromolecular structures: a powerful tool for structural genomics.
Acta Crystallogr D Biol Crystallogr. 57: 239-49, 2001. [Journal]
100)  Aghaiypour K, Wlodawer A, Lubkowski J.
Structural basis for the activity and substrate specificity of Erwinia chrysanthemi L-asparaginase.
Biochemistry. 40: 5655-64, 2001. [Journal]
101)  Jaskólski M, Kozak M, Lubkowski J, Palm G, Wlodawer A.
Structures of two highly homologous bacterial L-asparaginases: a case of enantiomorphic space groups.
Acta Crystallogr D Biol Crystallogr. 57: 369-77, 2001. [Journal]
102)  Phylip LH, Lees WE, Brownsey BG, Bur D, Dunn BM, Winther JR, Gustchina A, Li M, Copeland T, Wlodawer A, Kay J.
The potency and specificity of the interaction between the IA3 inhibitor and its target aspartic proteinase from Saccharomyces cerevisiae.
J Biol Chem. 276: 2023-30, 2001. [Journal]
103)  Palm GJ, Billy E, Filipowicz W, Wlodawer A.
Crystal structure of RNA 3'-terminal phosphate cyclase, a ubiquitous enzyme with unusual topology.
Structure Fold Des. 8: 13-23, 2000. [Journal]
104)  Kent S, Marshall GR, Wlodawer A.
Determining the 3D structure of HIV-1 protease.
Science. 288: 1590, 2000. [Journal]
105)  Yang F, Dauter Z, Wlodawer A.
Effects of crystal twinning on the ability to solve a macromolecular structure using multiwavelength anomalous diffraction.
Acta Crystallogr D Biol Crystallogr. 56 ( Pt 8): 959-64, 2000. [Journal]
106)  Yang F, Forrer P, Dauter Z, Conway JF, Cheng N, Cerritelli ME, Steven AC, Plückthun A, Wlodawer A.
Novel fold and capsid-binding properties of the lambda-phage display platform protein gpD.
Nat Struct Biol. 7: 230-7, 2000. [Journal]
107)  Wlodawer A, Gustchina A.
Structural and biochemical studies of retroviral proteases.
Biochim Biophys Acta. 1477: 16-34, 2000. [Journal]
108)  Li M, Morris GM, Lee T, Laco GS, Wong CH, Olson AJ, Elder JH, Wlodawer A, Gustchina A.
Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease.
Proteins. 38: 29-40, 2000. [Journal]
109)  Hofmann A, Zdanov A, Genschik P, Ruvinov S, Filipowicz W, Wlodawer A.
Structure and mechanism of activity of the cyclic phosphodiesterase of Appr>p, a product of the tRNA splicing reaction.
EMBO J. 19: 6207-17, 2000. [Journal]
110)  Li M, Phylip LH, Lees WE, Winther JR, Dunn BM, Wlodawer A, Kay J, Gustchina A.
The aspartic proteinase from Saccharomyces cerevisiae folds its own inhibitor into a helix.
Nat Struct Biol. 7: 113-7, 2000. [Journal]

This page was last updated on 9/15/2008.