Publications |
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HERE to search NCBI PubMed for publications by Alexander
Wlodawer. |
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RECENT PUBLICATIONS: |
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| E. E. Melnikov,
A. G. Andrianova, A. D. Morozkin, A. A. Stepnov, O. V. Makhovskaya, I. Botos,
A. Gustchina, A. Wlodawer, and T. V. Rotanova. 2008. Limited proteolysis of the
E. coli ATP-dependent protease Lon - a unified view of the subunit architecture
and characterization of isolated enzyme fragments. Acta Biochim.
Polon.55, 281-296. |
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| A. S.
Nascimento, S. Krauchenco, A. M. Golubev, A. Gustchina, A. Wlodawer, and I.
Polikarpov. 2008. Statistical coupling analysis of aspartic proteinases based
on crystal structures of the Trichoderma reesei enzyme and its complex with
pepstatin A. J. Mol. Biol., in press. |
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| S. Pletnev, D.
Shcherbo, D. Chudakov, N. Pletneva, E. Merzlyak, A. Wlodawer, Z. Dauter, and
Vladimir Pletnev. 2008. A crystallographic study of bright far-red fluorescent
protein mKate reveals pH-induced cis-trans isomerization of the chromophore.
J. Biol. Chem., in press. |
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| M. Li, A.
Gustchina, J. Alexandratos, A. Wlodawer, S. Wünschmann, C. L. Kepley, M.
D. Chapman, and A. Pomés. 2008. Crystal structure of a dimerized
cockroach allergen Bla g 2 complexed with a monoclonal antibody. J. Biol.
Chem., in press. |
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| O. V.
Makhovskaya, S. Kozlov, I. Botos, A. A. Stepnova, A. G. Andrianova, A. E.
Gustchina, A. Wlodawer, E. E. Melnikov, and T. V. Rotanova. 2007. Forms of LonB
protease from Archaeoglobus fulgidus devoid of the transmembrane domain: the
contribution of the quaternary structure to the regulation of enzyme
proteolytic activity. Russ. J. Bioorg. Chem. 33,
610-613. |
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| M. Jaskolski, M.
Gilski, Z. Dauter, and A. Wlodawer. 2007. Numerology versus reality: a voice in
a recent dispute. Acta Crystallogr. D63, 1282-1283. |
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| T. Moulaei, I.
Botos, N. E. Ziólkowska, H. R. Bokesch, L. R. Krumpe, T. C. McKee, B. R.
O'Keefe, Z. Dauter and A. Wlodawer. 2007. Atomic-resolution crystal structure
of the antiviral lectin scytovirin. Protein Sci. 16,
2756-2760. |
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| N. Pletneva, V.
Pletnev, T. Tikhonova, A. A. Pakhomov, V. Popov, V. I. Martynov, A. Wlodawer,
Z. Dauter and S. Pletnev. 2007. Refined crystal structures of red and green
fluorescent proteins from the button polyp Zoanthus. Acta Crystallogr.
D63, 1082-1093. |
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| N. V. Pletneva,
S. V. Pletnev, D. M. Chudakov, T. V. Tikhonova, V. O. Popov, V. I. Martynov, A.
Wlodawer, Z. Dauter and V. Z. Pletnev. 2007. Three-dimensional structure of
yellow fluorescent protein zYFP538 from Zoanthus sp. at the resolution of 1.8
Å. Russ. J. Bioorg. Chem. 33, 390-398. |
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| J. Wang, A.
Wlodawer and Z. Dauter. 2007. What happens when the signs of anomalous
differences or the handedness of substructure are inverted? Acta
Crystallogr. D63, 751-758. |
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| N. E.
Ziólkowska, S. R. Shenoy, B. R. O'Keefe and A. Wlodawer. 2007.
Crystallographic studies of the complexes of antiviral protein griffithsin with
glucose and N-acetylglucosamine. Protein Sci. 16, 1485-1489
(2007). |
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| M. Sanches, S.
Krauchenco, N. H. Martins, A. Gustchina, A. Wlodawer and I. Polikarpov. 2007.
Structural characterization of B and non-B subtypes of HIV-protease: insights
into the natural susceptibility to drug resistance development. J. Mol.
Biol., 369, 1029-1040. |
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| M. Jaskolski, M.
Gilski, Z. Dauter and A. Wlodawer. 2007. Stereochemical restraints revisited:
how accurate are refinement targets and how much should protein structures be
allowed to deviate from them? Acta Crystallogr. D63,
611-620. |
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| Q. Xu, H. Guo,
A. Wlodawer, T. Nakayama and H. Guo. 2007. The QM/MM molecular dynamics and
free energy simulations of the acylation reaction catalyzed by the serine
carboxyl peptidase kumamolisin-As. Biochemistry, 46,
3784-3792. |
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| N. E.
Ziólkowska, S. R. Shenoy, B. R. O'Keefe, J. B. McMahon, K. E. Palmer, R.
A. Dwek, M. R. Wormald and A. Wlodawer. 2007. Crystallographic, thermodynamic,
and molecular modeling studies of the mode of binding of oligosaccharides to
the potent antiviral protein griffithsin. Proteins: Struct. Funct.
Bioinform., 67, 661-670. |
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| N.
LaRonde-LeBlanc, A. N. Santhanam, A. R. Baker, A. Wlodawer, and N. H. Colburn.
2007. Structural basis for inhibition of translation by the tumor suppressor
Pdcd4. Mol. Cell. Biol., 27, 147-156. |
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| D. R. Demartini,
A. Wlodawer, and C. R. Carlini. 2007. A comparative study of the expression of
serine proteinases in quiescent seeds and in developing Canavalia ensiformis
plants. J. Exper. Botany, 58, 521-532. |
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| H. Guo, A.
Wlodawer, T. Nakayama, Q. Xu, and H. Guo. 2006. Catalytic role of proton
transfers in the formation of a tetrahedral adduct in a serine carboxyl
peptidase. Biochemistry, 45, 9129-9137. |
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| N. E.
Ziólkowska, B. R. O'Keefe, T. Mori, C. Zhu, B. Giomarelli, F. Vojdani,
K. E. Palmer, J. B. McMahon, and A. Wlodawer. 2006. Domain-swapped structure of
the potent antiviral protein griffithsin and its mode of carbohydrate binding.
Structure, 14, 1127-1135. |
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| Q. Xu, H. Guo,
A. Wlodawer, and H. Guo. 2006. The Importance of dynamics in substrate-assisted
catalysis and specificity. J. Amer. Chem. Soc., 128,
5994-5995. |
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| M. D. Prasanna,
J. Vondrasek, A. Wlodawer, H. Rodriguez, and T. N. Bhat. 2006. Chemical
compound navigator: A web-based Chem-BLAST, chemical taxonomy based search
engine for browsing compounds. Proteins: Struct., Funct. Bioinf., 63,
907-917. |
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| A. Gustchina, M. Jaskólski, and A.
Wlodawer. 2006. Lessons learned fighting HIV can be applied to anti-cancer drug
design. Cell Cycle, 5, 463-464. |
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| M. Jaskólski, M. Li, G. Laco, A.
Gustchina, and A. Wlodawer. 2006. Molecular replacement with pseudosymmetry and
model dissimilarity: a case study. Acta Crystallogr. D62,
208-215. |
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| C. Xiong, B.
O'Keefe, I. Botos, A. Wlodawer and J. McMahon. 2006. Overexpression and
purification of scytovirin, a potent novel anti-HIV protein from the cultured
cyanobacterium Scytonema varium. Protein Expr Purif., 46,
233-239. |
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| A. Okubo, M.
Li, M. Ashida, H. Oyama, A. Gustchina, K. Oda, B. M. Dunn, A. Wlodawer, and T.
Nakayama. 2006. Processing, catalytic activity, and crystal structures of
kumamolisin-As with an engineered active site. FEBS J., 273,
2563-2576. |
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| M. Miller.
2006. Phospho-Dependent Protein Recognition Motifs Contained in C/EBP Family of
Transcription Factors. Cell Cycle 5:21, 2501-2508. |
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| M. Li, G. S.
Laco, M. Jaskólski, J. Rozycki, J. Alexandratos, A. Wlodawer, and A.
Gustchina. 2005. Crystal structure of human T-cell leukemia virus protease, a
novel target for anti-cancer drug design. Proc. Natl. Acad. Sci. USA,
102, 18332-18337. |
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| H. Guo, A.
Wlodawer, and H. Guo. 2005. A general acid-base mechanism for the stabilization
of tetrahedral adduct in a serine-carboxyl peptidase: a computational study.
J. Amer. Chem. Soc., 127, 15662-15663. |
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| M. Li, F.
Rasulova, E. E. Melnikov, T. V. Rotanova, A. Gustchina, M. R. Maurizi and A.
Wlodawer. 2005. Crystal structure of the N-terminal domain of E. coli
Lon protease. Protein Science, 14, 2895-2900. |
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| S. Pletnev , E.
Magracheva , A. Wlodawer and A. Zdanov. 2005. A model of the ternary complex of
interleukin-10 with its soluble receptors. BMC Structural Biology 5:10.
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| I. Botos, E. E.
Melnikov, S. Cherry, S. Kozlov, O. V. Makhovskaya, J. E. Tropea, A. Gustchina,
T. V. Rotanova and A. Wlodawer. 2005. Atomic-resolution crystal structure of
the proteolytic domain of Archaeoglobus fulgidus Lon reveals the
conformational variability in the active sites of Lon proteases. J. Mol.
Biol., 351, 144-157. |
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| N.
LaRonde-LeBlanc, T. Guszczynski, T. Copeland and A. Wlodawer. 2005. Structure
and activity of the atypical serine kinase Rio1. FEBS Journal, 272,
3698-3713. |
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| A. Brik, J.
Alexandratos, Y.-C. Lin, J. H. Elder, A. J. Olson, A. Wlodawer, D. S. Goodsell
and C.-H. Wong. 2005. 1,2,3-Triazole as a peptide surrogate in the rapid
synthesis of HIV-1 protease inhibitors. ChemBioChem 6, 1167-1169.
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| H. Oyama, T.
Fujisawa, T. Suzuki, B. M. Dunn, A. Wlodawer and K. Oda. 2005. Catalytic
residues and substrate specificity of recombinant human tripeptidyl peptidase I
(CLN2). J. Biochem. (Tokyo), 138, 127-134. |
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| Z. Dauter, I.
Botos, N. LaRonde-LeBlanc and A. Wlodawer. 2005. Pathological crystallography -
case studies of several unusual macromolecular crystals. Acta
Crystallogr. D61, 967-975. |
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| N.
LaRonde-LeBlanc, T. Guszczynski, T. Copeland and A. Wlodawer. 2005.
Autophosphorylation of A. fulgidus Rio2 and crystal structures of its
nucleotide-metal ion complexes. FEBS Journal, 272,
2800-2810. |
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| A. Gustchina, M.
Li, S. Wünschmann, M. D. Chapman, A. Pomés and A. Wlodawer. 2005.
Crystal structure of cockroach allergen Bla g 2, an unusual zinc binding
aspartic protease with a novel mode of self-inhibition. J. Mol. Biol.,
348, 433-444. |
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| H. Zakowicz,
H.-S. Yang, C. Stark, A. Wlodawer, N. LaRonde-LeBlanc and N. H. Colburn. 2005.
Mutational analysis of the DEAD box RNA helicase eIF4AII characterizes its
interaction with transformation suppressor Pdcd4 and eIF4GI. RNA, 11,
261-274. |
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| M. D. Prasanna,
J. Vondrasek, A. Wlodawer, T. N. Bhat. 2005. Application of InChI to curate,
index and query 3-D structures. Proteins: Struct., Funct. Bioinf., 60,
1-4. |
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| J.
Tözsér, J. E. Tropea, S. Cherry, P. Bagossi, T. D. Copeland, A.
Wlodawer and D. S. Waugh. 2005. Comparison of the substrate specificity of two
potyvirus proteases. FEBS Journal, 272, 514-523. |
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| J. Snasel, Z.
Krejcik, V. Jencova, I. Rosenberg, T. Ruml, J. Alexandratos, A. Gustchina and
I. Pichova. 2005. Integrase of Mason-Pfizer monkey virus. FEBS Journal,
272, 203-216 |
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| A. M. Yusof, N.
Hu, A. Nögel, M. Schleicher, A. Wlodawer and A. Hofmann. 2005. Structural
evidence for variable oligomerization of the N-terminal domain of
cyclase-associated protein (CAP). Proteins: Struct. Funct. Bioinf., 58,
255-262. |
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| T. V. Rotanova ,
E. E. Melnikov, A. G. Khalatova, O. V. Makhovskaya, I. Botos, A. Wlodawer and
A. Gustchina. 2004. Classification of ATP-dependent proteases Lon and
comparison of the active sites of their proteolytic domains. Eur. J.
Biochem, 271, 4865-4871. |
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| P. Forrer, C.
Chang, D. Ott, A. Wlodawer and A. Plückthun. 2004. Kinetic stability and
crystal structure of the viral capsid protein SHP. J. Mol. Biol., 344,
179-193. |
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| N.
LaRonde-LeBlanc and A. Wlodawer. 2004. Crystal Structure of A. fulgidus
Rio2 Defines a New Family of Serine Protein Kinases. Structure, Vol. 12,
1–20. |
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| F. Sheikh, V. V.
Baurin, A. Lewis-Antes, N. K. Shah, S. V. Smirnov, S. Anantha, H. Dickensheets,
L. Dumoutier, J. Renauld, A. Zdanov, R. P. Donnelly and S. V. Kotenko. 2004.
Cutting Edge: IL-26 Signals through a Novel Receptor Complex Composed of IL-20
Receptor 1 and IL-10 Receptor 2. The Journal of Immunology, 172,
2006-2010. |
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| C. Chang, A.
Plückthun and A. Wlodawer. 2004. Crystal structure of a truncated version
of the phage λ protein gpD. Proteins: Struct. Funct. Bioinf., 57,
866-868. |
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| A. Wlodawer, M.
Li, A. Gustchina, N. Tsuruoka, M. Ashida, H. Minakata, H. Oyama, K. Oda, T.
Nishino, and T. Nakayama. 2004. Crystallographic and biochemical Investigations
of kumamolisin-As, a serine-carboxyl peptidase with collagenase activity. J.
Biol. Chem. 279, 21500-21510. |
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| I. Botos, E. E.
Melnikov, S. Cherry, J. E. Tropea, A. G. Khalatova, F. Rasulova, Z. Dauter, M.
R. Maurizi, T. V. Rotanova, A. Wlodawer and A. Gustchina. 2004. The catalytic
domain of E. coli Lon protease has a unique fold and a Ser-Lys dyad in
the active site. J. Biol. Chem. 279, 8140-8148. |
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| I. Botos, E. E.
Melnikov, S. Cherry, A. G. Khalatova, F. Rasulova, J. E. Tropea, M. R. Maurizi,
T. V. Rotanova, A. Gustchina and A. Wlodawer. 2004. Crystal structure of the
AAA α domain of E. coli Lon protease at 1.9 Å resolution.
J. Struct. Biol., 146, 113-122. |
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| A. Wlodawer, M.
Li, A. Gustchina, H. Oyama, K. Oda, B. B. Beyer, J. Clemente and B. M. Dunn.
2004. Two inhibitor molecules bound in the active site of Pseudomonas
sedolisin: a model for the bi-product complex following cleavage of peptide
substrate. Biochemical and Biophysical Research Communications, 314,
638-645. |
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| A.
Wlodawer, S. R. Durell, M. Li, H. Oyama, K. Oda and B. M. Dunn. 2003. A model
of tripeptidyl-peptidase I (CLN2), a ubiquitous and highly conserved member of
the sedolisin family of serine-carboxyl peptidases. BMC Structural
Biology, 3:8. |
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| S. Pletnev, E.
Magracheva, S. Kozlov, G. Tobin, S. V. Kotenko, A. Wlodawer and A. Zdanov.
2003. Characterization of the recombinant extracellular domains of human
interleukin-20 receptors and their complexes with interleukin-19 and
interleukin-20. Biochemistry, 42, 12617-12624. |
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| M. Miller, J. D.
Shuman, T. Sebastian, Z. Dauter and P. F. Johnson. 2003. Structural basis for
DNA recognition by the basic region leucine zipper transcription factor
CCAAT/enhancer-binding protein alpha. J. Biol. Chem., 278,
15178-15184. |
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| C. Gasche, P.
Grundtner, P. Zwirn, W. Reinisch, S. H. Shaw, A. Zdanov, U. Sarma, L. M.
Williams, B. M. Foxwell and A. Gangl. 2003. Novel variants of the IL-10
receptor 1 affect inhibition of monocyte TNF-α production. J.
Immunol., 170, 5578-5582. |
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| A. Wlodawer, M.
Li, A. Gustchina, H. Oyama, B. M. Dunn and K. Oda. 2003. Structural and
enzymatic properties of the sedolisin family of serine-carboxyl peptidases.
Acta Biochim. Polon., 50, 81-102. |
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| C. Chang, E.
Magracheva, S. Kozlov, S. Fong, G. Tobin, S. Kotenko, A. Wlodawer and A.
Zdanov. 2003. Crystal structure of interleukin-19 defines a new subfamily of
helical cytokines. J. Biol. Chem., 278, 3308-3313. |
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| J. Lubkowski, M.
Dauter, K. Aghaiypour, A. Wlodawer and Z. Dauter. 2003. Atomic Resolution
Structure of Erwinia chrysanthemi L-asparaginase. Acta Crystallogr.,
D59, 84-92. |
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| A. Maurady, A.
Zdanov, D. de Moissac, D. Beaudry and J. Sygusch. 2002. A conserved glutamate
residue exhibits multifunctional catalytic roles in D-fructose-1,6-bisphosphate
aldolases. J. Biol. Chem., 277, 9474-9483. |
|
| J. Phan, A.
Zdanov, A. G. Evdokimov, J. E. Tropea, H. K. Peters III, R. B. Kapust, M. Li,
A. Wlodawer and D. S. Waugh. 2002. Structural basis for the substrate
specificity of tobacco etch virus protease. J. Biol. Chem., 277,
50564-50472. |
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| J. Vondrasek and
A. Wlodawer. 2002. HIVdb-a database of the structures of human immunodeficiency
virus protease. Proteins: Struct. Funct. Genet., 49, 429-431. |
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| I. Botos, B. R.
O'Keefe, S. R. Shenoy, L. K. Cartner, D. M. Ratner, P. H. Seeberger, M. R. Boyd
and A. Wlodawer. 2002. Structures of the complexes of a potent anti-HIV protein
cyanovirin-N and high-mannose oligosaccharides. J. Biol. Chem., 277,
34336-34342. |
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| A. Gustchina, M.
Li, L. H. Phylip, W. E. Lees, J. Kay and A. Wlodawer. 2002. An unusual
orientation for Tyr75 in the active site of the aspartic proteinase from
Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun., 295,
1020-1026. |
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| A. Hofmann, S.
Hess, A. A. Noegel, M. Schleicher and A. Wlodawer. 2002. Crystallization of
cyclase associated protein from Dictyostelium discoideum. Acta
Crystallogr., D58, 1858-1861. |
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| A. Hofmann, H.
Iwai, S. Hess, A. Plückthun and A. Wlodawer. 2002. Crystal structure of
cyclized green fluorescent protein. Acta Crystallogr., D58, 1400-1406.
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| I. Botos, T.
Mori, L. K. Cartner, M. R. Boyd, and A. Wlodawer. 2002. Domain-swapped
structure of a mutant of cyanovirin N. Biochem. Biophys. Res. Commun.,
294, 184-190. |
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| A. Hofmann, S.
Ruvinov, S. Hess, R. Schantz, D. P. Delmer and A. Wlodawer. 2002. Plant
annexins form calcium-independent oligomers in solution. Protein
Science, 11, 2033-2040. |
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| E. K. Jaffe, J.
Kervinen, J. Martins, F. Stauffer, R. Neier, A. Wlodawer and A. Zdanov. 2002.
Species-specific inhibition of porphobilinogen synthase by 4-oxosebacic acid.
J. Biol. Chem., 277, 19792-19799. |
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| L. G.
Barrientos, J. M. Louis, I. Botos, T. Mori, Z. Han, B. R. O'Keefe, M. R. Boyd,
A. Wlodawer and A. M. Gronenborn. 2002. The domain-swapped dimer of
cyanovirin-N is a metastable folding intermediate. Reconciliation of X-ray and
NMR structures. Structure, 10, 673-686. |
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| A. Hofmann, S.
Tarasov, M. Grella, S. Ruvinov, F. Nasr, W. Filipowicz and A. Wlodawer. 2002.
Biophysical characterization of cyclic nucleotide phosphodiesterases.
Biochem. Biophys. Res. Commun., 291, 875-883. |
|
| C. Chang, D. L.
Newton, S. M. Rybak, and A. Wlodawer. 2002. Crystallographic and functional
studies of a modified form of eosinophil-derived neurotoxin (EDN) with novel
biological activities. J. Mol. Biol., 317, 119-130. |
|
| A. Hofmann, M.
Grella, I. Botos, W. Filipowicz and A. Wlodawer. 2002. Crystal structures of
the semireduced and inhibitor-bound forms of cyclic nucleotide
phosphodiesterase from Arabidopsis thaliana. J. Biol. Chem., 277,
1419-1425. |
|
| A. Hofmann and
A. Wlodawer. 2002. PCSB - a program collection for structural biology and
biophysical chemistry. Bioinformatics, 18, 209-210. |
|
| M. Miller, K.
Ginalski, B. Lesyng, N. Nakaigawa, L. Schmidt and B. Zbar. 2001. Structural
basis of oncogenic activation caused by point mutations in the kinase domain of
the MET proto-oncogene: modeling studies. Proteins, 44, 32-43.
|
|
| A. Wlodawer, M.
Li, A. Gustchina, Z. Dauter, K. Uchida, H. Oyama, N. E. Goldfarb, B. M. Dunn
and K. Oda. 2001. Inhibitor complexes of the Pseudomonas serine-carboxyl
proteinase. Biochemistry, 40, 15602-15611. |
|
| I. Botos, Z. Wu,
W. Lu and A. Wlodawer. 2001. Crystal structure of a cyclic form of bovine
pancreatic trypsin inhibitor. FEBS Lett., 509, 90-94. |
|
| K. Aghaiypour,
A. Wlodawer and J. Lubkowski. 2001. Do bacterial L-asparaginases utilize a
catalytic triad Glu-Tyr-Thr? Biochim. Biophys. Acta, 1550,
117-128. |
|
| J. Kervinen, E.
K. Jaffe, F. Stauffer, R. Neier, A. Wlodawer and A. Zdanov. 2001. Suicide
inactivation of porphobilinogen synthase by 4,7-dioxosebacic acid shows
dramatic species-selectivity. Biochemistry,
40:8227-8236. |
|
| C. Chang, A.
Mooser, A. Plückthun and A. Wlodawer. 2001. Crystal structure of the
dimeric C-terminal domain of TonB reveals a novel fold. J. Biol. Chem.,
276:27535-27540. |
|
| K. Aghaiypour,
A. Wlodawer, and J. Lubkowski. 2001. Structural basis for the activity and
substrate specificity of Erwinia chrysanthemi L-asparaginase.
Biochemistry, 40:5655-5664 |
|
| A. Wlodawer, M.
Li, Z. Dauter, A. Gustchina, K. Uchida, H. Oyama, B. M. Dunn, and K. Oda. 2001.
Carboxyl proteinase from Pseudomonas defines a novel family of subtilisin-like
enzymes. Nature Struct. Biol. 8:442-446. |
|
| M.
Jaskólski, M. Kozak, J. Lubkowski, G. Palm and A. Wlodawer. 2001.
Crystal structures of two highly homologous bacterial L-asparaginases: a case
of enantiomorphic space groups. Acta Crystallogr.,
D57:369-377. |
|
| A. Hofmann, A.
Zdanov, P. Genschik, S. Ruvinov, W. Filipowicz and A. Wlodawer. 2000. Structure
and mechanism of activity of the cyclic phosphodiesterase of Appr>p, a
product of tRNA splicing reaction. EMBO J., 19:6207-6217.
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|
| F. Yang, P.
Forrer, Z. Dauter, J.F. Conway, N. Cheng, M.E. Cerritelli, A.C. Steven, A.
Plückthun and A. Wlodawer. 2000. Novel fold and capsid-binding properties
of the lambda-phage display platform protein gpD. Nature Struct., Biol.
7:230-237. |
|
| M. Li, L.H.
Phylip, W.E. Lees, J.R. Winther, B.M. Dunn, A. Wlodawer, J. Kay and A.
Gustchina. 2000. The aspartic proteinase from S. cerevisiae folds its own
inhibitor into a helix. Nature Struct. Biol., 7:113-117.
|
|
| G.J. Palm, E.
Billy, W. Filipowicz and A. Wlodawer. 2000. Crystal structure of RNA
3'-terminal phosphate cyclase, an ubiquitous enzyme with unusual topology.
Structure, 8:13-23. |
|
| J. Wilken, D.
Hoover, D.A. Thompson, P.N. Barlow, H. McSparron, L. Picard, A. Wlodawer, J.
Lubkowski and S.B.H. Kent. 1999. Total chemical synthesis and high-resolution
crystal structure of the potent anti-HIV protein AOP-RANTES. Chemistry and
Biology, 6:43-51. |
|
| J. Lubkowski, Z.
Dauter, F. Yang, J. Alexandratos, G. Merkel, A.M. Skalka and A. Wlodawer. 1999.
Atomic resolution structures of the core domain of avian sarcoma virus
integrase and its D64N mutant. Biochemistry, 38:13512-13522
. |
|
| J. Kervinen,
G.J. Tobin, J. Costa, D.S. Waugh, A. Wlodawer, and A. Zdanov. 1999. Crystal
structure of plant aspartic proteinase prophytepsin: Inactivation and vacuolar
targeting., EMBO J., 18:3947-3955. |
|
| J. Lubkowski, F.
Hennecke, A. Plückthun, and A. Wlodawer. 1999. Filamentous-phage
infection: Crystal structure of g3p in complex with its coreceptor, the
C-terminal domain of TolA. Structure, 7:711-722. |
|
| F. Yang, C.A.
Bewley, J.M. Louis, K.R. Gustafson, M.R. Boyd, A.M. Gronenborn, G.M. Clore, and
A. Wlodawer. 1999. Crystal structure of cyanovirin-N, a potent HIV-inactivating
protein, shows unexpected domain swapping. J. Mol. Biol.,
288:401-412. |
|
| J. Lubkowski and
A. Wlodawer. 1999. Decamers observed in the crystals of bovine pancreatic
trypsin inhibitor. Acta Crystallogr., D55, 335-337. |
|
| J.K.M. Rao, G.
Bujacz, and A. Wlodawer. 1998. Crystal structure of rabbit muscle creatine
kinase. FEBS Lett., 439:133-137. |
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| REVIEWS AND
MONOGRAPHS: |
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| |
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| M. Chruszcz, A.
Wlodawer and W. Minor. 2008. Determination of protein structures - a series of
fortunate events. Biophys. J., 95, 1-9. |
|
| A. Zdanov and A.
Wlodawer. 2008. A new look at cytokine signaling. Cell 132,
179-181. |
|
| A. Wlodawer, W.
Minor, Z. Dauter, and M. Jaskolski. 2008. Protein crystallography for
non-crystallographers or how to get the best (but not more) from the published
macromolecular structures. FEBS J., 275, 1-21. |
|
| I. Botos and A.
Wlodawer. 2007. The expanding diversity of serine hydrolases. Curr. Opin.
Struct. Biol., 17, 683-690. |
|
| A. Wlodawer.
2007. Deposition of structural data redux. Acta Crystallogr. D63,
421-423. |
|
| N. E.
Ziólkowska and A. Wlodawer. 2006. Structural studies of algal lectins
with anti-HIV activity. Acta Biochim. Polon., 53,
617-626. |
|
| T. V. Rotanova,
I. Botos, E.E. Melnikov, F. Rasulova, A. Gustchina, M. R. Maurizi, and A.
Wlodawer. 2006. Slicing a protease: structural features of the ATP-dependent
Lon proteases gleaned from investigations of isolated domains. Protein
Sci. 15, 1815-1828 (2006). |
|
| N.
LaRonde-LeBlanc and A. Wlodawer. 2005. A family portrait of the RIO kinases.
J. Biol. Chem., 280, 37297-37300. |
|
| N.
LaRonde-LeBlanc and A. Wlodawer. 2005. The RIO kinases: An atypical protein
kinase family required for ribosome biogenesis and cell cycle progression.
Biochim. Biophys. Acta, 1754, 14-24. |
|
| A. Wlodawer.
2004. How to kill an enzyme (in more ways than one). Structure, 12,
1117-1119. |
|
| A. Zdanov. 2004.
Structural features of the Interleukin-10 family of cytokines. Current
Pharmaceutical Design, 10, 3873-3874. |
|
| J. Kervinen, A.
Wlodawer and A. Zdanov. 2004. Phytepsin. In Handbook of proteolytic
enzymes, 2nd Edition, A. J. Barrett, N. D. Rawlings and J. F.
Woessner, eds., Elsevier Ltd., London, England, pp. 77-84. |
|
| I. Botos and A.
Wlodawer. 2005. Proteins that bind high-mannose sugars of the HIV envelope.
Prog. Biophys. Molec. Biol., 88, 233-282. |
|
| I. Botos and A.
Wlodawer. 2003. Cyanovirin-N - a sugar-binding antiviral protein with a new
twist. Cell Mol Life Sci., 60, 277-87. |
|
| A. Wlodawer.
2002. Structure-based design of AIDS drugs and the development of resistance.
Vox Sang. 83 (Suppl. 1), 23-26. |
|
| B. M. Dunn, M.
M. Goodenow, A. Gustchina and A. Wlodawer. 2002. Retroviral proteases.
Genome Biology, 3, 3006.1-3006.7. |
|
| A. Wlodawer.
2002. Rational approach to AIDS drug design through structural biology. Ann.
Rev. Med., 53, 595-614. |
|
| Wlodawer, A.,
and A. Gustchina. 2000. Structural and biochemical studies of retroviral
proteases. Biochim. Biophys. Acta, 1477:16-34. |
|
| Wlodawer, A.,
and J. Vondrasek. 1998. Inhibitors of HIV-1 protease: A major success of
structure-assisted drug design. Annu. Rev. Biophys. Biomol. Struct.,
27:249-284. |
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| |
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| OLDER
PUBLICATIONS: |
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| |
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| Powell, D.J., D.
Bur, A. Wlodawer, A. Gustchina, B.M. Dunn, and J. Kay. 1998. The aspartic
proteinase from equine infectious anaemia virus. Adv. Exp. Med. Biol.,
436:41-45. |
|
| Dodson, G., and
A. Wlodawer. 1998. Catalytic triads and their relatives. Trends Biochem.
Sci., 23:347-352. |
|
| Alexandratos,
J., G. Bujacz, M. Jaskólski, A. Wlodawer, G. Merkel, R.A. Katz, and A.M.
Skalka. 1997. Crystal structure of avian sarcoma virus integrase with bound
essential cations. In Techniques in Protein Chemistry VIII (D.R.
Marshak, ed.), Academic Press, pp. 417-425. |
|
| Schalk-Hihi, C.,
J. Lubkowski, A. Zdanov, A. Wlodawer, A. Gustchina, G.S. Laco, and J.H. Elder.
1997. Structure of the D30N active site mutant of FIV proteinase complexed with
a statine-based inhibitor. In Techniques in Protein Chemistry VIII (D.R.
Marshak, ed.), Academic Press, pp. 643-654. |
|
| Vondrasek, J.,
and A. Wlodawer. 1997. Database of HIV proteinase structures. Trends
Biochem. Sci., 22:183. |
|
|
Hodge, C.N., T.P. Straatsma, J.A.
McCommon, and A. Wlodawer. 1997. Rational design of HIV protease inhibitors. In
Structural Biology of Viruses (W. Chiu, ed.), Oxford University Press.
|
|
| Vondrasek, J.,
and A. Wlodawer. 1997. Database of three-dimensional structures of HIV
proteinases. Nat. Struct. Biol., 4:8. |
|
| Bujacz, G., M.
Jaskólski, J. Alexandratos, A. Wlodawer, G. Merkel, R.A. Katz, and A.M.
Skalka. 1996. Crystal structure of the catalytic domain of avian sarcoma virus
integrase. In Techniques in Protein Chemistry VII (D.R. Marshak, ed.),
Academic Press, pp. 383-390. |
|
| Rao, J.K.M., M.
Gribskov, J. Lubkowski, M. Miller, A.L. Swain, and A. Wlodawer. 1996. A
comparison of the crystal structures of bacterial L-asparaginases. In
Techniques in Protein Chemistry VII (D.R. Marshak, ed.), Academic Press,
pp. 373-381. |
|
| Vondrasek, J.,
and A. Wlodawer. 1996. New database. Science, 272:337-338.
|
|
| Wlodawer, A.
1995. Inhibitor complexes of HIV-1 protease in AIDS. In Molecular Biology
and Biotechnology (R.A. Myers, ed.), VCH Publishers Inc., New York, NY, pp.
6-10. |
|
| Cameron, C.E.,
H. Burstein, D. Bizub-Bender, T. Ridky, I.T. Weber, A. Wlodawer, A.M. Skalka,
and J. Leis. 1995. Identification of amino acid residues of the retroviral
aspartic proteinases important for substrate specificity and catalytic
efficiency. Adv. Exp. Med. Biol., 362:399-406. |
|
| Wlodawer, A.
1995. Proteasome: A complex protease with a new fold and a distinct mechanism.
Structure, 3:417-420. |
|
|
Davies, D.R., and A. Wlodawer. 1995.
Cytokines and their receptor complexes. FASEB J., 9:50-56.
|
|
| Dunn, B.M., A.
Gustchina, A. Wlodawer, and J. Kay. 1994. Subsite preferences of retroviral
proteinases. Methods Enzymol., 241:254-278. |
|
| Wlodawer, A.,
and J.W. Erickson. 1993. Structure-based inhibitors of HIV-1 protease. Annu.
Rev. Biochem., 62:543-585. |
|
| Wlodawer, A.
1992. Inhibitor complexes of HIV-1 protease: A target for drug design. In
Proceedings of the Robert A. Welch Foundation Conference on Chemical
Research XXXV, Houston, TX, pp. 71-84. |
|
| Wlodawer, A.,
A.L. Swain, and A. Gustchina. 1992. Comparison of crystal structures of
inhibitor complexes of the human immunodeficiency virus protease. In
Molecular Aspects of Chemotherapy (D. Shugar, W. Rode, and E. Borowski,
eds.), Polish Scientific Publishers, pp. 173-186. |
|
| Sjölin, L.,
A. Wlodawer, G. Bergqvist, P. Holm, K. Loth, H. Malmstrom, J. Zaar, L.A.
Svensson, J. Dill, and G.L. Gilliland. 1992. Protein crystals grown on board
MASER-3 extend the ribonuclease-A structure to 1.06 Å resolution. In
SP-1132, Vol. 2, European Space Agency, pp. 92-103. |
|
| Swain, A., A.
Gustchina, and A. Wlodawer. 1992. Comparison of three inhibitor complexes of
human immunodeficiency virus protease. In Structure and Function of the
Aspartic Proteinase: Genetics, Structure, and Mechanisms (B. Dunn, ed.),
Plenum Press, New York, NY, pp. 433-441. |
|
| Wlodawer, A., M.
Miller, A. Swain, and M. Jaskólski. 1991. Structures of three inhibitor
complexes of HIV-1 proteases. In Methods in Protein Sequence Analysis
(H. Jornvall, J.-O. Hoog, and A.-M. Gustavsson, eds.), Birkhauser Verlag,
Basel, Switzerland, pp. 215-221. |
|
| Baldwin, E., J.
Sussman, R. St. Charles, and A. Wlodawer. 1991. Molecular replacement structure
solution of interleukin-8 using the NMR model. In Techniques in Protein
Chemistry II (J.J. Villafranca, ed.), Academic Press, San Diego, CA, pp.
347-356. |
|
| Sjölin, L.,
A. Wlodawer, G. Bergqvist, P. Holm, K. Loth, H. Malmstrom, J. Zaar, L.A.
Svensson, J. Dill, and G.L. Gilliland. 1991. Protein crystals grown aboard
MASER-3 extend the ribonuclease-A structure to 1.06 Å resolution. In
Structure, Mechanism, and Function of Ribonucleases (C.M. Cuchillo, R.
de Llorens, M.V. Nogues, and X. Pares, eds.), IBF Publications, Barcelona,
Spain, pp. 39-50. |
|
| Gustchina, A.,
I.T. Weber, and A. Wlodawer. 1991. Molecular modeling of HIV-2 protease. In
Structure and Function of the Aspartic Proteinases (B.M. Dunn, ed.),
Plenum Press, New York, NY, pp. 549-553. |
|
| Miller, M., A.L.
Swain, M. Jaskólski, B.K. Sathyanarayana, G.R. Marshall, D.H. Rich,
S.B.H. Kent, and A. Wlodawer. 1990. X-ray analysis of HIV-1 protease and its
complexes with inhibitors. In Retroviral Proteases: Control of Maturation
and Morphogenesis (L. Pearl, ed.), MacMillan Press, pp. 93-106.
|
|
| Erickson, J.,
J.K.M. Rao, C. Abad-Zapatero, and A. Wlodawer. 1989. Structural comparisons of
retroviral and eukaryotic aspartic proteinases. In Viral Proteinases as
Targets for Chemotherapy (H.-G. Krausslich, S. Oroszlan, and E. Wimmer,
eds.), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp.
191-210. |
|
| Miller, M., M.
Jaskólski, J.K.M. Rao, A. Wlodawer, and J. Leis. 1989. Preliminary
crystallographic investigation of a protease from Rous sarcoma virus. In
Proteases of Retroviruses (V. Kostka, ed.), Walter de Gruyter, West
Berlin, Germany, pp. 165-174. |
|
| Jaskólski, M., M. Miller, J.K.M. Rao, J. Leis, and A.
Wlodawer. 1989. Structure of the aspartic proteinase from Rous sarcoma
retrovirus at 2 Å resolution. In Viral Proteinases as Targets for
Chemotherapy (H.-G. Krausslich, S. Oroszlan, and E. Wimmer, eds.), Cold
Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 175-180.
|
|
| Foundling, S.I.,
F.R. Salemme, B. Korant, J.J. Wendoloski, P.C. Weber, A.C. Treharne, M.C.
Schadt, M. Jaskólski, M. Miller, A. Wlodawer, P. Strop, V. Kostka, J.
Sedlacek, and D.H. Ohlendorf. 1989. Crystal structure of a retroviral protease
from avian myeloblastosis associated virus. In Viral Proteinases as Targets
for Chemotherapy (H.-G. Krausslich, S. Oroszlan, and E. Wimmer, eds.), Cold
Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 181-190.
|
|
| Leis, J., D.
Bizub, I.T. Weber, C. Cameron, R. Katz, A. Wlodawer, and A.M. Skalka. 1989.
Structure-function analysis of retroviral aspartic protease. In Viral
Proteinases as Targets for Chemotherapy (H.-G. Krausslich, S. Oroszlan, and
E. Wimmer, eds.), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY,
pp. 235-243. |
|
| Nachman, J., M.
Miller, G.L. Gilliland, R. Carty, M. Pincus, and A. Wlodawer. 1989. Crystal
structure of two covalent nucleoside derivatives of ribonuclease A. In
Structure and Chemistry of Ribonucleases (A. Pavlovsky and K. Polyakov,
eds.), IUCR, Moscow, USSR, pp. 22-30. |
|
| Wlodawer, A.,
G.L. Gilliland, L. Sjölin, and L.A. Svensson. 1987. Crystal structure of
phosphate-free ribonuclease. In Protein Structure and Design, UCLA Symposia
on Molecular and Cellular Biology, New Series, Vol. 69, pp. 109-118.
|
|
| Harrison, R.W.,
I.T. Weber, H.L. Ammon, K.C. Murphy, A. Wlodawer, G.L. Gilliland, and J.
Roberts. 1987. Crystal structures of bacterial glutaminase–asparaginases.
In Protein Structure and Design, UCLA Symposia on Molecular and Cellular
Biology, New Series, Vol. 69, pp. 83-92. |
|
| Raghavan, N.V.,
and A. Wlodawer. 1987. Neutron crystallography of proteins. In Methods in
Experimental Physics: Neutron Scattering, Vol. 23 (K. Sköld and D.L.
Price, eds.), Academic Press, Orlando, FL, pp. 335-365. |
|
| Savage, H., and
A. Wlodawer. 1986. Determination of water structure around biomolecules using
X-ray and neutron diffraction methods. Methods Enzymol., 127:162-183.
|
|
| Wlodawer, A.
1985. Neutron diffraction: A facility for data collection and processing at the
National Bureau of Standards reactor. Methods Enzymol., 114:551-564.
|
|
| Wlodawer, A.
1984. Structure of bovine pancreatic ribonuclease. In Biological
Macromolecules and Assemblies, Vol. II: Nucleic Acids and Interactive
Proteins (A. McPherson and F. Jurnak, eds.), John Wiley, New York, NY, pp.
393-439. |
|
| Gunning, J., S.
Bedarkar, G.L. Taylor, J.M. Goodfellow, T.L. Blundell, A. Wlodawer, K.O.
Hodgson, E.M. Shooter, R. Fourme, B. Gaber, and R. Williams. 1982.
Conformational studies of polypeptide growth factors: IGF and NGF. Prog.
Clin. Biol. Res. 102A:221-230. |
|
| Wlodawer, A.
1982. Neutron diffraction of crystalline proteins. Prog. Biophys. Mol.
Biol., 40:115-159. |
|
| Phillips, J.C.,
A. Wlodawer, and K.O. Hodgson. 1976. On the application of synchrotron
radiation to X-ray diffraction: Polarization and anomalous scattering.
Stanford Synchrotron Radiation Project, SSRP-76/01, Stanford University,
Stanford, CA. |
|
| Lubas, B., A.
Blum, and A. Wlodawer. 1975. Fourier transform NMR spectroscopy and its
application in the studies of conformational changes of proteins with low
molecular weight. In Proceedings of the 8th Symposium on NMR
Applications, Cracow, Poland, pp. 185-198. |
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